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Neuronal Replacement by Transplantation

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Neural Stem Cells

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References

  • Abrous N, Guy J, Vigny A, Calas A, Le Moal M, Herman JP (1988) Development of intracerebral dopaminergic grafts: a combined immunohistochemical and autoradiographic study of its time course and environmental influences. J. Comp Neurol 273:26–41.

    Article  CAS  PubMed  Google Scholar 

  • Armstrong RJ, Hurelbrink CB, Tyers P, Ratcliffe EL, Richards A, Dunnett SB, Rosser AE, Barker RA (2002) The potential for circuit reconstruction by expanded neural precursor cells explored through porcine xenografts in a rat model of Parkinson’s disease. Exp Neurol 175: 98–111.

    Article  PubMed  Google Scholar 

  • Auerbach JM, Eiden MV, McKay RD (2000) Transplanted CNS stem cells form functional synapses in vivo. Eur J Neurosci 12:1696–704.

    Article  CAS  PubMed  Google Scholar 

  • Bachoud-Levi A-C, Remy P, Nguyen J-P, Brugieres P, Lefaucheur J-P, Bourdet C, Baudic S, Gaura V, Maison P, Haddad B, Boisse M-F, Grandmougin T, Jeny R, Bartolomeo P, Barba GD, Degos J-D, Lisovoski F, Ergis A-M, pailhous E, Cesaro P, Hantraye P, Peschanski M (2000) Motor and cognitive improvements in patients with Huntington’s disease after neural transplantation. Lancet 9:1975–1979.

    Google Scholar 

  • Bain G, Kitchens D, Yao M, Huettner JE, Gottlieb DI (1995) Embryonic stem cells express neuronal properties in vitro. Dev Biol 168:342–357.

    Article  CAS  PubMed  Google Scholar 

  • Barami K, Hao HN, Lotoczky GA, Diaz FG, Lyman WD (2001) Transplantation of human fetal brain cells into ischemic lesions of adult gerbil hippocampus. J Neurosurg 95:308–15.

    CAS  PubMed  Google Scholar 

  • Basso DM, Beattie MS, Bresnahan JC (1995) A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12:1–21.

    CAS  PubMed  Google Scholar 

  • Bengzon J, Kokaia Z, Elmer E, Nanobashvili A, Kokaia M, Lindvall O (1997) Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures. Proc Natl Acad Sci USA 94:10432–10437.

    Article  CAS  PubMed  Google Scholar 

  • Benninger Y, Marino S, Hardegger R, Weissmann C, Aguzzi A, Brandner S (2000) Differentiation and histological analysis of embryonic stem cell-derived neural transplants in mice. Brain Pathol 10:330–341.

    CAS  PubMed  Google Scholar 

  • Billon N, Jolicoeur C, Ying QL, Smith A, Raff M (2002) Normal timing of oligodendrocyte development from genetically engineered, lineage-selectable mouse ES cells. J Cell Sci 115:3657–3665.

    Article  CAS  PubMed  Google Scholar 

  • Bjorklund A, Stenevi U (1979) Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants. Brain Res 177:555–560.

    CAS  PubMed  Google Scholar 

  • Bjorklund A, Lindvall O (2000) Cell replacement therapies for central nervous system disorders. Nat Neurosci 3:537–544.

    CAS  PubMed  Google Scholar 

  • Bjorklund LM, Sanchez-Pernaute R, Chung S, Andersson T, Chen IY, McNaught KS, Brownell AL, Jenkins BG, Wahlestedt C, Kim KS, Isacson O (2002) Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci USA 99:2344–2349.

    Article  CAS  PubMed  Google Scholar 

  • Borlongan CV, Tajima Y, Trojanowski JQ, Lee VM, Sanberg PR (1998) Cerebral ischemia and CNS transplantation: differential effects of grafted fetal rat striatal cells and human neurons derived from a clonal cell line. NeuroReport 9:3703–3709.

