Skip to main content

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 528))

Summary

Clearly, complex aphthosis alone does not constitute BD. Furthermore, the patient with complex aphthosis should be evaluated for associated conditions or diseases, some of which are “correctable causes” of RAS. The oral lesions of BD are aphthous in nature and are best classified as complex aphthosis. While some patients with complex aphthosis will develop BD, some will remain as sufferers of complex aphthosis for years until a cause is identified or the disease enters a spontaneous or therapeutically induced remission. Complex aphthosis is the major pseudo-Behçet’s disease encountered in a referral practice22.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Rogers, R.S., III, 1997, Recurrent aphthous stomatitis in the diagnosis of Behçet’s disease. Yonsei Med. J. 38: 370–379.

    PubMed  Google Scholar 

  2. Lee, S., Bang, D., Lee, E.-S., et al., 2001, Diagnosis of Behçet’s disease. In Behçet’s disease (S. Lee, D. Bang, E.-S. Lee, and S. Sohn, eds.), Springer, Berlin, pp. 51–57.

    Google Scholar 

  3. Jorizzo, J.L., and Rogers, R.S., III, 1990, Behçet’s disease. J. Am. Acad. Dermatol. 23: 738–741.

    CAS  PubMed  Google Scholar 

  4. Ghate, J.V., and Jorizzo, J.L., 1999, Behçet’s disease and complex aphthosis. J. Am. Acad. Dermatol. 40: 1–18.

    Article  CAS  PubMed  Google Scholar 

  5. Jorizzo, J.L., Taylor, R.S., Schmalstieg, F.C., et al., 1985, Complex aphthosis: A forme fruste of Behçet’s syndrome? J. Am. Acad. Dermatol. 13: 80–84.

    CAS  PubMed  Google Scholar 

  6. Rogers, R.S., III, 1977, Recurrent aphthous stomatitis: Clinical characteristics and evidence for an immunopathogenesis. J. Invest. Dermatol. 69: 499–509.

    PubMed  Google Scholar 

  7. Rogers, R.S., III, 1998, Recurrent aphthous stomatitis: Clinical characteristics and associated systemic disorders. Sem. Cutan. Med. Surg. 16: 278–283.

    Google Scholar 

  8. Schreiner, D.T., and Jorizzo, J.L., 1987, Behçet’s disease and complex aphthosis. Dermatol. Clin. 5: 760–778.

    Google Scholar 

  9. Lehner, T., 1968, Autoimmunity in oral diseases, with special reference to recurrent oral ulcerations. Proc. R. Soc. Med. 61: 515–524.

    CAS  PubMed  Google Scholar 

  10. Bang, D., Hur, W., Lee, E.-S., et al., 1995, Prognosis and clinical relevance of recurrent oral ulceration in Behçet’s disease. J. Dermatol. 22: 926–929.

    CAS  PubMed  Google Scholar 

  11. Ferguson, M.M., Wray, D., Carmichael, H.A., et al., 1980, Coeliac disease associated with recurrent aphthae. Gut 21: 223–226.

    CAS  PubMed  Google Scholar 

  12. Rogers, R.S., III, and Hutton, K.P., 1986, Screening for hematinic deficiencies in otherwise healthy patients with recurrent aphthous stomatitis. Aust. J. Dermatol. 27: 98–103.

    Google Scholar 

  13. Nolan, A., McIntosh, W.B., Allam, B.F., et al., 1991, Recurrent aphthous ulceration: vitamin B1, B2 and B6 status and response to replacement therapy. J. Oral Pathol. Med. 20: 389–391.

    CAS  PubMed  Google Scholar 

  14. Porter, S., Flint, S., and Scully, C., 1992, Recurrent aphthous stomatitis: The efficacy of replacement therapy in patients with underlying hematinic deficiencies. Ann. Dent. 51: 14–16.

    CAS  PubMed  Google Scholar 

  15. DuBois, A., and van den Berghe, L., 1948, Diseases of the warm climates: Their clinical features, diagnosis, and treatment. Grune & Stratton, New York, p. 380.

    Google Scholar 

  16. Wray, D., 1981, Gluten-sensitive recurrent aphthous stomatitis. Dig. Dis. Sci. 26: 737–740.

    Article  CAS  PubMed  Google Scholar 

  17. Hunter, I.P., Ferguson, M.M., Scully, C., et al., 1993, Effects of dietary gluten elimination in patients with recurrent minor aphthous stomatitis and no detectable gluten enteropathy. Oral Surg. Oral Med. Oral Pathol. 75:595–598.

    Article  CAS  PubMed  Google Scholar 

  18. Jorizzo, J.L., Hudson, R.D., Schmalstieg, F.C., et al., 1984, Behçet’s syndrome: immune regulation, circulating immune complexes, neutrophil migration, and colchicine therapy. J. Am. Acad. Dermatol. 10: 205–214.

    CAS  PubMed  Google Scholar 

  19. Lee, S., Bang, D., Lee, E.-S., et al., 2001, Clinical manifestations. In Behçet’s disease (S. Lee, D. Bang, E.-S. Lee, and S. Sohn, eds.), Springer, Berlin, pp. 19–50.

    Google Scholar 

  20. Levine, J.A., and O’Duffy, J.D., 1993, Pseudo Behçet’s syndrome. In Behçet’s disease (B. Weshsler, and P. Godeau, eds.), Behçet’s disease, Excerpta Medica, Amsterdam, pp. 295–298.

    Google Scholar 

  21. Rogers, R.S., III, and O’Duffy, J.D., 1984, Behçet’s syndrome and treatment with colchicine. J. Am. Acad. Dermatol. 4: 483–484.

    Google Scholar 

  22. Rogers, R.S. III, 2000, Pseudo Behcet’s disease. In Behçet’s Disease (D. Bang, E.-S Lee, and S. Lee, eds.), Design Mecca Publishing, Seoul, pp. 116–119.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Kluwer Academic Publishers

About this chapter

Cite this chapter

Rogers, R.S. (2004). Complex Aphthosis. In: Zouboulis, C.C. (eds) Adamantiades-Behçet’s Disease. Advances in Experimental Medicine and Biology, vol 528. Springer, Boston, MA. https://doi.org/10.1007/0-306-48382-3_61

Download citation

  • DOI: https://doi.org/10.1007/0-306-48382-3_61

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-47757-7

  • Online ISBN: 978-0-306-48382-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics