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Is Long Term Observation of Patients with Recurrent Aphthous Stomatitis Necessary?

Clinical follow-up of 1238 cases
  • Pelin Ekmekçi
  • Ayşel Boyvat
  • Esin Özdemir
  • Aysel Gürler
  • Erbak Gçrgey
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 528)

Conclusion

Behçet’s disease is a chronic inflammatory disorder effecting many organ systems1,2. Clinical manifestations of Behçet’s disease may occur concurrently or subsequently. Generally oral aphthous lesions are the initial symptoms of Behçet’s disease and other manifestations occur subsequently within varying periods during the course of the disease3,4. However, it is a great dilemma to predict if patients presenting only with recurrent aphthous stomatitis will indeed develop Behçet’s disease in the future or not5—6.

The retrospective analysis of the clinical data of 1238 RAS patients who were regularly followed up at multidisciplinary Behçet’s Disease Unit showed that 36 (2.9%) of them developed Behçet’s disease within a period ranging between 2 months and 15 years after the onset of aphthous lesions. Our results indicate that even though recurrent aphthous stomatitis is a rather common condition in general population, especially those patients who have major ulcerations and earlier onset of aphthous lesions should be regularly followed-up. We also suggest to perform the three-step pathergy test in every patient with recurrent aphthous stomatitis and closely follow-up patients with positive test results particularly in countries where Behçet’s disease is prevalent.

Keywords

Ophthalmologic Examination Chronic Inflammatory Disorder Recurrent Aphthous Stomatitis Term Observation Disease Unit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Wong, R.C., Ellis, C.N., and Diaz, L.A., 1984, Behçet’s disease. Int. J. Dermatol. 23: 25–33.PubMedGoogle Scholar
  2. 2.
    Bang, D., 2001, Clinical spectrum of Behçet’s disease. J. Dermatol. 28: 610–613.PubMedGoogle Scholar
  3. 3.
    Gürler, A., Boyvat, A., and Türsen, Ü., 1997, Clinical manifestations of Behçet’s disease: An analysis of 2147 patients. Yonsei Med. J. 38: 423–427.PubMedGoogle Scholar
  4. 4.
    Arbesfeld, S.J., and Kurban, A.K., 1998, Behçet’s disease: New perspectives on an enigmatic syndrome. J. Am. Acad. Dermatol. 19: 767–779.Google Scholar
  5. 5.
    Bang, D., Lee, E.S., Whang, M.R., et al., 1997, Aphthous ulcers and Behçet’s disease. In Dermatology at the millenium. The proceedings of the 19th World Congress of Dermatology (D. Dyall-Smith, and R. Marks, eds.), Parthenon, Sydney, pp. 648–650.Google Scholar
  6. 6.
    Verpilleux, M..P, Garin, S.B, and Revuz, J., 1999, Comparative analysis of severe aphtosis and Behçet’s disease: 104 cases. Dermatology 198: 247–251.CrossRefPubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Pelin Ekmekçi
    • 1
  • Ayşel Boyvat
    • 1
  • Esin Özdemir
    • 1
  • Aysel Gürler
    • 1
  • Erbak Gçrgey
    • 1
  1. 1.Department of Dermatology and Multidisciplinary Behçet’s Disease UnitAnkara University Faculty of MedicineAnkaraTurkey

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