    CAS  PubMed  Google Scholar 

  • Borlongan CV, Tajima Y, Trojanowski JQ, Lee VM, Sanberg PR (1998) Transplantation of cryopreserved human embryonal carcinoma-derived neurons (NT2N cells) promotes functional recovery in ischemic rats. Exp Neurol 149:310–321.

    Article  CAS  PubMed  Google Scholar 

  • Briscoe J, Sussel L, Serup P, Hartigan-O’Connor D, Jessell TM, Rubenstein JL, Ericson J (1999) Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signaling. Nature 398:622–627.

    CAS  PubMed  Google Scholar 

  • Brustle O, Maskos U, McKay RD (1995) Host-guided migration allows targeted introduction of neurons into the embryonic brain. Neuron 15:1275–1285.

    Article  CAS  PubMed  Google Scholar 

  • Brustle O, Choudhary K, Karram K, Huttner A, Murray K, Dubois-Dalcq M, McKay RD (1998) Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats. Nat Biotech 16:1040–1044.

    CAS  Google Scholar 

  • Brustle O (1999) Building brains: neural chimeras in the study of nervous system development and repair. Brain Pathol 9:527–545.

    CAS  PubMed  Google Scholar 

  • Campbell K, Kalen P, Wictorin K, Lundberg C, Mandel RJ, Bjorklund A (1993) Characterization of GABA release from intrastriatal striatal transplants: dependence on host-derived afferents. Neurosci 53:403–415.

    Article  CAS  Google Scholar 

  • Campbell K, Olsson M, Bjorklund A (1995) Regional incorporation and site-specific differentiation of striatal precursors transplanted to the embryonic forebrain ventricle. Neuron 15:1259–1273.

    Article  CAS  PubMed  Google Scholar 

  • Cao QL, Zhang YP, Howard RM, Walters WM, Tsoulfas P, Whittemore SR (2001) Pluripotent stem cells engrafted into the normal or lesioned adult rat spinal cord are restricted to a glial lineage. Exp Neurol 167:48–58.

    Article  CAS  PubMed  Google Scholar 

  • Chen YL, Chen XG, Wang L, Gautam SC, Xu YX, Katakowski M, Zhang LJ, Lu M, Janakiraman N, Chopp M (2002) Human marrow stromal cell therapy for stroke in rat: Neurotrophins and functional recovery. Neurol 59:514–523.

    Google Scholar 

  • Chow SY, Moul J, Tobias CA, Himes BT, Liu Y, Obrocka M, Hodge L, Tessler A, Fischer I (2000) Characterization and intraspinal grafting of EGF/bFGF-dependent neurospheres derived from embryonic rat spinal cord. Brain Res 874:87–106.

    Article  CAS  PubMed  Google Scholar 

  • Coumans JV, Lin TT, Dai HN, MacArthur L, McAtee M, Nash C, Bregman BS (2001) Axonal regeneration and functional recovery after complete spinal cord transection in rats by delayed treatment with transplants and neurotrophins. J Neurosci 21:9334–9344.

    CAS  PubMed  Google Scholar 

  • Davidson BL, Allen ED, Kozarsky KF, Wilson JM, Roessler BJ (1993) A model system for in vivo gene transfer into the central nervous system using an adenoviral vector. Nat Genet 3:219–223.

    Article  CAS  PubMed  Google Scholar 

  • Deacon T, Schumacker J, Dinsmore J, Thomas C, Palmer P, Kott S, Edge A, Penney D, Kassissieh S, Dempsey P, Isacson O (1997) Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson’s disease. Nat Med 3:350–353.

    Article  CAS  PubMed  Google Scholar 

  • Deckel AW, Robinson RG, Coyle JT, Sanberg PR (1983) Reversal of long-term locomotor abnormalities in the kainic acid model of Huntington’s disease by day 18 fetal striatal implants. Eur J Pharmacol 93:287–288.

