Evolution of Pathogenic Yersinia, Some Lights in the Dark

  • Elisabeth Carniel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 529)


Although there is still a lot of speculation about the emergence and evolution of Y. pestis, recent advances made by different laboratories and the promising approach of comparative functional genomics should bring major insights in our knowledge of this field in the near future.


Yersinia Enterocolitica Yersinia Pestis Yersinia Species Pestis Strain Pneumonic Plague 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Achtman, M., Zurth, K., Morelli, C., Torrea, G., Guiyoule, A., and Carniel, E., 1999, Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis. Proc. Natl. Acad. Sci. U.S.A. 96: 14043–14048.CrossRefPubMedGoogle Scholar
  2. Aleksic, S., Steigerwalt, A.G., Bockemuhl, J., Huntley-Carter, G.P., and Brenner, D.J., 1987, Yersinia rodhei sp. nov. Isolated from Human and Dog Feces and Surface Water. Int. J. Syst. Bact. 37: 327–332.Google Scholar
  3. Bacot, A.W., and Martin, C.J., 1914, Observations on the mechanisms of the transmission of plague by fleas. J. Hyg. 13 (Plague supplement III): 423–439.Google Scholar
  4. Bercovier, H., Mollaret, H.H., Alonso, J.M., Brault, J., Fanning, G.R., Steigerwalt, A.G., and Brenner, D.J., 1980a, Intra-and interspecies relatedness of Yersinia pestis by DNA hybridization and its relationship to Yersinia pseudotuberculosis. Curr. Microbiol. 4: 225–229.Google Scholar
  5. Bercovier, H., Steigerwalt, A.G., Guiyoule, A., Huntley-Carter, G., and Brenner, D.J., 1984, Yersinia aldovae (Formerly Yersinia enterocolitica-Like Group X2): a New Species of Enterobacteriaceae Isolated from Aquatic Ecosystems. Int. J. Syst. Bact. 34: 166–175.Google Scholar
  6. Bercovier, H., Ursing, J., Brenner, D.J., Steigerwalt, A.G., Fanning, G.R., Carter, G.P., and Mollaret, H.H., 1980b, Yersinia kristensenii: a new species of Enterobacteriaceae composed of sucrose-negative strains (formerly called atypical Yersinia enterocolitica or Yersinia enterocolitica-like). Current Microbiol. 4: 219–224.Google Scholar
  7. Brenner, D.J., Bercovier, H., Ursing, J., Alonso, J.M., Steigerwalt, A.G., Fanning, G.R., Carter, G.P., and Mollaret, H.H., 1980a, Y. intermedia: a new species of Enterobacteriaceae composed of rhamnose-positive, melibiose-positive, raffinose-positive strains (formerly called atypical Yersinia enterocolitica or Yersinia enterocolitica-like). Current Microbiol. 4: 207–212.Google Scholar
  8. Brenner, D.J., Ursing, J., Bercovier, H., Steigerwalt, A.G., Fanning, G.R., Alonso, J.M., and Mollaret, H.H., 1980b, Deoxyribonucleic acid relatedness in Yersinia enterocolitica and Yersinia enterocolitica-like organisms. Curr. Microbiol. 4: 195–200.Google Scholar
  9. Davis, K.J., Fritz, D.L., Pitt, M.L., Welkos, S.L., Worsham, P.L., and Friedlander, A.M., 1996, Pathology of experimental pneumonic plague produced by fraction l-positive and fraction l-negative Yersinia pestis in African green monkeys (Cercopithecus aethiops). Arch. Pathol. Lab. Med. 120: 156–163.PubMedGoogle Scholar
  10. De Grandis, S.A., Krell, P.J., Flett, D.E., and Stevenson, R.M.W., 1988, DNA relatedness of serovars of Yersinia ruckeri the enteric Redmouth Bacterium. Int. J. Syst. Bacteriol. 38: 49–55.Google Scholar
  11. Deng, W., Burland, V., Plunkett, G., Boutin, A., Mayhew, G.F., Liss, P., Perna, N.T., Rose, D.J., Mau, B., Zhou, S.G., Schwartz, D.C., Fetherston, J.D., Lindler, L.E., Brubaker, R.R., Piano, G.V., Straley, S.C., McDonough, K.A., Nilles, M.L., Matson, J.S., Blattner, F.R., and Perry, R.D., 2002, Genome sequence of Yersinia pestis KIM. J. Bacteriol. 184: 4601–4611.CrossRefPubMedGoogle Scholar
  12. Ewing, W.H., Ross, A.J., Brenner, D.J., and Fanning, G.R., 1978, Yersinia ruckeri sp. nov., the redmouth (RM) Bacterium. Int. J. Syst. Bact. 28: 37–44.Google Scholar
  13. Friedlander, A.M., Welkos, S.L., Worsham, P.L., Andrews, G.P., Heath, D.G., Anderson, G.W., Pitt, M.L.M., Estep, J., and Davis, K., 1995, Relationship between virulence and immunity as revealed in recent studies of the F1 capsule of Yersinia pestis. Clin. Infect. Dis. 21: S178–S181.PubMedGoogle Scholar
  14. Hinnebusch, B.J., Perry, R.D., and Schwan, T.G., 1996, Role of the Yersinia pestis hemin storage (hms) locus in the transmission of plague by fleas. Science 273: 367–370.PubMedGoogle Scholar
