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Defensive Function of Phagocytes in Pseudotuberculosis

  • Natalya G. Plekhova
  • Larisa M. Somova-Isachkova
  • Felix N. Shubin
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 529)

Conclusions

The results of our investigations showed that plasmid-harbouring Y. pseudotuberculosis actively suppress the phagocytic activity of neutrophils and macrophages. It is likely that deactivation of phagocytes is caused by secretion of Yops. Moreover, bacteriological studies showed that only a few of the ingested bacteria were destroyed and the remaining killed the macrophages.

However, a collaborative action of neutrophils and macrophages on the virulent extra- and intracellular Y. pseudotuberculosis takes place. For the bactericidal activity macrophages require exposure to extracellular biologically-active products (in particular, myeloperoxidase) of neutrophils already activated by bacteria. Neutrophils are able to cause L-transformation of Y. pseudotuberculosis (Plekhova and Isachkova, 1998). Myeloperoxidase together with other oxygen-dependent bactericidal systems breaks the permeability of the cell wall of Yersinia and thus enables the macrophages to ingest and digest the bacteria with the help hydrolytic enzymes.

Keywords

Polymorphonuclear Leukocyte Phagocytic Activity Collaborative Action Bacteriological Study Human Polymorphonuclear Leukocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Leung K.-P., and Goren M. B., 1989, Uptake and utilization of human polymorphonuclear leukocyte granule myeloperoxidase by mouse peritoneal. Cell and Tiss. Res. 257 (3): 653–656.Google Scholar
  2. Levy O., 2000, Antimicrobial proteins and peptides of blood: templates for novel antimicrobial agents. Blood 96 (8): 2664–2672.PubMedGoogle Scholar
  3. Plekhova N. G., and Isachkova L. M., 1998, Electronic-cytochemical characteristic of process interaction neutrophils and macrophages with Yersinia pseudotuberculosis Med. J. Russia 1–2: 61–65.Google Scholar

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Natalya G. Plekhova
    • 1
  • Larisa M. Somova-Isachkova
    • 1
  • Felix N. Shubin
    • 1
  1. 1.Research Institute of Epidemiology and MicrobiologySiberian Branch of RAMSVladivostokRussia

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