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Mechanisms of Yersinia enterocolitica Evasion of the Host Innate Immune Response by V Antigen

  • Andreas Sing
  • Dagmar Rost
  • Natalia Tvardovskaia
  • Andreas Roggenkamp
  • Anna M. Geiger
  • Carsten J. Kirschning
  • Agnès Wiedemann
  • Martin Aepfelbacher
  • Jürgen Heesemann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 529)

Conclusions

Our data demonstrate a new ligand specificity of TLR2, since LcrV is the first known secreted and non-lipidatedvirulence-associated protein of a Gram-negative bacterium utilizing TLR2 for cell activation. We conclude that yersiniae might exploit host innatepattern recognition molecules and defense mechanisms to evade the host immune response.

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References

  1. Motin, V. L., Nakajima, R., Smirnov, G. B., and Brubaker, R. R, 1994, Passive immunity to yersiniae mediated by anti-recombinant V antigen and protein A-V antigen fusion peptide. Infect. Immun. 62:4192–4201.PubMedGoogle Scholar
  2. Nedialkov, Y.A., Motin, V.L., and Brubaker, R.R., 1997, Resistance to lipopolysaccharide mediated by the Yersinia pestis V antigen-polyhistidine fusion peptide: amplification of interleukin-10. Infect. Immun. 65:1196–1203.PubMedGoogle Scholar
  3. Sing, A., Roggenkamp, A., Geiger, A. M., and Heesemann, J., 2002a, Yersinia enterocolitica evasion of the host innate immune response by V antigen-induced IL-10 production of macrophages is abrogated in IL-10-deficient mice. J. Immunol. 168: 1315–1321.PubMedGoogle Scholar
  4. Sing, A., Rost, D., Tvardovskaia, N., Roggenkamp, A., Wiedemann A., Kirschning, C.J., Aepfelbacher, M., and Heesemann, J., 2002b, Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin-10 mediated immunosuppression. J. Exp. Med. 196: 1017–1024.CrossRefPubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Andreas Sing
    • 1
  • Dagmar Rost
    • 1
  • Natalia Tvardovskaia
    • 1
  • Andreas Roggenkamp
    • 1
  • Anna M. Geiger
    • 1
  • Carsten J. Kirschning
    • 2
  • Agnès Wiedemann
    • 1
  • Martin Aepfelbacher
    • 1
  • Jürgen Heesemann
    • 1
  1. 1.Max von Pettenkofer-Institut für Hygiene und Medizinische MikrobiologieLudwig Maximilians-Universität MünchenMünchenGermany
  2. 2.Institut für Medizinische Mikrobiologie, Immunologie und HygieneTechnische Universität MünchenMünchenGermany

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