Conclusions
In the past two decades solid state NMR has exploded from its humble beginnings into a formidable methodology with enormous potential and flexibility. With giant leaps continuing to be made in both hardware and computational aspects of the technique as well as continual development of increasingly complex pulse sequences, solid state NMR will continue to provide a unique insight into the structure and behaviour of important biological molecules and their association with cell membranes.
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References
Gawrisch, K. and Koenig, B. W., 2002, Lipid-peptide interaction investigated by NMR. Current Topics in Membranes 52: 163–190.
Drechsler, A. and Separovic, F., 2003, Solid-state NMR structure determination. IUBMB Life, 55: 515–523.
Thompson, L. K., 2002, Solid-state NMR studies of the structure and mechanisms of proteins. Current Opinions in Structural Biology 12: 661–669.
Bechinger, B., 1999, The structure, dynamics and orientation of antimicrobial peptides in membranes by multidimensional solid-state NMR spectroscopy. Biochim. Biophys. Acta 1642: 157–183.
Marassi, F. M., 2002, NMR of peptides and proteins in oriented membranes. Concepts in Magnetic Resonance 14: 212–224.
Lam, Y-H, Wassall, S. R., Morton, C. J., Smith, R. & Separovic, F., 2001, Solid-state NMR structure determination of melittin in a lipid environment. Biophys. J. 81: 2752–2761.
Castellani, F., van Rossum, B., Diehl, A., Schubert, M., Rehbein, K. and Oschkinat, H., 2002, Structure of a protein determined by solid-state magic-angle-spinning NMR spectroscopy. Nature 420: 98–102.
Ernst, R. R., Bodenhausen, G. and Wokaun, A., 1987, Principle of Nuclear Magnetic Resonace in One and Two Dimensions, Clarendon Press, Oxford.
Laws, D. D., Bitter, H.-M.L. and Jerschow, A., 2002, Solid-state NMR spectroscopic methods in chemistry. Angew. Chem. Int. Ed. 41: 3096–3129.
Watts, A, 2002, Direct studies of ligand-receptor interactions and ion channel blocking. Molec. Membr. Biol.19: 267–275.
Bonev, B. B., Lam, Y-H, Anderluh, G., Watts, A., Norton, R. S. & Separovic, F., 2003, Effects of the eukaryotic pore-forming cytolysin equinatoxin II on lipid membranes and the role of sphingomyelin.” Biophys. J. 84: 2382–2392.
Marcotte, I. Wegener, K. L., Lam, Y-H, Chia, B. C. S., de Planque, M. R. R., Bowie, J. H., Auger, M. & Separovic, F., 2003, Interaction of antimicrobial peptides from Australian amphibians with lipid membranes, Chem. Phys. Lipids, 122: 107–120.
Smith, R., Separovic, F., Milne, T. J., Whittaker, A., Bennett, F. M., Cornell, B. A, & Makriyannis, A., 1994, Structure and orientation of the pore-forming peptide, melittin, in lipid bilayers. J. Mol. Biol. 241: 456–466.
Cornell, B. A., Separovic, F., Smith, R. and Baldassi, A. J., 1988, Conformation and orientation of gramicidin A in oriented phospholipid bilayers measured by solid state carbon-13 NMR. Biophys. J. 53: 67–76.
Gullion, T. and Schaeffer, J., 1989, Rotational Echo Double Resonance NMR, J. Magn. Reson., 81, 196–200.
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Dodd, A., Separovic, F. (2005). An Introduction to Biological Solid State NMR. In: Pifat-Mrzljak, G. (eds) Supramolecular Structure and Function 8. Springer, Boston, MA. https://doi.org/10.1007/0-306-48662-8_9
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DOI: https://doi.org/10.1007/0-306-48662-8_9
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