    CAS  PubMed  Google Scholar 

  • Doetsch F, Caille I, Lim DA, Garcia-Verdugo JM, Alvarez-Buylla A (1999) Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97:703–716.

    Article  CAS  PubMed  Google Scholar 

  • Englund U, Bjorklund A, Wictorin K, Lindvall O, Kokaia M (2002) Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry. Proc Natl Acad Sri USA 99:17089–17094.

    CAS  Google Scholar 

  • Evans MJ, Kaufman MH (1981) Establishment in culture of pluripotential cells from mouse embryos. Nature 292:154–156.

    CAS  PubMed  Google Scholar 

  • Finley, M.E, Kulkarni, N, Huettner, JE (1996) Synapse formation and establishment of neuronal polarity by P19 embryonic carcinoma cells and embryonic stem cells. J. Neurosci 16:1056–1065.

    CAS  PubMed  Google Scholar 

  • Fishell G (1995) Striatal precursors adopt cortical identities in response to local cue. Development 121:803–812.

    CAS  PubMed  Google Scholar 

  • Fisher LJ, Young SJ, Tepper JM, Groves PM, Gage FH (1991) Electrophysiological characteristics of cells within mesencephalon suspension grafts. Neurosci 40:109–122.

    Article  CAS  Google Scholar 

  • Flax JD, Aurora S, Yang C, Simonin C, Wills AM, Billinghurst LL, Jendoubi M, Sidman RL, Wolfe JH, Kim SU, Snyder EY (1998) Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes. Nat Biotech 16:1033–1039.

    CAS  Google Scholar 

  • Freed CR (2002) Will embryonic stem cells be a useful source of dopamine neurons for transplant into patients with Parkinson’s disease? Proc Natl Adad Sci USA 99:1755–1757.

    CAS  Google Scholar 

  • Freed CR, Greene PE, Breeze RE, Tsai WY, DuMouchel W, Kao R, Dillon S, Winfield H, Culver S, Trojanowski JQ, Eidelberg D, Fahn S (2001) Transplantation of embryonic dopamine neurons for severe Parkinson’s disease. N Engl J Med 344:710–719.

    Article  CAS  PubMed  Google Scholar 

  • Freeman TB, Hauser RA, Sanberg PR, Saporta S (2000) Neural transplantation for the treatment of Huntington’s disease. Prog Brain Res 127:405–411.

    CAS  PubMed  Google Scholar 

  • Freeman TB, Cicchetti F, Hauser RA, Deacon TW, Li XJ, Hersch SM, Nauert GM, Sanberg PR, Kordower JH, Saporta S, Isacson O (2000) Transplanted fetal striatum in Huntington’s disease: phenotypic development and lack of pathology. Proc Natl Acad Sci USA 97:13877–13882.

    Article  CAS  PubMed  Google Scholar 

  • Fricker RA, Carpenter MK, Winkler C, Greco C, Gates MA, Bjorklund A (1999) Site-specific migration and neuronal differentiation of human neural progenitor cells after transplantation in the adult rat brain. J Neurosci 19:5990–6005.

    CAS  PubMed  Google Scholar 

  • Gage FH, Kempermann G, Palmer TD, Peterson DA, Ray J (1998) Multipotent progenitor cells in the adult dentate gyrus. J Neurobiol 36:249–66.

    Article  CAS  PubMed  Google Scholar 

  • Goldstein RS, Drukker M, Reubinoff BE, Benvenisty N (2002) Integration and differentiation of human embryonic stem cells transplanted to the chick embryo. Dev Dyn 225:80–86.

    Article  CAS  PubMed  Google Scholar 

  • Gould E, McEwen BS, Tanapat P, Galea LA, Fuchs E (1997) Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMD A receptor activation. J Neurosci 17:2492–2498.

    CAS  PubMed  Google Scholar 

  • Gould E, Tanapat P (1997) Lesion-induced proliferation of neuronal progenitors in the dentate gyrus of the adult rat. Neuroscience 80:427–436.

