Advertisement

Role of T Cells and Gamma Interferon in Yersinia pseudotuberculosis -Derived Mitogen (YPM)-Induced Toxicity in Mice

  • Hirotsugu Kano
  • Yasuhiko Ito
  • Kentaro Matsuoka
  • Tutomu Iwata
  • Hirohisa Saito
  • Takao Kohsaka
  • Jun Abe
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 529)

Conclusion

YPM had an acute toxic effect on BALB/c mice, which was dependent on the presence of T cells and correlated with the elevation of serum IFN-gamma. One monoclonal antibody (YSA8E3) rescued BALB/c mice from development of toxic shock after YPM injection.

Keywords

Gamma Interferon Coronary Aneurysm Mouse Splenocytes Acute Toxic Effect Massive Necrosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Hirotsugu Kano
    • 1
    • 2
  • Yasuhiko Ito
    • 1
  • Kentaro Matsuoka
    • 3
  • Tutomu Iwata
    • 2
  • Hirohisa Saito
    • 1
  • Takao Kohsaka
    • 4
  • Jun Abe
    • 1
  1. 1.Dep. of Allergy and ImmunologyNational Research Institute for Child Health and DevelopmentTokyo
  2. 2.Dep. of Pediatrics, Faculty of MedicineThe University of TokyoTokyoJapan
  3. 3.Dep. of Clinical PathologyNational Center for Child Health and DevelopmentTokyoJapan
  4. 4.Dep. of GastroenterologyNational Center for Child Health and DevelopmentTokyoJapan

Personalised recommendations