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Immunophenotype and Th1/Th2 Cytokines in Patients with Adamantiades-Behçet’s Disease

  • K. Psarra
  • V. Kapsimali
  • G. Vaiopoulos
  • M. Nikolopoulou
  • Ph. Kaklamanis
  • G. Palimeris
  • E. Kaklamani
  • C. Papasteriades
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 528)

Conclusion

In a high percentage of ABD patients a significant increase of TCR-γδT lymphocytes was found irrespective of disease activity. A previous study by Suzuki et al.4 reported similar findings. Type 1 immune response (indicated by the increased expression of IL-2 in T CD3+ lymphocytes) was also observed. The work by Frassanito et al.5, support the Th1 polarization of the immune response as well. These observations may help in understanding the immunopathophysiology of the disease. They may also be of use in designing therapeutic interventions for ABD patients.

Keywords

Immune Response Natural Killer Cell Rheumatic Disease Neurologic Involvement Lymphocyte Subpopulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    O’Duffy, J.D., 1997, Behçet’s disease. Curr. Opin. Rheumatol. 6: 39–43.Google Scholar
  2. 2.
    Boismenu, R., and Havran, W.L., 1997, An innate view of γδT cells. Curr. Opin. Immunol. 9: 57–63.CrossRefPubMedGoogle Scholar
  3. 3.
    Raziuddin, S., Al-Dalaan, A., Bahabri, S., et al., 1998, Divergent cytokine production profile in Behçet’s disease. Altered Th1/Th2 cell cytokine pattern. J. Rheumatol. 25: 329–333.PubMedGoogle Scholar
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    Suzuki, Y., Hoshi, K., Matsuda, T., et al., 1992, Increased peripheral blood γδ+T cells and natural killer cells in Behçet’s disease, J. Rheumatol. 19: 588–592.PubMedGoogle Scholar
  5. 5.
    Frassanito, M.A., Dammacco, R, Cafforio, P., et al., 1999, Th1 polarization of the immune response in Behçet’s disease. Arthritis Rheum. 42: 1967–1974.CrossRefPubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • K. Psarra
    • 2
  • V. Kapsimali
    • 2
  • G. Vaiopoulos
    • 3
  • M. Nikolopoulou
    • 2
  • Ph. Kaklamanis
    • 3
  • G. Palimeris
    • 1
  • E. Kaklamani
    • 1
  • C. Papasteriades
    • 2
  1. 1.Medical SchoolNational and Capodistrian University of AthensAthensGreece
  2. 2.Department of Immunology and Histocompatibility, Evangelismos HospitalNational and Capodistrian University of AthensAthensGreece
  3. 3.Athens Medical CenterNational and Capodistrian University of AthensAthensGreece

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