Salicylanilides are Potent Inhibitors of Type III Secretion in Yersinia
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We have identified O-acyl salicylanilides as potent inhibitors of type III secretion in Y. pseudotuberculosis. These compounds can serve as a starting point for development of novel antibacterial agents that target virulence. Furthermore, compounds that affect bacterial virulence can be employed as chemical tools to study and further understand the processes involved in bacterial virulence. We now plan to use these derivatives in in vitro and in vivo experiments to study type III secretion in Yersinia and other Gramnegative bacteria. The Yersinia targets of these salicylanilides are unknown and our future work will also focus on target identification and optimisation of promising compounds with the goal to increase potency and selectivity.
KeywordsPotent Inhibitor Bacterial Virulence Target Virulence luxA Gene Secretion Machinery
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