Defensive Function of Phagocytes in Pseudotuberculosis
The results of our investigations showed that plasmid-harbouring Y. pseudotuberculosis actively suppress the phagocytic activity of neutrophils and macrophages. It is likely that deactivation of phagocytes is caused by secretion of Yops. Moreover, bacteriological studies showed that only a few of the ingested bacteria were destroyed and the remaining killed the macrophages.
However, a collaborative action of neutrophils and macrophages on the virulent extra- and intracellular Y. pseudotuberculosis takes place. For the bactericidal activity macrophages require exposure to extracellular biologically-active products (in particular, myeloperoxidase) of neutrophils already activated by bacteria. Neutrophils are able to cause L-transformation of Y. pseudotuberculosis (Plekhova and Isachkova, 1998). Myeloperoxidase together with other oxygen-dependent bactericidal systems breaks the permeability of the cell wall of Yersinia and thus enables the macrophages to ingest and digest the bacteria with the help hydrolytic enzymes.
KeywordsPolymorphonuclear Leukocyte Phagocytic Activity Collaborative Action Bacteriological Study Human Polymorphonuclear Leukocyte
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