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Reemergence of Established Pathogens in the 21st Century pp 155–204Cite as

Vancomycin-resistant Enterococci

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Part of the book series: Emerging Infectious Diseases of the 21st Century ((EIDC,volume 2))

Conclusion

The incidence of nosocomial infections caused by VRE has consistently increased during the past decade across all types of health-care facilities, especially in the United States. More rigorous infection control measures and reduction in the use of antimicrobials for the treatment of human infections and/or new preventative modalities will likely be necessary to decrease the development of drug resistance in enterococci, as well as in other microorganisms. Restriction of the use of antibiotics as animal growth enhancers in the EU has resulted in decreased transmission of these organisms (and their resistant genes) from animals to humans. This interchange between animals and humans has become even more worrisome after a recent description of an E. faecium outbreak causing severe hemorrhagic disease in pigs and 40 local farmers (12 of them died) in a region of China (Lu et al., 2002). Newer therapeutic agents have been developed and used with relative effectiveness (although without a bactericidal activity) for the treatment of VRE infections, but the propensity of enterococci to develop resistance suggest that VRE will continue to be a therapeutic and infection control challenge for the immediate future.

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References

  • Aarestrup, F. M., Seyfarth, A. M., Emborg, H. D., Pedersen, K., Hendriksen, R. S., & Bager, F. (2001). Effect of abolishment of the use of antimicrobial agents for growth promotion on occurrence of antimicrobial resistance in fecal enterococci from food animals in Denmark. Antimicrob Agents Chemother 45, 2054–2059.

    Article  PubMed  CAS  Google Scholar 

  • Allen, N. E., LeTourneau, D. L., & Hobbs, J. N., Jr. (1997). The role of hydrophobic side chains as determinants of antibacterial activity of semisynthetic glycopeptide antibiotics. J Antibiot (Tokyo) 50, 677–684.

    CAS  Google Scholar 

  • Allerberger, F., & Klare, I. (1999). In-vitro activity of fosfomycin against vancomycin-resistant enterococci. J Antimicrob Chemother 43, 211–217.

    Article  PubMed  CAS  Google Scholar 

  • Arias, C. A., Courvalin, P., & Reynolds, P. E. (2000). vanC cluster of vancomycin-resistant Enterococcus gallinarum BM4174. Antimicrob Agents Chemother 44, 1660–1666.

    Article  PubMed  CAS  Google Scholar 

  • Arthur, M., & Courvalin, P. (1993). Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother 37, 1563–1571.

    PubMed  CAS  Google Scholar 

  • Arthur, M., Depardieu, F., Cabanie, L., Reynolds, P., & Courvalin, P. (1998). Requirement of the VanY and VanX D,D-peptidases for glycopeptide resistance in enterococci. Mol Microbiol 30, 819–830.

    Article  PubMed  CAS  Google Scholar 

  • Arthur, M., Depardieu, F., Molinas, C., Reynolds, P., & Courvalin, P. (1995). The vanZ gene of Tn1546 from Enterococcus faecium BM4147 confers resistance to teicoplanin. Gene 154, 87–92.

    Article  PubMed  CAS  Google Scholar 

  • Arthur, M., Depardieu, F, Reynolds, P., & Courvalin, P. (1996). Quantitative analysis of the metabolism of soluble cytoplasmic peptidoglycan precursors of glycopeptide-resistant enterococci. Mol Microbiol 21, 33–44.

    Article  PubMed  CAS  Google Scholar 

  • Arthur, M., Depardieu, F., Reynolds, P., & Courvalin, P. (1999). Moderate-level resistance to glycopeptide LY333328 mediated by genes of the vanA and vanB clusters in enterococci. Antimicrob Agents Chemother 43, 1875–1880.

    PubMed  CAS  Google Scholar 

  • Arthur, M., Molinas, C., & Courvalin, P. (1992). The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J Bacterial 174, 2582–2591.

    CAS  Google Scholar 

  • Arthur, M., Molinas, C., Depardieu, F, & Courvalin, P. (1993). Characterization of Tn1546, aTn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J Bacterial 175, 117–127.

    CAS  Google Scholar 

  • Arthur, M., & Quintiliani, R., Jr. (2001). Regulation of VanA-and VanB-type glycopeptide resistance in enterococci. Antimicrob Agents Chemother 45, 375–381.

    Article  PubMed  CAS  Google Scholar 

  • Aslangul, E., Baptista, M., Fantin, B., Depardieu, F., Arthur, M., Courvalin, P., & Carbon, C. (1997). Selection of glycopeptide-resistant mutants of VanB-type Enterococcus faecalis BM4281 in vitro and in experimental endocarditis. J Infect Dis 175, 598–605.

    PubMed  CAS  Google Scholar 

  • Austin, D. J., Bonten, M. J., Weinstein, R. A., Slaughter, S., & Anderson, R. M. (1999). Vancomycin-resistant enterococci in intensive-care hospital settings: Transmission dynamics, persistence, and the impact of infection control programs. Proc Natl Acad Sci USA 96, 6908–6913.

    PubMed  CAS  Google Scholar 

  • Axelrod, P., & Talbot, G. H. (1989). Risk factors for acquisition of gentamicin-resistant enterococci. A multivariate analysis. Arch Intern Med 149, 1397–1401.

    Article  PubMed  CAS  Google Scholar 

  • Babcock, H. M., Ritchie, D. J., Christiansen, E., Starlin, R., Little, R., & Stanley, S. (2001). Successful treatment of vancomycin-resistant Enterococcus endocarditis with oral linezolid. Clin Infect Dis 32, 1373–1375.

    Article  PubMed  CAS  Google Scholar 

  • Baden, L. R., Thiemke, W., Skolnik, A., Chambers, R., Strymish, J., Gold, H. S., Moellering, Jr, R. C., & Eliopoulos, G. M. (2001). Prolonged colonization with vancomycin-resistant Enterococcus faecium in long-term care patients and the significance of clearance. Clin Infect Dis 33, 1654–1660.

    Article  PubMed  CAS  Google Scholar 

  • Balas, D., Perea, B., Wilhelmi, I., Romanyk, J., Alos, J. I., & Gomez-Garces, J. L. (1997). Prevalence of antimicrobial resistance in enterococci isolated from blood in Madrid (1994–1995). Enferm Infecc Microbiol Clin 15, 22–23.

    PubMed  CAS  Google Scholar 

  • Balzereit-Scheuerlein, F., & Stephan, R. (2001). Prevalence of colonisation and resistance patterns of vancomycin-resistant enterococci in healthy, non-hospitalised persons in Switzerland. Swiss Med Wkly 131, 280–282.

    PubMed  CAS  Google Scholar 

  • Bates, J., Jordens, J. Z., & Griffiths, D. T. (1994). Farm animals as a putative reservoir for vancomycin-resistant enterococcal infection in man. J Antimicrob Chemother 34, 507–514.

    PubMed  CAS  Google Scholar 

  • Bell, J., Turnidge, J., Coombs, G., & O’Brien, F. (1998). Emergence and epidemiology of vancomycin-resistant enterococci in Australia. Commun Dis Intell 22, 249–252.

    PubMed  CAS  Google Scholar 

  • Bignardi, G. E. (1998). Risk factors for Clostridium difficile infection. J Hasp Infect 40, 1–15.

    CAS  Google Scholar 

  • Bingen, E., Lambert-Zechovsky, N., Mariani-Kurkdjian, P., Cezard, J. P., & Navarro, J. (1989). Bacteremia caused by a vancomycin-resistant Enterococcus. Pediatr Infect Dis J 8, 475–476.

    PubMed  CAS  Google Scholar 

  • Bingen, E. H., Denamur, E., Lambert-Zechovsky, N. Y, & Elion, J. (1991). Evidence for the genetic unrelatedness of nosocomial vancomycin-resistant Enterococcus faecium strains in a pediatric hospital. J Clin Microbiol 29, 1888–1892.

    PubMed  CAS  Google Scholar 

  • Bonilla, H. F., Zervos, M. A., Lyons, M. J., Bradley, S. F., Hedderwick, S. A., Ramsey, M. A., Paul, L. K., & Kauffman, C. A. (1997). Colonization with vancomycin-resistant Enterococcus faecium: Comparison of a long-term-care unit with an acute-care hospital. Infect Control Hosp Epidemiol 18, 333–339.

    PubMed  CAS  Google Scholar 

  • Bonten, M. J., Hayden, M. K., Nathan, C., van Voorhis, J., Matushek, M., Slaughter, S., Rice, T., & Weinstein, R. A. (1996). Epidemiology of colonisation of patients and environment with vancomycin-resistant enterococci. Lancet 348, 1615–1619.

    Article  PubMed  CAS  Google Scholar 

  • Bonten, M. J., Slaughter, S., Ambergen, A. W., Hayden, M. K., van Voorhis, J., Nathan, C., & Weinstein, R. A. (1998). The role of “colonization pressure” in the spread of vancomycin-resistant enterococci: An important infection control variable. Arch Intern Med 158, 1127–1132.

    Article  PubMed  CAS  Google Scholar 

  • Bouza, E., San Juan, R., Munoz, P., Voss, A., & Kluytmans, J. (2001). A European perspective on nosocomial urinary tract infections I. Report on the microbiology workload, etiology and antimicrobial susceptibility (ESGNI-003 study). European Study Group on Nosocomial Infections. Clin Microbiol Infect 7, 523–531.

    PubMed  CAS  Google Scholar 

  • Boyce, J. M. (1989). Methicillin-resistant Staphylococcus aureus. Detection, epidemiology, and control measures. Infect Dis Clin North Am 3, 901–913.

    PubMed  CAS  Google Scholar 

  • Boyce, J. M., Mermel, L. A., Zervos, M. J., Rice, L. B., Potter-Bynoe, G., Giorgio, C., & Medeiros, A. A. (1995). Controlling vancomycin-resistant enterococci [see comments] [erratum appears in Infect Control Hosp Epidemiol 1996 Apr;17(4), 211]. Infect Control Hosp Epidemiol 16, 634–637.

    PubMed  CAS  Google Scholar 

  • Boyce, J. M., Opal, S. M., Chow, J. W., Zervos, M. J., Potter-Bynoe, G., Sherman, C. B., Romulo, R. L., Fortna, S., & Medeiros, A. A. (1994). Outbreak of multidrug-resistant Enterococcus faecium with transferable vanB class vancomycin resistance. J Clin Microbiol 32, 1148–1153.

    PubMed  CAS  Google Scholar 

  • Boyd, D. A., Conly, J., Dedier, H., Peters, G., Robertson, L., Slater, E., & Mulvey, M. R. (2000). Molecular characterization of the vanD gene cluster and a novel insertion element in a vancomycin-resistant Enterococcus isolated in Canada. J Clin Microbiol 38, 2392–2394.

    PubMed  CAS  Google Scholar 

  • Bozdogan, B., & Leclercq, R. (1999). Effects of genes encoding resistance to streptogramins A and B on the activity of quinupristin-dalfopristin against Enterococcus faecium. Antimicrob Agents Chemother 43, 2720–2725.

    PubMed  CAS  Google Scholar 

  • Bradley, S. J., Wilson, A. L., Allen, M. C., Sher, H. A., Goldstone, A. H., & Scott, G. M. (1999). The control of hyperendemic glycopeptide-resistant Enterococcus spp. on a haematologyunit by changing antibiotic usage. J Antimicrob Chemother 43, 261–266.

    Article  PubMed  CAS  Google Scholar 

  • Brandt, C. M., Rouse, M. S., Laue, N. W., Stratton, C. W., Wilson, W. R., & Steckelberg, J. M. (1996). Effective treatment of multidrug-resistant enterococcal experimental endocarditis with combinations of cell wall-active agents. J Infect Dis 173, 909–913.

