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Autoimmune Diseases Affecting the Ocular Surface

  • Chapter
Ocular Surface Disease Medical and Surgical Management

Summary

The three autoimmune diseases discussed herein present a range of pathogenic mechanisms, and each produces devastating multifactorial ocular surface disease. Clinicians who care for such patients must remain mindful of the need to comprehensively treat all aspects of the disease processes in order to optimize rehabilitation of the ocular surface. Great strides have been made in our ability to intervene surgically to achieve a healthier ocular surface. Stem cell transplantation and amnioticmembrane grafting offer hope that many eyes previously considered lost may be rehabilitated. However, in treating ocular surface disease related to autoimmune systemic disease, timing is everything. In most patients, the primary immunologic process must be controlled before surgical intervention may be reasonably attempted. There are few experiences more disheartening than watching an excellent surgical outcome following a delicate stem cell graft destroyed within days in the face of uncontrolled inflammation. Future advances in our ability to modulate the immunopathophysiologic process will facilitate better success in the restoration of vision to these severely diseased eyes.

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Tauber, J. (2002). Autoimmune Diseases Affecting the Ocular Surface. In: Ocular Surface Disease Medical and Surgical Management. Springer, New York, NY. https://doi.org/10.1007/0-387-21570-0_9

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