Skip to main content

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

  • 409 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bhandari, N., Sylvester, S. L. et al. (1996). Source Book of Substance Abuse and Addiction.

    Google Scholar 

  2. Hiemke, C., Stolp, M. et al. (1996). Expression of alpha subunit genes of nicotinic acetylcholine receptors in human lymphocytes. Neurosci. Lett. 214(2–3):171–174.

    Article  PubMed  CAS  Google Scholar 

  3. Baron, J. A. (1996). Beneficial effects of nicotine and cigarette smoking: The real, the possible and the spurious. Br. Med. Bull. 52(1):58–73.

    PubMed  CAS  Google Scholar 

  4. Cinciripini, P. M., Hecht, S. S. et al. (1997). Tobacco addiction: Implications for treatment and cancer prevention. J. Natl. Cancer. Inst. 89(24):1852–1867.

    Article  PubMed  CAS  Google Scholar 

  5. Domino, E. F. (1998). Tobacco smoking and nicotine neuropsychopharmacology: Some future research directions. Neuropsychopharmacology 18(6):456–468.

    Article  PubMed  CAS  Google Scholar 

  6. Gorell, J. M., Rybicki, B. A. et al. (1999). Smoking and Parkinson’s disease: A dose-response relationship. Neurology 52(1):115–119.

    PubMed  CAS  Google Scholar 

  7. Hughes, J. R., Goldstein, M. G. et al. (1999). Recent advances in the pharmacotherapy of smoking. JAMA 281(1):72–76.

    Article  PubMed  CAS  Google Scholar 

  8. Miller, K., Hudspith, B. et al. (1996). Effect of cigarette smoke exposure on biomarkers of lung injury in the rat. Inhalation Toxicol. 8:803–817.

    Article  CAS  Google Scholar 

  9. Hoffmann, D., Djordjevic, M. V. et al. (1997). The changing cigarette. Prev. Med. 26(4):427–434.

    Article  PubMed  CAS  Google Scholar 

  10. Prokopczyk, B., Cox, J. E. et al. (1997). Identification of tobacco-specific carcinogen in the cervical mucus of smokers and nonsmokers. J. Natl. Cancer. Inst. 89(12):868–873.

    Article  PubMed  CAS  Google Scholar 

  11. Chowdhury, P., Doi, R., et al. (1993). Tissue distribution of [3H]-nicotine in rats. Biomed. Environ. Sci. 6(1):59–64.

    PubMed  CAS  Google Scholar 

  12. Henningfield, J. E., Stapleton, J. M., et al. (1993). Higher levels of nicotine in arterial than in venous blood after cigarette smoking. Drug Alcohol Depend. 33(1):23–29.

    Article  PubMed  CAS  Google Scholar 

  13. Benowitz, N. (1996). Pharmacology of nicotine: Addiction and therapeutics. Annu. Rev. Pharmacol. Toxicol. 36: 597–613.

    Article  PubMed  CAS  Google Scholar 

  14. Heller, J. and Taylor, P. (1996). Goodman and Gilman’s The Pharmological Basis of Therapeutics, McGraw-Hill, New York.

    Google Scholar 

  15. Benowitz, N. L. (1997). Systemic absorption and effects of nicotine from smokeless tobacco. Adv. Dent. Res. 11(3):336–341.

    PubMed  CAS  Google Scholar 

  16. Warpman, U., Friberg, L. et al. (1998). Regulation of nicotinic receptor subtypes following chronic nicotinic agonist exposure in M10 and SH-SY5Y neuroblastoma cells. J. Neurochem. 70(5):2028–2037.

    Article  PubMed  CAS  Google Scholar 

  17. Rosecrans, J. A. and Karin, L. D. (1998). Effects of nicotine on the hypothalamic-pituitaryaxis (HPA) and immune function: Introduction to the Sixth Nicotine Round Table Satellite, American Society of Addiction Medicine Nicotine Dependence Meeting, November 15, 1997. Psychoneuroendocrinology 23(2):95–102.

    Article  PubMed  CAS  Google Scholar 

  18. Nordberg, A., Fuxe, K., Holmstedt, B., and Sundwall, A. (eds) (1989). Nicotinic Receptors in the CNSU—Their Role in Synaptic Transmission, Progress in Brain Research. Elsevier, Amsterdam.

    Google Scholar 

  19. Rinne, J. O., Myllykyla, T. et al. (1991). A postmortem study of brain nicotinic receptors in Parkinson’s and Alzheimer’s disease. Brain Res. 547(1):167–170.

