Advertisement

Detection of Microbial DNA in Skin Lesions from Patients with Behçet’s Disease

  • Michiko Tojo
  • Hirokatsu Yanagihori
  • Xueyi Zheng
  • Noritaka Oyama
  • Emiko Isogai
  • Koichiro Nakamura
  • Fumio Kaneko
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 528)

Conclusion

The presence of Bes-1 DNA seems to be more closely related to the pathogenesis of BD than the presence of HSV1/2. Our results suggest a causative role for Bes-1 in the pathogenesis of BD and a correlation with chronic focal infection in the oral cavity. Consistent PCR-ISH findings are crucial for demonstrating a causal association between an infectious agent, Bes-1, and skin lesions in patients with BD. Therefore, further studies, probably utilizing double staining for characterizing of PCR-ISH-positive cells, may elucidate the role of the streptococcal antigen, Bes-1, in the pathogenesis of BD lesions.

Keywords

Retinal Ganglion Cell Streptococcal Infection Genital Ulcer Oral Flora Immunogenic Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Mizushima, Y., Hoshi, K., Matsuda, T., et al. (The Behçet’s Research Committee of Japan), 1989, Skin hypersensitivity of streptococcal antigens and the induction of systemic symptoms by the antigens in Behçet’s disease — A multicenter study. J. Rheumatol. 16:506–511.Google Scholar
  2. 2.
    Kaneko, F., Takahashi, Y., Muramatsu, R., et al., 1985, Immunological studies on aphthous ulcer and erythema nodosum-like eruptions in Behçet’s disease. Br. J. Dermatol. 113:303–312.PubMedGoogle Scholar
  3. 3.
    Kaneko, F., Oyama, N., and Nishibu, A., 1997, Streptococcal infection in the pathogenesis of Behçet’s disease and clinical effects of minocycline on the disease symptoms. Yonsei Med. J. 38: 444–454.PubMedGoogle Scholar
  4. 4.
    Hirohata, S., Oka, H., and Mizushima, Y., 1992, Streptococcal-related antigens stimulate production of IL-6 and interferon-γ by T cells from patients with Behçet’s disease. Cell. Immunol. 140:410–419.CrossRefPubMedGoogle Scholar
  5. 5.
    Isogai, E., Ohno, S., Takeshi, K., et al., 1990, Close association of Streptococcus sanguis uncommon serotype with Behçet’s disease. Bifidobact. Microflora 9: 27–41.Google Scholar
  6. 6.
    Isogai, E., Ohno, S., Kotake, S., et al., 1990, Chemiluminescence of neutrophils from patients with Behçet’s disease and its correlation with an increased proportion of uncommon serotypes of Streptococcus sanguis in the oral flora. Arch. Oral Biol. 35: 43–48.PubMedGoogle Scholar
  7. 7.
    Yokota, K., Hayashi, S., Fujii, N., et al., 1992, Antibody response to oral streptococci in Behçet’s disease. Microbiol. Immunol. 36: 815–822.PubMedGoogle Scholar
  8. 8.
    Yokota, K., Hayashi, S., Araki, Y., et al., 1995, Characterization of Streptococcus sanguis isolated from patients with Behçet’s disease. Microbiol. Immunol. 39: 729–732.PubMedGoogle Scholar
  9. 9.
    Isogai, E., Isogai, H., Fujii, N., et al., 1990, Adhesive properties of Streptococcus sanguis isolated from patients with Behçet’s disease. Microb. Ecol. Health Dis. 3: 321–328.Google Scholar
  10. 10.
    Yoshikawa, K., Kotake, S., Kubota, T., et al., 1998, Cloning and sequencing of BES-1 gene encoding the immunogenic antigen of Streptococcus sanguis KTH-1 isolated from the patients with Behçet’s disease. Zbl. Bakteriot. 287: 449–460.Google Scholar
  11. 11.
    Xiang, M., Zhou, L., Peng, Y., et al., 1993, Brn-3b’: a POU domain gene expressed in a subset of retinal ganglion cells. Neuron 11: 689–701.CrossRefPubMedGoogle Scholar
  12. 12.
    Lee, S., Bang, D., Ho Cho, Y., et al, 1996, Polymerase chain reaction reveals herpes simplex virus DMA in saliva of patients with Behçet’s disease. Arch. Dermatol. Res. 288: 179–183.CrossRefPubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Michiko Tojo
    • 1
  • Hirokatsu Yanagihori
    • 1
  • Xueyi Zheng
    • 1
  • Noritaka Oyama
    • 1
  • Emiko Isogai
    • 2
  • Koichiro Nakamura
    • 1
  • Fumio Kaneko
    • 1
  1. 1.Department of DermatologyFukushima Medical University School of MedicineFukushimaJapan
  2. 2.Department of Preventive DentistryHealth Sciences University of HokkaidoHokkaidoJapan

Personalised recommendations