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Immunosurveillance Mechanisms of the Fetoplacental Unit

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Origin of Anti-Tumor Immunity Failure in Mammals

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References

  • Abo T. (2001). Extrathymic pathways of T-cell differentiation and immunomodulation. Int Immunopharmacol. 7:1261–1273.

    Article  Google Scholar 

  • Adkins B., Charyulu V., Sun Q.L. et al. (2000). Early block in maturation is associated with thymic involution in mammary tumor-bearing mice. J Immunol. 164:5635–5640.

    PubMed  CAS  Google Scholar 

  • Agarwal R., Loganath A., Roy A.C. el al. (2001). Expression profiles of IL-15 in early and late gestational human placenta and in pre-eclamptic Placenta. Mol Hum Reprod. 7:97–101.

    Article  PubMed  CAS  Google Scholar 

  • Agarwal R., Loganath A., Roy A.C. et al. (2000). Increased expression of IL-6 in term compared to the first trimester human placental villi. Horm Metab Res. 32:164–168.

    PubMed  CAS  Google Scholar 

  • Akcali K.C., Khan S.A., Moulton B.C. (1996). Effect of decidualization on the expression of bax and bcl-2 in the rat uterine endometrium. Endocrinol. 137:3123–131.

    Article  CAS  ISI  Google Scholar 

  • Allen W.R., Short R.V. (1997). Interspecific and extraspecific pregnancies in equids: anything goes. J Hered. 88:384–392.

    PubMed  CAS  Google Scholar 

  • Amiot L., Onno M., Drénou B. el al. (1998). HLA-G class I expression in normal and malignant hematopoietic cells. Hum. Immunol. 59:524–528.

    Article  PubMed  CAS  Google Scholar 

  • Arck P.C. (1997). Soluble receptors neutralizing TNF-α and IL-1 block stress-triggered murine abortion. Am J Reprod Immunol. 37:262–266.

    PubMed  CAS  Google Scholar 

  • Armitage R.J., Macduff B.M., Eisenman J. et al. (1995). IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J Immunol. 154:483–490.

    PubMed  CAS  Google Scholar 

  • Baines M.G., Duclos A.J., Antecka E. et al. (1997). Decidual infiltration and activation of macrophages leads to early embryo loss. Am J Reprod Immunol. 37:471–477.

    PubMed  CAS  Google Scholar 

  • Barlow P., Owen D.A., Graham C. (1972). DNA synthesis in the preimplantation mouse embryo. J Embryol Exp Morphol. 27:431–445.

    PubMed  CAS  Google Scholar 

  • Batuman O.A., Ferrero A.P., Diaz A. et al. (1991). Regulation of TGF-β 1 gene expression by glucocorticoids in normal human T lymphocytes. J Clin Invest. 88:1574–1579.

    Article  Google Scholar 

  • Beaman K., Angkachatchai V., Gilman-Sachs A. (1996). TJ6:The Pregnancy-Associated Cytokine. Am J Reprod Immunol. 35:338–341.

    PubMed  CAS  Google Scholar 

  • Beutler B.A. (1999). The role of TNF in health and disease. J Rheumatol. 57:16–21.

    CAS  Google Scholar 

  • Blaschitz A., Lenfant F., Mallet V. et al. (1997). Endothelial cells inchorionic fetal vessels of first trimester placenta express HLA-G. Eur J Immunol. 27:3380–3385.

    Article  PubMed  CAS  Google Scholar 

  • Bluestone J.A., Cron R.Q., Barrett T.A. et al. (1991). Repertoire development and ligand specificity of murine TCR γδ cells. Immunol Rev. 120:5–20.

    Article  PubMed  CAS  Google Scholar 

  • Bogdan C, Nathan C. et al. (1993). Modulation of macrophage function by TGF-β, IL-4 and IL-10. Ann NY Acad Sci. 685:713–720.

    Article  PubMed  CAS  Google Scholar 

  • Born W., Happ M.P., Dallas A. et al. (1990). Recognition of heat shock proteins and γδ cell function. Immunol Today. 11:40–43.

    Article  PubMed  CAS  Google Scholar 

  • Brannstorm M., Wang L, Norman R.J. (1993). Effect of cytocines on prostaglandin production and steroidogenesis of incubated preovulatory follicles of the rat. Biol Reprod. 48:165–171.

    Article  Google Scholar 

  • Brenner C.A., Adler R.R., Rappolee D.A. et al. (1989). Genes for extracellular-matrix-degrading metalloproteinases and their inhibitor, TIMP, are expressed during early mammalian development. Genes Dev. 3:848–859.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Bubanovic I. (2003a). Crossroads of extrathymic lymphocytes maturation pathways. Med Hypotheses. 61:235–239.

    Article  PubMed  CAS  Google Scholar 

  • Bubanovic I. (2003b). Induction of thymic tolerance as possibility in prevention of recurrent spontaneous abortion. Med Hypotheses. 60:520–524.

    Article  PubMed  CAS  Google Scholar 

  • Bubanovic I. (2003c). Failure of blood-thymus barrier as a mechanism of tumor and trophoblast escape. Med Hypotheses. 60:315–320.

    Article  PubMed  CAS  Google Scholar 

  • Bubanovic I. (2004). 1α,25-dihydroxy-vitamin-D3 As New Immunotherapy in Treatment of Recurrent Spontaneous Abortion. Med Hypotheses. In press.

    Google Scholar 

  • Bulmer J.N., Smith J., Morrison L., et al. (1988). Maternal and fetal cellular relationship in the human placental basal plate. Placenta. 9:237–241.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Carp H.J., Serr D.M., Mashiach S. et al. (1984). Influence of insemination on the implantation of transferred rat blastocyst. Gynecol Obstet Invest. 18:194–198.

    Article  PubMed  CAS  Google Scholar 

  • Carson D.D., Tang J.P., Julian J. (1993). Heparan sulfate proteoglycan (perlecan) expression by mouse embryos during acquisition of attachment competence. Dev Biol. 155:97–106.

    Article  PubMed  CAS  Google Scholar 

  • Cascino I., Papoff G., De Maria R. et al. (1996). Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from fas-mediated apoptosis. J Immunol. 156:13–17.

    PubMed  CAS  Google Scholar 

  • Chan C.C., Lao T.T., Cheung A.N. (1999). Apoptotic and proliferative activities in first trimester placentae. Placenta. 20:223–227.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Chang J.T. et al. (2000). The coslimulatory effect of IL-18 on the induction of antigen-specific IFN-γ production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor β2 subunit. Eur J Immunol. 30:1113–1119.

    Article  PubMed  CAS  Google Scholar 

  • Chaouat G. (1994). Synergy of lipopolysaccharide and inflammatory cytokines in murine pregnancy: alloimmunization prevents abortion but does not affect the induction of preterm delivery. Cell Immunol. 157:328–340.