    Article  CAS  PubMed  Google Scholar 

  • Han SS, Kang DY, Mujtaba T, Rao MS, Fischer I (2002) Grafted lineage-restricted precursors differentiate exclusively into neurons in the adult spinal cord. Exp Neurol 177:360–375.

    Article  PubMed  Google Scholar 

  • Hantraye P, Riche D, Maziere M, Isacson O (1992) Intrastriatal transplantation of cross-species fetal striatal cells reduces abnormal movements in a primate model of Huntington disease. Proc Natl Acad Sci USA 89:4187–4191.

    CAS  PubMed  Google Scholar 

  • Herrera DG, Garcia-Verdugo JM, Alvarez-Buylla A (1999) Adult-derived neural precursors transplanted into multiple regions in the adult brain. Ann Neurol 46:867–877.

    Article  CAS  PubMed  Google Scholar 

  • Hida H, Hashimoto M, Fujimoto I, Nakajima K, Shimano Y, Nagatsu T, Mikoshiba K, Nishino H (1999) Dopa-producing astrocytes generated by adenoviral transduction of human tyrosine hydroxylase gene: in vitro study and transplantation to hemiparkinsonian model rats. Neurosci Res 35:101–112.

    Article  CAS  PubMed  Google Scholar 

  • Hitoshi S, Tropepe V, Ekker M, van der Kooy D (2002) Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain. Development 129:233–244.

    CAS  PubMed  Google Scholar 

  • Hudson JL, Bickford P, Johansson M, Hoffer BJ, Stromberg I (1994) Target and neurotransmitter specificity of fetal central nervous system transplants: importance for functional reinnervation. J Neurosci 14:283–290.

    CAS  PubMed  Google Scholar 

  • Issacson O, Brundin P, Kelly PA, Gage FH, Bjorklund A (1984) Functional neuronal replacement by grafted striatal neurons in the ibotenic acid-lesioned rat striatum. Nature 311:458460.

    Google Scholar 

  • Jessell TM (2000) Neuronal specification in the spinal cord: inductive signals and transcriptional codes. Nat Rev Genet 1:20–29.

    Article  CAS  PubMed  Google Scholar 

  • Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, Du J, Aldrich S, Lisberg A, Low WC, Largaespada DA, Verfaillie CM (2002) Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418:41–49.

    Article  CAS  PubMed  Google Scholar 

  • Jin K, Minami M, Lan JQ, Mao XO, Batteur S, Simon RP, Greenberg DA (2001) Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat. Proc Natl Acad Sci USA 98:4710–4715.

    CAS  PubMed  Google Scholar 

  • Jori FP, Galderisi U, Piegari E, Cippollaro M, Cascino A, Peluso G, Cotrufo R, Giordana A, Melone MAB (2003) EGF-responsive rat neural stem cells: molecular follow-up of neuron and astrocyte differentiation in vitro. J Cell Physiol 195:220–233.

    Article  CAS  PubMed  Google Scholar 

  • Kalyani AJ, Piper D, Mujtaba T, Lucero MT, Rao MS (1998) Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture. J Neurosci 18:7856–7868.

    CAS  PubMed  Google Scholar 

  • Kendall AL, Rayment FD, Torres EM, Baker HF, Ridley RM, Dunnett SB (1998) Functional integration of striatal allografts in a primate model of Huntington’s disease. Nat Med 4:727–729.

    Article  CAS  PubMed  Google Scholar 

  • Kim JH, Auerbach JM, Rodriguez-Gomez JA, Velasco I, Gavin D, Lumelsky N, Lee SH, Nguyen J, Sanchez-Pernaute R, Bankiewicz K, McKay R (2002) Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson’s disease. Nature 418:50–56.

    Article  CAS  PubMed  Google Scholar 

  • Kukekov VG, Laywell ED, Suslov O, Davies K, Scheffler B, Thomas LB, O’Brien TF, Kusakabe M, Steindler DA (1999) Multipotent stem/progenitor cells with similar properties arise from two neurogenic regions of adult human brain. Exp Neurol 156:333–344.

