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MICA Transmembrane Region Polymorphism and HLA B51 in Tunisian Behçeťs Disease Patients

  • M. Ben Ahmed
  • H. Houman
  • S. Abdelhak
  • I. Ben Ghorbel
  • M. Miled
  • K. Dellagi
  • H. Louzir
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 528)

Conclusion

None of MICA microsatellite alleles was significantly increased in Tunisian BD patients. Only HLA-B51 was primarily associated to BD in this population. These data, similar to those found in other ethnics6,9, further support the hypothesis that the amino-acids, common to all HLA-B51 encoding alleles and absent in other HLA-B antigens, probably confer high affinity binding for peptides that may contribute to BD development. However, the possibility that HLA-B contributes to the pathogenesis as an additional or complementary risk factor cannot be excluded.

Keywords

Mica Gene Gene Polymerase Chain Reaction Mica Allele Rabta Hospital Triplet Repeat Polymorphism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • M. Ben Ahmed
  • H. Houman
    • 3
  • S. Abdelhak
    • 1
  • I. Ben Ghorbel
    • 3
  • M. Miled
    • 3
  • K. Dellagi
    • 2
  • H. Louzir
    • 2
  1. 1.Laboratory of GeneticsInstitut PasteurTunisTunisia
  2. 2.Laboratory of ImmunologyInstitut PasteurTunisTunisia
  3. 3.Department of Internal MedicineLa Rabta HospitalTunisTunisia

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