    Article  PubMed  CAS  Google Scholar 

  • Chaouat G., Assal Meliani A., Martal J. (1995). IL-10 prevents naturally occurring fetal loss in the CBAxDBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFNTau. J Immunol. 154:4261–4266.

    PubMed  CAS  Google Scholar 

  • Chaouat G., Tranchot Diallo J., Volumenie L. et al. (1997). Immune suppression and Th1/Th2 balance in pregnancy revisited: a (very) personal tribute to Tom Wegmann. Am J Reprod Immunol. 37:427–434.

    PubMed  CAS  Google Scholar 

  • Chien Y.H., Jores R., Crowley M.P. (1996). Recognition by T cells. Annu Rev Immunol. 14:511–517.

    Article  PubMed  CAS  Google Scholar 

  • Choi B.C., Polgar K,, Xiao L. et al. (2000). Progesterone inhibits in vitro embryotoxic Th1 cytokine production to trophoblast in women with recurrent pregnancy loss. Hum Reprod. 1:46–59.

    Google Scholar 

  • Clark D.A., Drake B., Head J.R. et al (1990). Decidua-associated suppressor activity and viability of the individual implantation sites of allopregnant C3H mice. J Reprod Immunol. 17:253–264.

    Article  PubMed  CAS  Google Scholar 

  • Clark D.A., Lea R.G., Dehburg J. et al. (1991). TGF-β related suppressor factor in mammalian pregnancy decidua; homologies between the mouse and human in successful pregnancy and in recurrent unexplained abortion Clloque. INSERM. 212:171–179.

    CAS  Google Scholar 

  • Clark D.A. et al. (1992). Role of unique species TGF-β in preventing rejection of the conceptus during pregnancy. In: Gergely J. et al. Progress in immunology VII. Budapest: Springer-Verlag. pp.841–852.

    Google Scholar 

  • Clark D.A. (1993). Cytokines, decidua and early pregnancy. Oxf Rev Reprod Biol. 15:83–111.

    PubMed  CAS  Google Scholar 

  • Clark D.A., Vince G., Flanders K.C. et al. (1994). CD56+ lymphoid cells in human first trimester pregnancy decidua as a source of novel TGFβ 2-related immunosuppressive factors. Hum Reprod. 9:22070–2277.

    Google Scholar 

  • Clark D.A., Merali F.S., Hoskin D.W. et al (1997). Decidua associated suppressor cells in abortion-Pron DBA/mated CBA/2mated CBA/J mice that release bioactive TGFβ2-related immunosuppressive molecules express a bone marrow-derived natural suppressor cell marker and γδ T-cell receptor. Biol Repord. 56:1351–1360.

    Article  CAS  Google Scholar 

  • Clark D.A. (1999) Signaling at the fetomaternal interface. Am J Reprod Immunol. 41:169–173.

    PubMed  CAS  Google Scholar 

  • Clarke A.G., Kendall M.D. (1989). Histological changes in the thymus during mouse pregnancy. Thymus. 14:65–78.

    PubMed  CAS  ISI  Google Scholar 

  • Clover L.M., Sargent I.L., Townsend A. et al. (1995). Expression of TAP1 by human trophoblast. Eur J Immunol. 25:543–553.

    Article  PubMed  CAS  Google Scholar 

  • Copeman J., Robin N.N., Caniggia I.H. et al. (2000). Posttranscriptional Regulation of Human Leukocyte Antigen G During Human Extravillous Cytotrophoblast Differentiation. Biol Reprod. 62:1543–1550.

    Article  PubMed  CAS  Google Scholar 

  • Correale J., Arias M., Gilmore W. (1998). Steroid Hormone Regulation of Cytokine Secretion by Proteolipid Protein-Specific CD4+ T Cell Clones Isolated from Multiple Sclerosis Patients and Normal Control Subjects1. J Immunol. 161:3365–3374.

    PubMed  CAS  Google Scholar 

  • Coulam C.B., Beaman K.D. (1995a). Reciprocal alteration in circulating TJ6+ CD19+ and TJ6+ CD56+ leukocytes in early pregnancy predicts success or miscarriage. Am J Reprod Immunol. 34:219–224.

    PubMed  CAS  Google Scholar 

  • Coulam C.B., Stem J. (1995b). Effect of seminal plasma on implantation rates. Early Pregnancy. 1:33–36.

    PubMed  CAS  Google Scholar 

  • Coumans B., Thellin O., Zorzi W. et al. (1999). Lymphoid cell apoptosis induced by trophoblastic cells: a model of active foeto-placental tolerance. J Immunol Methods. 224:185–196.

    Article  PubMed  CAS  Google Scholar 

  • Crisa L., McMaster M.T., Ishii J.K. et al. (1997). Identification of a thymic epithelial cell subset sharing expression of the class Ib HLA-G molecule with fetal trophoblasts. J Exp Med. 186:289–293.

    Article  PubMed  CAS  Google Scholar 

  • Croy B.A. et al. (1995). Characterization of murine decidual natural (NK) cells and their relevance to the success of pregnancy. Cell Immunol. 93:315–326.

    Article  Google Scholar 

  • Croy B.A., Guimond M.J., Luross J. et al. (1997). Uterine natural killer cells do not require IL-2 for their differentiation or maturation. Am J Reprod Immunol. 37:463–470.

    PubMed  CAS  Google Scholar 

  • Cua D.J., Hinton D.R, Stohlman S.A. (1995). Self-antigen-induced Th2 responses in experimental allergic encephalomyelitis (EAE)-resistant mice: Th2-mediated suppression of auto-immune disease. J Immunol. 155:4052–4057.

    PubMed  CAS  Google Scholar 

  • Dalal M., Kim S., Voskuhl R.R. (1997). Testosterone therapy ameliorates experimental auto-immune encephalomyelitis and induces a T helper 2 bias in the autoantigen-specific T lymphocyte response. J Immunol. 159:3–7.

    PubMed  CAS  Google Scholar 

  • Davis M.M., Chien Y. (1995). Issues concerning the nature of antigen recognition by α beta and γδ T-cell receptors. Immunol Today. 16:316–318.

    Article  PubMed  CAS  Google Scholar 

  • Daynes R.A., Araneo B.A., Hennebold J. et al., (1995). Steroids as regulators of the mammalian immune response. J Invest Dermatol. 105:14S.

    Article  PubMed  CAS  Google Scholar 

  • de Moraes Pinto M.I., Vince G.S. Flanagan B.F. et al. (1997). Localization of IL-4 and IL-4 receptors in the human term placenta, decidua and amniochorionic membranes. Immunol. 90:87–91.

    Article  Google Scholar 

  • Denison F.C., Kelly R.W., Calder A.A. et al. (1998). Cytokine secretion by human fetal membranes, decidua and placenta at term. Hum Reprod. 13:3560–3565.

    Article  PubMed  CAS  Google Scholar 

  • Ditzian-Kadanoff R., Garon G., Verp M.S. et al. (1993). γδT cells in human decidua. Am J Obstet Gynecol. 168:831–836.