    PubMed  CAS  Google Scholar 

  • Brennen, C., Wagener, M. M., & Muder, R. R. (1998). Vancomycin-resistant Enterococcus faecium in a long-term care facility. J Am Geriatr Soc 46, 157–160.

    PubMed  CAS  Google Scholar 

  • Brooks, S., Khan, A., Stoica, D., Griffith, J., Friedeman, L., Mukherji, R., Hameed, R., & Schupf, N. (1998). Reduction in vancomycin-resistant Enterococcus and Clostridium difficile infections following change to tympanic thermometers. Infect Control Hasp Epidemiol 19, 333–336.

    CAS  Google Scholar 

  • Brown, A. R., Townsley, A. C., & Amyes, S. G. (2001). Diversity of Tn1546 elements in clinical isolates of glycopeptide-resistant enterococci from Scottish hospitals. Antimicrob Agents Chemother 45, 1309–1311.

    Article  PubMed  CAS  Google Scholar 

  • Budavari, S. M., Saunders, G. L., Liebowitz, L. D., Khoosal, M., & Crewe-Brown, H. H. (1997). Emergence of vancomycin-resistant enterococci in South Africa. S Afr Med J 87, 1557.

    PubMed  CAS  Google Scholar 

  • Byers, K. E., Anglim, A. M., Anneski, C. J., Germanson, T. P., Gold, H. S., Durbin, L. J., Simonton, B. M., & Farr, B. M. (2001). A hospital epidemic of vancomycin-resistant Enterococcus: Risk factors and control. Infect Control Hosp Epidemiol 22, 140–147.

    PubMed  CAS  Google Scholar 

  • Byers, K. E., Durbin, L. J., Simonton, B. M., Anglim, A. M., Adal, K. A., & Farr, B. M. (1998). Disinfection of hospital rooms contaminated with vancomycin-resistant Enterococcus faecium. Infect Control Hosp Epidemiol 19, 261–264.

    PubMed  CAS  Google Scholar 

  • Caballero-Granado, F. J., Becerril, B., Cuberos, L., Bernabeu, M., Cisneros, J. M., & Pachon, J. (2001). Attributable mortality rate and duration of hospital stay associated with enterococcal bacteremia. Clin Infect Dis 32, 587–594.

    Article  PubMed  CAS  Google Scholar 

  • Caballero-Granado, F. J., Cisneros, J. M., Luque, R., Torres-Tortosa, M., Gamboa, F., Diez, F., Villanueva, J. L., Perez-Cano, R., Pasquau, J., Merino, D., Menchero, A., Mora, D., Lopez-Ruz, M. A., & Vergara, A. (1998). Comparative study of bacteremias caused by Enterococcus spp. with and without high-level resistance to gentamicin. The grupo Andaluz para el estudio de las enfermedades infecciosas. J Clin Microbiol 36, 520–525.

    PubMed  CAS  Google Scholar 

  • Canepari, P., Boaretti, M., del Mar Lleo, M., & Satta, G. (1990). Lipoteichoic acid as a new target for activity of antibiotics: Mode of action of daptomycin (LY146032). Antimicrob Agents Chemother 34, 1220–1226.

    PubMed  CAS  Google Scholar 

  • Carias, L. L., Rudin, S. D., Donskey, C. J., & Rice, L. B. (1998). Genetic linkage and cotransfer of a novel, vanB-containing transposon (Tn5382) and a low-affinity penicillin-binding protein 5 gene in a clinical vancomycin-resistant Enterococcus faecium isolate. J Bacteriol 180, 4426–4434.

    PubMed  CAS  Google Scholar 

  • Caron, F., Gold, H. S., Wennersten, C. B., Farris, M. G., Moellering, R. C., Jr., & Eliopoulos, G. M. (1997). Influence of erythromycin resistance, inoculum growth phase, and incubation time on assessment of the bactericidal activity of RP 59500 (quinupristin-dalfopristin) against vancomycin-resistant Enterococcus faecium. Antimicrob Agents Chemother 41, 2749–2753.

    PubMed  CAS  Google Scholar 

  • Caron, F., Pestel, M., Kitzis, M. D., Lemeland, J. F., Humbert, G., & Gutmann, L. (1995). Comparison of different beta-lactam-glycopeptide-gentamicin combinations for an experimental endocarditis caused by a highly beta-lactam-resistant and highly glycopeptide-resistant isolate of Enterococcus faecium. J Infect Dis 171, 106–112.

    PubMed  CAS  Google Scholar 

  • Casadewall, B., & Courvalin, P. (1999). Characterization of the vanD glycopeptide resistance gene cluster from Enterococcus faecium BM4339. J Bacteriol 181, 3644–3648.

    PubMed  CAS  Google Scholar 

  • CDC. (1994). Preventing the Spread of Vancomycin Resistance—A Report from the Hospital Infection Control Practices Advisory Committee prepared by the Subcommittee on Prevention and Control of Antimicrobial-Resistant Microorganisms in Hospitals; comment period and public meeting—CDC. Notice. Federal Register 59, 25758–25763.

    Google Scholar 

  • CDC. (2002a). Staphylococcus aureus resistant to vancomycin—United States, 2002. MMWR 51, 565–567.

    Google Scholar 

  • CDC. (2002b). Vancomycin-resistant Staphylococcus aureus—Pennsylvania, 2002. MMWR 51, 902.

    Google Scholar 

  • CDC. (1995). Recommendations for preventing the spread of vancomycin resistance. Recommendations of the Hospital Infection Control Practices Advisory Committee (HICPAC). MMWR 44, 1–13.

    Google Scholar 

  • Chia, J. K., Nakata, M. M., Park, S. S., Lewis, R. P., & McKee, B. (1995). Use of bacitracin therapy for infection due to vancomycin-resistant Enterococcus faecium. Clin Infect Dis 21, 1520.

    PubMed  CAS  Google Scholar 

  • Chien, J. W., Kucia, M. L., & Salata, R. A. (2000). Use of linezolid, an oxazolidinone, in the treatment of multidrug-resistant Gram-positive bacterial infections. Clin Infect Dis 30, 146–151.

    Article  PubMed  CAS  Google Scholar 

  • Chiew, Y. E, & Ling, M. L. (1998). Two cases of vancomycin-resistant enterococci from Singapore. J Infect 36, 133–134.

    Article  PubMed  CAS  Google Scholar 

  • Chirurgi, V. A., Oster, S. E., Goldberg, A. A., & McCabe, R. E. (1992). Nosocomial acquisition of beta-lactamase—negative, ampicillin-resistant Enterococcus. Arch Intern Med 152, 1457–1461.

    Article  PubMed  CAS  Google Scholar 

  • Chow, J. W., Davidson, A., Sanford, E., 3rd, & Zervos, M. J. (1997). Superinfection with Enterococcus faecalis during quinupristin/dalfopristin therapy. Clin Infect Dis 24, 91–92.

    PubMed  CAS  Google Scholar 

  • Clabots, C. R., Johnson, S., Olson, M. M., Peterson, L. R., & Gerding, D. N. (1992). Acquisition of Clostridium difficile by hospitalized patients: Evidence for colonized new admissions as a source of infection. J Infect Dis 166, 561–567.

    PubMed  CAS  Google Scholar 

  • Clark, N. C., Teixeira, L. M., Facklam, R. R., & Tenover, F.C. (1998). Detection and differentiation of vanC-1, vanC-2, and vanC-3 glycopeptide resistance genes in enterococci. J Clin Microbiol 36, 2294–2297.

    PubMed  CAS  Google Scholar 

  • Collins, L. A., Malanoski, G. J., Eliopoulos, G. M., Wennersten, C. B., Ferraro, M. J., & Moellering, R. C., Jr. (1993). In vitro activity of RP59500, an injectable streptogramin antibiotic, against vancomycin-resistant Gram-positive organisms. Antimicrob Agents Chemother 37, 598–601.

    PubMed  CAS  Google Scholar 

  • Coque, T. M., Tomayko, J. F., Ricke, S. C., Okhyusen, P. C., & Murray, B. E. (1996). Vancomycin-resistant enterococci from nosocomial, community, and animal sources in the United States. Antimicrob Agents Chemother 40, 2605–2609.

    PubMed  Google Scholar 

  • Coudron, P. E., Markowitz, S. M., & Wong, E. S. (1992). Isolation of a beta-lactamase-producing, aminoglycoside-resistant strain of Enterococcus faecium. Antimicrob Agents Chemother 36, 1125–1126.

    PubMed  CAS  Google Scholar 

  • Coudron, P. E., Mayhall, C. G., Facklam, R. R., Spadora, A. C., Lamb, V A., Lybrand, M. R., & Dalton, H. P. (1984). Streptococcus faecium outbreak in a neonatal intensive care unit. J Clin Microbiol 20, 1044–1048.

    PubMed  CAS  Google Scholar 

  • Das, I., & Gray, J. (1998). Enterococcal bacteremia in children: A review of seventy-five episodes in a pediatric hospital. Pediatr Infect Dis J 17, 1154–1158.

    Article  PubMed  CAS  Google Scholar 

  • Dembry, L. M., Uzokwe, K., & Zervos, M. J. (1996). Control of endemic glycopeptide-resistant enterococci. Infect Control Hosp Epidemiol 17, 86–292.

    Google Scholar 

  • Descheemaeker, P., Ieven, M., Chapelle, S., Lammens, C., Hauchecorne, M., Wijdooghe, M., Vandamme, P., & Goossens, H. (2000). Prevalence and molecular epidemiology of glycopeptide-resistant enterococci in Belgian renal dialysis units. J Infect Dis 181, 235–241.

    Article  PubMed  CAS  Google Scholar 

  • Dever, L. L., Smith, S. M., Handwerger, S., & Eng, R. H. (1995). Vancomycin-dependent Enterococcus faecium isolated from stool following oral vancomycin therapy. J Clin Microbiol 33, 2770–2773.

    PubMed  CAS  Google Scholar 

  • Devriese, L. A., Vandamme, P., Pot, B., Vanrobaeys, M., Kersters, K., & Haesebrouck, F. (1998). Differentiation between Streptococcus gallolyticus strains of human clinical and veterinary origins and Streptococcus bovis strains from the intestinal tracts of ruminants. J Clin Microbiol 36, 3520–3523.

    PubMed  CAS  Google Scholar 

  • Dodge, R. A., Daly, J. S., Davaro, R., & Glew, R. H. (1997). High-dose ampicillin plus streptomycin for treatment of a patient with severe infection due to multi-resistant enterococci. Clin Infect Dis 25, 1269–1270.

    PubMed  CAS  Google Scholar 

  • Donskey, C. J., Chowdhry, T. K., Hecker, M. T., Hoyen, C. K., Hanrahan, J. A., Hujer, A. M., Hutton-Thomas, R. A., Whalen, C. C., Bonomo, R. A., & Rice, L. B. (2000a). Effect of antibiotic therapy on the density of vancomycin-resistant enterococci in the stool of colonized patients [see comments]. N Engl J Med 343, 1925–1932.

    Article  PubMed  CAS  Google Scholar 

  • Donskey, C. J., Hanrahan, J. A., Hutton, R. A., & Rice, L. B. (1999a). Effect of parenteral antibiotic administration on persistence of vancomycin-resistant Enterococcus faecium in the mouse gastrointestinal tract. J Infect Dis 180, 384–390.