    Article  CAS  PubMed  Google Scholar 

  • Lai K, Kaspar BK, Gage FH, Schaffer DV (2003) Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nat Neurosci 6:21–27.

    Article  CAS  PubMed  Google Scholar 

  • Laywell ED, Rakic P, Kukekov VG, Holland EC, Steindler DA (2000) Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain. Proc Natl Acad Sci USA 97:13883–13888.

    Article  CAS  PubMed  Google Scholar 

  • Li, M, Pevny L, Lovell-Badge R, Smith A (1998) Generation of purified neural precursors from embryonic stem cells by lineage selection. Curr Biol 8:971–977.

    Article  CAS  PubMed  Google Scholar 

  • Li XJ (1999) The early cellular pathology of Huntington’s disease. Mol Neurobiol 20:111–124.

    PubMed  Google Scholar 

  • Lee SH, Lumelsky N, Studer L, Auerbach JM, McKay RD (2000) Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat Biotech 18:675–679.

    CAS  Google Scholar 

  • Lim DA, Fishell GJ, Alvarez-Buylla A (1997) Postnatal mouse subventricular zone neuronal precursors can migrate and differentiate within multiple levels of the developing neuraxis. Proc Natl Acad Sri USA 94:14832–14836.

    CAS  Google Scholar 

  • Lim DA, Tramontin AD, Trevejo JM, Herrera DG, Garcia-Verdugo JM, Alvarez-Buylla A (2000) Noggin antagonizes BMP signaling to create a niche for adult neurogenesis. Neuron 28:713–726.

    Article  CAS  PubMed  Google Scholar 

  • Lindvall O, Sawle G, Widner H, Rothwell JC, Bjorklund A, Brooks D, Brundin P, Frackowiak R, Marsden CD, Odin P, et al (1994) Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson’s disease. Ann Neurol 35:172–180.

    Article  CAS  PubMed  Google Scholar 

  • Liu S, Qu Y, Stewart TJ, Howard MJ, Chakrabortty S, Holekamp TF, McDonald JW (2000) Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation. Proc Natl Acad Sci USA 97:6126–6131.

    CAS  PubMed  Google Scholar 

  • Magavi SS, Leavitt BR, Macklis JD (2000) Induction of neurogenesis in the neocortex of adult mice. Nature 405:951–955.

    CAS  PubMed  Google Scholar 

  • Magavi SS, Macklis JD (2001) Manipulation of neural precursors in situ: induction of neurogenesis in the neocortex of adult mice. Neuropsychopharm 25: 816–835.

    CAS  Google Scholar 

  • Mayer-Proschel M, Kalyani AJ, Mujtaba T, Rao MS (1997) Isolation of lineage-restricted neuronal precursors from multipotent neuroepithelial stem cells. Neuron 19:773–785

    CAS  PubMed  Google Scholar 

  • McDonald JW, Liu Z, Qu Y, Liu S, Mickey SK, Turetsky D, Gottlieb DI, Choi DW (1999) Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat Med 5:1410–1412.

    Article  CAS  PubMed  Google Scholar 

  • Morshead CM, Benveniste P, Iscove NN, van der Kooy D (2002) Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations. Nat Med 8:268–273.

    CAS  PubMed  Google Scholar 

  • Munsie MJ, Michalska AE, O’Brien CM, Trounson AO, Pera MF, Mountford PS (2000) Isolation of pluripotent embryonic stem cells from reprogrammed adult mouse somatic cell nuclei. Curr Biol 10:989–992.

    Article  CAS  PubMed  Google Scholar 

  • Nakatomi H, Kuriu T, Okabe S, Yamamoto S, Hatano O, Kawahara N, Tamura A, Kirino T, Nakafuku M (2002) Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell 110:429–441.

    Article  CAS  PubMed  Google Scholar 

  • Nottebohm F (2002) Neuronal replacement in adult brain. Brain Res Bull 57:737–749.