    PubMed  CAS  Google Scholar 

  • D’Orazio T.J., Niederkorn J.Y. (1998). A novel role for TGF-beta and IL-10 in the induction of immune privilege. J Immunol. 160:2089–2098.

    Google Scholar 

  • Eberl M.et al. (2000). IL-18 potentiates the adjuvant properties of IL-12 in the induction of a strong Th1 type immune response against a recombinant antigen. Vaccine. 18:2002–2008.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Ellis S.A., Palmer M.S, McMichael A.J. et al. (1990). Human trophoblast and the choriocarcinoma cell line BeWo express a truncated HLA class I molecule. J Immunol. 144:731–736.

    PubMed  CAS  Google Scholar 

  • Fazleabas A.T., Strakova Z. (2002). Endometrial function: cell specific changes in the uterine environment. Mol Cell Endocrinol. 186:143–147.

    Article  PubMed  CAS  Google Scholar 

  • Fein A., Magid N., Savion S. et al. (2002). Diabetes teratogcniciiy in mice is accompanied with distorted expression of TGF-β2 in the uterus. Teratog Carcinog Mutagen. 22:59–71.

    Article  PubMed  CAS  Google Scholar 

  • Ferry B.L., Starkey P.M., Sargent I.L. et al. (1990). Cell populations in the human early pregnancy decidua: natural killer activity and response to IL-2 of CD56-positive large granular lymphocytes. Immunol. 70:446–452.

    CAS  ISI  Google Scholar 

  • Fisher S.J., Cui T.Y., Zhang L. et al. (1989). Adhesive and degradative properties of human placental cytotrophoblast cells in vitro. J Cell Biol. 109:891–902.

    Article  PubMed  CAS  Google Scholar 

  • Fujihashi K., Kweon M.N., Kiyono H., et al. (1997). A T cell/B cell/epithelial cell internet for mucosal inflammation and immunity. Springer Semin Immunopathol. 18:477–494.

    Article  PubMed  CAS  Google Scholar 

  • Garcia-Lloret M.I., Yui J., Winkler-Lowen B. et al. (1996). Epidermal growth factor inhibits cytokine-induced apoptosis of primary human trophoblasts. J Cell Physiol. 167:324–332.

    Article  PubMed  CAS  Google Scholar 

  • Geiselhart A., Dietl J., Marzusch K. et al. (1995). Comparative analysis of the immunophenotypes of decidual and peripheral blood large granular lymphocytes and T cells during early human pregnancy. Am J Reprod Immunol. 33:315–322.

    PubMed  CAS  Google Scholar 

  • Oiri J.G., Ahdieh M., Eisenman J. et al. (1994). Utilization of the beta and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J. 13:2822–2830.

    Google Scholar 

  • Giri J.G., Kumaki S., Ahdieh M. et al. (1995). Identification and cloning of a novel IL-15 binding protein that is structurally related to the α chain of the IL-2 receptor. EMBO J. 14:3654–3663.

    PubMed  CAS  ISI  Google Scholar 

  • Gorczynski R.M., Hadidi S., Yu G. et al. (2002). The same immunoregulatory molecules contribute to successful pregnancy and transplantation. Am J Reprod Immunol. 48:18–26.

    Article  PubMed  Google Scholar 

  • Gorelik L., Fields E.P., Flavell A.R. et al. (2000). TGF-β Inhibits Th Type 2 Development Through Inhibition of GATA-3 Expression. J Immunol. 165:4773–4777.

    PubMed  CAS  Google Scholar 

  • Gorham D.J., Güler L.M., Fenoglio D. et al. (1998). Low Dose TGF-β Attenuates IL-12 Responsiveness in Murine Th Cells1. J Immunol. 161:1664–1670.

    PubMed  CAS  Google Scholar 

  • Grabstein K.H., Eisenman J., Shanebeck K., et al. (1994). Cloning of a T cell growth factor that interacts with the beta chain of the IL-2 receptor. Science. 264:965–268.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Griffith T.S., Brunner T., Fletcher S.M. et al. (1995). Fas ligand-induced apoptosis as a mechanism of immune privilege. Science. 270:1189–1192.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Hammer A. et al. (1997). Amnion epithelial cells, in contrast to trophoblast cells, express all classical HLA class I molecules together with HLA-G. Am J Reprod Immunol. 37:161–171.

    PubMed  CAS  Google Scholar 

  • Hayakawa S. et al. (2000a). Murine fetal resorption and experimental pre-eclampsia are induced by both excessive Th1 and Th2 activation. J Reprod Immunol. 47(2):121–138.

    Article  PubMed  CAS  Google Scholar 

  • Hayakawa S., Karasaki-Suzuki M., Itoh T. et al. (2000b). Effects of paternal lymphocyte immunization on peripheral Th1/Th2 balance and TCR Vβ and Vγ repertoire usage of patients with recurrent spontaneous abortions. Am J Reprod Immunol. 43:107–115.

    Article  PubMed  CAS  Google Scholar 

  • Haynes M.K., Flanagan M.T., Perussia B. et al. (1995). Isolation of decidual lymphocytes from chorionic villus samples: phenotypic analysis and growth in vitro. Am J Reprod Immunol. 33:190–199.

    PubMed  CAS  Google Scholar 

  • Hertig A.T., Rock J. (1956). A description of 34 human ova within the first 17 days of development. Am J Anat. 98:435–494.

    Article  PubMed  Google Scholar 

  • Hill J.A. (1995). Immunological factors in recurrent spontaneous abortion. In: Kurpisz M, Fernandez N, ed. Immunology of human reproduction. Oxford: Bios Scientific Publishers; pp.:401–424.

    Google Scholar 

  • Hill J.A., Polgar K., Anderson D.J. (1995). T-helper 1 Type immunity to trophoblast in women with recurrent spontaneous abortion. J Am Med Ass. 273:1933–1938.

    Article  CAS  Google Scholar 

  • Ho H.N., Chao K.H., Chen C.K. et al. (1996). Activation status of T and NK cells in the endometrium throughout menstrual cycle and normal and abnormal early pregnancy. Hum Immunol. 49:130–136.

    Article  PubMed  CAS  Google Scholar 

  • Ho S., Winkler-Lowen B., Morrish D.W. et al. (1999). The role of Bcl-2 expression in EGF inhibition of TNF-α/IFN-γ-induced villous trophoblast apoptosis. Placenta. 20:423–430.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Huber S.A., Kupperman J., Newell M.K. (1999). Estradiol prevents and testosterone promotes Fasdependent apoptosis in CD4+ Th2 cells by altering Bcl 2 expression. Lupus. 8:384–387.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Hunt J.S. (1989). Cytokine networks in the uteroplacental unit: macrophages as pivotal regulatory cells. J Reprod Immunol. 16:1–11.

