Anatomy and Pathophysiology of Intervertebral Discs

  • Sohail K. Mirza


The intervertebral disc is considered to be the primary focus of pathology for the majority of patients with low back pain. The structure of the disc has been well described in the literature. The metabolism and nutrition of the intervertebral disc remain unclear. Physicochemical changes in disc tissue with mechanical loading and aging have been identified to a limited extent. Innervation of the normal and abnormal disc and neurochemical changes within the disc in pathologic conditions are the focus of current investigations. The mechanism of pain generation and the pathway of pain conduction in low back pain and sciatica, however, are not known.


Nerve Root Intervertebral Disc Nucleus Pulposus Disc Herniation Disc Degeneration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag New York, Inc. 2003

Authors and Affiliations

  • Sohail K. Mirza

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