    Article  PubMed  Google Scholar 

  • Novitch BG, Chen AI, Jessell TM (2001) Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2. Neuron 31:773–789.

    Article  CAS  PubMed  Google Scholar 

  • Ogawa Y, Sawamoto K, Miyata T, Miyao S, Watanabe M, Nakamura M, Bregman BS, Koike M, Uchiyama Y, Toyama Y, Okano H (2002) Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats. J Neurosci Res 69:925–933.

    Article  CAS  PubMed  Google Scholar 

  • Okabe S, Forsberg-Nilsson K, Spiro AC, Segal M, McKay RDG (1996) Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro. Mech Dev 59:89–102.

    Article  CAS  PubMed  Google Scholar 

  • Olsson M, Campbell K, Turnbull DH (1997) Specification of mouse telencephalic and mid-hindbrain progenitors following heterotopic ultrasound-guided embryonic transplantation. Neuron 19:761–772.

    Article  CAS  PubMed  Google Scholar 

  • Ostenfeld T, Joly E, Tai YT, Peters A, Caldwell M, Jauniaux E, Svendsen CN (2002) Regional specification of rodent and human neurospheres. Dev Brain Res 134:43–55.

    Article  CAS  Google Scholar 

  • Ourednik V, Ourednik J, Flax JD, Zawada WM, Hutt C, Yang C, Park KI, Kim SU, Sidman RL, Freed CR, Snyder EY (2001) Segregation of human neural stem cells in the developing primate forebrain. Science 293:1820–1824.

    Article  CAS  PubMed  Google Scholar 

  • Palfi S, Conde F, Riche D, Brouillet E, Dautry C, Mittoux V, Chibois A, Peschanski M, Hantraye P (1998) Fetal striatal allografts reverse cognitive deficits in a primate model of Huntington’s disease. Nat Med 4:963–966.

    Article  CAS  PubMed  Google Scholar 

  • Palmer TD, Takahashi J, Gage FH (1997) The adult rat hippocampus contains primordial neural stem cells. Mol Cell Neurosci 8:389–404.

    Article  CAS  PubMed  Google Scholar 

  • Parent JM, Yu TW, Leibowitz RT, Geschwind DH, Sloviter RS, Lowenstein DH (1997) Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J Neurosci 17:3727–3738.

    CAS  PubMed  Google Scholar 

  • Park KI, Teng YD, Snyder EY (2002) The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue. Nat Biotech 20:1111–1117.

    Article  CAS  Google Scholar 

  • Perlow MJ, Freed WJ, Hoffer BJ, Seiger A, Olson L, Wyatt RJ (1979) Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system. Science 204:643–647.

    CAS  PubMed  Google Scholar 

  • Piccini P, Brooks DJ, Bjorklund A, Gunn RN, Grasby PM, Rimoldi O, Brundin P, Hagell P, Rehncrona S, Widner H, Lindvall O (1999) Dopamine release from nigral transplants visualized in vivo in a Parkinson’s patient. Nat Neurosci 2:1137–1140.

    Article  CAS  PubMed  Google Scholar 

  • Qian X, Shen Q, Goderie SK, He W, Capela A, Davis AA, Temple S (2000) Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cells. Neuron 28:69–80.

    Article  CAS  PubMed  Google Scholar 

  • Reynolds BA, Tetzlaff W, Weiss S (1992) A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes. J Neurosci 12:4565–4574.

    CAS  PubMed  Google Scholar 

  • Richardson WD (2001) Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon. Development 128:2545–2554.

    PubMed  Google Scholar 

  • Rosser AE, Tyers P, ter Borg M, Dunnett SB, Svendsen CN (1997) Co-expression of MAP-2 and GFAP in cells developing from rat EGF responsive precursor cells. Brain Res Dev Brain Res 98:291–295.

