The Role of Infectious Agents in the Pathogenesis of Behçet’s Disease

  • Fumio Kaneko
  • Michiko Tojo
  • Masataka Sato
  • Emiko Isogai
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 528)


Heat Shock Protein Kawasaki Disease Erythema Nodosum Infectious Focus Mucocutaneous Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Kaneko, F., Takahashi, Y., and Miura Y., 1985, Immunological studies on aphthous ulcer and erythema nodosum-like eruption in Behçet’s disease. Br. J. Dermatol. 113: 303–312.PubMedGoogle Scholar
  2. 2.
    Kaneko, F., and Oyama, N., 2001, Immunological aspects of hyperreactivity to streptococcal antigens in Behcet’s disease. In: Behcet’s Disease — A guide to its clinical understanding (S. Lee, D. Bang, E.-S. Lee, and S. Sohn, eds.), Springer, Berlin, pp. 193–200.Google Scholar
  3. 3.
    Yokota, K., Hayashi, S., Araki, Y., et al., 1995, Characterization of Streptococcus sanguis isolated from patients with Behçet’s disease. Microbiol. Immunol. 39: 729–732.PubMedGoogle Scholar
  4. 4.
    Hirohata, S., Oka, H., and Mizushima, Y., 1992, Streptococcal-related antigens stimulate production of IL-6 and interferon-γ by T cells from patients with Behçet’s disease. Cell. Immunol. 140:410–419.CrossRefPubMedGoogle Scholar
  5. 5.
    Suzuki, Y., Hoshi, K., Matsuda, T., et al., 1992, Increased peripheral blood γδ+T cells and natural killer cells in Behçet’s disease. J. Rheumatol. 19: 588–592.PubMedGoogle Scholar
  6. 6.
    Lehner, T., Lavery, E., Smith, R., et al., 1991, Association between the 65-kilodalton heat shock protein, Streptococcus sanguis, and the corresponding antibodies in Behçet’s syndrome. Infect. Immunity 59: 1434–1441.Google Scholar
  7. 7.
    Ergun, T., Ince, U., Eksioglu-Demiralp, E., et al., 2001, HSP 60 expression in mucocutaneous lesions of Behçet’s disease. J. Am. Acad. Dermatol. 45: 904–909.CrossRefPubMedGoogle Scholar
  8. 8.
    Yoshikawa, K.., Kotake, S., Kubota, T., et al., 1997, Cloning and sequencing of BES-1 gene encoding the immunogenic antigen of Streptococcus sanguis KTH-1 isolated from the patients with Behçet’s disease. Zbl. Bakteriol. 287: 449–460.Google Scholar
  9. 9.
    Tojo, M, Zheng, X., Oyama, N., et al., 2003, Detection of microbial DNA in skin lesions from patients with Behcet’s disease. In Adamantiades-Behcet’s disease (Ch.C. Zouboulis, ed.), Kluwer/Plenum, London, pp. 185–190.Google Scholar

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Fumio Kaneko
    • 1
  • Michiko Tojo
    • 1
  • Masataka Sato
    • 1
  • Emiko Isogai
    • 2
  1. 1.Department of DermatologyFukushima Medical University School of MedicineFukushimaJapan
  2. 2.Department of Preventive DentistryHealth Science University of HokkaidoIshikari-TobetsuJapan

Personalised recommendations