MICA Transmembrane Region Polymorphism and HLA B51 in Tunisian Behçeťs Disease Patients
None of MICA microsatellite alleles was significantly increased in Tunisian BD patients. Only HLA-B51 was primarily associated to BD in this population. These data, similar to those found in other ethnics6,9, further support the hypothesis that the amino-acids, common to all HLA-B51 encoding alleles and absent in other HLA-B antigens, probably confer high affinity binding for peptides that may contribute to BD development. However, the possibility that HLA-B contributes to the pathogenesis as an additional or complementary risk factor cannot be excluded.
KeywordsMica Gene Gene Polymerase Chain Reaction Mica Allele Rabta Hospital Triplet Repeat Polymorphism
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