Skip to main content

Legionella Infection and Cannabinoids

  • Chapter
Infectious Diseases and Substance Abuse

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

  • 409 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Blanchard, D. K., Friedman, H., Stewart, II, W. E., Klein, T. W., and Djeu, J. Y. (1988). Role of γ-interferon in induction of natural killer activity by Legionella pneumophila in vitro and in an experimental murine infection model. Infect. Immun. 56:1187–1193.

    PubMed  CAS  Google Scholar 

  2. Friedman, H., Widen, R., Klein, T., and Johnson, W. (1984). Immunostimulation by Legionella pneumophila antigen preparations in vivo and in vitro. Infect. Immun. 43:347–352.

    PubMed  CAS  Google Scholar 

  3. Yamamoto, Y., Klein, T. W., Newton, C. A., and Friedman, H. (1992). Differing macrophage and lymphocyte roles in resistance to Legionella pneumophila infection. J. Immunol. 148:584–589.

    PubMed  CAS  Google Scholar 

  4. Blanchard, D. K., Newton, C., Klein, T. W., Stewart II, W. E., and Friedman, H. (1986). In vitro and in vivo suppressive effects of Δ9-tetrahydrocannabinol on interferon production by murine spleen cells. Intl. J. Immunopharmacol. 8:819–824.

    Article  CAS  Google Scholar 

  5. Klein, T. W., Newton, C., Larsen, K., Chou, J., Perkins, I., Lu, L. et al. (1993). Cannabinoid receptors and T helper cells. J. Neuroimmunol. 147:91–94. 2004.

    Article  CAS  Google Scholar 

  6. Newton, C. A., Klein, T. W., and Friedman, H. (1994). Secondary immunity to Legionella pneumophila and Th1 activity are suppressed by delta-9-tetrahydrocannabinol injection. Infect. Immun. 62:4015–4020.

    PubMed  CAS  Google Scholar 

  7. Klein, T. W., Lane, B., Newton, C. A., and Friedman, H. (2000). The cannabinoid system and cytokine network. Proc. Soc. Exp. Biol. Med. 225:1–8.

    Article  PubMed  CAS  Google Scholar 

  8. Bradley, S. G., Munston, A. E., Dewey, W. L., and Harris, L. S. (1977). Enhanced susceptibility of mice to combinations of Δ9-tetrahydrocannabinol and live or killed gram-negative bacteria. Infect. Immun. 17:325–329.

    PubMed  CAS  Google Scholar 

  9. Cabral, G. A., Lockmuller, J. C., and Mishkin, E. M. (1986). Δ9-Tetrahydrocannabinol decreases α/β-interferon response to herpes simplex virus type 2 in the B6C3F1 mouse. Proc. Soc. Exp. Biol. Med. 181:305–311.

    PubMed  CAS  Google Scholar 

  10. Cabral, G. A., Mishkin, E. M., Marciano-Cabral, F., Coleman, P., Harris, L., and Munson, A. E. (1986). Effect of Δ9-tetrahydrocannabinol on herpes simplex virus type 2 vaginal infection in the guinea pig. Proc. Soc. Exp. Biol. Med. 182:181–186.

    PubMed  CAS  Google Scholar 

  11. Cabral, G. and Dove Pettit, D. (1998). Drugs and immunity: Cannabinoids and their role in decreased resistance to infectious diseases. J. Neuroimmunol. 83:116–123.

    Article  PubMed  CAS  Google Scholar 

  12. Juel-Jensen, B. E. (1972). Cannabis and recurrent herpes simplex. Br. Med. J. 4:296.

    Article  PubMed  CAS  Google Scholar 

  13. Morahan, P. S., Klykken, P. C., Smith, S. H., Harris, L. S., and Munson, A. E. (1979). Effects of cannabinoids on host resistance to Listeria monocytogenes and herpes simplex virus. Infect. Immun. 23:670–674.

    PubMed  CAS  Google Scholar 

  14. Specter, S., Lancz, G., Westrich, G., and Friedman, H. (1991). Delta-9-tetrahydrocannabinol augments murine retroviral induced immunosuppression and infection. Int. J. Immunopharmacol. 13:411–417.

    Article  PubMed  CAS  Google Scholar 

  15. Friedman, H., Klein, T., and Specter, S. (1991). Immunosuppression by marijuana and components. In R. Ader, D. L. Felten, and H. Cohen (eds), Psychoneuroimmunology, 2nd edn. Academic Press, New York, pp. 931–953.

    Google Scholar 

  16. Friedman, H., Shivers, S., and Klein, T. W. (1994). Drugs of abuse and the immune system. In J. Dean, M. Luster, A. Munson, and I. Kimber (eds), Immunotoxicology Immunopharmacology, 2nd edn. Raven Press, New York, pp. 303–322.

    Google Scholar 

  17. Klein, T. W., Newton, C., Widen, R., and Friedman, H. (1993). Δ9-tetrahydrocannabinol injection induces cytokine-mediated mortality of mice infected with Legionella pneumophila. J. Pharmacol. Exp. Ther. 267:635–640.

    PubMed  CAS  Google Scholar 

  18. Klein, T. W., Newton, C., and Friedman, H. (1994). Resistance to Legionella pneumophila suppressed by the marijuana component, tetrahydrocannabinol. J. Infect. Dis. 169:1177–1179.