    CAS  PubMed  Google Scholar 

  • Rossi F, Cattaneo E (2002) Opinion: neural stem cell therapy for neurological diseases: dreams and reality. Nat Rev Neurosci 3:401–409.

    Article  CAS  PubMed  Google Scholar 

  • Rubio FJ, Bueno C, Villa A, Navarro B, Martinez-Serrano A (2000) Genetically perpetuated human neural stem cells engraft and differentiate into the adult mammalian brain. Mol Cell Neurosci 16:1–13.

    Article  CAS  PubMed  Google Scholar 

  • Sanberg PR, Borlongan CV, Koutouzis TK, Norgren RB Jr, Cahill DW, Freeman TB (1997) Human fetal striatal transplantation in an excitotoxic lesioned model of Huntington’s disease. Ann NY Acad Sci 831:452–460.

    CAS  PubMed  Google Scholar 

  • Shihabuddin LS, Horner PJ, Ray J, Gage FH (2000) Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyms. J Neurosci 20:8727–8735.

    CAS  PubMed  Google Scholar 

  • Snyder EY, Deitcher DL, Walsh C, Arnold-Aldea S, Hartwieg EA, Cepko CL (1992) Multipotent neural cell lines can engraft and participate in development of mouse cerebellum. Cell 68:3355.

    Article  Google Scholar 

  • Song HJ, Stevens CF, Gage FH (2002) Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons. Nat Neurosci 5:438–445.

    CAS  PubMed  Google Scholar 

  • Studer L, Tabar V, McKay RD (1998) Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats. Nat Neurosci 1:290–295.

    Article  CAS  PubMed  Google Scholar 

  • Suhonen JO, Peterson DA, Ray J, Gage FH (1996) Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo. Nature 383:624–627.

    Article  CAS  PubMed  Google Scholar 

  • Svendsen CN, Caldwell MA, Shen J, ter Borg MG, Rosser AE, Tyers P, Karmiol S, Dunnett SB (1997) Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson’s disease. Exp Neurol 148:135–146.

    Article  CAS  PubMed  Google Scholar 

  • Svendsen CN, Caldwell MA (2000) Neural stem cells in the developing central nervous system: implications for cell therapy through transplantation, in SB dunnett and A. Bjorklund (Eds.), Progress in Brain Research, Vol 127, 13–34.

    Google Scholar 

  • Takayama H, Ray J, Raymon HK, Baird A, Hogg J, Fisher LJ, Gage FH (1995) Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson’s disease. Nat Med 1:53–58.

    Article  CAS  PubMed  Google Scholar 

  • Tamaki S, Eckert K, He D, Sutton R, Doshe M, Jain G, Tushinski R, Reitsma M, Harris B, Tsukamoto A, Gage F, Weissman I, Uchida N (2002) Engraftment of sorted/expanded human central nervous system stem cells from fetal brain. J Neurosci Res 69:976–986.

    Article  CAS  PubMed  Google Scholar 

  • Tekki-Kessaris N, Woodruff R, Hall AC, Gaffield W, Kimura S, Stiles CD, Rowitch DH, Temple S (2001) The development of neural stem cells. Nature 414:112–117.

    Google Scholar 

  • Toda H, Takahashi J, Iwakami N, Kimura T, Hoki S, Mozumi-Kitamura K, Ono S, Hashimoto N (2001) Grafting neural stem cells improved the impaired spatial recognition in ischemic rats. Neurosci Lett 316:9–12.

    Article  CAS  PubMed  Google Scholar 

  • Toma JG, Akhavan M, Fernandes KJ, Barnabe-Heider F, Sadikot A, Kaplan DR, Miller FD (2001) Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol 3:778–784.

    Article  CAS  PubMed  Google Scholar 

  • Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM (1998) Embryonic stem cell lines derived from human blastocysts. Science 282:1145–1147.

    Article  CAS  PubMed  Google Scholar 

  • Tropepe V, Craig CG, Morshead CM, van der Kooy D (1997) Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma. J Neurosci 17:7850–7859.