    Article  PubMed  CAS  Google Scholar 

  • Donskey, C. J., Hanrahan, J. A., Hutton, R. A., & Rice, L. B. (2000b). Effect of parenteral antibiotic administration on the establishment of colonization with vancomycin-resistant Enterococcus faecium in the mouse gastrointestinal tract. J Infect Dis 181, 1830–1833.

    Article  PubMed  CAS  Google Scholar 

  • Donskey, C. J., Schreiber, J. R., Jacobs, M. R., Shekar, R., Salata, R. A., Gordon, S., Whalen, C. C., Smith, F., & Rice, L. B. (1999b). A polyclonal outbreak of predominantly VanB vancomycin-resistant enterococci in northeast Ohio. Northeast Ohio vancomycin-resistant Enterococcus surveillance program. Clin Infect Dis 29, 573–579.

    PubMed  CAS  Google Scholar 

  • Dunne, W. M. (1996). Watch out where the huskies go. ASM News 62, 283.

    Google Scholar 

  • Durand, M. L., Calderwood, S. B., Weber, D. J., Miller, S. I., Southwick, F. S., Caviness, V S., Jr., & Swartz, M. N. (1993). Acute bacterial meningitis in adults. A review of 493 episodes. N Engl J Med 328, 21–28.

    Article  PubMed  CAS  Google Scholar 

  • Dutka-Malen, S., Blaimont, B., Wauters, G., & Courvalin, P. (1994). Emergence of high-level resistance to glycopeptides in Enterococcus gallinarum and Enterococcus casseliftavus. Antimicrob Agents Chemother 38, 1675–1677.

    PubMed  CAS  Google Scholar 

  • Dutka-Malen, S., Molinas, C., Arthur, M., & Courvalin, P. (1992). Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a d-alanine: d-alanine ligase-related protein necessary for vancomycin resistance. Gene 112, 53–58.

    Article  PubMed  CAS  Google Scholar 

  • Edmond, M. B., Ober, J. F., Dawson, J. D., Weinbaum, D. L., & Wenzel, R. P. (1996). Vancomycin-resistant enterococcal bacteremia: Natural history and attributable mortality. Clin Infect Dis 23, 1234–1239.

    PubMed  CAS  Google Scholar 

  • Edmond, M. B., Ober, J. F., Weinbaum, D. L., Pfaller, M. A., Hwang, T., Sanford, M. D., & Wenzel, R. P. (1995). Vancomycin-resistant Enterococcus faecium bacteremia: Risk factors for infection. Clin Infect Dis 20, 1126–1133.

    PubMed  CAS  Google Scholar 

  • Edmond, M. B., Wallace, S. E., McClish, D. K., Pfaller, M. A., Jones, R. N., & Wenzel, R. P. (1999). Nosocomial bloodstream infections in United States hospitals: A three-year analysis. Clin Infect Dis 29, 239–244.

    PubMed  CAS  Google Scholar 

  • Eliopoulos, G. M., Wennersten, C., Zighelboim-Daum, S., Reiszner, E., Goldmann, D, & Moellering, R. C., Jr. (1988). High-level resistance to gentamicin in clinical isolates of Streptococcus (Enterococcus) faecium. Antimicrob Agents Chemother 32, 1528–1532.

    PubMed  CAS  Google Scholar 

  • Eliopoulos, G. M., Wennersten, C. B., Gold, H. S., Schulin, T., Souli, M., Farris, M. G., Cerwinka, S., Nadler, H. L., Dowzicky, M., Talbot, G. H., & Moellering, R. C., Jr. (1998). Characterization of vancomycin-resistant Enterococcus faecium isolates from the United States and their susceptibility in vitro to dalfopristin-quinupristin. Antimicrob Agents Chemother 42, 1088–1092.

    PubMed  CAS  Google Scholar 

  • Endtz, H. P., van den Braak, N., van Belkum, A., Kluytmans, J. A., Koeleman, J. G., Spanjaard, L., Voss, A., Weersink, A. J., Vandenbroucke-Grauls, C. M., Buiting, A. G., van Duin, A., & Verbrugh, H. A. (1997). Fecal carriage of vancomycin-resistant enterococci in hospitalized patients and those living in the community in The Netherlands. J Clin Microbiol 35, 3026–3031.

    PubMed  CAS  Google Scholar 

  • Evers, S., & Courvalin, P. (1996). Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583. J Bacteriol 178, 1302–1309.

    PubMed  CAS  Google Scholar 

  • Facklam, R., Hollis, D., & Collins, M. D. (1989). Identification of Gram-positive coccal and coccobacillary vancomycin-resistant bacteria. J Clin Microbiol 27, 724–730.

    PubMed  CAS  Google Scholar 

  • Fantin, B., Leclercq, R., Garry, L., & Carbon, C. (1997). Influence of inducible cross-resistance to macrolides, lincosamides, and streptogramin B-type antibiotics in Enterococcus faecium on activity of quinupristin-dalfopristin in vitro and in rabbits with experimental endocarditis. Antimicrob Agents Chemother 41, 931–935.

    PubMed  CAS  Google Scholar 

  • Fines, M., Perichon, B., Reynolds, P., Sahm, D. F., & Courvalin, P. (1999). VanE, a new type of acquired glycopeptide resistance in Enterococcus faecalis BM4405. Antimicrob Agents Chemother 43, 2161–2164.

    PubMed  CAS  Google Scholar 

  • Finland, M., Wilcox, C., & Frank, P. F. (1950). In vitro sensitivity of human pathogens strains of streptococci to seven antibiotics. Am J Clin Pathol 20, 208–217.

    PubMed  CAS  Google Scholar 

  • Fontana, R., Cerini, R., Longoni, P., Grossato, A., & Canepari, P. (1983). Identification of a streptococcal penicillin-binding protein that reacts very slowly with penicillin. J Bacteriol 155, 1343–1350.

    PubMed  CAS  Google Scholar 

  • Fontana, R., Ligozzi, M., Pedrotti, C., Padovani, E. M., & Cornaglia, G. (1997). Vancomycin-resistant Bacillus circulans carrying the vanA gene responsible for vancomycin resistance in enterococci. Eur J Clin Microbiol Infect Dis 16, 473–474.

    Article  PubMed  CAS  Google Scholar 

  • Fraimow, H. S., Jungkind, D. L., Lander, D. W., Delso, D. R., & Dean, J. L. (1994). Urinary tract infection with an Enterococcus faecalis isolate that requires vancomycin for growth. Ann Intern Med 121, 22–26.

    PubMed  CAS  Google Scholar 

  • Fridkin, S. K., Edwards, J. R., Courval, J. M., Hill, H., Tenover, F. C., Lawton, R., Gaynes, R. P., & McGowan, J. E., Jr. (2001). The effect of vancomycin and third-generation cephalosporins on prevalence of vancomycin-resistant enterococci in 126 U.S. adult intensive care units. Ann Intern Med 135, 175–183.

    PubMed  CAS  Google Scholar 

  • Fridkin, S. K., Yokoe, D. S., Whitney, C. G., Onderdonk, A., & Hooper, D. C. (1998). Epidemiology of a dominant clonal strain of vancomycin-resistant Enterococcus faecium at separate hospitals in Boston, Massachusetts. J Clin Microbiol 36, 965–970.

    PubMed  CAS  Google Scholar 

  • Frieden, T. R., Munsiff, S. S., Low, D. E., Willey, B. M., Williams, G., Faur, Y, Eisner, W., Warren, S., & Kreiswirth, B. (1993). Emergence of vancomycin-resistant enterococci in New York City. Lancet 342, 76–79.

    Article  PubMed  CAS  Google Scholar 

  • Fujita, N., Yoshimura, M., Komori, T., Tanimoto, K., & Ike, Y. (1998). First report of the isolation of high-level vancomycin-resistant Enterococcus faecium from a patient in Japan. Antimicrob Agents Chemother 42, 2150.

    PubMed  CAS  Google Scholar 

  • Furlong, W. B., & Rakowski, T. A. (1997). Therapy with RP 59500 (quinupristin/dalfopristin) for prosthetic valve endocarditis due to enterococci with VanA/VanB resistance patterns. Clin Infect Dis 25, 163–164.

    PubMed  CAS  Google Scholar 

  • Gales, A. C., & Jones, R. N. (2000). Antimicrobial activity and spectrum of the new glycylcycline, GAR-936 tested against 1,203 recent clinical bacterial isolates. Diagn Microbiol Infect Dis 36, 19–36.

    PubMed  CAS  Google Scholar 

  • Garbutt, J. M., Ventrapragada, M., Littenberg, B., & Mundy, L. M. (2000). Association between resistance to vancomycin and death in cases of Enterococcus faecium bacteremia. Clin Infect Dis 30, 466–72.

    Article  PubMed  CAS  Google Scholar 

  • Geraci, J. E., & Martin, W. J. (1954). Antibiotic therapy of bacterial endocarditis. VI. Subacute enterococcal endocarditis: Clinical, pathologic and therapeutic consideration of 33 cases. Circulation 10, 173–194.

    PubMed  CAS  Google Scholar 

  • Gerding, D. N. (1997). Is there a relationship between vancomycin-resistant enterococcal infection and Clostridium difficile infection? Clin Infect Dis 25(Suppl 2), S206–210.

    Google Scholar 

  • Gerding, D. N., Buxton, A. E., Hughes, R. A., Cleary, P. P., Arbaczawski, J., & Stamm, W. E. (1979). Nosocomial multiply resistant Klebsiella pneumoniae: Epidemiology of an outbreak of apparent index case origin. Antimicrob Agents Chemother 15, 608–615.

    PubMed  CAS  Google Scholar 

  • Goldstein, F. W. (2000). Antibiotic susceptibility of bacterial strains isolated from patients with community-acquired urinary tract infections in France. Multicentre Study Group. Eur J Clin Microbiol Infect Dis 19, 112–117.

    Article  PubMed  CAS  Google Scholar 

  • Gonzales, R. D., Schreckenberger, P. C., Graham, M. B., Kelkar, S., DenBesten, K., & Quinn, J. P. (2001). Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid. Lancet 357, 1179.

    Article  PubMed  CAS  Google Scholar 

  • Goodall, B., & Tompkins, D. S. (1994). Methicillin resistant staphylococcal infection. Nursing homes act as reservoir, [letter; comment], BMJ 308, 58.

    PubMed  CAS  Google Scholar 

  • Gordon, S., Swenson, J. M., Hill, B. C., Pigott, N. E., Facklam, R. R., Cooksey, R. C., Thornsberry, C., Jarvis, W. R., & Tenover, F. C. (1992). Antimicrobial susceptibility patterns of common and unusual species of enterococci causing infections in the United States. Enterococcal Study Group. J Clin Microbiol 30, 2373–2378.

    PubMed  CAS  Google Scholar 

  • Grayson, M. L., Eliopoulos, G. M., Wennersten, C. B., Ruoff, K. L., De Girolami, P. C., Ferraro, M. J., & Moellering, R. C. (1991). Increasing resistance to beta-lactam antibiotics among clinical isolates of Enterococcus faecium: A 22-year review at one institution. Antimicrob Agents Chemother 35, 2180–2184.

    PubMed  CAS  Google Scholar 

  • Green, M., Barbadora, K., & Michaels, M. (1991). Recovery of vancomycin-resistant Gram-positive cocci from pediatric liver transplant recipients. J Clin Microbiol 29, 2503–2506.

    PubMed  CAS  Google Scholar 

  • Green, M., Shlaes, J. H., Barbadora, K., & Shlaes, D. M. (1995). Bacteremia due to vancomycin-dependent Enterococcus faecium. Clin Infect Dis 20, 712–714.

