Role of T Cells and Gamma Interferon in Yersinia pseudotuberculosis -Derived Mitogen (YPM)-Induced Toxicity in Mice
YPM had an acute toxic effect on BALB/c mice, which was dependent on the presence of T cells and correlated with the elevation of serum IFN-gamma. One monoclonal antibody (YSA8E3) rescued BALB/c mice from development of toxic shock after YPM injection.
KeywordsGamma Interferon Coronary Aneurysm Mouse Splenocytes Acute Toxic Effect Massive Necrosis
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