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References

  1. J.A.V. Coates, N. Cammack, H.J. Jenkinson, A.J. Jowett, M.I. Jowett, B.A. Pearson, C.R. Penn, P.L. Rouse, K.C. Viner, and J.M. Cameron. (−)2′-Deoxy-3′-thiacytidine is a potent, highly selective inhibitor of human immunodeficiency virus type 1 and type 2 replication In Vitro. Antimicrob. Agents Chemother. 36:733–739 (1992).

    CAS  PubMed  Google Scholar 

  2. J.M. Pludda, T.P. Cooley, J.S.G. Montaner, L.E. Shay, N.E. Reinhalter, S.N. Warthan, J. Reudy, H.M. Hirst, C.A. Vicary, J.B. Quinn, G.J. Yuen, M.A. Wainberg, M. Rubin, and R. Yarchoan. A Phase I/II Study of (−)2′-deoxy-3′-thiacytidine (Lamivudine) in patients with advanced human immunodeficiency virus infection. J Infect. Dis. 171:1438–1447 (1995).

    Google Scholar 

  3. P.A. Furman, J.A. Fyfe, M.H. St Clair, K. Weinhold, J.L. Rideout, G.A. Freeman, S. Nusinoff Lehrman, D.P. Bolognesi, S. Broder, H. Mitsuya, and D.W. Barry. Phosphorylation of 3′-azido-3′-deoxythimidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus reverse transcriptase. Proc. Natl. Acad. Sci. 83:8333–8337 (1986).

    CAS  PubMed  Google Scholar 

  4. H. Mitsuya, S. Broder. Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associate virus (HTLV-III/LAV) by 2′,3′-dideoxynucleosides. Proc. Natl. Acad. Sc. 83:1911–1915 (1986).

    CAS  Google Scholar 

  5. M.H. St Clair, C.A. Richards, T. Spector, K.J. Weinhold, W.H. Miller, A.J. Langlois, and P.A. Furman. 3′-Azido-3′-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase. Antimicrob. Agents. Chemother. 31:1972–1977 (1987).

    CAS  PubMed  Google Scholar 

  6. B.L. Robbins, B.H. Waibel, and A. Fridland. Quantitation of intracellular zidovudine phosphates by use of combined cartridge-radio immunoassay methodology. Antimicrob. Agents Chemother. 40:2651–2654 (1996).

    CAS  PubMed  Google Scholar 

  7. D.Z. D’Argenio and A. Schumitzky. ADAPT II User’s Guide: Pharmacokinetic/Pharmacodynamic Systems Analysis Software. University of Southern California, Los Angeles, 1997.

    Google Scholar 

  8. M.A. Cabrita, S.A. Baldwin, J.D. Young, and C.E. Cass. Molecular biology and regulation of nucleoside and nucleobase transporter proteins in eukaryotes and prokaryotes. Biochem. Cell Biol. 80:623–638 (2002).

    Article  CAS  PubMed  Google Scholar 

  9. C.N. Chang, S.L. Doong, J.H. Zhou, H.W. Beach, L.S Jeong, C.K. Ch, C.H. Tsai, and Y.C. Cheng. Deoxycytidine deaminase-resistant stereoisomer is the active form of ()-2′3′-dideoxy-3′-thiacytidine, in the inhibition of hepatitis B virus replication. J. Biol. Chem. 267:13938–13942 (1992).

    CAS  PubMed  Google Scholar 

  10. C.N. Chang, V. Skalski, J.H. Zhou, and Y.C. Cheng, Biochemical pharmacology of (+)-and (−)-2′,3′-dideoxy-3′-thiacytidine as anti-hepatitis B virus agent. J. Biol. Chem. 267:22414–22420 (1992).

    CAS  PubMed  Google Scholar 

  11. J.Y. Liou, G.E. Dutschman,, W. Lam, Z. Jiang, and Y.C. Cheng. Characterization of human UMP/CMPkinase and its phosphorylation of D and L-form deoxycytidine analogue monophosphates. Cancer Research 62:1624–1631 (2002).

    CAS  PubMed  Google Scholar 

  12. P. Kriehnan, J.Y. Liou, and Y.C. Cheng. Phosphorylation of pyrimidine L-deoxynucleoside analog diphosphates. J. Biol. Chem. 277:31593–31600 (2002).

    Google Scholar 

  13. P. Krishnan, Q. Fu, W. Lam, J.Y. Liou, G. Dutschman, and Y.C. Cheng, Phosphorylation of pyrimidine deoxynucleoside analog diphosphates. J. Biol. Chem. 277:5453–5459 (2002).

    CAS  PubMed  Google Scholar 

  14. A. Kreimeyer, B. Schneider, R. Sarfati, A. Faraj, J.P. Sommadossi, M. Veron, and D. Deville-Bonne. NDP kinase reactivity towards 3TC nucleotides. Antiviral Reasearch 50:14–156 (2001).

    Google Scholar 

  15. Kennedy E., et al. Possible metabolic functions of deoxycytidine diphosphate choline and deoxycytidine diphosphate ethanolamine. J. Biol. Chem. 234:1998–2000 (1959).

    Google Scholar 

  16. G. Spyrou, and P. Reichard. Intracellular compartmentation of deoxycytidine nucleotide pools in S phase mouse 3T3 fibroblasts. J. Biol. Chem. 264:960–964 (1989).

    CAS  PubMed  Google Scholar 

  17. Y.Z. Su, P. Huang, and W. Plunkett. Functional compartmentation of dCTP Pools. J. Biol. Chem. 270:631–637 (1995).

    Article  Google Scholar 

  18. C.V. Fletcher, S.P. Kawle, T.N. Kakuda, P.L. Anderson, D. Weller, L.R. Bushman, R.C. Brundage, and R.P. Remmel. Zidovudine triphosphate and lamivudine triphosphate concentration-response relationships in HIV-infected persons. AIDS 14:2137–2144 (2000).

    CAS  PubMed  Google Scholar 

  19. O. Turriziani, J.D. Shuetz, F. Focher, C. Scagnolari, J. Sampath, M. Adachi, F. Bambacioni, E. Riva, and B. Antonelli. Impaired 2′3′-dideoxy-3′-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11. J. Biochem. 368:325–332 (2002).

    CAS  Google Scholar 

  20. G. Reid, P. Wiellinga, N. Zelcer, M.D. Haas, L.V. Deemter, J. Wijnholds, J. Balzarini, and P. Borst, Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol. Pharmacol. 63:1094–1103 (2003).

    Article  CAS  PubMed  Google Scholar 

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Zhou, Z., D’Argenio, D.Z., Robbins, B.L., Rodman, J.H. (2004). Intracellular Metabolism of Lamivudine. In: D’Argenio, D.Z. (eds) Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis Volume 3. The International Series in Engineering and Computer Science, vol 765. Springer, Boston, MA. https://doi.org/10.1007/0-306-48523-0_2

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  • DOI: https://doi.org/10.1007/0-306-48523-0_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4020-7804-0

  • Online ISBN: 978-0-306-48523-7

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