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Modeling Heart Development

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Cardiovascular Soft Tissue Mechanics

Abstract

Mechanics plays a major role in heart development. This paper reviews some of the mechanical aspects involved in theoretical modeling of the embryonic heart as it transforms from a single tube into a four-chambered pump. In particular, large deformations and significant alterations in structure lead to highly nonlinear boundary value problems. First, the biological background for the problem is discussed. Next, a modified elasticity theory is presented that includes active contraction and growth, and the theory is incorporated into a finite element analysis. Finally, models for the heart are presented to illustrate the developmental processes of growth, remodeling, and morphogenesis. Combining such models with appropriate experiments should shed light on the complex mechanisms involved in cardiac development.

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Author information

Authors and Affiliations

  1. Department of Biomedical Engineering, Washington University, St. Louis, MO, 63130, USA

    Larry A. Taber

  2. Department of Mechanical Engineering, University of Rochester, Rochester, NY, 14627, USA

    Renato Perucchio

Authors
  1. Larry A. Taber
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  2. Renato Perucchio
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Editor information

Editors and Affiliations

  1. Department of Mechanical Engineering New York Center for Biomedical Engineering, The City College, New York, USA

    Stephen C. Cowin

  2. Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA

    Jay D. Humphrey

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© 2001 Kluwer Academic Publishers

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Taber, L.A., Perucchio, R. (2001). Modeling Heart Development. In: Cowin, S.C., Humphrey, J.D. (eds) Cardiovascular Soft Tissue Mechanics. Springer, Dordrecht. https://doi.org/10.1007/0-306-48389-0_6

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  • DOI: https://doi.org/10.1007/0-306-48389-0_6

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-0220-5

  • Online ISBN: 978-0-306-48389-9

  • eBook Packages: Springer Book Archive

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