    PubMed  CAS  Google Scholar 

  • Grosso, M. D., Caprioli, A., Chinzari, P., Fontana, M. C., Pezzotti, G., Manfrin, A., Giannatale, E. D., Goffredo, E., & Pantosti, A. (2000). Detection and characterization of vancomycin-resistant enterococci in farm animals and raw meat products in Italy. Microb Drug Resist 6, 313–318.

    PubMed  Google Scholar 

  • Hachem, R., Afif, C., Gokaslan, Z., & Raad, I. (2001). Successful treatment of vancomycin-resistant Enterococcus meningitis with linezolid. Eur J Clin Microbiol Infect Dis 20, 432–434.

    Article  PubMed  CAS  Google Scholar 

  • Handwerger, S., Raucher, B., Altarac, D., Monka, J., Marchione, S., Singh, K. V, Murray, B. E., Wolff, J., & Walters, B. (1993). Nosocomial outbreak due to Enterococcus faecium highly resistant to vancomycin, penicillin, and gentamicin. Clin Infect Dis 16, 750–755.

    PubMed  CAS  Google Scholar 

  • Handwerger, S., & Skoble, J. (1995). Identification of chromosomal mobile element conferring highlevel vancomycin resistance in Enterococcus faecium. Antimicrob Agents Chemother 39, 2446–2453.

    PubMed  CAS  Google Scholar 

  • Handwerger, S., & Tomasz, A. (1985). Antibiotic tolerance among clinical isolates of bacteria. Rev Infect Dis 7, 368–386.

    PubMed  CAS  Google Scholar 

  • Haroche, J., Allignet, J., Aubert, S., Van Den Bogaard, A. E., & El Solh, N. (2000). satG, conferring resistance to streptogramin A, is widely distributed in Enterococcus faecium strains but not in staphylococci. Antimicrob Agents Chemother 44, 190–191.

    Article  PubMed  CAS  Google Scholar 

  • Hartman, C. S., Leach, T. S., Kaja, R. W., Schaser, R. J., Todd, W. M., & Hafkin, B. (2000, September 17–20). Linezolid in the treatment of vancomycin-resistant Enterococcus: A dose comparative, multicenter phase III trial. Proceedings of 40th Interscience Conference on Antimicrobial Agents and Chemotherapy (Abstract No. 2235), Toronto, Canada. Washington, DC: American Society for Microbiology.

    Google Scholar 

  • Hayden, M. K. (2000). Insights into the epidemiology and control of infection with vancomycin-resistant enterococci. Clin Infect Dis 31, 1058–1065.

    Article  PubMed  CAS  Google Scholar 

  • Hayden, M. K., Trenholme, G. M., Schultz, J. E., & Sahm, D. F. (1993). In vivo development of teicoplanin resistance in a VanB Enterococcus faecium isolate. J Infect Dis 167, 1224–1227.

    PubMed  CAS  Google Scholar 

  • Herrero, I. A., Issa, N. C., & Patel, R. (2002). Nosocomial spread of linezolid-resistant, vancomycin-resistant Enterococcus faecium. N Engl J Med 346, 867–869.

    Article  PubMed  Google Scholar 

  • Herwaldt, L. A. (1999). Control of methicillin-resistant Staphylococcus aureus in the hospital setting. Am J Med 106, 11S–18S; discussion 48S–52S.

    Article  PubMed  CAS  Google Scholar 

  • Herzstein, J., Ryan, J. L., Mangi, R. J., Greco, T. P., & Andriole, V T. (1984). Optimal therapy for enterococcal endocarditis. Am J Med 76, 186–191.

    Article  PubMed  CAS  Google Scholar 

  • Horodniceanu, T., Bougueleret, L., El-Solh, N., Bieth, G., & Delbos, F. (1979). High-level, plasmidborne resistance to gentamicin in Streptococcus faecalis subsp. zymogenes. Antimicrob Agents Chemother 16, 686–689.

    PubMed  CAS  Google Scholar 

  • Howe, R. A., Robson, M., Oakhill, A., Cornish, J. M., & Millar, M. R. (1997). Successful use of tetracycline as therapy of an immunocompromised patient with septicaemia caused by a vancomycin-resistant Enterococcus. J Antimicrob Chemother 40, 144–145.

    PubMed  CAS  Google Scholar 

  • Iwen, P. C., Kelly, D. M., Linder, J., Hinrichs, S. H., Dominguez, E. A., Rupp, M. E., & Patil, K. D. (1997). Change in prevalence and antibiotic resistance of Enterococcus species isolated from blood cultures over an 8-year period. Antimicrob Agents Chemother 41, 494–495.

    PubMed  CAS  Google Scholar 

  • Jensen, L. B., Ahrens, P., Dons, L., Jones, R. N., Hammerum, A. M., & Aarestrup, F. M. (1998a). Molecular analysis of Tn1546 in Enterococcus faecium isolated from animals and humans. J Clin Microbiol 36, 437–442.

    PubMed  CAS  Google Scholar 

  • Jensen, L. B., Hammerum, A. M., Aerestrup, F. M., van den Bogaard, A. E., & Stobberingh, E. E. (1998b). Occurrence of satA and vgb genes in streptogramin-resistant Enterococcus faecium isolates of animal and human origins in the Netherlands. Antimicrob Agents Chemother 42, 3330–3331.

    PubMed  CAS  Google Scholar 

  • Johnson, A. P., Uttley, A. H., Woodford, N., & George, R. C. (1990). Resistance to vancomycin and teicoplanin: An emerging clinical problem. Clin Microbiol Rev 3, 280–291.

    PubMed  CAS  Google Scholar 

  • Johnson, S., & Gerding, D. N. (1998). Clostridium difficile—Associated diarrhea. Clin Infect Dis 26, 1027–1034; quiz 1035–1026.

    PubMed  CAS  Google Scholar 

  • Jones, R. N., Marshall, S. A., Pfaller, M. A., Wilke, W. W., Hollis, R. J., Erwin, M. E., Edmond, M. B., & Wenzel, R. P. (1997). Nosocomial enterococcal blood stream infections in the SCOPE Program: Antimicrobial resistance, species occurrence, molecular testing results, and laboratory testing accuracy. SCOPE Hospital Study Group. Diagn Microbiol Infect Dis 29, 95–102.

    PubMed  CAS  Google Scholar 

  • Karanfil, L. V., Murphy, M., Josephson, A., Gaynes, R., Mandel, L., Hill, B. C., & Swenson, J. M. (1992). A cluster of vancomycin-resistant Enterococcus faecium in an intensive care unit. Infect Control Hosp Epidemiol 13, 195–200.

    PubMed  CAS  Google Scholar 

  • Kawalec, M., Gniadkowski, M., Kedzierska, J., Skotnicki, A., Fiett, J., & Hryniewicz, W. (2001). Selection of a teicoplanin-resistant Enterococcus faecium mutant during an outbreak caused by vancomycin-resistant enterococci with the VanB phenotype. J Clin Microbiol 39, 4274–4282.

    PubMed  CAS  Google Scholar 

  • Kim, K. H., Fekety, R., Batts, D. H., Brown, D., Cudmore, M., Silva, J., Jr., & Waters, D. (1981). Isolation of Clostridium difficile from the environment and contacts of patients with antibiotic-associated colitis. J Infect Dis 143, 42–50.

    PubMed  CAS  Google Scholar 

  • Kim, W. J., Weinstein, R. A., & Hayden, M. K. (1999). The changing molecular epidemiology and establishment of endemicity of vancomycin resistance in enterococci at one hospital over a 6-year period. J Infect Dis 179, 163–171.

    Article  PubMed  CAS  Google Scholar 

  • Kirkpatrick, B. D., Harrington, S. M., Smith, D., Marcellus, D., Miller, C., Dick, J., Karanfil, L., & Perl, T. M. (1999). An outbreak of vancomycin-dependent Enterococcus faecium in a bone marrow transplant unit. Clin Infect Dis 29, 1268–1273.

    Article  PubMed  CAS  Google Scholar 

  • Kirst, H. A., Thompson, D. G., & Nicas, T. I. (1998). Historical yearly usage of vancomycin. Antimicrob Agents Chemother 42, 1303–1304.

    PubMed  CAS  Google Scholar 

  • Kjerulf, A., Pallesen, L., & Westh, H. (1996). Vancomycin-resistant enterococci at a large university hospital in Denmark. APMIS 104, 475–479.

    Article  PubMed  CAS  Google Scholar 

  • Klare, I., Badstubner, D., Konstabel, C., Bohme, G., Claus, H., & Witte, W. (1999). Decreased incidence of VanA-type vancomycin-resistant enterococci isolated from poultry meat and from fecal samples of humans in the community after discontinuation of avoparcin usage in animal husbandry. Microb Drug Resist 5, 45–52.

    PubMed  CAS  Google Scholar 

  • Krogstad, D. J., & Pargwette, A. R. (1980). Defective killing of enterococci: A common property of antimicrobial agents acting on the cell wall. Antimicrob Agents Chemother 17, 965–968.

    PubMed  CAS  Google Scholar 

  • Lafaurie, M., Perichon, B., Lefort, A., Carbon, C., Courvalin, P., & Fantin, B. (2001). Consequences of VanE-type resistance on efficacy of glycopeptides in vitro and in experimental endocarditis due to Enterococcus faecalis. Antimicrob Agents Chemother 45, 2826–2830.

    Article  PubMed  CAS  Google Scholar 

  • Laganas, V., & Silverman, J. A. (2001, December 16–19). Inhibition of lipoteichoic acid biosynthesis is not the target of daptomycin in Staphylococcus aureus. Proceedings of 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (Abstract No. C1-1802). Chicago, IL. Washington, DC: American Society for Microbiology.

    Google Scholar 

  • Lai, K. K. (1996). Treatment of vancomycin-resistant Enterococcus faecium infections. Arch Intern Med 156, 2579–2584.

    Article  PubMed  CAS  Google Scholar 

  • Lai, K. K., Kelley, A. L., Melvin, Z. S., Belliveau, P. P., & Fontecchio, S. A. (1998). Failure to eradicate vancomycin-resistant enterococci in a university hospital and the cost of barrier precautions. Infect Control Hosp Epidemiol 19, 647–652.

    PubMed  CAS  Google Scholar 

  • Lautenbach, E., Bilker, W. B., & Brennan, P. J. (1999). Enterococcal bacteremia: Risk factors for vancomycin resistance and predictors of mortality. Infect Control Hosp Epidemiol 20, 318–323.

    PubMed  CAS  Google Scholar 

  • Lautenbach, E., Schuster, M. G., Bilker, W. B., & Brennan, P. J. (1998). The role of chloramphenicol in the treatment of bloodstream infection due to vancomycin-resistant Enterococcus. Clin Infect Dis 27, 1259–1265.

    PubMed  CAS  Google Scholar 

  • Leach, T. S., Schaser, R. J., Hempsall, K. A., & Todd, W. M. (2000). Clinical efficacy of linezolid for infections caused by vancomycin-resistant enterococci (VRE) in a compassionate-use program (abstract no. 66). Clin Infect Dis 31, 224.

    Google Scholar 

  • Leber, A. L., Hindler, J. F., Kato, E. O., Bruckner, D. A., & Pegues, D. A. (2001). Laboratory-based surveillance for vancomycin-resistant enterococci: Utility of screening stool specimens submitted for Clostridium difficile toxin assay. Infect Control Hosp Epidemiol 22, 160–164.

    PubMed  CAS  Google Scholar 

  • Leclercq, R., Bingen, E., Su, Q. H., Lambert-Zechovski, N., Courvalin, P., & Duval, J. (1991). Effects of combinations of beta-lactams, daptomycin, gentamicin, and glycopeptides against glycopeptide-resistant enterococci. Antimicrob Agents Chemother 35, 92–98.

