6. Conclusions
The discovery of anticancer activity of glutamate antagonists provides new challenges for cancer biologists and the pharmaceutical industry. One crucial issue to resolve is determining whether glutamate antagonists exert similar anticancer activity in vivo. It will be important to decipher the molecular pathways that glutamate antagonists utilize to limit tumor growth, invasiveness, and migration. The electrophysiological and binding properties of glutamate receptor/ion channels present on tumor cells will need to be investigated as well as their subunits better characterized and sequenced. Having achieved this, hopefully it will be possible to support existing chemotherapy armamentarium with a new class of drugs that have primarily been developed for neurological disorders.
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Rzeski, W., Turski, L., Ikonomidou, C. (2005). Anticancer Effects of Glutamate Antagonists. In: Gill, S., Pulido, O. (eds) Glutamate Receptors in Peripheral Tissue: Excitatory Transmission Outside the CNS. Springer, Boston, MA. https://doi.org/10.1007/0-306-48644-X_4
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