    Article  PubMed  CAS  Google Scholar 

  • Hunt J.S. (1994) Immunologically relevant cells in the uterus. Biol Reprod. 50:461–470.

    Article  PubMed  CAS  Google Scholar 

  • Hunt J.S., Robertson S.A. (1996). Uterine macrophages and environmental programming for pregnancy success. J Reprod Immunol. 32:1–25.

    Article  PubMed  CAS  Google Scholar 

  • Huppertz B., Frank H.G., Kingdom J.C. et al. (1998). Villous cytotrophoblast regulation of the syncytial apoptotic cascade in the human Placenta. Histochem Cell Biol. 110:495–508.

    Article  PubMed  CAS  Google Scholar 

  • Ida A., Tsuji Y., Muranaka J. et al. (2000). IL-18 in pregnancy; the elevation of IL-18 in maternal peripheral blood during labour and complicated pregnancies. J Reprod Immunol. 47:65–74.

    Article  PubMed  CAS  Google Scholar 

  • Ingman V., Robertson V. (2002). Defining the actions of TGFβ in reproduction. Bioessays. 24: 904–914.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Ishikawa T., Uchiyama T. et al. (1991). IL-4 down-regulates IL-2 receptor p75 by accelerating its endocytosis. Int Immunol. 3:517–525.

    Article  PubMed  CAS  Google Scholar 

  • Jacobs A.L., Carson D.D. (1993). Uterine cell secretion of IL-1α induces prostaglandin E 2 (PGE 2) and PGF 2α secretion by uterine stromal cells in vitro. Endocrinol. 132:300–308.

    Article  CAS  ISI  Google Scholar 

  • Kankofer M., Wiercinski J. (1999). Prostaglandin E2 9-keto reductase from bovine term placenta. Prost Leukot Essent Fatty Acids. 61:29–32.

    Article  CAS  Google Scholar 

  • Karre K. (1995). Express yourself or die: peptides, MHC molecules, and NK cells. Science. 267:978–979.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Kaufmann S. (1996). γδ and other unconventional T lymphocytes: what do they see and what do they do? Proc Natl Acad Sci USA. 93:2272–2279.

    Article  PubMed  CAS  Google Scholar 

  • Kauma S.W., Huff T.F., Hayes N. et al. (1999). Placental Fas ligand expression is a mechanism for maternal immune tolerance to the foetus. J Clin Endocrinol Metab. 84:2188–2194.

    Article  PubMed  CAS  Google Scholar 

  • Kendall M.D., Clarke A.G. (2000). The thymus in the mouse changes its activity during pregnancy: a study of the microenvironment. J Anat. 197:393–411.

    Article  PubMed  Google Scholar 

  • Kelly R.W. et al. (1997). Immunomodulation by human seminal plasma: benefit for spermatozoon and pathogen. Hum Reprod. 12:2200–2207.

    PubMed  CAS  Google Scholar 

  • Kim J., Modlin R.L., Moy R.L. et al. (1995). IL-10 production in cutaneous basal squamous cell carcinoma — A mechanism for evading the local T cell immune response. J Immunol. 155:2240–2247.

    PubMed  CAS  Google Scholar 

  • King A., Balendran N., Wooding P. et al. (1991). CD3-leukocytes present in the human uterus during early placentation: phenotypic and morphologic characterization of the CD56 ++ population. Dev Immunol. 1:169–190.

    Article  PubMed  CAS  Google Scholar 

  • King A., Jokhi P.P., Burrows T.D. et al. (1996a). Functions of human decidual NK cells. Am J Reprod Immunol. 35:258–260.

    PubMed  CAS  Google Scholar 

  • King A., Boocock C, Sharkey A.M. et al. (1996b). Evidence for the expression of HLA-C class I mRNA and protein by human first trimester trophoblast. J Immunol. 156:2068–2076.

    PubMed  CAS  Google Scholar 

  • King A., Loke Y.W., Chaouat G. (1997). NK cells and reproduction. Immunol Today. 18:64–66.

    Article  PubMed  CAS  Google Scholar 

  • King A., Burrows T., Verma S. et al. (1998). Human uterine lymphocytes. Hum Reprod. 4:480–485.

    Article  CAS  Google Scholar 

  • King A., Hiby S.E., Gardner L. et al. (2000). Recognition of trophoblast HLA class I molecules by decidual NK cell receptors-a review. Placenta. 21Suppl A:S81–85.

    Article  Google Scholar 

  • Klonoff-Cohen H.S., Savitz D.A., Cefalo R.C. et al. (1989). An epidemiologic study of contraception and preeclampsia. JAMA. 262:3143–3147.

    Article  PubMed  CAS  Google Scholar 

  • Knapp L.A., Ha J.C., Sackett G.P. (1996). Parental MHC antigen sharing and pregnancy wastage in captive pigtail macaques. J Reprod Immunol. 32:73–88.

    Article  PubMed  CAS  Google Scholar 

  • Knofler M., Mosl B., Bauer S. et al. (2000). TNF-α/TNFR1 in primary and immortalized first trimester cytotrophoblasts. Placenta. 21:525–535.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Kokawa K., Shikone T., Nakano R. (1998). Apoplosis in human chorionic villi and decidua during normal embryonic development and spontaneous abortion in the first trimester. Placenta. 19:21–26.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Kovalevskaya G., Birken S., Kakuma T., et al. (1999). Evaluation of nicked human chorionic gonadotropin content in clinical specimens by a specific immunometric assay. Clin Chem. 45:68–74.

    PubMed  CAS  Google Scholar 

  • Krishnamurthy P., Bird I.M., Sheppard C. et al. (1999). Effect of angiogenetic groeth factor on endothelium-derived prostacycline production by ovine uterine and placental arteries. Prostaglandins Other Lipid Mediat. 57:1–12.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Krishnan L., Guilbert L.J., Wegmann T.G. et al. (1996). T helper 1 response against Leishmania major in pregnant C57BL/6 mice increases implantation failure and fetal resorptions. Correlation with increased IFN-γ and TNF and reduced IL-10 production by placental cells. J Immunol. 156:653–662.

    PubMed  CAS  Google Scholar 

  • Laird S.M., Tuckerman E.M., Cork B.A. et al. (2003). A review of immune cells and molecules in women with recurrent miscarriage. Hum Reprod Update. 9:163–174.

    Article  PubMed  CAS  Google Scholar 

  • Lala P.K., Kennedy T.G., Parhar S. (1988). Suppression of lymphocyte alloreactivity by early gestational human decidua. II. Characterization of suppressor mechanisms. Cell Immunol. 116:411–422.

    Article  PubMed  CAS  Google Scholar 

  • Lala P.K., Scodras J.M., Graham C.H. et al. (1990). Activation of maternal killer cells in the pregnant uterus with chronic indomethacin therapy, IL-2 therapy, or a combination therapy is associated with embryonic demise. Cell Immunol. 127:368–381.