    PubMed  CAS  Google Scholar 

  • Leclercq, R., Derlot, E., Duval, J., & Courvalin, P. (1988). Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium. N Engl J Med 319, 157–161.

    Article  PubMed  CAS  Google Scholar 

  • Lefort, A., Baptista, M., Fantin, B., Depardieu, F., Arthur, M., Carbon, C., & Courvalin, P. (1999). Twostep acquisition of resistance to the teicoplanin-gentamicin combination by VanB-type Enterococcus faecalis in vitro and in experimental endocarditis. Antimicrob Agents Chemother 43, 476–482.

    PubMed  CAS  Google Scholar 

  • Lefort, A., Mainardi, J. L., Tod, M., & Lortholary, O. (2000a). Antienterococcal antibiotics. Med Clin North Am 84, 1471–1495.

    Article  PubMed  CAS  Google Scholar 

  • Lefort, A., Saleh-Mghir, A., Garry, L., Carbon, C., & Fantin, B. (2000b). Activity of LY333328 combined with gentamicin in vitro and in rabbit experimental endocarditis due to vancomycin-susceptible or-resistant Enterococcus faecalis. Antimicrob Agents Chemother 44, 3017–3021.

    PubMed  CAS  Google Scholar 

  • Lewis, C. M., & Zervos, M. J. (1990). Clinical manifestations of enterococcal infection. Eur J Clin Microbiol Infect Dis 9, 111–117.

    Article  PubMed  CAS  Google Scholar 

  • Liassine, N., Frei, R., Jan, I., & Auckenthaler, R. (1998). Characterization of glycopeptide-resistant enterococci from a Swiss hospital. J Clin Microbiol 36, 1853–1858.

    PubMed  CAS  Google Scholar 

  • Linden, P. K., Pasculle, A. W., Manez, R., Kramer, D. J., Fung, J. J., Pinna, A. D., & Kusne, S. (1996). Differences in outcomes for patients with bacteremia due to vancomycin-resistant Enterococcus faecium or vancomycin-susceptible E. faecium. Clin Infect Dis 22, 663–670.

    PubMed  CAS  Google Scholar 

  • Livornese, L. L., Dias, S., Samel, C., Romanowski, B., Taylor, S., May, P., Pitsakis, P., Woods, G., Kaye, D., & Levison, M. E. (1992). Hospital-acquired infection with vancomycin-resistant Enterococcus faecium transmitted by electronic thermometers. Ann Intern Med 117, 112–116.

    PubMed  Google Scholar 

  • Lodise, T. P., McKinnon, P. S., Tam, V H., & Rybak, M. J. (2002). Clinical outcomes for patients with bacteremia caused by vancomycin-resistant Enterococcus in a level 1 trauma center. Clin Infect Dis 34, 922–929.

    Article  PubMed  Google Scholar 

  • Lu, H. Z., Weng, X. H., Li, H., Yin, Y. K., Pang, M. Y., & Tang, Y. W. (2002). Enterococcus faecium-related outbreak with molecular evidence of transmission from pigs to humans. J Clin Microbiol 40, 913–917.

    Article  PubMed  Google Scholar 

  • Lucas, G. M., Lechtzin, N., Puryear, D. W., Yau, L. L., Flexner, C. W., & Moore, R. D. (1998). Vancomycin-resistant and vancomycin-susceptible enterococcal bacteremia: Comparison of clinical features and outcomes. Clin Infect Dis 26, 1127–1133.

    PubMed  CAS  Google Scholar 

  • Maki, D. G., & Agger, W. A. (1988). Enterococcal bacteremia: Clinical features, the risk of endocarditis, and management. Medicine (Baltimore), 67, 248–269.

    CAS  Google Scholar 

  • Marin, M. E., Mera, J. R., Arduino, R. C., Correa, A. P., Coque, T. M., Stamboulian, D., & Murray, B. E. (1998). First report of vancomycin-resistant Enterococcus faecium isolated in Argentina. Clin Infect Dis 26,235–236.

    Article  PubMed  CAS  Google Scholar 

  • Marshall, C. G., Broadhead, G., Leskiw, B. K., & Wright, G. D. (1997). D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB. Proc Natl Acad Sci USA 94, 6480–6483.

    Article  PubMed  CAS  Google Scholar 

  • Marshall, C. G., Lessard, I. A., Park, L, & Wright, G. D. (1998). Glycopeptide antibiotic resistance genes in glycopeptide-producing organisms. Antimicrob Agents Chemother 42, 2215–2220.

    PubMed  CAS  Google Scholar 

  • Mathai, D., Jones, R. N., & Pfaller, M. A. (2001). Epidemiology and frequency of resistance among pathogens causing urinary tract infections in 1,510 hospitalized patients: A report from the SEN-TRY Antimicrobial Surveillance Program (North America). Diagn Microbiol Infect Dis 40, 129–136.

    Article  PubMed  CAS  Google Scholar 

  • McCarthy, A. E., Victor, G., Ramotar, K., & Toye, B. (1994). Risk factors for acquiring ampicillin-resistant enterococci and clinical outcomes at a Canadian tertiary-care hospital. J Clin Microbiol 32, 2671–2676.

    PubMed  CAS  Google Scholar 

  • McDonald, L. C., Kuehnert, M. J., Tenover, F. C., & Jarvis, W. R. (1997). Vancomycin-resistant enterococci outside the health-care setting: Prevalence, sources, and public health implications. Emerg Infect Dis 3, 311–317.

    PubMed  CAS  Google Scholar 

  • McDonald, L. C., Rossiter, S., Mackinson, C., Wang, Y. Y., Johnson, S., Sullivan, M., Sokolow, R., DeBess, E., Gilbert, L., Benson, J. A., Hill, B., & Angulo, F. J. (2001). Quinupristin-dalfopristin-resistant Enterococcus faecium on chicken and in human stool specimens. N Engl J Med 345, 1155–1160.

    Article  PubMed  CAS  Google Scholar 

  • McKessar, S. J., Berry, A. M., Bell, J. M., Turnidge, J. D., & Paton, J. C. (2000). Genetic characterization of vanG, a novel vancomycin resistance locus of Enterococcus faecalis. Antimicrob Agents Chemother 44, 3224–3228.

    Article  PubMed  CAS  Google Scholar 

  • McNeil, S. A., Clark, N. M., Chandrasekar, P. H., & Kauffman, C. A. (2000). Successful treatment of vancomycin-resistant Enterococcus faecium bacteremia with linezolid after failure of treatment with synercid (quinupristin/dalfopristin). Clin Infect Dis 30, 403–404.

    Article  PubMed  CAS  Google Scholar 

  • Megran, D. W. (1992). Enterococcal endocarditis. Clin Infect Dis 15, 63–71.

    PubMed  CAS  Google Scholar 

  • Melhus, A., & Tjernberg, I. (1996). First documented isolation of vancomycin-resistant Enterococcus faecium in Sweden. Scand J Infect Dis 28, 191–193.

    Article  PubMed  CAS  Google Scholar 

  • Mevius, D., Devriese, L., Butaye, P., Vandamme, P., Verschure, M., & Veldman, K. (1998). Isolation of glycopeptide resistant Streptococcus gallolyticus strains with vanA, vanB, and both vanA and vanB genotypes from faecal samples of veal calves in The Netherlands. J Antimicrob Chemother 42, 275–276.

    Article  PubMed  CAS  Google Scholar 

  • Miranda, A. G., Singh, K. V., & Murray, B. E. (1991). DNA fingerprinting of Enterococcus faecium by pulsed-field gel electrophoresis may be a useful epidemiologic tool. J Clin Microbiol 29, 2752–2757.

    PubMed  CAS  Google Scholar 

  • Moellering, R. C., Jr. (1992). Emergence of Enterococcus as a significant pathogen. Clin Infect Dis 14, 1173–1176.

    PubMed  Google Scholar 

  • Moellering, R. C., Linden, P. K., Reinhardt, J., Blumberg, E. A., Bompart, F., & Talbot, G. H. (1999). The efficacy and safety of quinupristin/dalfopristin for the treatment of infections caused by vancomycin-resistant Enterococcus faecium. Synercid emergency-use study group. J Antimicrob Chemother 44, 251–261.

    PubMed  CAS  Google Scholar 

  • Montecalvo, M. A., Horowitz, H., Gedris, C., Carbonaro, C., Tenover, F. C., Issah, A., Cook, P., & Wormser, G. P. (1994). Outbreak of vancomycin-, ampicillin-, and aminoglycoside-resistant Enterococcus faecium bacteremia in an adult oncology unit. Antimicrob Agents Chemother 38, 1363–1367.

    PubMed  CAS  Google Scholar 

  • Montecalvo, M. A., Horowitz, H., Wormser, G. P., Seiter, K., & Carbonaro, C. A. (1995). Effect of novobiocin-containing antimicrobial regimens on infection and colonization with vancomycin-resistant Enterococcus faecium. Antimicrob Agents Chemother 39, 794.

    PubMed  CAS  Google Scholar 

  • Montecalvo, M. A., Jarvis, W. R., Uman, J., Shay, D. K., Petrullo, C., Rodney, K., Gedris, C., Horowitz, H. W., & Wormser, G. P. (1999). Infection-control measures reduce transmission of vancomycin-resistant enterococci in an endemic setting. Ann Intern Med 131, 269–272.

    PubMed  CAS  Google Scholar 

  • Moreno, F., Grota, P., Crisp, C., Magnon, K., Melcher, G. P., Jorgensen, J. H., & Patterson, J. E. (1995). Clinical and molecular epidemiology of vancomycin-resistant Enterococcus faecium during its emergence in a city in southern Texas. Clin Infect Dis 21, 1234–1237.

    PubMed  CAS  Google Scholar 

  • Morris, J. G., Jr., Shay, D. K., Hebden, J. N., McCarter, R. J., Jr., Perdue, B. E., Jarvis, W, Johnson, J. A., Dowling, T. C., Polish, L. B., & Schwalbe, R. S. (1995). Enterococci resistant to multiple antimicrobial agents, including vancomycin. Establishment of endemicity in a university medical center. Ann Intern Med 123, 250–259.

    PubMed  CAS  Google Scholar 

  • Mundy, L. M., Sahm, D. F., & Gilmore, M. (2000). Relationships between enterococcal virulence and antimicrobial resistance. Clin Microbiol Rev 13, 513–522.

    Article  PubMed  CAS  Google Scholar 

  • Murphy, T. M., Deitz, J. M., Petersen, P. J., Mikels, S. M., & Weiss, W. J. (2000). Therapeutic efficacy of GAR-936, a novel glycylcycline, in a rat model of experimental endocarditis. Antimicrob Agents Chemother 44, 3022–3027.

    Article  PubMed  CAS  Google Scholar 

  • Murray, B. E. (1990). The life and times of the Enterococcus. Clin Microbiol Rev 3, 46–65.

    PubMed  CAS  Google Scholar 

  • Murray, B. E. (1994). Can antibiotic resistance be controlled? [letter; comment]. N Engl J Med 330, 1229–1230.

    Article  PubMed  CAS  Google Scholar 

  • Murray, B. E. (1997). Vancomycin-resistant enterococci. Am J Med 102, 284–293.

    Article  PubMed  CAS  Google Scholar 

  • Murray, B. E., & Mederski-Samaroj, B. (1983). Transferable beta-lactamase. A new mechanism for in vitro penicillin resistance in Streptococcus faecalis. J Clin Invest 72, 1168–1171.

