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Drug-resistant Malaria

  • Chapter
Reemergence of Established Pathogens in the 21st Century

Part of the book series: Emerging Infectious Diseases of the 21st Century ((EIDC,volume 2))

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Conclusion

Drug-resistant malaria is a major public health problem worldwide, however substantial progress has been made in the last decade in elucidating the underlying mechanisms of drug action and resistance. This knowledge should facilitate the rationale design of new effective and well-tolerated antimalarial drugs. Combination therapies, particularly regimens that include the rapid-acting artemisinin derivatives, are important new strategies to prevent drug resistance, increase treatment efficacy, and lower transmission rates in malaria-endemic areas (White et al., 1996). This strategy combined with other cost-effective interventions such as the implementation of insecticide impregnated bed nets, should substantially reduce malaria-associated morbidity and mortality in the short term, a fundamental objective of the Roll Back Malaria initiative of the WHO. Finally, the sequencing of the Plasmodium and human genomes should contribute substantially to our understanding of the pathophysiology of severe and fatal malaria and permit the identification of novel therapeutic strategies and new plasmodial targets for drug and vaccine development (Carucci, 2001; Fletcher, 1998; Hoffman et al., 1997, 1998; Riley, 1995).

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Authors
  1. Mona R. Loutfy
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  2. Kevin C. Kain
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  1. St. Michael’s Hospital, University of Toronto Head of Infectious Diseases, Canada

    I. W. Fong

  2. St. Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada

    I. W. Fong

  3. The Public Health Research Institute, Newark, New Jersey

    Karl Drlica

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Loutfy, M.R., Kain, K.C. (2004). Drug-resistant Malaria. In: Fong, I.W., Drlica, K. (eds) Reemergence of Established Pathogens in the 21st Century. Emerging Infectious Diseases of the 21st Century, vol 2. Springer, Boston, MA. https://doi.org/10.1007/0-306-48411-0_9

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