    Article  PubMed  CAS  Google Scholar 

  20. Yamamura, M., Amano, Y. et al. (1998). Calcium mobilization during nicotine-induced cell death in human glioma and glioblastoma cell lines. Anticancer Res. 18(4A):2499–2502.

    PubMed  CAS  Google Scholar 

  21. Sopori, M. L. and Kozak, W. (1998). Immunomodulatory effects of cigarette smoke. J. Neuroimmunol. 83(1–2):148–156.

    Article  PubMed  CAS  Google Scholar 

  22. Sopori, M. L., Kozak, W. et al. (1998). Nicotine-induced modulation of T Cell function. Implications for inflammation and infection. Adv. Exp. Med. Biol. 437:279–289.

    PubMed  CAS  Google Scholar 

  23. Aoshiba, K., Nagai, A. et al. (1996). Nicotine prolongs neutrophil survival by suppressing apoptosis. J. Lab. Clin. Med. 127(2):186–194.

    Article  PubMed  CAS  Google Scholar 

  24. Wecker, L. and Yu, Z. J. (1995). Function of nicotinic receptors in the CNS. In T.W. Stone (ed.), CNS Neurotransmitters and Neuromodulators—acetylcholine, CRC Press, Boca Raton, FL, pp. 105–113.

    Google Scholar 

  25. Whiting, P. and Lindstrom, J. (1986). Pharmacological properties of immuno-isolated neuronal nicotinic receptors. J. Neurosci. 6(10):3061–3069.

    PubMed  CAS  Google Scholar 

  26. Maslinski, W., Laskowska-Bozek, H. et al. (1992). Nicotinic receptors of rat lymphocytes during adjuvant polyarthritis. J. Neurosci. Res. 31(2):336–340.

    Article  PubMed  CAS  Google Scholar 

  27. Ashakumary, L. and Vijayammal, P. L. (1997). Effect of nicotine on lipoprotein metabolism in rats. Lipids 32(3):311–315.

    PubMed  CAS  Google Scholar 

  28. Davies, B. D., Hoss, W. et al. (1982). Evidence for a noncholinergic nicotine receptor on human phagocytic leukocytes. Mol. Cell. Biochem. 44(1):23–31.

    Article  PubMed  CAS  Google Scholar 

  29. Adem, A., Nordberg, A. et al. (1986). Extraneural cholinergic markers in Alzheimer’s and Parkinson’s disease. Prog. Neuropsychopharmacol. Biol. Psychiatry 10(3–5):247–257.

    Article  PubMed  CAS  Google Scholar 

  30. Sato, K. Z., Fujii, T. et al. (1999). Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines. Neurosci. Lett. 266(1):17–20.

    Article  PubMed  CAS  Google Scholar 

  31. Geng, Y., Savage, S. M. et al. (1995). Effects of nicotine on the immune response. I. Chronic exposure to nicotine impairs antigen receptor-mediated signal transduction in lymphocytes. Toxicol. Appl. Pharmacol. 135(2):268–278.

    Article  PubMed  CAS  Google Scholar 

  32. Laskowska-Bozek, H., Bany, U. et al. (1996). Effect of cholinergic stimulation on free intracellular Ca2+ concentration in human lymphocytes. Neuroimmunomodulation 3(4):247–253.

    Article  PubMed  CAS  Google Scholar 

  33. Zhang, S. and Petro, Thomas M. (1996). The effect of nicotine on murine CD4 T cell responses. Int. J. Immunopharmacol. 18:467–478.

    Article  PubMed  CAS  Google Scholar 

  34. Carlson, N. G., Wieggel, W. A. et al. (1999). Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways. J. Immunol. 163(7):3963–3968.

    PubMed  CAS  Google Scholar 

  35. Hallquist, N., Hakki, A. et al. (2000). Differential effects of nicotine and aging on splenocyte proliferation and the production of Th1-versus Th2-type cytokines. Proc. Soc. Exp. Biol. Med. 224(3):141–146.

    Article  PubMed  CAS  Google Scholar 

  36. Madretsma, S., Wolters, L. M. et al. (1996). In-vivo effect of nicotine on cytokine production by human non-adherent mononuclear cells. Eur. J. Gastroenterol. Hepatol. 8(10):1017–1020.

    PubMed  CAS  Google Scholar 

  37. Hakki, A., Hallquist, N. et al. (2000). Differential impact of nicotine on cellular proliferation and cytokine production by LPS-stimulated murine splenocytes. Int. J. Immunopharmacol. 22(6):403–410.