    CAS  PubMed  Google Scholar 

  • van Praag H, Schinder AF, Christie BR, Toni N, Palmer TD, Gage FH (2002) Functional neurogenesis in the adult hippocampus. Nature 415:1030–1034.

    PubMed  Google Scholar 

  • Vescovi AL, Snyder EY (1999) Establishment and properties of neural stem cell clones: plasticity in vitro and in vivo. Brain Pathol 9:569–598.

    CAS  PubMed  Google Scholar 

  • Wichterle H, Lieberam I, Porter JA, Jessell TM (2002) Directed differentiation of embryonic stem cells into motor neurons. Cell 110:385–397.

    Article  CAS  PubMed  Google Scholar 

  • Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH (1997) Viable offspring derived from fetal and adult mammalian cells. Nature 385:810–813.

    Article  CAS  PubMed  Google Scholar 

  • Winkler C, Fricker RA, Gates MA, Olsson M, Hammang JP, Carpenter MK, Bjorklund A (1998) Incorporation and glial differentiation of mouse EGF-responsive neural progenitor cells after transplantation into the embryonic rat brain. Mol Cell Neurosci 11:99–116.

    Article  CAS  PubMed  Google Scholar 

  • Yang H, Mujtaba T, Venkatraman G, Wu YY, Rao MS, Luskin MB (2000) Region-specific differentiation of neural tube-derived neuronal restricted progenitor cells after heterotopic transplantation. Proc Natl Acad Sci USA 97:13366–13371.

    CAS  PubMed  Google Scholar 

  • Yandava BD, Billinghurst LL, Snyder EY (1999) “Global” cell replacement is feasible via neural stem cell transplantation: evidence from the dysmyelinated shiverer mouse brain. Proc Natl Acad Sci USA 96:7029–7034.

    Article  CAS  PubMed  Google Scholar 

  • Ying QL, Nichols J, Evans EP, Smith AG (2002) Changing potency by spontaneous fusion. Nature 416:545–548.

    Article  CAS  PubMed  Google Scholar 

  • Yoshimura S, Takagi Y, Harada J, Teramoto T, Thomas SS, Waeber C, Bakowska JC, Breakefield XO, Moskowitz MA (2001) FGF-2 regulation of neurogenesis in adult hippocampus after brain injury. Proc Natl Acad Sci USA 98:5874–5479.

    Article  CAS  PubMed  Google Scholar 

  • Zhang SC, Wernig M, Duncan ID, Brustle O, Thomson JA (2001) In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat Biotech 19:11291133.

    Google Scholar 

  • Zhou Q, Anderson DJ (2002) The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell 109:61–73.

    Article  CAS  PubMed  Google Scholar 

  • Zlomanczuk P, Mrugala M, de la Iglesia HO, Ourednik V, Quesenberry PJ, Snyder EY, Schwartz WJ (2002) Transplanted clonal neural stem-like cells respond to remote photic stimulation following incorporation within the suprachiasmatic nucleus. Exp Neurol 174:162–168.

    Article  PubMed  Google Scholar 

  • Zwaka TP, Thomson JA (2003) Homologous recombination in human embryonic stem cells. Nat Biotech 21:319–321.

    Article  CAS  Google Scholar 

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Authors
  1. Daniel J. Guillaume
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  2. Su-Chun Zhang
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Editors and Affiliations

  1. Marine Biomedical Institute and Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX

    Jane E. Bottenstein

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© 2003 Kluwer Academic Publishers

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Guillaume, D.J., Zhang, SC. (2003). Neuronal Replacement by Transplantation. In: Bottenstein, J.E. (eds) Neural Stem Cells. Springer, Boston, MA. https://doi.org/10.1007/0-306-48356-4_10

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  • DOI: https://doi.org/10.1007/0-306-48356-4_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4020-7588-9

  • Online ISBN: 978-0-306-48356-1

  • eBook Packages: Springer Book Archive

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