  15. Hinnebusch, B.J., Rosso, M.L., Schwan, T.G., and Carniel, E., 2002a, High-frequency conjugative transfer of antibiotic resistance genes to Yersinia pestis in the flea midgut. Mol. Microbiol. 46: 349–354.CrossRefPubMedGoogle Scholar
  16. Hinnebusch, B.J., Rudolph, A.E., Cherepanov, P., Dixon, J.E., Schwan, T.G., and Forsberg, Å., 2002b, Role of Yersinia murine toxin in survival of Yersinia pestis in the midgut of the flea vector. Science 296: 733–735.CrossRefPubMedGoogle Scholar
  17. Hinnebusch, J., Cherepanov, P., Du, Y., Rudolph, A., Dixon, J.D., Schwan, T., and Forsberg, A., 2000, Murine toxin of Yersinia pestis shows phospholipase D activity but is not required for virulence in mice. Int. J. Med. Microbiol. 290: 483–487.PubMedGoogle Scholar
  18. Kutyrev, V.V., Filippov, A.A., Shavina, N., and Protsenko, O.A., 1989, Genetic analysis and simulation of the virulence of Yersinia pestis. Molekuliarnaia Genetika, Mikrobiologia, i Virusologa: 42–7.Google Scholar
  19. Malassez, L., and Vignal, W., 1883, Physiologic pathologique — Tuberculose zoogléique. Académie des Sciences-Comptes Rendus Hebdomadaires des Séances de ľAcadémie des Sciences 97: 1006–1009.Google Scholar
  20. Mollaret, H.H., and Thal, E., 1974, Yersinia. In Bergey’s manual of determinative bacteriology Buchanan, R.E.a.G., N. E., (eds), baltimore: Williams and Wilkins, pp. 330–332.Google Scholar
  21. Parkhill, J., Wren, B.W., Thomson, N.R., Titball, R.W., Holden, M.T.G., Prentice, M.B., Sebaihia, M., James, K.D., Churcher, C., Mungall, K.L., Baker, S., Basham, D., Bentley, S.D., Brooks, K., Cerdeño-Tárraga, A.M., Chillingworth, T., Cronin, A., Davies, R.M., Davis, P., Dougan, G., Feltwell, T., Hamlin, N., Holroyd, S., Jagels, K., Karlyshev, A.V., Leather, S., Moule, S., Oyston, P.C.F., Quail, M., Rutherford, K., Simmonds, M., Skelton, J., Stevens, K., Whitehead, S., and Barrell, B.G., 2001, Genome sequence of Yersinia pestis, the causative agent of plague. Nature 413: 523–527.PubMedGoogle Scholar
  22. Pendrak, M.L., and Perry, R.D., 1991, Characterization of a hemin-storage locus of Yersinia pestis. Biol. Met. 4: 41–47.PubMedGoogle Scholar
  23. Prentice, M.B., James, K.D., Parkhill, J., Baker, S.G., Stevens, K., Simmonds, M.N., Mungall, K.L., Churcher, C., Oyston, P.C.F., Titball, R.W., Wren, B.W., Wain, J., Pickard, D., Hien, T.T., Farrar, J.J., and Dougan, G., 2001, Yersinia pestis pFra shows biovar-specific differences and recent common ancestry with a Salmonella enterica serovartyphi plasmid. J. Bacteriol. 183: 2586–2594.CrossRefPubMedGoogle Scholar
  24. Rudolph, A.E., Stuckey, J.A., Zhao, Y., Matthews, H.R., Patton, W.A., Moss, J., and Dixon, J.E., 1999, Expression, characterization, and mutagenesis of the Yersinia pestis murine toxin, a phospholipase D superfamily member. J. Biol. Chem. 274: 11824–11831.PubMedGoogle Scholar
  25. Samoilova, S.V., Samoilova, L.V., Yezhov, I.N., Drozdov, I.G., and Anisimov, A.P., 1996, Virulence of pPst(+) and pPst(-) strains of Yersinia pestis for guinea-pigs. J. Med. Microbiol. 45: 440–444.PubMedGoogle Scholar
  26. Schleifstein, J.I., and Coleman, M.B., 1939, An unidentified microorganism resembling B. lignieri and Past, pseudotuberculosis, and pathogenic for man. N.Y. State J. Med. 39: 1749–1753.Google Scholar
  27. Sodeinde, O.A., Subrahmanyam, Y.V.B.K., Stark, K., Quan, T., Bao, Y.D., and Goguen, J.D., 1992, A surface protease and the invasive character of plague. Science 258: 1004–1007.PubMedGoogle Scholar
  28. Ursing, J., Brenner, D.J., Bercovier, H., Fanning, G.R., Steigerwalt, A.G., Brault, J., and Mollaret, H.H., 1980, Y. frederiksenii: a new species of Enterobacteriaceae composed of rhamnose-positive strains (formerly called atypical Yersinia enterocolitica or Yersinia enterocolitica-like). Current Microbiol. 4: 213–217.Google Scholar
  29. Van Loghem, J.J., 1944, The classification of the plague bacillus. Antonie van Leeuwenhoek J. Microbiol. Serol. 10: 15–16.Google Scholar
  30. Wauters, G., Janssens, M., Steigerwalt, A.G., and Brenner, D.J., 1988, Y. mollaretii sp. nov. and Y. bercovieri sp. nov., formerly called Yersinia enterocolitica biogroups 3A and 3B. Int. J. Syst. Bacteriol. 38: 424–429.Google Scholar
  31. Welkos, S.L., Friedlander, A.M., and Davis, K.J., 1997, Studies on the role of plasminogen activator in systemic infection by virulent Yersinia pestis strain C092. Microb. Pathog. 23: 211–223.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Elisabeth Carniel
    • 1
  1. 1.Laboratoire des YersiniaInstitut PasteurParis Cedex 15France

Personalised recommendations