Advertisement

Rho-GTP Binding Proteins in Yersinia Target Cell Interaction

  • Martin Aepfelbacher
  • Claudia Trasak
  • Agnès Wiedemann
  • Andreas Andor
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 529)

Keywords

Yersinia Enterocolitica Wiskott Aldrich Syndrome Protein Bacterial Uptake Yersinia Species Enterocolitica Strain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alrutz, M. A., Srivastava, A., Wong, K. W., D’ouza-Schorey, C., Tang, M., Ch’Ng L. E., Snapper, S. B., and Isberg, R. R., 2001, Efficient uptake of Yersinia pseudotuberculosis via integrin receptors involves a Rac1-Arp 2/3 pathway that bypasses N-WASP function. Mol. Microbiol. 42: 689–703.CrossRefPubMedGoogle Scholar
  2. Aepfelbacher, M., 2001, Modulation of RhoGTPases and the actin cytoskeleton by Yersinia outer proteins (Yops). Int. J. Med. Microbiol. 291: 269–276.CrossRefPubMedGoogle Scholar
  3. Andor, A., Trülzsch, K., Essler, M., Wiedemann, A., Roggenkamp, A., Heesemann, J., and Aepfelbacher, M., 2001, YopE of Yersinia, a GAP for Rho-GTPases, selectively modulates Rac-dependent actin structures in endothelial cells. Cell. Microbiol 3: 301–310.CrossRefPubMedGoogle Scholar
  4. Barz, C., Abahji, T. N., Trülzsch, K., and Heesemann, J., 2000, The Yersinia Ser/Thr protein kinase YpkA/YopO directly interacts with the small GTPases RhoA and Rac-1. FEBS Lett. 482: 139–143.CrossRefPubMedGoogle Scholar
  5. Bishop, A. L., Hall, A., 2000, Rho GTPases and their effector proteins. Biochem. J. 348: 241–255.CrossRefPubMedGoogle Scholar
  6. Black, D. S., and Bliska, J. B., 2000, The RhoGAP activity of the Yersinia pseudotuberculosis cytotoxin YopE is required for antiphagocytic function and virulence. Mol. Microbiol. 37: 515–527.CrossRefPubMedGoogle Scholar
  7. Cornelis, G. R., and Wolf-Watz, H., 1997, The Yersinia Yop virulon: a bacterial system for subverting eukaryotic cells. Mol. Microbiol. 23: 861–867.CrossRefPubMedGoogle Scholar
  8. Cornelis, G. R., Boland, A., Boyd, A.P., Geuijen, C., Iriarte, M., Neyt, C., Sory, M. P., and Stainier, I., 1998, The virulence plasmid of Yersinia, an antihost genome. Microbiol. Mol. Biol. Rev. 62: 1315–1352.PubMedGoogle Scholar
  9. Dukuzumuremyi, J. M., Rosqvist, R., Hallberg, B., Akerstrom, B., Wolf-Watz, H., Schesser, K.: The Yersinia protein kinase A is a host-factor inducible RhoA/Rac-binding virulence factor. J. Biol. Chem. 275: 35281–35290.Google Scholar
  10. Hakansson, S., Galyov, E. E., Rosqvist, R., and Wolf Watz, H., 1996, The Yersinia YpkA Ser/Thr kinase is translocated and subsequently targeted to the inner surface of the HeLa cell plasma membrane. Mol. Microbiol. 20: 593–603.CrossRefPubMedGoogle Scholar
  11. Higgs, H. N., and Pollard, T. D., 1999, Regulation of actin polymerization by Arp2/3 complex and WASp/Scar proteins. J. Biol. Chem. 274: 3253–3254.CrossRefGoogle Scholar
  12. Iriarte, M., and Cornelis, G. R., 1998, YopT, a new Yersinia effector protein, affects the cytoskeleton of host cells. Mol. Microbiol. 29: 915–929.CrossRefPubMedGoogle Scholar
  13. Isberg, R. R., Hamburger, Z., and Dersch, P., 2000, Signaling and invasin-promoted uptake via integrin receptors. Microbes Infect. 2: 793–801.CrossRefPubMedGoogle Scholar
  14. Jacobi, C. A., Roggenkamp, A., Rakin, A., Zumbihl, R., Leitritz, L., and Heesemann, J., 1998, In vitro and in vivo expression studies of yopE from Yersinia enterocolitica using the gfp reporter gene. Mol. Microbiol. 30: 865–882.CrossRefPubMedGoogle Scholar
  15. Juris, S.J., Rudolph, A.E., Huddler, D., Orth, K., and Dixon, J.E., 2000, A distinctive role for the Yersinia protein kinase: actin binding, kinase activation, and cytoskeleton disruption. Proc. Natl. Acad. Sci. U S A 17: 9431–9436.Google Scholar
  16. McGee K., Zettl, M., Way, M., and Fallman, M., 2001, A role for N-WASP in invasin-promoted internalisation. FEBS Lett. 509: 59–65.CrossRefPubMedGoogle Scholar
  17. Olofsson, B., 1999, Rho Guanine Dissociation Inhibitors: Pivotal Molecules in Cellular Signalling. Cell. Signal. 11: 545–554.CrossRefPubMedGoogle Scholar
  18. Pawel-Rammingen von, U., Telepnev, M. V., Schmidt, G., Aktories, K., Wolf-Watz, H., and Rosqvist, R., 2000, GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: a mechanism for disruption of actin microfilament structure. Mol. Microbiol. 36: 737–748.Google Scholar
  19. Scheffzek, K., Ahmadian, M.R., Wittinghofer, A., 1998, GTPase-activating proteins: helping hands to complement an active site. Trends Biochem. Sci. 23: 257–262.CrossRefPubMedGoogle Scholar
  20. Shao, F., Merritt, P., Bao, Z., Innes, R. W., and Dixon, J. E., 2002, A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis. Cell 109: 576–588.CrossRefGoogle Scholar
  21. Wiedemann, A., Linder, S., Grassl, G., Albert, M., Autenrieth, I., and Aepfelbacher, M., 2001, Yersinia enterocolitica invasin triggers phagocytosis via betal integrins, CDC42Hs and WASp in macrophages. Cell. Microbiol. 3: 693–702.CrossRefPubMedGoogle Scholar
  22. Zumbihl, R., Aepfelbacher, M., Andor, A., Jacobi, C. A., Ruckdeschel, K., Rouot, B., and Heesemann, J., 1999, The cytotoxin YopT of Yersinia enterocolitica induces modification and cellular redistribution of the small GTP-binding protein RhoA. J. Biol. Chem. 274: 29289–29293.CrossRefPubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Martin Aepfelbacher
    • 1
  • Claudia Trasak
    • 1
  • Agnès Wiedemann
    • 1
  • Andreas Andor
    • 1
  1. 1.Max von Pettenkofer-Institut für Medizinische MikrobiologieLMU MünchenMunichGermany

Personalised recommendations