Complex Aphthosis

  • Roy S. RogersIII
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 528)


Clearly, complex aphthosis alone does not constitute BD. Furthermore, the patient with complex aphthosis should be evaluated for associated conditions or diseases, some of which are “correctable causes” of RAS. The oral lesions of BD are aphthous in nature and are best classified as complex aphthosis. While some patients with complex aphthosis will develop BD, some will remain as sufferers of complex aphthosis for years until a cause is identified or the disease enters a spontaneous or therapeutically induced remission. Complex aphthosis is the major pseudo-Behçet’s disease encountered in a referral practice22.


Oral Lesion Erythema Multiforme Aphthous Ulcer Recurrent Aphthous Stomatitis Inflammatory Ocular Disease 
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  1. 1.
    Rogers, R.S., III, 1997, Recurrent aphthous stomatitis in the diagnosis of Behçet’s disease. Yonsei Med. J. 38: 370–379.PubMedGoogle Scholar
  2. 2.
    Lee, S., Bang, D., Lee, E.-S., et al., 2001, Diagnosis of Behçet’s disease. In Behçet’s disease (S. Lee, D. Bang, E.-S. Lee, and S. Sohn, eds.), Springer, Berlin, pp. 51–57.Google Scholar
  3. 3.
    Jorizzo, J.L., and Rogers, R.S., III, 1990, Behçet’s disease. J. Am. Acad. Dermatol. 23: 738–741.PubMedGoogle Scholar
  4. 4.
    Ghate, J.V., and Jorizzo, J.L., 1999, Behçet’s disease and complex aphthosis. J. Am. Acad. Dermatol. 40: 1–18.CrossRefPubMedGoogle Scholar
  5. 5.
    Jorizzo, J.L., Taylor, R.S., Schmalstieg, F.C., et al., 1985, Complex aphthosis: A forme fruste of Behçet’s syndrome? J. Am. Acad. Dermatol. 13: 80–84.PubMedGoogle Scholar
  6. 6.
    Rogers, R.S., III, 1977, Recurrent aphthous stomatitis: Clinical characteristics and evidence for an immunopathogenesis. J. Invest. Dermatol. 69: 499–509.PubMedGoogle Scholar
  7. 7.
    Rogers, R.S., III, 1998, Recurrent aphthous stomatitis: Clinical characteristics and associated systemic disorders. Sem. Cutan. Med. Surg. 16: 278–283.Google Scholar
  8. 8.
    Schreiner, D.T., and Jorizzo, J.L., 1987, Behçet’s disease and complex aphthosis. Dermatol. Clin. 5: 760–778.Google Scholar
  9. 9.
    Lehner, T., 1968, Autoimmunity in oral diseases, with special reference to recurrent oral ulcerations. Proc. R. Soc. Med. 61: 515–524.PubMedGoogle Scholar
  10. 10.
    Bang, D., Hur, W., Lee, E.-S., et al., 1995, Prognosis and clinical relevance of recurrent oral ulceration in Behçet’s disease. J. Dermatol. 22: 926–929.PubMedGoogle Scholar
  11. 11.
    Ferguson, M.M., Wray, D., Carmichael, H.A., et al., 1980, Coeliac disease associated with recurrent aphthae. Gut 21: 223–226.PubMedGoogle Scholar
  12. 12.
    Rogers, R.S., III, and Hutton, K.P., 1986, Screening for hematinic deficiencies in otherwise healthy patients with recurrent aphthous stomatitis. Aust. J. Dermatol. 27: 98–103.Google Scholar
  13. 13.
    Nolan, A., McIntosh, W.B., Allam, B.F., et al., 1991, Recurrent aphthous ulceration: vitamin B1, B2 and B6 status and response to replacement therapy. J. Oral Pathol. Med. 20: 389–391.PubMedGoogle Scholar
  14. 14.
    Porter, S., Flint, S., and Scully, C., 1992, Recurrent aphthous stomatitis: The efficacy of replacement therapy in patients with underlying hematinic deficiencies. Ann. Dent. 51: 14–16.PubMedGoogle Scholar
  15. 15.
    DuBois, A., and van den Berghe, L., 1948, Diseases of the warm climates: Their clinical features, diagnosis, and treatment. Grune & Stratton, New York, p. 380.Google Scholar
  16. 16.
    Wray, D., 1981, Gluten-sensitive recurrent aphthous stomatitis. Dig. Dis. Sci. 26: 737–740.CrossRefPubMedGoogle Scholar
  17. 17.
    Hunter, I.P., Ferguson, M.M., Scully, C., et al., 1993, Effects of dietary gluten elimination in patients with recurrent minor aphthous stomatitis and no detectable gluten enteropathy. Oral Surg. Oral Med. Oral Pathol. 75:595–598.CrossRefPubMedGoogle Scholar
  18. 18.
    Jorizzo, J.L., Hudson, R.D., Schmalstieg, F.C., et al., 1984, Behçet’s syndrome: immune regulation, circulating immune complexes, neutrophil migration, and colchicine therapy. J. Am. Acad. Dermatol. 10: 205–214.PubMedGoogle Scholar
  19. 19.
    Lee, S., Bang, D., Lee, E.-S., et al., 2001, Clinical manifestations. In Behçet’s disease (S. Lee, D. Bang, E.-S. Lee, and S. Sohn, eds.), Springer, Berlin, pp. 19–50.Google Scholar
  20. 20.
    Levine, J.A., and O’Duffy, J.D., 1993, Pseudo Behçet’s syndrome. In Behçet’s disease (B. Weshsler, and P. Godeau, eds.), Behçet’s disease, Excerpta Medica, Amsterdam, pp. 295–298.Google Scholar
  21. 21.
    Rogers, R.S., III, and O’Duffy, J.D., 1984, Behçet’s syndrome and treatment with colchicine. J. Am. Acad. Dermatol. 4: 483–484.Google Scholar
  22. 22.
    Rogers, R.S. III, 2000, Pseudo Behcet’s disease. In Behçet’s Disease (D. Bang, E.-S Lee, and S. Lee, eds.), Design Mecca Publishing, Seoul, pp. 116–119.Google Scholar

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© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Roy S. RogersIII
    • 1
  1. 1.Department of DermatologyMayo ClinicRochesterUSA

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