Conclusion
These results suggest that thalidomide can modulate both cytokine and chemokine expression and also induce death in cells involved in producing excessive inflammatory reactions in order to produce measurable improvements in the symptoms of BD-like mice.
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References
Marriott, J. B., Muller G., and Dalgleish, A.G., 1999, Thalidomide as an emerging immunotherapeutic agent. Immunol. Today 20: 538–540.
Sampaio, E. P., Kaplan, G., Miranda, A., et al., 1993, The influence of thalidomide on the clinical and immunologic manifestation of erythema nodosum leprosum. J. Infect. Dis. 168: 408–414.
Vogelsang, G.B., Santos, G.W., Colvin, O.M., et al., 1988, Thalidomide for graft-versus-host disease. Lancet I: 827.
Lim, S.H., McWhannell, A., Vora, A.J., et al., 1988, Successful treatment with thalidomide of acute graft-versus-host disease after marrow transplantation. Lancet I: 117.
Gutierrez-Rodriguez, O., 1984, Thalidomide: a promising new treatment for rheumatoid arthritis. Arthritis Rheum. 27: 1118–1121.
Schoeman, J.F., Ravenscroft, A., and Hartzenberg, H.B., 2001, Possible role of adjunctive thalidomide therapy in the resolution of a massive intracranial tuberculous abscess. Child’s Nerv. Syst. 17: 370–372.
Ginsburg, P.M., Dassopoulos, T., and Ehrenpreis, E.D., 2001, Thalidomide treatment for refractory Crohn’s disease: a review of the history, pharmacological mechanisms and clinical literature. Ann. Med. 33: 516–525.
Taiwo, B.O., 2001, Use of thalidomide in HIV infection. AIDS Read. 11: 511–524.
Hamuryudan, V., Mat, C., Saip, S., et al., 1998, Thalidomide in the treatment of the mucocutaneous lesions of the Behçet syndrome. A randomized, double-blind, placebo-controlled trial. Ann. Intern. Med. 128: 443–450.
Sohn, S., Lee, E.S., Bang, D., et al., 1998, Behçet’s disease-like symptoms induced by the herpes simplex virus in ICR mice. Eur. J. Dermatol. 8: 21–23.
Lee, S., Bang, D., Lee, E.S., et al., 2001, Immunologic aspects. In: Behçet’s disease—a guide to its clinical understanding. (Lee, S., Bang, D., Lee, E.S., and. Sohn, S., eds.), Springer, Heidelberg, pp. 59–62.
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Sohn, S. et al. (2004). Therapeutic Effect of Thalidomide through Cytokine and Chemokine Regulation in Herpes Simplex Virus-induced Behçet’s Disease-Like Animal Model. In: Zouboulis, C.C. (eds) Adamantiades-Behçet’s Disease. Advances in Experimental Medicine and Biology, vol 528. Springer, Boston, MA. https://doi.org/10.1007/0-306-48382-3_119
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DOI: https://doi.org/10.1007/0-306-48382-3_119
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