    Article  PubMed  CAS  Google Scholar 

  • Lauritzsen G.F., Hofgaard P.O., Schenck K. et al. (1998). Clonal deletion of thymocytes as a tumor escape mechanism. Int J Cancer. 78:216–222.

    Article  PubMed  CAS  Google Scholar 

  • Le Bouteiller P. et al. (2000). HLA-G in the human placenta: expression and potential functions. Biochem Soc Trans. 28:208–212.

    PubMed  Google Scholar 

  • Lea R.G., Al-Sharekh N., Tulppala M. et al. (1997). The immunolocalization of bcl-2 at the maternal-foetal interface in healthy and failing pregnancies. Hum Reprod. 12:153–158.

    Article  PubMed  CAS  Google Scholar 

  • Lea R.G., Riley S.C., Antipatis C. et al. (1999). Cytokines and the regulation of apoptosis in reproductive tissues: a review. Am J Reprod Immunol. 42:100–109.

    PubMed  CAS  Google Scholar 

  • Lee N., Llano M., Carretero M. et al. (1998). HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A. Proc Natl Acad Sci USA. 95:5199–5204.

    Article  PubMed  CAS  Google Scholar 

  • Lewko W.M., Smith T.L., Bowman D.J. et al. (1995). IL-15 and the growth of tumor derived activated T-cells. Cancer Biother. 10:13–20.

    PubMed  CAS  ISI  Google Scholar 

  • Lodererova A., Honsova E., Viklicky O. (2003). Detection of HLA-G on human extravillous cytotrophoblast and skeletal muscle with a new monoclonal antibody MEM-G/1. Folia Microbiol. 48:239–242.

    Article  CAS  ISI  Google Scholar 

  • Loke Y.W., King A. (2000). Immunology of implantation. Baillieres Best Pract Res Clin Obstet Gynaecol. 14:827–837.

    Article  PubMed  CAS  Google Scholar 

  • Ljunggren H.G., Käre K. (1990). In search of the “missing self”: MHC molecules and NK cell recognition. Immunol Today. 11:237–244.

    Article  PubMed  CAS  Google Scholar 

  • Maeurer M.J., Lotze M.T. (1998). IL-7 knockout mice. Implications for lymphopoiesis and organ-specific immunity. Int Rev Immunol. 16:309–322.

    Article  PubMed  CAS  Google Scholar 

  • Maki K., Sunaga S., Komagata Y. (1996). IL 7 receptor-deficient mice lack γδ T cells. Proc Natl Acad Sci USA. 93:7172–7177.

    Article  PubMed  CAS  Google Scholar 

  • Mandal M., Nichols T.C. Beaman K.D. et al. (1995). Purification and characterization of a pregnancy associated protein: TJ6. Am J Reprod Immunol. 33:60–65.

    PubMed  CAS  Google Scholar 

  • Martin-Villa J.M., Luque I., Martinez-Quiles N. et al. (1996). Diploid expression of human leukocyte antigen class I and class II molecules on spermatozoa and their cyclic inverse correlation with inhibin concentration. Biol Reprod. 55:620–629.

    Article  PubMed  CAS  Google Scholar 

  • Marzi M., Vigano A., Trabattoni D. et al. (1996). Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy. Clin Exp Immunol. 106:127–131.

    Article  PubMed  CAS  Google Scholar 

  • Mc Kenzie M., Cooper W. (1994). MHC class II variability in a marsupial. Reprod Fertil Dev. 6:721–726.

    Article  CAS  Google Scholar 

  • Mc Master M., Zhou Y., Shorter S. et al. (1998). HLA-G Isotype Produced by Placental Cytotrophoblasts and Found in Amniotic Fluid Are Due to Unusual Glycosylation1. J Immunol. 160:5922–5928.

    CAS  Google Scholar 

  • Miller L., Hunt J.S. (1996). Sex steroid hormones and macrophage function. Life Sci. 59:1–14.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Mincheva-Nilsson L., Baranov V., Yeung M.M. et al. (1994). Immunomorphologic studies of human decidua-associated lymphoid cells in normal early pregnancy. J Immunol. 152:2020–2032.

    PubMed  CAS  Google Scholar 

  • Mincheva-Nilsson L., Nagaeva O., Sundqvist K.G et al. (2000). γδT cells of human early pregnancy decidua: evidence for cytotoxic potency. Internal Immunol. 12:585–596.

    Article  CAS  Google Scholar 

  • Mochizuki M., Maruo T., Matsuo H. et al. (1998). Biology of human trophoblast. Int J Gynaecol Obstet. 60:21–28.

    Article  Google Scholar 

  • Murray F.A., Grifo A.P. Jr, Parker CF. (1983). Increased litter size in gilts by intrauterine infusion of seminal and sperm antigens before breeding. J Anim Sci. 56:895–900.

    PubMed  CAS  Google Scholar 

  • Nagata S. (1997). Apoptosis by death factor. Cell. 88:355–365.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Nakanishi K. et al. (2001a). IL-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev. 12:53–72.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Nakanishi K. et al. (2001 b). IL-18 regulates both th1 and th2 responses. Annu Rev Immunol. 19:423–474.

    Article  PubMed  CAS  Google Scholar 

  • Ng S.C., Gilman-Sachs A., Thaker P. et al. (2002). Expression of intracellular Th1 and Th2 cytokines in women with recurrent spontaneous abortion, implantation failures after IVF/ET or normal pregnancy. Am J Reprod Immunol. 48:77–86.

    Article  PubMed  Google Scholar 

  • Nichols T.C., Kang J.A., Angkachatchai V. et al. (1994). Expression of membrane form of the pregnancy associated protein TJ6 on lymphocytes. Cell Immunol. 155:219–223.

    Article  PubMed  CAS  Google Scholar 

  • Norman S.J., Poyser N.L. (1998). Prostaglandin production by guinea-pig placenta and other uterine tissues during mid-pregnancy. Placenta. 19:631–641.

    Article  PubMed  CAS  ISI  Google Scholar 

  • O W.S., Chen H.Q., Chow P.H. (1988). Effects of male accessory sex gland secretions on early embryonic development in the golden hamster. J Reprod Fertil. 84:341–344.

    PubMed  CAS  Google Scholar 

  • Ober C, Aldrich CL. (1997). HLA-G polymorphisms: neutral evolution or novel function? J Reprod Immunol. 36:1–21.

    Article  PubMed  CAS  Google Scholar 

  • Ober C., Hyslop T., Elias S. et al. (1998). Human leucocyte antigen matching and fetal loss: a result of a 10-year prospective study. Hum Reprod. 13:33–38.

    Article  PubMed  CAS  Google Scholar 

  • Ohno Y., Kasugai M., Kurauchi O. et al. (1994). Effect of IL 2 on the production of progesterone and prostaglandin E 2 in human fetal membranes and its consequences for preterm uterine contraction. Eur J Endocrinol. 130:478–484.

    PubMed  CAS  Google Scholar 

  • Okada S., Okada H., Sanezumi M. et al. (2000). Expression of IL-15 in human endometrium and decidua. Mol Hum Reprod. 6:75–80.

    Article  PubMed  CAS  Google Scholar 

  • Ortega F.V., Vergara M.A. (2000). Apoptosis in trophoblast of patients with recurrent spontaneous abortion of unidentified cause. Ginecol Obstet Mex. 68:122–131.

    Google Scholar 

  • Paliogianni F., Ahuja S.S., Balow J.P. et al. (1993). Novel mechanism for inhibition of human T cells by glucocorticoids: glucocorticoids inhibit signal transduction through IL-2 receptor. J Immunol. 151:4081–4085.

    PubMed  CAS  Google Scholar 

  • Pang S.F., Chow P.H., Wong T.M. (1979). The role of the seminal vesicles, coagulating glands and prostate glands on the fertility and fecundity of mice. J Reprod Fertil. 56:129–132.

    PubMed  CAS  Google Scholar 

  • Par G., Bartok B., Szekeres-Bartho J. (2000). Cyclooxygenase is involved in the effects of progesterone-induced blocking factor on the production of IL-12. Am J Obstet Gynecol. 183:126–130.

    Article  PubMed  CAS  Google Scholar 

  • Patel F.A., Clifton V.L., Chwalisz K. et al. (1999). Steroid regulation of prostaglandin dehydrogenase activity and expression in human term placenta and chorio-decidua in relation to labor. J Clin Endocrinol Metab. 84:291–299.

    Article  PubMed  CAS  Google Scholar 

  • Paul P., Rouas-Freiss N., Khalil-Daher I. et al. (1998). HLA-G expression in melanoma: A way for tumor cells to escape from immunosurveillance. Proc Natl Acad Sci USA. 95:4510–4515.

    Article  PubMed  CAS  Google Scholar 

  • Payne G.S., Smith C.S., Davidge T.S. et al. (1999). Death Receptor Fas/Apo-1/CD95 Expressed by Human Placental Cytotrophoblasts Does Not Mediate Apoptosisl. Biol Reprod. 60:1144–1150.

    Article  PubMed  CAS  Google Scholar 

  • Peitz B., Olds-Clarke P. (1986). Effects of seminal vesicle removal on fertility and uterine sperm motility in the house mouse. Biol Reprod. 35:608–617.

    Article  PubMed  CAS  Google Scholar 

  • Perona R.M., Wassarman P.M. (1986). Mouse blastocyst hatch in vitro by using a trypsin-like proteinase associated with cells of mural trophectoderm. Dev Biol. 114:42–52.

    Article  PubMed  CAS  Google Scholar 

  • Piccinni M.P., Ciudizi M.G, Biagiotti R. el al. (1995). Progesterone favors the development of human T helper cells producing Th2Type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones. J lmmunol. 155:128–136.

    CAS  Google Scholar 

  • Piccinni M.P., Beloni L., Livi C., et al. (1998). Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions. Nat Med. 4:1020–1025.

    Article  PubMed  CAS  Google Scholar 

  • Piccinni M.P., Romagnani S. (1996). Regulation of fetal allograft survival by hormone-controlled Th1-and Th2Type cytokines. Immimol Res. 15:141–148.

    Article  CAS  Google Scholar 

  • Pijnenborg R. et al. (2000). Cytotoxic effects of TNF-α and IFN-γ on cultured human trophoblast are modulated by fibronectin. Am J Reprod Immunol. 43:107–115.

    Article  Google Scholar 

  • Pitzel L., Jarry H., Wuttke W. (1993). Effect and interactions of prostaglandin F 2 α, oxytocin and cytokines on steroidogenesis of porcine luteal cells. Endocrinol. 132:751–756.

    Article  CAS  ISI  Google Scholar 

  • Plevyak M., Hanna N., Mayer S. et al. (2002). Deficiency of decidual IL-10 in first trimester missed abortion: a lack of correlation with the decidual immune cell profile. Am J Reprod Immunol. 47:242–250.

    Article  PubMed  Google Scholar 

  • Polgar B., Barakonyi A., Xynos I. et al., (1999). The role of γ/δ T cell receptor positive cells in pregnancy. Am J Reprod Immunol. 41:239–244.

    PubMed  CAS  Google Scholar 

  • Pop Trajkovic Z., Najman S., Kamenov B. et al. (2002). Effects of indometacin on allogeneic and singeneic pregnancy. Facta Universitatis. 9:166–170.

    Google Scholar 

  • Porter B.O., Malek T.R. (2000). Thymic and intestinal intraepithelial T lymphocyte development are each regulated by the γc-dependent cytokines IL-2, IL-7, and IL-15. Semin Immunol. 12:465–474.

    Article  PubMed  CAS  Google Scholar 

  • Quenby S., Brazeau C., Drakeley A. et al. (1998). Oncogene and tumour suppressor gene products during trophoblast differentiation in the first trimester. Mol Hum Reprod. 4:477–481.

    Article  PubMed  CAS  Google Scholar 

  • Raghupathy R. (1997). Th1 Type immunity is incompatible with successful pregnancy. Immunol Today. 18:478–482.

    Article  PubMed  CAS  Google Scholar 

  • Raghupathy R., Makhseed M., Azizieh F. et al. (2000). Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion. Hum Reprod. 15:713–718.

    Article  PubMed  CAS  Google Scholar 

  • Raghupathy R. (2001). Pregnancy: success and failure within the Th1/Th2/Th3 paradigm. Semin Immunol. 13:219–227.

    Article  PubMed  CAS  Google Scholar 

  • Reid B.L. (1966). The fate of the nucleic acid of sperm phaged by regenerating cells. Aust NZJ Obstet Gynaecol. 6:30–34.

    Article  CAS  Google Scholar 

  • Robertson S.A. et al. (1997). Cytokine-leukocyte network and the establishment of pregnancy. Am J Reprod Immunol. 37:438–442.

    PubMed  CAS  Google Scholar 

  • Robertson S.A., Ingman W.V., O’Leary S. et al. (2002). TGFα mediator of immune deviation in seminal plasma. J Reprod Immunol. 57:109–128.

    Article  PubMed  CAS  Google Scholar 

  • Robertson S.A., Bromfield J.J., Tremellen K.P. (2003). Seminal ‘priming’ for protection from pre-eclampsia-a unifying hypothesis. J Reprod Immunol. 59:253–265.

    Article  PubMed  Google Scholar 

  • Roby K.F., Gershon D., Hunt J.S. (1996). Expression of the transporter for antigen processing-1 (Tap-1) Gene in subpopulations of human trophoblast cells. Placenta. 17:27–32.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Rodriguez A.M., Mallet V., Lenfant F. et al. (1997). IFN-γ rescues HLA class Ia cell surface expression in term villous trophoblast cells by inducing synthesis of TAP proteins. Eur J Immunol. 27:45–54.