    Article  PubMed  CAS  Google Scholar 

  38. Madretsma, G. S., Donze, G. J. et al. (1996). Nicotine inhibits the in vitro production of interleukin 2 and tumour necrosis factor-alpha by human mononuclear cells. Immunopharmacology 35(1):47–51.

    Article  PubMed  CAS  Google Scholar 

  39. Hockertz, S., Emmendorffer, A. et al. (1994). Acute effects of smoking and high experimental exposure to environmental tobacco smoke (ETS) on the immune system. Cell Biol. Toxico. 10.

    Google Scholar 

  40. Cohen, J. J., Duke, R. C. et al. (1992). Apoptosis and programmed cell death in immunity. Annu. Rev. Immunol. 10:267–293.

    Article  PubMed  CAS  Google Scholar 

  41. Aggarwal, S. and Gupta, S. (1998). Increased apoptosis of T cell subsets in aging humans: Altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax. J. Immunol. 160(4):1627–1637.

    PubMed  CAS  Google Scholar 

  42. Kerr, J. F., Wyllie, A. H. et al. (1972). Apoptosis: A basic biological phenomenon with wideranging implications in tissue kinetics. Br. J. Cancer 26(4):239–257.

    PubMed  CAS  Google Scholar 

  43. Martin, S. J. and D. R. Green (1995). Apoptosis and cancer: The failure of controls on cell death and cell survival. Crit. Rev. Oncol. Hematol. 18(2):137–153.

    PubMed  CAS  Google Scholar 

  44. Martin, S. J. and D. R. Green (1995). Protease activation during apoptosis: Death by a thousand cuts? Cell 82(3):349–352.

    Article  PubMed  CAS  Google Scholar 

  45. Biola, A., Andreau, K. et al. (2000). The glucocorticoid receptor and STAT6 physically and functionally interact in T-lymphocytes. FEBS Lett. 487(2):229–233.

    Article  PubMed  CAS  Google Scholar 

  46. Planey, S. L. and Litwack G., (2000). Glucocorticoid-induced apoptosis in lymphocytes [In Process Citation]. Biochem. Biophys. Res. Commun. 279(2):307–312.

    Article  PubMed  CAS  Google Scholar 

  47. Woronicz, J., Calnan, B. et al. (1995). Death genes in T cells. Curr. Top. Microbiol. Immunol. 200:137–46.

    PubMed  CAS  Google Scholar 

  48. Wright, S. C., Zhong, J. et al. (1994). Inhibition of apoptosis as a mechanism of tumor promotion. FASEB J. 8(9):654–660.

    PubMed  CAS  Google Scholar 

  49. Allen, R. T., Cluck, M. W. et al. (1998). Mechanisms controlling cellular suicide: Role of Bcl-2 and caspases. Cell Mol. Life Sci. 54(5):427–445.

    Article  PubMed  CAS  Google Scholar 

  50. Lorenzen, J., Thiele, J. et al. (1997). The mummified Hodgkin cell: Cell death in Hodgkin’s disease. J. Pathol. 182(3):288–298.

    Article  PubMed  CAS  Google Scholar 

  51. Kitamura, Y., Shimohama, S. et al. (1998). Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer’s disease. Brain Res. 780(2):260–269.

    Article  PubMed  CAS  Google Scholar 

  52. Williams, G. T. (1991). Programmed cell death: Apoptosis and oncogenesis. Cell 65:1097–1098.

    Article  PubMed  CAS  Google Scholar 

  53. Volm, M. and Koomagi, R. (1999). The implications of proliferation and apoptosis for lung cancer metastasis. Oncol. Rep. 6(2):373–376.

    PubMed  CAS  Google Scholar 

  54. Kawiak, J., Hoser, G. et al. (1998). Apoptosis and some of its medical implications. Folia Histochem. Cytobiol. 36(3):99–110.

    PubMed  CAS  Google Scholar 

  55. Calderon, T. M., Factor, S. M. et al. (1994). An endothelial cell adhesion protein for monocytes recognized by monoclonal antibody IG9. Expression in vivo in inflamed human vessels and atherosclerotic human and Watanabe rabbit vessels. Lab. Invest. 70(6):836–849.

    PubMed  CAS  Google Scholar 

  56. Wick, G., Schett, G. et al. (1995). Is atherosclerosis an immunologically mediated disease? Immunol. Today 16(1):27–33.

    Article  PubMed  CAS  Google Scholar 

  57. Wick, G., Perschinka, H. et al. (1999). Autoimmunity and atherosclerosis. Am. Heart J. 138(5 Pt 2):444–449.

    Article  Google Scholar 

  58. Owasoyo, J. O., Jay, M. et al. (1988). Impact of nicotine on myocardial neutrophil uptake. Toxicol. Appl. Pharmacol. 92(1):86–94.