    PubMed  CAS  Google Scholar 

  19. Klein, T. W., Newton, C. A. and Friedman, H. (2001). Cannabinoid and the immune system. Pain Res. Manage. 6:95–101.

    CAS  Google Scholar 

  20. Huber, G. L., Simmons, G. A., McCarthy, C. R., Cutting, M. B., Laguarda, R., and Pereira, W. (1975). Depressant effect of marijuana smoke on antibacterial activity of pulmonary alveolar macrophages. Chest 68:769–773.

    PubMed  CAS  Google Scholar 

  21. Mann, P. E. G., Cohen, A. B., Finley, T. N., and Ladman, A. L. (1971). Alveolar macrophages: Structural and functional differences between nonsmokers and smokers of marijuana and tobacco. Lab. Invest. 25:111–120.

    PubMed  CAS  Google Scholar 

  22. Klein, T., Friedman, H., and Specter, S. (1998). Marijuana immunity and infection. J. Neuroimmunol. 83:102–115.

    Article  PubMed  CAS  Google Scholar 

  23. Lopez-Cepero, M., Friedman, M., Klein, T., and Friedman, H. (1986). Tetrahydrocannabinol-induced suppression of macrophage spreading and phagocytic activity in vitro. J. Leukoc. Biol. 39:679–686.

    PubMed  CAS  Google Scholar 

  24. Rachelefsky, G. S., Opelz, G., Mickey, M. R., Lessin, P., Kiuch, M., Silverstein, M. J. et al. (1976). Humoral and cell-mediated immunity in chronic marijuana smoking. J. Allergy Clin. Immunol. 58:483–490.

    Article  PubMed  CAS  Google Scholar 

  25. Raz, A. and Goldman, R. (1976). Effect of hashish compounds on mouse peritoneal macrophages. Lab. Invest. 34:69–76.

    PubMed  CAS  Google Scholar 

  26. Zimmerman, S., Zimmerman, A., M., Cameron, I. L., and Laurence, H. L. (1977). Δ1-Tetrahydrocannabinol, cannabidiol, and cannabinol effects on immune response of mice. Pharmacology. 15:10–23.

    Article  PubMed  CAS  Google Scholar 

  27. Specter, S., Lancz, G., and Friedman, H. (1990). Marijuana and immunosuppression in man. In R.R. Watson (ed.), Drugs of Abuse and Immune Function, CRC Press, Boca Raton, FL, pp. 73–85.

    Google Scholar 

  28. Pross, S., Klein, T., Newton, C., and Friedman, H. (1987). Differential effects of marijuana components on proliferation of spleen, lymph node and thymus cells. Int. J. Immunopharmacol. 9:363–370.

    Article  PubMed  CAS  Google Scholar 

  29. Klein, T., Newton, C., and Friedman, H. (1998). Cannabinoid receptors and immunity. Immunol. Today 19:373–381.

    Article  PubMed  CAS  Google Scholar 

  30. Klein, T. W., Newton, C. A., Nakachi, H., and Friedman, H. (2000). Δ9-Tetrahydrocannabinol treatment suppresses immunity and early IFN-γ, IL-12, and IL-12 receptor β2 responses to Legionella pneumophila infection. J. Immunol. 164:6461–6466.

    PubMed  CAS  Google Scholar 

  31. Yuan, M., Kiertscher, S. M., Cheng, Q., Zoumalan, R., Tashkin, D. P., and Roth, M. D. (2002). Δ9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells. J. Neuroimmunol. 133:124–131.

    Article  PubMed  CAS  Google Scholar 

  32. Zhu, L. X., Sharma, S., Stolina, M., Gardner, B., Roth, M. D., Tashkin, D. P. et al. (2000). Δ9-Tetrahydrocannabinol inhibits antitumor immunity by a CB2 receptor-mediated, cytokine-dependent pathway. J. Immunol. 165:373–380.

    PubMed  CAS  Google Scholar 

  33. Munro, S., Thomas, K. L., and Abu-Shaar, M. (1993). Molecular characterization of a peripheral receptor for cannabinoids. Nature 365:61–65.

    Article  PubMed  CAS  Google Scholar 

  34. Shire, D., Calandra, B., Rinaldi-Carmona, M., Oustric, D., Pesegue, B., Bonnin-Cabanne, O. et al. (1996). Molecular cloning, expression, and function of the murine CB2 peripheral cannabinoid receptor. Biochim. Biophys. Acta 1307:132–136.

    PubMed  Google Scholar 

  35. Moser, M. and Murphy, K. (2000). Dendritic cell regulation of Th1-Th2 development. Nat. Immunol. 1:199–205.

    Article  PubMed  CAS  Google Scholar 

  36. Ouyang, W., Ranganath, S. H., Weindel, K., Bhattacharya, D., Murphy, T. L., Sha, W. C. et al. (1998). Inhibition of Th1 development mediated by GATA 3 through an IL-4-independent mechanism. Immunity 9:745–755.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer Science+Business Media, Inc.

About this chapter

Cite this chapter

Friedman, H., Newton, C., Klein, T.W. (2005). Legionella Infection and Cannabinoids. In: Friedman, H., Klein, T.W., Bendinelli, M. (eds) Infectious Diseases and Substance Abuse. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/0-306-48688-1_5

Download citation

Publish with us

Policies and ethics