    PubMed  CAS  Google Scholar 

  • Murray, B. E., Singh, K. V, Markowitz, S. M., Lopardo, H. A., Patterson, J. E., Zervos, M. J., Rubeglio, E., Eliopoulos, G. M., Rice, L. B., & Goldstein, F. W. (1991). Evidence for clonal spread of a single strain of beta-lactamase-producing Enterococcus (Streptococcus) faecalis to six hospitals in five states. J Infect Dis 163, 780–785.

    PubMed  CAS  Google Scholar 

  • Mylotte, J. M., Goodnough, S., & Tayara, A. (2001). Antibiotic-resistant organisms among long-term care facility residents on admission to an inpatient geriatrics unit: Retrospective and prospective surveillance. Am J Infect Control 29, 139–144.

    PubMed  CAS  Google Scholar 

  • Nachman, S. A., Verma, R., & Egnor, M. (1995). Vancomycin-resistant Enterococcus faecium shunt infection in an infant: An antibiotic cure. Microb Drug Resist 1, 95–96.

    PubMed  CAS  Google Scholar 

  • Nannini, E. C., Singh, K. V, & Murray, B. E. (2001, December 16–19). Efficacy of GAR-936, a novel glycylcycline, against enterococci in a mouse peritonitis model. Proceedings of 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (Abstract No. B-1651). Chicago, IL. Washington, DC: American Society for Microbiology.

    Google Scholar 

  • Navarro, F., & Courvalin, P. (1994). Analysis of genes encoding d-alanine-d-alanine ligase-related enzymes in Enterococcus casseliflavus and Enterococcus flavescens. Antimicrob Agents Chemother 38, 1788–1793.

    PubMed  CAS  Google Scholar 

  • Neely, A. N., & Maley, M. P. (2000). Survival of enterococci and staphylococci on hospital fabrics and plastic, [see comments]. J Clin Microbiol 38, 724–726.

    PubMed  CAS  Google Scholar 

  • NNIS. (2000). National Nosocomial Infections Surveillance (NNIS) system report, data summary from January 1992–April 2000, issued June 2000. Am J Infect Control 28, 429–448.

    Google Scholar 

  • NNIS. (2001). National Nosocomial Infections Surveillance (NNIS) System Report, Data Summary from January 1992–June 2001, issued August 2001. Am J Infect Control 29, 404–421.

    Google Scholar 

  • Noble, W. C., Virani, Z., & Cree, R. G. (1992). Co-transfer of vancomycin and other resistance genes from Enterococcus faecalis NCTC 12201 to Staphylococcus aureus. FEMS Microbiol Lett 72, 195–198.

    PubMed  CAS  Google Scholar 

  • Noskin, G. A., Peterson, L. R., & Warren, J. R. (1995a). Enterococcus faecium and Enterococcus faecalis bacteremia: Acquisition and outcome. Clin Infect Dis 20, 296–301.

    PubMed  CAS  Google Scholar 

  • Noskin, G. A., Stosor, V., Cooper, I., & Peterson, L. R. (1995b). Recovery of vancomycin-resistant enterococci on fingertips and environmental surfaces [see comments]. Infect Control Hosp Epidemiol 16, 577–581.

    PubMed  CAS  Google Scholar 

  • Nourse, C., Byrne, C., Kaufmann, M., Keane, C. T., Fenelon, L., Smyth, E. G., Hone, R., & Butler, K. (2000). VRE in the Republic of Ireland: Clinical significance, characteristics and molecular similarity of isolates. J Hosp Infect 44, 288–293.

    PubMed  CAS  Google Scholar 

  • O’Donovan, C. A., Fan-Havard, P., Tecson-Tumang, F. T., Smith, S. M., & Eng, R. H. (1994). Enteric eradication of vancomycin-resistant Enterococcus faecium with oral bacitracin. Diagn Microbiol Infect Dis 18, 105–109.

    Google Scholar 

  • Olsen, R. J., Lynch, P., Coyle, M. B., Cummings, J., Bokete, T., & Stamm, W. E. (1993). Examination gloves as barriers to hand contamination in clinical practice. JAMA 270, 350–353.

    Article  PubMed  CAS  Google Scholar 

  • Ostrowsky, B. E., Clark, N. C., Thauvin-Eliopoulos, C., Venkataraman, L., Samore, M. H., Tenover, F. C., Eliopoulos, G. M., Moellering, R. C., Jr., & Gold, H. S. (1999). A cluster of VanD vancomycin-resistant Enterococcus faecium: Molecular characterization and clinical epidemiology. J Infect Dis 180, 1177–1185.

    Article  PubMed  CAS  Google Scholar 

  • Ostrowsky, B. E., Trick, W. E., Sohn, A. H., Quirk, S. B., Holt, S., Carson, L. A., Hill, B. C., Arduino, M. J., Kuehnert, M. J., & Jarvis, W. R. (2001). Control of vancomycin-resistant Enterococcus in health care facilities in a region. N Engl J Med 344, 1427–1433.

    Article  PubMed  CAS  Google Scholar 

  • O’Toole, R. D., Drew, W. L., Dahlgren, B. J., & Beaty, H. N. (1970). An outbreak of methicillin-resistant Staphylococcus aureus infection. Observations in hospital and nursing home. JAMA 213, 257–263.

    Google Scholar 

  • Pallares, R., Pujol, M., Pena, C., Ariza, J., Martin, R., & Gudiol, F. (1993). Cephalosporins as risk factor for nosocomial Enterococcus faecalis bacteremia. A matched case-control study. Arch Intern Med 153, 1581–1586.

    Article  PubMed  CAS  Google Scholar 

  • Papanicolaou, G. A., Meyers, B. R., Meyers, J., Mendelson, M. H., Lou, W., Emre, S., Sheiner, P., & Miller, C. (1996). Nosocomial infections with vancomycin-resistant Enterococcus faecium in liver transplant recipients: Risk factors for acquisition and mortality. Clin Infect Dis 23, 760–766.

    PubMed  CAS  Google Scholar 

  • Patel, R. (2000). Enterococcal-type glycopeptide resistance genes in non-enterococcal organisms. FEMS Microbiol Lett 185, 1–7.

    PubMed  CAS  Google Scholar 

  • Patel, R., Piper, K., Cockerill, F. R., 3rd, Steckelberg, J. M., & Yousten, A. A. (2000). The biopesticide Paenibacillus popilliae has a vancomycin resistance gene cluster homologous to the enterococcal vanA vancomycin resistance gene cluster. Antimicrob Agents Chemother 44, 705–709.

    PubMed  CAS  Google Scholar 

  • Patel, R., Rouse, M. S., Piper, K. E., & Steckelberg, J. M. (2001). Linezolid therapy of vancomycin-resistant Enterococcus faecium experimental endocarditis. Antimicrob Agents Chemother 45, 621–623.

    Article  PubMed  CAS  Google Scholar 

  • Patel, R., Uhl, J. R., Kohner, P., Hopkins, M. K., & Cockerill, F. R., 3rd. (1997a). Multiplex PCR detection of vanA, vanB, vanC-1, and vanC-2/3 genes in enterococci. J Clin Microbiol 35, 703–707.

    PubMed  CAS  Google Scholar 

  • Patel, S. S., Balfour, J. A., & Bryson, H. M. (1997b). Fosfomycin tromethamine. A review of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy as a single-dose oral treatment for acute uncomplicated lower urinary tract infections. Drugs 53, 637–656.

    PubMed  CAS  Google Scholar 

  • Patterson, J. E., Sweeney, A. H., Simms, M., Carley, N., Mangi, R., Sabetta, J., & Lyons, R. W. (1995). An analysis of 110 serious enterococcal infections. Epidemiology, antibiotic susceptibility, and outcome. Medicine (Baltimore), 74, 191–200.

    Article  CAS  Google Scholar 

  • Perez Mato, S., Robinson, S., & Begue, R. E. (1999). Vancomycin-resistant Enterococcus faecium meningitis successfully treated with chloramphenicol. Pediatr Infect Dis J 18, 483–484.

    PubMed  CAS  Google Scholar 

  • Perichon, B., Casadewall, B., Reynolds, P., & Courvalin, P. (2000). Glycopeptide-resistant Enterococcus faecium BM4416 is a VanD-type strain with an impaired d-Alanine:d-Alanine ligase. Antimicrob Agents Chemother 44, 1346–1348.

    Article  PubMed  CAS  Google Scholar 

  • Perichon, B., Reynolds, P., & Courvalin, P. (1997). VanD-type glycopeptide-resistant Enterococcus faecium BM4339. Antimicrob Agents Chemother 41, 2016–2018.

    PubMed  CAS  Google Scholar 

  • Peset, V., Tallon, P., Sola, C., Sanchez, E., Sarrion, A., Perez-Belles, C., Vindel, A., Canton, E., & Gobernado, M. (2000). Epidemiological, microbiological, clinical, and prognostic factors of bacteremia caused by high-level vancomycin-resistant Enterococcus species. Eur J Clin Microbiol Infect Dis 19, 742–749.

    Article  PubMed  CAS  Google Scholar 

  • Power, E. G., Abdulla, Y. H., Talsania, H. G., Spice, W., Aathithan, S., & French, G. L. (1995). vanA genes in vancomycin-resistant clinical isolates of Oerskovia turbata and Arcanobacterium (Corynebacterium) haemolyticum. J Antimicrob Chemother 36, 595–606.

    PubMed  CAS  Google Scholar 

  • Poyart, C., Pierre, C., Quesne, G., Pron, B., Berche, P., & Trieu-Cuot, P. (1997). Emergence of vancomycin resistance in the genus Streptococcus: Characterization of a vanB transferable determinant in Streptococcus bovis. Antimicrob Agents Chemother 41, 24–29.

    PubMed  CAS  Google Scholar 

  • Prystowsky, J., Siddiqui, E., Chosay, J., Shinabarger, D. L., Millichap, I, Peterson, L. R., & Noskin, G. A. (2001). Resistance to linezolid: Characterization of mutations in rRNA and comparison of their occurrences in vancomycin-resistant enterococci. Antimicrob Agents Chemother 45, 2154–2156.

    Article  PubMed  CAS  Google Scholar 

  • Quale, J., Landman, D., Saurina, G., Atwood, E., DiTore, V., & Patel, K. (1996). Manipulation of a hospital antimicrobial formulary to control an outbreak of vancomycin-resistant enterococci. Clin Infect Dis 23, 1020–1025.

    PubMed  CAS  Google Scholar 

  • Rafferty, M. E., McCormick, M. I., Bopp, L. H., Baltch, A. L., George, M., Smith, R. P., Rheal, C., Ritz, W., & Schoonmaker, D. (1997). Vancomycin-resistant enterococci in stool specimens submitted for Clostridium difficile cytotoxin assay. Infect Control Hosp Epidemiol 18, 342–344.

    PubMed  CAS  Google Scholar 

  • Rasmussen, B. A., Gluzman, Y, & Tally, F. P. (1994). Inhibition of protein synthesis occurring on tetracycline-resistant, TetM-protected ribosomes by a novel class of tetracyclines, the glycylcyclines. Antimicrob Agents Chemother 38, 1658–1660.

    PubMed  CAS  Google Scholar 

  • Reid, K. C., Cockerill, I. F., & Patel, R. (2001). Clinical and epidemiological features of Enterococcus casseliflavus/flavescens and Enterococcus gallinarum bacteremia: A report of 20 cases. Clin Infect Dis 32, 1540–1546.

    Article  PubMed  CAS  Google Scholar 

  • Reynolds, P. E. (1989). Structure, biochemistry and mechanism of action of glycopeptide antibiotics. Eur J Clin Microbiol Infect Dis 8, 943–950.