    Article  PubMed  CAS  Google Scholar 

  59. Cluette-Brown, J., Mulligan, J. et al. (1986). Oral nicotine induces an atherogenic lipoprotein profile. Proc. Soc. Exp. Biol. Med. 182(3):409–413.

    PubMed  CAS  Google Scholar 

  60. Powell, J. T. (1998). Vascular damage from smoking: Disease mechanisms at the arterial wall. Vasc. Med. 3(1):21–28.

    Article  PubMed  CAS  Google Scholar 

  61. Carty, C. S., Soloway, P. D. et al. (1996). Nicotine and cotinine stimulate secretion of basic fibroblast growth factor and affect expression of matrix metalloproteinases in cultured human smooth muscle cells (published erratum appears in J. Vasc. Surg. 1997 Apr, 25(4):628). J. Vasc. Surg. 24(6):927–934; discussion 934–935.

    Google Scholar 

  62. Hoffmann, D., Hecht, S. S. et al. (1983). Tumor promoters and cocarcinogens in tobacco carcinogenesis. Environ. Health Perspect. 50:247–257.

    PubMed  CAS  Google Scholar 

  63. Mathur, R. S., Mathur, S. P. et al. (2000). Up-regulation of epidermal growth factor-receptors (EGF-R) by nicotine in cervical cancer cell lines: This effect may be mediated by EGF [In Process Citation]. Am. J. Reprod. Immunol. 44(2):114–120.

    Article  PubMed  CAS  Google Scholar 

  64. Chowdhury, P., Rayford, P. L. et al. (1998). Pathophysiological effects of nicotine on the pancreas. Proc. Soc. Exp. Biol. Med. 218(3):168–173.

    PubMed  CAS  Google Scholar 

  65. Chowdhury, P. and Rayford, P. L., (2000). Smoking and pancreatic disorders [In Process Citation]. Eur. J. Gastroenterol. Hepatol. 12(8):869–877.

    Article  PubMed  CAS  Google Scholar 

  66. Maneckjee, R. and Minna, J. D. (1994). Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. Cell Growth Differ. 5(10):1033–1040.

    PubMed  CAS  Google Scholar 

  67. Quik, M., Chan, J. et al. (1994). Alpha-Bungarotoxin blocks the nicotinic receptor mediated increase in cell number in a neuroendocrine cell line. Brain Res. 655(1–2):161–167.

    Article  PubMed  CAS  Google Scholar 

  68. Pratesi, G., Cervi, S. et al. (1996). Effect of serotonin and nicotine on the growth of a human small cell lung cancer xenograft. Anticancer Res. 16(6B):3615–3619.

    PubMed  CAS  Google Scholar 

  69. Cattaneo, M. G., D’Atri, F. et al. (1997). Mechanisms of mitogen-activated protein kinase activation by nicotine in small-cell lung carcinoma cells. Biochem. J. 328(Pt 2):499–503.

    PubMed  CAS  Google Scholar 

  70. Wright, S. C., Zhong, J. et al. (1993). Nicotine inhibition of apoptosis suggests a role in tumor promotion. FASEB J 7(11):1045–1051.

    PubMed  CAS  Google Scholar 

  71. Plummer, H. K., 3rd, Sheppard, B. J. et al. (2000). Interaction of tobacco-specific toxicants with nicotinic cholinergic regulation of fetal pulmonary neuroendocrine cells: Implications for pediatric lung disease [In Process Citation]. Exp. Lung. Res. 26(2):121–135.

    Article  PubMed  CAS  Google Scholar 

  72. Rakowicz-Szulczynska, E. M., McIntosh, D. G. et al. (1994). Growth factor-mediated mechanisms of nicotine-dependent carcinogenesis. Carcinogenesis 15(9):1839–1846.

    PubMed  CAS  Google Scholar 

  73. Waggoner, S. E. and Wang, X. (1994). Effect of nicotine on proliferation of normal, malignant, and human papillomavirus-transformed human cervical cells. Gynecol. Oncol. 55(1):91–95.

    Article  PubMed  CAS  Google Scholar 

  74. West, K. A., Brognard, J. et al. (2003). Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. J. Clin. Invest. 111(1):81–90.

    Article  PubMed  CAS  Google Scholar 

  75. Ye, Y. N., Liu, E. S. et al. (2003). Nicotine promoted colon cancer growth via EGFR, c-Src and 5-Lipoxygenase mediated signal pathway. J. Pharmacol. Exp. Ther. 20:20.

