Immunophenotype and Th1/Th2 Cytokines in Patients with Adamantiades-Behçet’s Disease
In a high percentage of ABD patients a significant increase of TCR-γδT lymphocytes was found irrespective of disease activity. A previous study by Suzuki et al.4 reported similar findings. Type 1 immune response (indicated by the increased expression of IL-2 in T CD3+ lymphocytes) was also observed. The work by Frassanito et al.5, support the Th1 polarization of the immune response as well. These observations may help in understanding the immunopathophysiology of the disease. They may also be of use in designing therapeutic interventions for ABD patients.
KeywordsImmune Response Natural Killer Cell Rheumatic Disease Neurologic Involvement Lymphocyte Subpopulation
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