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Growth Factors and their Receptors in Cancer Metastasis pp 51–65Cite as

Interleukin-8 and Angiogenesis

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Part of the book series: Cancer Metastasis - Biology and Treatment ((CMBT,volume 2))

Abstract

Interleukin-8 (IL-8) is an angiogenic CXC chemokine produced by a variety of cell types. Although initially described as a chemokine for neutrophils, IL-8 has become known as a potent angiogenic factor, involved in normal physiological processes such as wound healing, and abnormal processes such as cancer metastasis. IL-8 is secreted by numerous solid tumour types and associated inflammatory cells, and has been shown to exert a potent angiogenic effect via paracrine and autocrine routes in tumourigenesis, and as such represents an valid opportunity for intervention in cancer metastasis.

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Authors and Affiliations

  1. Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, UK

    Tracey A. Martin

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  1. Tracey A. Martin
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Editors and Affiliations

  1. University of Kansas, Lawrence, Kansas

    C. R. Snyder

  2. University of Wales College of Medicine, Cardiff, UK

    Wen G. Jiang

  3. University of Osaka Medical School, Osaka, Japan

    Kunio Matsumoto  & Toshikazu Nakamura  & 

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© 2001 Kluwer Academic Publishers

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Martin, T.A. (2001). Interleukin-8 and Angiogenesis. In: Snyder, C.R., Jiang, W.G., Matsumoto, K., Nakamura, T. (eds) Growth Factors and their Receptors in Cancer Metastasis. Cancer Metastasis - Biology and Treatment, vol 2. Springer, Dordrecht. https://doi.org/10.1007/0-306-48399-8_3

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  • DOI: https://doi.org/10.1007/0-306-48399-8_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-7141-0

  • Online ISBN: 978-0-306-48399-8

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