    Google Scholar 

  76. Waldum, H. L., Nilsen, O. G. et al. (1996). Long-term effects of inhaled nicotine. Life Sci. 58(16):1339–1346.

    Article  PubMed  CAS  Google Scholar 

  77. Meliska, C. J., Stunkard, M. E. et al. (1995). Immune function in cigarette smokers who quit smoking for 31 days. J. Allergy Clin. Immunol. 95(4):901–910.

    Article  PubMed  CAS  Google Scholar 

  78. Qandil, R., Sandhu, H. S. et al. (1997). Tobacco smoking and periodontal diseases. J. Can. Dent. Assoc. 63(3):187–192, 194–195.

    PubMed  CAS  Google Scholar 

  79. Tang, K., Wu, H. et al. (1998). A crucial role for the mitogen-activated protein kinase pathway in nicotinic cholinergic signaling to secretory protein transcription in pheochromocytoma cells. Mol. Pharmacol. 54(1):59–69.

    PubMed  CAS  Google Scholar 

  80. Heusch, W. L. and Maneckjee, R. (1998). Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells. Carcinogenesis 19(4):551–556.

    Article  PubMed  CAS  Google Scholar 

  81. Yoshida, H., Sakagami, H. et al. (1998). Induction of DNA fragmentation by nicotine in human myelogenous leukemic cell lines. Anticancer Res. 18(4A):2507–2511.

    PubMed  CAS  Google Scholar 

  82. Hakki, A., Pennypacker, K. et al. (2001). Nicotine inhibition of apoptosis in murine immune cells. Exp. Biol. Med. (Maywood) 226(10):947–953.

    CAS  Google Scholar 

  83. Hakki, A., Friedman, H. et al. (2002). Nicotine modulation of apoptosis in human coronary artery endothelial cells. Int. Immunopharmacol. 2(10):1403–1409.

    Article  PubMed  CAS  Google Scholar 

  84. Pugh, P. C. and Margiotta, J. F., (2000). Nicotinic acetylcholine receptor agonists promote survival and reduce apoptosis of chick ciliary ganglion neurons. Mol. Cell. Neurosci. 15(2):113–122.

    Article  PubMed  CAS  Google Scholar 

  85. Fuchs, B. A. and Pruett, S. B. (1993). Morphine induces apoptosis in murine thymocytes in vivo but not in vitro: Involvement of both opiate and glucocorticoid receptors. J. Pharmacol. Exp. Ther. 266(1):417–423.

    PubMed  CAS  Google Scholar 

  86. Nair, M. P., Schwartz, S. A. et al. (1997). Immunoregulatory effects of morphine on human lymphocytes. Clin. Diagn. Lab. Immunol. 4(2): 127–132.

    PubMed  CAS  Google Scholar 

  87. Sharp, B. M., Roy, S. et al. (1998). Evidence for opioid receptors on cells involved in host defense and the immune system. J. Neuroimmunol. 83(1–2):45–56.

    Article  PubMed  CAS  Google Scholar 

  88. Berger, F., Gage, F. H. et al. (1998). Nicotinic receptor-induced apoptotic cell death of hippocampal progenitor cells. J. Neurosci. 18(17):6871–6881.

    PubMed  CAS  Google Scholar 

  89. Matsunaga, K., Klein, T. W. et al. (2001). Involvement of nicotinic acetylcholine receptors in suppression of antimicrobial activity and cytokine responses of alveolar macrophages to Legionella pneumophila infection by nicotine. J. Immunol. 167(11):6518–6524.

    PubMed  CAS  Google Scholar 

  90. Yamaguchi, H., Friedman, H. et al. (2003). Involvement of nicotinic acetylcholine receptors in controlling Chlamydia pneumoniae growth in epithelial HEp-2 cells. Infect. Immun. 71(6):3645–3647.

    Article  PubMed  CAS  Google Scholar 

  91. Myles, M. E., Alack, C. et al. (2003). Nicotine applied by transdermal patch induced HSV-1 reactivation and ocular shedding in latently infected rabbits. J. Ocul. Pharmacol. Ther. 19(2):121–133.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer Science+Business Media, Inc.

About this chapter

Cite this chapter

Pross, S., Friedman, H. (2005). Nicotine and Immunity. In: Friedman, H., Klein, T.W., Bendinelli, M. (eds) Infectious Diseases and Substance Abuse. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/0-306-48688-1_6

Download citation

Publish with us

Policies and ethics