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Low Serum Mannose-binding Lectin Levels in Behçet’s Disease

  • Nevsun Inanc
  • Elif Birtas
  • Sule Yavuz
  • Tulin Ergun
  • Haner Direskeneli
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 528)

Conclusion

Very low levels of MBL were detected in a significantly higher number of BD patients compared to HC, ROU and RA. This observation needs to be confirmed with genetic analysis as low MBL levels are shown to correlate with MBL gene mutations.

These results suggest that MBL deficiency might contribute to the pathogenesis of BD by impairing “innate” immune responses against microorganisms.

Keywords

Rheumatoid Arthritis Systemic Lupus Erythematosus Dilute Serum Sample Recurrent Oral Ulceration Unbind Component 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Sakane, T., Takeno, M., Suzuki, N., et al., 1999, Behçet’s disease. N. Engl. J. Med. 341: 1284–1291.CrossRefPubMedGoogle Scholar
  2. 2.
    Direskeneli, H., 2001, Behçet’s disease: infectious aetiology, new autoantigens, and HLA-B5l. Ann. Rheum. Dis. 60: 996–1002.CrossRefPubMedGoogle Scholar
  3. 3.
    Gadjeva, M., Thiel, S., and Jensenius, J.C., 2001, The mannan-binding-lectin pathway of the innate immune response. Curr. Opin. Immunol. 13: 74–78.CrossRefPubMedGoogle Scholar
  4. 4.
    Turner, W.T., 1996, Mannose-binding lectin: the pluripotent molecule of the innate immune system. Immunol. Today 17: 532–540.CrossRefPubMedGoogle Scholar
  5. 5.
    Graudal, N.A., Homann, C., and Madsen, H.O., 1998, Mannan binding lectin in rheumatoid arthritis. A longitudinal study. J. Rheumatol. 25: 629–635.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Nevsun Inanc
    • 3
  • Elif Birtas
    • 2
  • Sule Yavuz
    • 3
  • Tulin Ergun
    • 1
  • Haner Direskeneli
    • 3
  1. 1.Department of Dermatology, Faculty of MedicineMarmara UniversityIstanbulTurkey
  2. 2.Department of Internal Medicine Faculty of MedicineMarmara UniversityIstanbulTurkey
  3. 3.Division of Rheumatology Faculty of MedicineMarmara UniversityIstanbulTurkey

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