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Integrating and Tagging Biological Structures with Nanoscale Semiconductor Quantum dot Structures

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Book cover Biological Nanostructures and Applications of Nanostructures in Biology

Part of the book series: Bioelectric Engineering ((BEEG))

Conclusion

This account has highlighted the recent progress in using semiconductor biotags based on their narrow, tunable and symmetric emission spectra as well as their temporal stability and resistance to photobleaching, especially as compared to fluorescent dyes. This progress has been possible as a result of key developments underlying the synthesis and functionalization of semiconductor nanocrystals. The advances in binding fluorescent semiconductor nanocrystals to biomolecules have facilitated the selective binding of these nanoscale fluorescent structures to specific subcellular structures. To go beyond using nanocrystals as biotags by integrating semiconductor nanocrystals directly with biological structures, it is necessary to further understand the physical properties of semiconductor nanocrystals in biological environments and in direct contact with biological structures. This review has highlighted several such interaction mechanisms, including the interaction of electrolytes with nanocrystals, the modification of the photoluminescence spectra of nanocrystals due to the environmentally-induced changes in the acoustic phonon spectra in nanocrystals, and the role of surface states on the observed intermittent blinking of quantum dots. To realize the possible uses of semiconductor nanocrystals as elements of coupled nanocrystal-biological-systems, it is necessary to study such interaction mechanisms in greater detail.

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Authors and Affiliations

  1. Depts. of Bioengineering, Electrical and Computer Engineering, and Physics, Univ of IL at Chicago, Chicago, IL, 60607

    Michael A. Stroscio

  2. Depts. of Electrical and Computer Engineering, and Physics, Univ of IL at Chicago, Chicago, IL, 60607

    Mitra Dutta, Babak Kohanpour & Salvador Rufo

  3. Dept. of Bioengineering, Univ of IL at Chicago, Chicago, IL, 60607

    Kavita Narwani, Peng Shi & Dinakar Ramadurai

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Stroscio, M.A. et al. (2004). Integrating and Tagging Biological Structures with Nanoscale Semiconductor Quantum dot Structures. In: Stroscio, M.A., Dutta, M. (eds) Biological Nanostructures and Applications of Nanostructures in Biology. Bioelectric Engineering. Springer, Boston, MA. https://doi.org/10.1007/0-306-48628-8_1

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