Summary
The nucleotide sequence of the entire genome of the cyanobacterium Synechocystis sp. PCC6803 has been determined. The primary structures and the positions of all the genes in this genome can be obtained from the genome information database called CyanoBase. The information in the CyanoBase allows a variety of experimental methods to be utilized for the elucidation of the function of each gene and for the unraveling of the regulatory network controlling gene expression. Systematic gene disruption projects employing the natural transformation ability of this organism are in progress and the results are compiled in the database CyanoMutants, which is closely linked to CyanoBase. Further, CyanoBase permits the use of proteome and transcriptome technologies for the study of Synechocystis gene expression and regulation at the genome-wide level. These technologies can significantly accelerate screening of the transcription and translation of genes under various conditions. The combination of all these resources should allow us to rapidly and comprehensively identify the functions of all the Synechocystis genes, thus permitting the level of understanding of the functional and regulatory mechanisms of the Synechocystis genome that was not previously possible.
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Kaneko, T., Tabata, S. (2001). Functional Genomics in Synechocystis sp. PCC6803: Resources for Comprehensive Studies of Gene Function and Regulation. In: Aro, EM., Andersson, B. (eds) Regulation of Photosynthesis. Advances in Photosynthesis and Respiration, vol 11. Springer, Dordrecht. https://doi.org/10.1007/0-306-48148-0_31
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DOI: https://doi.org/10.1007/0-306-48148-0_31
Publisher Name: Springer, Dordrecht
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