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Glutamate Receptors in Peripheral Tissue: Excitatory Transmission Outside the CNS pp 87–96Cite as

Glutamate Receptors and their Role in Acute and Inflammatory Pain

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7. Summary

Data from both animals and humans indicate that peripheral glutamate receptors are involved in nociceptive transmission in the normal and inflamed state. Studies in animal models indicate that peripheral glutamate receptors may provide novel targets for treatment of inflammatory pain. The variety of peripheral iGlu and mGlu receptors provides many targets for drug development. Manipulating the peripheral glutamatergic system could lead to advances in treating maladaptive pain while avoiding CNS side effects.

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  1. University of Texas Medical Branch, Galveston, TX, 77555-1069

    Susan M. Carlton

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  1. Toxicology Research Division, HPFB, Health Canada, Ottawa, Canada

    Santokh Gill  & Olga Pulido  & 

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© 2005 Kluwer Academic / Plenum Publishers, New York

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Carlton, S.M. (2005). Glutamate Receptors and their Role in Acute and Inflammatory Pain. In: Gill, S., Pulido, O. (eds) Glutamate Receptors in Peripheral Tissue: Excitatory Transmission Outside the CNS. Springer, Boston, MA. https://doi.org/10.1007/0-306-48644-X_5

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