    Article  PubMed  CAS  Google Scholar 

  • Roth I., Corry D.B., Locksley R.M. et al. (1996). Human placental cytotrophoblasts produce the immunosuppressive cytokine IL 10. J Exp Med. 184:539–542.

    Article  PubMed  CAS  Google Scholar 

  • Rukavina D., Rubesa G., Gudelj L. et al. (2000). Characteristics of perforin expressing lymphocytes within the first trimester decidua of human pregnancy. Am J Reprod Immunol. 33:394–404.

    Google Scholar 

  • Runic R., Lockwood C.J., Ma Y. et al. (1996). Expression of Fas ligand by human cytotrophoblasts: implications in placentation and fetal survival. J Clin Endocrinol Metab. 81:3119–3122.

    Article  PubMed  CAS  Google Scholar 

  • Saito S., Nishikawa K., Morii T. et al. (1994). A study of CD45RO, CD45RA and CD29 antigen expression on human decidual T cells in an early stage of pregnancy. Immunol Lett. 40:193–197.

    Article  PubMed  CAS  Google Scholar 

  • Saito S. et al. (1996). IL-4 blocks the IL-12 induced increase in natural killer activity and DNA synthesis of decidual CD16–CD56bright+ NK cells by inhibiting expression of the IL-2Rα, β and γ. Cell Immunol. 170:71–77.

    Article  PubMed  CAS  Google Scholar 

  • Saito S., Tsukaguchi N., Hasegawa T. et al. (1999). Distribution of Th1, Th2, and Th0 and the Th1/Th2 cell ratios in human peripheral and endometrial T cells. Am J Reprod Immunol. 42:240–245.

    PubMed  CAS  Google Scholar 

  • Saito S. (2000). Cytokine network at the feto-maternal interface. J Reprod Immunol. 47:87–103.

    Article  PubMed  CAS  Google Scholar 

  • Saito S. (2001). Cytokine cross-talk between mother and the embryo/placenta. J Reprod Immunol. 52:15–33.

    Article  PubMed  CAS  Google Scholar 

  • Saji F., Samejima Y., Kamiura S. et al. (2000). Cytokine production in chorioamnionitis. J Reprod Immunol. 47:185–196.

    Article  PubMed  CAS  Google Scholar 

  • Salafia C.M., Mill J.F., Ossandon M. (1996). Markers of regulation of apoptosis and cell proliferation in preterm and term placental villi. J Soc Gynecol Invest. 3:80A.

    Article  Google Scholar 

  • Salazar-Onfray F., Charo J., Petersson M. et al. (1997). Down-regulation of the expression and function of the transporter associated with antigen processing in murine tumor cell lines expressing IL-10. J Immunol. 159:3195–3200.

    PubMed  CAS  Google Scholar 

  • Savion S., Toder V. (1995). Pregnancy-associated effect on mouse thymocytes in vitro. Cell Immunol. 162:282–287.

    Article  PubMed  CAS  Google Scholar 

  • Savion S., Zeldich E., Orenstein H. et al. (2002). Cytokine expression in the uterus of mice with pregnancy loss: effect of maternal immunopotentiation with GM-CSF. Reproduction. 123:399–409.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Scodras J.M., Parhar R.S., Kennedy T.G. et al. (1990). Prostaglandin-mediated inactivation of natural killer cells in the murine decidua. Cell Immunol. 127:352–367.

    Article  PubMed  CAS  Google Scholar 

  • Shanker A., Singh M., Sodhi A. (2000). Ascitic growth of a spontaneous transplantable T cell lymphoma induces thymic involution. 2. Induction of apoptosis in thymocytes. Tumour Biol. 21:315–327.

    Article  PubMed  CAS  Google Scholar 

  • Shimaoka Y., Hidaka Y., Tada H. et al. (2000). Changes in cytokine production during and after normal pregnancy. Am J Reprod Immunol. 44:143–147.

    Article  PubMed  CAS  Google Scholar 

  • Shimizu T., Kawamura T., Miyaji C. et al. (2000). Resistance of extrathymic T cells to stress and the role of endogenous glucocorticoids in stress associated immunosuppression. Scand J Immunol. 51:285–292.

    Article  PubMed  CAS  Google Scholar 

  • Shull M.M., Ormsby I., Kier A.B, et al. (1992). Targeted disruption of the mouse TGF-β1 gene results in multifocal inflammatory disease. Nature. 359:693–695.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Smith S.C., Baker P.N., Symonds E.M. (1997). Placental apoptosis in normal human pregnancy. Am J Obstet Gynecol. 177:57–65.

    Article  PubMed  CAS  Google Scholar 

  • Sprinks M.T., Sellens M.H., Dealtry G.B. et al. (1993). Fernandez H. Preimplantation mouse embryos express Mhc class I genes before the first cleavage division. Immunogenetics. 38:35–40.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Stephanie M., Liva R., Rhonda R.V. (2001). Testosterone Acts Directly on CD4+ T Lymphocytes to Increase IL-10 Production. J Immunol. 167:2060–2067.

    Google Scholar 

  • Stone W.H., Manis G.S., Hoffman E.S. et al. (1997). Fate of allogeneic skin transplantations in a marsupial (Monodelphis domestica). Lab Anim Sci. 47:283–287.

    PubMed  CAS  Google Scholar 

  • Streilein J.W. (1996). Peripheral tolerance induction: lessons from immune privileged sites and tissues. Transplant Proc. 28:2066–2070.

    PubMed  CAS  Google Scholar 

  • Strickland J.E., Saviolakis G.A., Fowler A.K. et al. (1976). Impaired estrogen-mediated production of type C viral DNA polymerase in aged NH swiss mouse uteri. Proc Soc Exp Biol Med. 153:63–69.

    PubMed  CAS  Google Scholar 

  • Swat W., Ignatowicz L., von Boehmer H. et al. (1991). Clonal deletion of immature CD4+CD8+ thymocytes in suspension culture by extrathymic antigen-presenting cells. Nature. 351:150–153.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Szekeres-Bartho J. et al. (1985). Progesterone treated lymphocytes of healthy pregnant women release a factor inhibiting cytotoxicity and prostaglandin synthesis. Am J Reprod Immunol Microbiol. 9:15–19.

    PubMed  CAS  Google Scholar 

  • Szekeres-Bartho J. et al. (1989a). Lymphocytic progesterone receptors in human pregnancy. J Reprod Immunol. 16:239–247.

    Article  PubMed  CAS  Google Scholar 

  • Szekeres-Bartho J. et al. (1989b). Progesterone receptors in lymphocyte of liver-transplanted and transfused patients. Immunol Letters. 22:259–261.

    Article  CAS  Google Scholar 

  • Szekeres-Bartho J. et al. (1990). The effect of a progesterone induced immunologic blocking factor on NK-mediated resorption. Am J Reprod Immunol. 24:273–283.

