Clinical Manifestations and Course of 200 Japanese Patients with Behçet’s Disease

Conclusion

BD is a multisystemic inflammatory disorder with heterogeneous clinical features. The time of onset of oral aphthae was earlier than any other manifestation, and final incidence was 95% of our patients, and incidence was 56% in their thirties. The time of onset of several other clinical manifestations, including uveitis, skin lesions, genital ulcers and arthralgia was delayed, being 30 to 40% in patients in their thirties. Oral aphthae was a different characteristic symptom as opposed to another clinical manifestation in BD. The cumulative final incidence of neurological symptoms was 11%, comprising a case group with ocular symptoms (25%) and a case group without ocular symptoms (5%) which demonstrated a link between ocular and neurological symptoms.