    Article  PubMed  CAS  Google Scholar 

  • Reynolds, P. E., Ambur, O. H., Casadewall, B., & Courvalin, P. (2001). The Van YD D,D-carboxypeptidase of Enterococcus faecium BM4339 is a penicillin-binding protein. Microbiol 147, 2571–2578.

    CAS  Google Scholar 

  • Reynolds, P. E., & Somner, E. A. (1990). Comparison of the target sites and mechanisms of action of glycopeptide and lipoglycodepsipeptide antibiotics. Drugs Exp Clin Res 16, 385–389.

    PubMed  CAS  Google Scholar 

  • Rice, L. B., Carias, L. L., Donskey, C. L., & Rudin, S. D. (1998). Transferable, plasmid-mediated VanB-type glycopeptide resistance in Enterococcus faecium. Antimicrob Agents Chemother 42, 963–964.

    PubMed  CAS  Google Scholar 

  • Rippere, K., Patel, R., Uhl, J. R., Piper, K. E., Steckelberg, J. M., Kline, B. C., Cockerill, F. R., 3rd, and Yousten, A. A. (1998). DNA sequence resembling vanA and vanB in the vancomycin-resistant biopesticide Bacillus popilliae. J Infect Dis 178, 584–588.

    PubMed  CAS  Google Scholar 

  • Roberts, M.C., Sutcliffe, J., Courvalin, P., Jensen, L.B., Rood, J., & Seppala, H. (1999). Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants. Antimicrob Agents Chemother 43, 2823–2830.

    PubMed  CAS  Google Scholar 

  • Robredo, B., Singh, K. V., Baquero, F., Murray, B. E., & Torres, C. (2000a). Vancomycin-resistant enterococci isolated from animals and food. Int J Food Microbiol 54, 197–204.

    Article  PubMed  CAS  Google Scholar 

  • Robredo, B., Singh, K. V., Torres, C., & Murray, B. E. (2000b). Streptogramin resistance and shared pulsed-field gel electrophoresis patterns in vanA-containing Enterococcus faecium and Enterococcus hirae isolated from humans and animals in Spain. Microb Drug Resist 6, 305–311.

    PubMed  CAS  Google Scholar 

  • Robredo, B., Torres, C., Singh, K. V, & Murray, B.E. (2000c). Molecular analysis of Tn1546 in vanA-containing Enterococcus spp. isolated from humans and poultry. Antimicrob Agents Chemother 44, 2588–2589.

    Article  PubMed  CAS  Google Scholar 

  • Roghmann, M.C., McCarter, R.J., Jr., Brewrink, J., Cross, A.S., & Morris, J.G., Jr. (1997). Clostridium difficile infection is a risk factor for bacteremia due to vancomycin-resistant enterococci (VRE) in VRE-colonized patients with acute leukemia. Clin Infect Dis 25, 1056–1059.

    PubMed  CAS  Google Scholar 

  • Rubin, L. G., Tucci, V., Cercenado, E., Eliopoulos, G., & Isenberg, H. D. (1992). Vancomycin-resistant Enterococcus faecium in hospitalized children. Infect Control Hosp Epidemiol 13, 700–705.

    PubMed  CAS  Google Scholar 

  • Safdar, A., Bryan, C. S., Stinson, S., & Saunders, D. E. (2002). Prosthetic valve endocarditis due to vancomycin-resistant Enterococcus faecium: Treatment with chloramphenicol plus minocycline. Clin Infect Dis 34, E61–63.

    Article  PubMed  Google Scholar 

  • Sahm, D. F., Kissinger, J., Gilmore, M. S., Murray, P. R., Mulder, R., Solliday, J., & Clarke, B. (1989). In vitro susceptibility studies of vancomycin-resistant Enterococcus faecalis. Antimicrob Agents Chemother 33, 1588–1591.

    PubMed  CAS  Google Scholar 

  • Saleh-Mghir, A., Lefort, A., Petegnief, Y., Dautrey, S., Vallois, J. M., Le Guludec, D., Carbon, C., & Fantin, B.(1999). Activity and diffusion of LY333328 in experimental endocarditis due to vancomycin-resistant Enterococcus faecalis. Antimicrob Agents Chemother 43, 115–120.

    PubMed  CAS  Google Scholar 

  • Schleifer, K.H., & Kilpper-Bälz, R. (1984). Transfer of Streptococcus faecalis and Streptococcus faecium to the genus Enterococcus nom. rev. as Enterococcus faecalis comb. nov. and Enterococcus faecium comb. nov. Int J Syst Bacteriol 34, 31–34.

    Google Scholar 

  • Schouten, M. A., Hoogkamp-Korstanje, J. A., Meis, J. F., & Voss, A. (2000). Prevalence of vancomycin-resistant enterococci in Europe. Eur J Clin Microbiol Infect Dis 19, 816–822.

    Article  PubMed  CAS  Google Scholar 

  • Schwalbe, R. S., McIntosh, A. C., Qaiyumi, S., Johnson, J. A., Johnson, R. J., Furness, K. M., Holloway, W. J., & Steele-Moore, L. (1996). In vitro activity of LY333328, an investigational glycopeptide antibiotic, against enterococci and staphylococci. Antimicrob Agents Chemother 40, 2416–2419.

    PubMed  CAS  Google Scholar 

  • Schwalbe, R. S., McIntosh, A. C., Qaiyumi, S., Johnson, J. A., & Morris, J. G., Jr. (1999). Isolation of vancomycin-resistant enterococci from animal feed in USA. Lancet 353, 722.

    Article  PubMed  CAS  Google Scholar 

  • Seetulsingh, P. S., Tomayko, J. F., Coudron, P. E., Markowitz, S. M., Skinner, C., Singh, K. V., & Murray, B.E.(1996). Chromosomal DNA restriction endonuclease digestion patterns of beta-lactamase-producing Enterococcus faecalis isolates collected from a single hospital over a 7-year period. J Clin Microbiol 34, 1892–1896.

    PubMed  CAS  Google Scholar 

  • Shaikh, Z. H., Peloquin, C. A., & Ericsson, C. D. (2001). Successful treatment of vancomycin-resistant Enterococcus faecium meningitis with linezolid: Case report and literature review. Scand J Infect Dis 33, 375–379.

    PubMed  CAS  Google Scholar 

  • Shay, D.K., Maloney, S.A., Montecalvo, M., Banerjee, S., Wormser, G.P., Arduino, M.J., Bland, L. A., & Jarvis, W.R. (1995). Epidemiology and mortality risk of vancomycin-resistant enterococcal bloodstream infections. J Infect Dis 172, 993–1000.

    PubMed  CAS  Google Scholar 

  • Sherman, J. M. (1937). The streptococci. Bacterial Rev 1, 3–97.

    CAS  Google Scholar 

  • Shinabarger, D. L., Marotti, K. R., Murray, R. W., Lin, A. H., Melchior, E. P., Swaney, S. M., Dunyak, D. S., Demyan, W. F., & Buysse, J. M. (1997). Mechanism of action of oxazolidinones: Effects of linezolid and eperezolid on translation reactions. Antimicrob Agents Chemother 41, 2132–2136.

    PubMed  CAS  Google Scholar 

  • Shlaes, D. M., Levy, J., & Wolinsky, E. (1981). Enterococcal bacteremia without endocarditis. Arch Intern Med 141, 578–581.

    Article  PubMed  CAS  Google Scholar 

  • Singh, K. V., Weinstock, G. M., & Murray, B. E. (2002). An Enterococcus faecalis ABC homologue (Lsa) is required for the resistance of this species to clindamycin and quinupristin-dalfopristin. Antimicrob Agents Chemother 46, 1845–1850.

    Article  PubMed  CAS  Google Scholar 

  • Slaughter, S., Hayden, M. K., Nathan, C., Hu, T. C., Rice, T., Van Voorhis, J., Matushek, M., Franklin, C., & Weinstein, R. A. (1996). A comparison of the effect of universal use of gloves and gowns with that of glove use alone on acquisition of vancomycin-resistant enterococci in a medical intensive care unit. Ann Intern Med 125, 448–456.

    PubMed  CAS  Google Scholar 

  • Soltani, M., Beighton, D., Philpott-Howard, J., & Woodford, N. (2000). Mechanisms of resistance to quinupristin-dalfopristin among isolates of Entemcoccus faecium from animals, raw meat, and hospital patients in Western Europe. Antimicrob Agents Chemother 44, 433–436.

    Article  PubMed  CAS  Google Scholar 

  • Steinmetz, M. P., Vogelbaum, M. A., De Georgia, M. A., Andrefsky, J. C., & Isada, C. (2001). Successful treatment of vancomycin-resistant enterococcus meningitis with linezolid: Case report and review of the literature. Crit Care Med 29, 2383–2385.

    PubMed  CAS  Google Scholar 

  • Stinear, T. P., Olden, D. C., Johnson, P. D., Davies, J. K., & Grayson, M. L. (2001). Enterococcal vanB resistance locus in anaerobic bacteria in human faeces. Lancet 357, 855–856.

    Article  PubMed  CAS  Google Scholar 

  • Stosor, V., Peterson, L. R., Postelnick, M., & Noskin, G. A. (1998). Enterococcus faecium bacteremia: Does vancomycin resistance make a difference? Arch Intern Med 158, 522–527.

    Article  PubMed  CAS  Google Scholar 

  • Stroud, L., Edwards, J., Danzing, L., Culver, D., & Gaynes, R. (1996). Risk factors for mortality associated with enterococcal bloodstream infections. Infect Control Hosp Epidemiol 17, 576–580.

    Article  PubMed  CAS  Google Scholar 

  • Suppola, J. P., Kuikka, A., Vaara, M., & Valtonen, V. V. (1998). Comparison of risk factors and outcome in patients with Enterococcus faecalis vs Enterococcus faecium bacteraemia. Scand J Infect Dis 30, 153–157.

    PubMed  CAS  Google Scholar 

  • Tally, F. P., & DeBruin, M. F. (2000). Development of daptomycin for Gram-positive infections. J Antimicrob Chemother 46, 523–526.

    Article  PubMed  CAS  Google Scholar 

  • Taylor, S. E., Paterson, D. L., & Yu, V. L. (1998). Treatment options for chronic prostatitis due to vancomycin-resistant Enterococcus faecium. Eur J Clin Microbiol Infect Dis 17, 798–800.

    PubMed  CAS  Google Scholar 

  • Tenorio, A. R., Badri, S. M., Sahgal, N. B., Hota, B., Matushek, M., Hayden, M. K., Trenholme, G. M., & Weinstein, R. A. (2001). Effectiveness of gloves in the prevention of hand carriage of vancomycin-resistant enterococcus species by health care workers after patient care. Clin Infect Dis 32, 826–829.

    Article  PubMed  CAS  Google Scholar 

  • Tokars, J. I., Satake, S., Rimland, D., Carson, L., Miller, E. R., Killum, E., Sinkowitz-Cochran, R. L., Arduino, M. J., Tenover, F. C., Marston, B., & Jarvis, W. R. (1999). The prevalence of colonization with vancomycin-resistant Enterococcus at a Veterans’ Affairs institution. Infect Control Hosp Epidemiol 20, 171–175.

    PubMed  CAS  Google Scholar 

  • Tornieporth, N. G., Roberts, R. B., John, J., Hafner, A., & Riley, L. W. (1996). Risk factors associated with vancomycin-resistant Enterococcus faecium infection or colonization in 145 matched case patients and control patients. Clin Infect Dis 23, 767–772.