    Google Scholar 

  • Szekeres-Bartho J. et al. (1995). Progesterone-induced blocking factor (PIBF) in normal and pathological pregnancy. Am J Reprod Immunol. 34:342–348.

    PubMed  CAS  Google Scholar 

  • Szekeres-Bartho J., Wegmann T.G. (1996). A progesterone-dependent immunomodulatory protein alters the Th1/Th2 balance. J Reprod Immunol. 31:81–95.

    Article  PubMed  CAS  Google Scholar 

  • Szekeres-Bartho J., Barakonyi A., Polgar B. et al. (1999a). The role of γ/δ T cells in progesterone-mediated immunomodulation during pregnancy: a review. Am J Reprod Immunol. 42:44–48.

    PubMed  CAS  Google Scholar 

  • Szekeres-Bartho J. et al, (1999b). Nonspecific Immunological mechanisms and hormones. In: Gupta S.K. Reproductive Immunology. Kluwer&Norsa Publishing House, Delhi pp.:218–224.

    Google Scholar 

  • Szekeres-Bartho J. (2002). Immunological relationship between the mother and the fetus. Int Rev Immunol. 21:471–495.

    Article  PubMed  CAS  Google Scholar 

  • Taga K., Moslowski H., Tosato G. (1993). Human interleukin-10 can directly inhibit T-cell growth. Blood. 81:2964–2999.

    PubMed  CAS  ISI  Google Scholar 

  • Tartakovsky B., Ben-Yair E. (1991). Cytokines modulate preimplantation development and pregnancy. Dev Biol. 146:345–352.

    Article  PubMed  CAS  Google Scholar 

  • Tessier-Prigent A., Willems R., Lagarde M. et al. (1999). Arachidonic acid induces differentiation of uterine stromal to decidual cells. Mol Endocrinol. 13:1005–1017.

    Article  Google Scholar 

  • Thaler CJ. (1989) Immunological role for seminal plasma in insemination and pregnancy. Am J Reprod Immunol. 21:147–150.

    PubMed  CAS  Google Scholar 

  • Toki T., Horiuchi A., Ichikawa N. et al. (1999). Inverse relationship between apoptosis and Bcl-2 expression in syncyliotrophoblast and fibrinType fibrinoid in early gestation. Mol Hum Reprod. 5:246–251.

    Article  PubMed  CAS  Google Scholar 

  • Uchikawa R., Matsuda S., Yamada M. et al. (1997). Nematode infection induces Th2 cell-associated immune responses in LEC mutant rats with helper T cell immunodeficiency. Parasite Immunol. 19:461–468.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Ulbrecht M., Rehberger B., Strobel I. et al. (1994). HLA-G: expression in human keratinocytes in vitro and in human skin in vivo. Eur J Immunol. 24:176–180.

    Article  PubMed  CAS  Google Scholar 

  • Vanderbeehen Y., Vleighe V., Duchateau J. et al. (1984). Suppressor T-lymphocytes in pregnancy. Am J Reprod Immunol. 5:20–24.

    Google Scholar 

  • Verma S., Hiby S.E., Loke Y.W. et al. (2000). Human decidual natural killer cells express the receptor for and respond to the cytokine IL 15. Biol Reprod. 62:959–968.

    Article  PubMed  CAS  Google Scholar 

  • von Minckwitz G., Grischke E.M., Schwab S. et al. (2000). Predictive value of serum IL-6 and-8 levels in preterm labor or rupture of the membranes. Acta Obstet Gynecol Scand. 79:667–672.

    Article  Google Scholar 

  • von Rango U., Classen-Linke I., Krusche C.A. et al. (1998). The receptive endometrium is characterised by apoptosis in the glands. Hum Reprod. 13:3177–3189.

    Article  Google Scholar 

  • Ware C.F. (1996). Apoptosis mediated by the TNF-related cytokine and receptor families. J Cell Biochem. 60:47–55.

    Article  PubMed  CAS  Google Scholar 

  • Watson E.D., Zanecosky H.G. (1991). Regulation of mitogen-induced and TCFG-induced lymphocyte blastogenesis by prostaglandins and supernatant from equine embriyos and endometrium. Res Vet Sci. 51:61–65.

    PubMed  CAS  Google Scholar 

  • Wegmann T.G., Lin H., Guilbert L., Mosmann R.T. (1993). Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a Th2 phenomenon? Immunol Today. 14:353–356.

    Article  PubMed  CAS  Google Scholar 

  • Wessells J., Wessner D., Parsells R. et al. (2000). Pregnancy specific glycoprotein 18 induces IL-10 expression in murine macrophages. Eur J Immunol. 30:1830–1840.

    Article  PubMed  CAS  Google Scholar 

  • Wood G.W. Kamel S. Smith K. (1988). Immunoregulation and prostaglandin production by mechanically-derived and enzyme-derived murine decidual cells. Cell Immunol. 116:411–422.

    Article  Google Scholar 

  • Xing Z., Zganiacz A., Santosuosso M. et al. (2000). Role of IL-12 in macrophage activation during intracellular infection: IL-12 and mycobacteria synergistically release TNF-and nitric oxide from macrophages via IFN-induction. J Leuk Biol. 68:897–902.

    CAS  Google Scholar 

  • Xu C., Mao D., Holers V.M. et al. (2000). A critical role for murine complement regulator Crry in fetomaternal tolerance. Science. 287:498–501.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Yamashita H., Otsuki Y., Matsumoto K. et al. (1999). Fas ligand, Fas antigen and Bcl-2 expression in human endometrium during the menstrual cycle. Mol Hum Reprod. 5:358–364.

    Article  PubMed  CAS  Google Scholar 

  • Yamazaki K., Kato Y. (1989). Sites of zona pellucida shedding by mouse embryo other than muran trophectoderm. J Exp Zool. 249:347–349.

    Article  PubMed  CAS  Google Scholar 

  • Yang Y., Chu W., Geraghty D.E. et al. (1996). Expression of HLA-G in human mononuclear phagocytes and selective induction by IFN-γ. J Immunol. 156:4224–4229.

    PubMed  CAS  Google Scholar 

  • Yokoyama M.W. (1997). The mother-child union: The case of missing-self and protection of the fetus. Proc Natl Acad Sci USA. 94:5998–6000.

    Article  PubMed  CAS  Google Scholar 

  • Yui J., Garcia-Lloret M., Wegmann T.G. el al. (1994). Cytotoxicity of TNF-α and γ-IFN against primary human placental trophoblasts. Placenta. 15:819–835.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Zeidler, R., Eissner, G., Meissner, P. et al., (1997). Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded IL-10. Blood. 90:2390–2397.

    PubMed  CAS  ISI  Google Scholar 

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(2004). Immunosurveillance Mechanisms of the Fetoplacental Unit. In: Origin of Anti-Tumor Immunity Failure in Mammals. Springer, Boston, MA. https://doi.org/10.1007/0-306-48630-X_4

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