    PubMed  CAS  Google Scholar 

  • Trick, W. E., Kuehnert, M. J., Quirk, S. B., Arduino, M. J., Aguero, S. M., Carson, L. A., Hill, B. C., Banerjee, S. N., & Jarvis, W. R. (1999). Regional dissemination of vancomycin-resistant enterococci resulting from interfacility transfer of colonized patients. J Infect Dis 180, 391–396.

    Article  PubMed  CAS  Google Scholar 

  • Uttley, A. H., Collins, C. H., Naidoo, J., & George, R. C. (1988). Vancomycin-resistant enterococci. Lancet 1, 57–58.

    PubMed  CAS  Google Scholar 

  • Uttley, A. H., George, R. C., Naidoo, J., Woodford, N., Johnson, A. P., Collins, C. H., Morrison, D., Gilfillan, A. J., Fitch, L. E., & Heptonstall, J. (1989). High-level vancomycin-resistant enterococci causing hospital infections. Epidemiol Infect 103, 173–181.

    Article  PubMed  CAS  Google Scholar 

  • Van Bambeke, F., Chauvel, M., Reynolds, P. E., Fraimow, H. S., & Courvalin, P. (1999). Vancomycin-dependent Enterococcus faecalis clinical isolates and revertant mutants. Antimicrob Agents Chemother 43, 41–47.

    PubMed  Google Scholar 

  • Van Caeseele, P., Giercke, S., Wylie, J., Boyd, D., Mulvey, M., Amin, S., & Ofner-Agostini, M. (2001). Identification of the first vancomycin-resistant Enterococcus faecalis harbouring vanE in Canada. Can Commun Dis Rep 27, 101–104.

    PubMed  Google Scholar 

  • van den Bogaard, A. E., Jensen, L. B., & Stobberingh, E. E. (1997a). Vancomycin-resistant enterococci in turkeys and farmers. N Engl J Med 337, 1558–1559.

    PubMed  Google Scholar 

  • van den Bogaard, A. E., Mertens, P., London, N. H., & Stobberingh, E. E. (1997b). High prevalence of colonization with vancomycin-and pristinamycin-resistant enterococci in healthy humans and pigs in The Netherlands: Is the addition of antibiotics to animal feeds to blame? J Antimicrob Chemother 40, 454–456.

    PubMed  Google Scholar 

  • van den Bogaard, A. E., & Stobberingh, E. E. (2000). Epidemiology of resistance to antibiotics. Links between animals and humans. Int J Antimicrob Agents 14, 327–335.

    PubMed  Google Scholar 

  • van den Braak, N., Ott, A., van Belkum, A., Kluytmans, J. A., Koeleman, J. G., Spanjaard, L., Voss, A., Weersink, A. J., Vandenbroucke-Grauls, C. M., Buiting, A. G., Verbrugh, H. A., & Endtz, H. P. (2000). Prevalence and determinants of fecal colonization with vancomycin-resistant Enterococcus in hospitalized patients in The Netherlands. Infect Control Hosp Epidemiol 21, 520–524.

    PubMed  Google Scholar 

  • Van der Auwera, P., Pensart, N., Korten, V., Murray, B. E., & Leclercq, R. (1996). Influence of oral glycopeptides on the fecal flora of human volunteers: Selection of highly glycopeptide-resistant enterococci. J Infect Dis 173, 1129–1136.

    PubMed  Google Scholar 

  • Vandamme, P., Vercauteren, E., Lammens, C., Pensart, N., Leven, M., Pot, B., Leclercq, R., & Goossens, H. (1996). Survey of enterococcal susceptibility patterns in Belgium. J Clin Microbiol 34, 2572–2576.

    PubMed  CAS  Google Scholar 

  • Venditti, M., Fimiani, C., Baiocchi, P., Santini, C., Tarasi, A., Capone, A., Di Rosa, R., & Micozzi, A. (1994). Infections by ampicillin-resistant enterococci: A case-control study. J Chemother 6, 121–126.

    PubMed  CAS  Google Scholar 

  • Vergis, E. N., Hayden, M. K., Chow, J. W., Snydman, D. R., Zervos, M. J., Linden, P. K., Wagener, M. M., Schmitt, B., & Muder, R. R. (2001). Determinants of vancomycin resistance and mortality rates in enterococcal bacteremia: A prospective multicenter study. Ann Intern Med 135, 484–92.

    PubMed  CAS  Google Scholar 

  • Viagappan, M., & Holliman, R. E. (1999), Risk factors for acquisition of gentamicin-resistant enterococcal infection: A case-controlled study. Postgrad Med J 75, 342–345.

    PubMed  CAS  Google Scholar 

  • Watanakunakorn, C., & Bakie, C. (1973). Synergism of vancomycin-gentamicin and vancomycin-streptomycin against enterococci. Antimicrob Agents Chemother 4, 120–124.

    PubMed  CAS  Google Scholar 

  • Weinstein, M. R., Dedier, H., Brunton, J., Campbell, I., & Conly, J. M. (1999). Lack of efficacy of oral bacitracin plus doxycycline for the eradication of stool colonization with vancomycin-resistant Enterococcus faecium. Clin Infect Dis 29, 361–366.

    PubMed  CAS  Google Scholar 

  • Wells, C. L., Juni, B. A., Cameron, S. B., Mason, K. R., Dunn, D. L., Ferrieri, P., & Rhame, F. S. (1995). Stool carriage, clinical isolation, and mortality during an outbreak of vancomycin-resistant enterococci in hospitalized medical and/or surgical patients. Clin Infect Dis 21, 45–50.

    PubMed  CAS  Google Scholar 

  • Wells, L. D., & von Graevenitz, A. (1980). Clinical significance of enterococci in blood cultures from adult patients. Infection 8, 147–151.

    Article  PubMed  CAS  Google Scholar 

  • Wells, V D., Wong, E. S., Murray, B. E., Coudron, P. E., Williams, D. S., & Markowitz, S. M. (1992). Infections due to beta-lactamase-producing, high-level gentamicin-resistant Enterococcus faecalis. Ann Intern Med 116, 285–292.

    PubMed  CAS  Google Scholar 

  • Wilke, W. W., Marshall, S. A., Coffman, S. L., Pfaller, M. A., Edmund, M. B., Wenzel, R. P., & Jones, R. N. (1997). Vancomycin-resistant Enterococcus raffinosus: Molecular epidemiology, species identification error, and frequency of occurrence in a national resistance surveillance program. Diagn Microbiol Infect Dis 29, 43–49.

    Article  PubMed  CAS  Google Scholar 

  • Willems, R. J., Top, J., van den Braak, N., van Belkum, A., Mevius, D. J., Hendriks, G., van Santen-Verheuvel, M., & van Embden, J. D. (1999). Molecular diversity and evolutionary relationships of Tn1546-like elements in enterococci from humans and animals. Antimicrob Agents Chemother 43, 483–491.

    PubMed  CAS  Google Scholar 

  • Willey, B. M., Kreiswirth, B. N., Simor, A. E., Faur, Y., Patel, M., Williams, G., & Low, D. E. (1993). Identification and characterization of multiple species of vancomycin-resistant enterococci, including an evaluation of Vitek software version 7.1. J Clin Microbiol 31, 2777–2779.

    PubMed  CAS  Google Scholar 

  • Williamson, J. C., Glazier, S. S., & Peacock, J. E., Jr. (2002). Successful treatment of ventriculostomy-related meningitis caused by vancomycin-resistant Enterococcus with intravenous and intraventricular quinupristin/dalfopristin. Clin Neurol Neurosurg 104, 54–56.

    Article  PubMed  Google Scholar 

  • Winston, D. J., Emmanouilides, C., Kroeber, A., Hindler, J., Bruckner, D. A., Territo, M. C., & Busuttil, R. W. (2000). Quinupristin/Dalfopristin therapy for infections due to vancomycin-resistant Enterococcus faecium. Clin Infect Dis 30, 790–797.

    PubMed  CAS  Google Scholar 

  • Wong, A. H., Wenzel, R. P., & Edmond, M. B. (2000). Epidemiology of bacteriuria caused by vancomycin-resistant enterococci-A retrospective study. Am J Infect Control 28, 277–281.

    Article  PubMed  CAS  Google Scholar 

  • Wong, M. T., Kauffman, C. A., Standiford, H. C., Linden, P., Fort, G., Fuchs, H. J., Porter, S. B., & Wenzel, R. P. (2001). Effective suppression of vancomycin-resistant Enterococcus species in asymptomatic gastrointestinal carriers by a novel glycolipodepsipeptide, ramoplanin. Clin Infect Dis 33, 1476–1482.

    PubMed  CAS  Google Scholar 

  • Woodford, N., Adebiyi, A. M., Palepou, M. F., & Cookson, B. D. (1998). Diversity of VanA glycopeptide resistance elements in enterococci from humans and nonhuman sources. Antimicrob Agents Chemother 42, 502–508.

    PubMed  CAS  Google Scholar 

  • Woodford, N., Jones, B. L., Baccus, Z., Ludlam, H. A., & Brown, D. F. (1995). Linkage of vancomycin and high-level gentamicin resistance genes on the same plasmid in a clinical isolate of Enterococcus faecalis. J Antimicrob Chemother 35, 179–184.

    PubMed  CAS  Google Scholar 

  • Zanella, R. C., Valdetaro, F., Lovgren, M., Tyrrel, G. J., Bokermann, S., Almeida, S. C., Vieira, V. S., & Brandileone, M. C. (1999). First confirmed case of a vancomycin-resistant Enterococcus faecium with VanA phenotype from Brazil: Isolation from a meningitis case in Sao Paulo. Microb Drug Resist 5, 159–162.

    Article  PubMed  CAS  Google Scholar 

  • Zeana, C., Kubin, C. J., Della-Latta, P., & Hammer, S. M. (2001). Vancomycin-resistant Enterococcus faecium meningitis successfully managed with linezolid: Case report and review of the literature. Clin Infect Dis 33, 477–482.

    Article  PubMed  CAS  Google Scholar 

  • Zervos, M. J., Dembinski, S., Mikesell, T., & Schaberg, D. R. (1986). High-level resistance to gentamicin in Streptococcus faecalis: Risk factors and evidence for exogenous acquisition of infection. J Infect Dis 153, 1075–1083.

    PubMed  CAS  Google Scholar 

  • Zervos, M. J., Kauffman, C. A., Therasse, P. M., Bergman, A. G., Mikesell, T. S., & Schaberg, D. R. (1987). Nosocomial infection by gentamicin-resistant Streptococcus faecalis. An epidemiologic study. Ann Intern Med 106, 687–691.

    PubMed  CAS  Google Scholar 

  • Zhanel, G. G., Hoban, D. J., & Karlowsky, J. A. (2001). Nitrofurantoin is active against vancomycin-resistant enterococci. Antimicrob Agents Chemother 45, 324–326.

    PubMed  CAS  Google Scholar 

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Authors
  1. Esteban C. Nannini
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  2. Barbara E. Murray
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Editors and Affiliations

  1. St. Michael’s Hospital, University of Toronto Head of Infectious Diseases, Canada

    I. W. Fong

  2. St. Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada

    I. W. Fong

  3. The Public Health Research Institute, Newark, New Jersey

    Karl Drlica

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© 2004 Kluwer Academic Publishers

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Nannini, E.C., Murray, B.E. (2004). Vancomycin-resistant Enterococci. In: Fong, I.W., Drlica, K. (eds) Reemergence of Established Pathogens in the 21st Century. Emerging Infectious Diseases of the 21st Century, vol 2. Springer, Boston, MA. https://doi.org/10.1007/0-306-48411-0_5

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  • DOI: https://doi.org/10.1007/0-306-48411-0_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-47500-9

  • Online ISBN: 978-0-306-48411-7

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