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Organ Preservation for Advanced Head and Neck Cancer Concomitant Chemoradiation

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Head and Neck Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 114))

Conclusion

Treatment options for patients with locoregionally advanced head and neck cancer are now diverse. Surgery plus radiation or surgery plus chemoradiation remain options for patients with resectable disease. The same patients, however, appear to have an equally efficacious option of concomitant chemoradiation, with surgery reserved for salvage only. When performed in experienced settings, non-comparative data seem to indicate the outcome to be equivalent or perhaps even better. Direct comparisons between surgery and chemoradiation are unavailable. These would be extremely useful in terms of understanding optimal treatment, both in terms of cure, organ preservation, function preservation, and quality of life. All patients referred for resection of locoregionally advanced head and neck cancer should also have the option of concomitant chemoradiation discussed if an experienced treatment group is available to the patient.

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References

  1. Pignon JP, Bourhis J, Domenge C, Designe L. Chemotherapy added to locoregional treatment for head and neck squamous cell carcinoma: three meta-analyses of updated individual patient data. Lancet 2000;355:949–955.

    PubMed  CAS  Google Scholar 

  2. Munro, A. An overview of randomized controlled trials of adjuvant chemotherapy in head and neck cancer. Br J Cancer 1995; 71:83–91.

    PubMed  CAS  Google Scholar 

  3. El-Sayed, S, Nelson, N. Adjuvant and adjunctive chemotherapy in the management of squamous cell carcinoma of the head and neck region: A meta-analysis of prospective and randomized trials. J Clin Oncol 1996; 14:838–847

    PubMed  CAS  Google Scholar 

  4. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. The Department of Veterans Affairs Cancer Study Group. N Engl J Med 1991; 324:1685–1690.

    Google Scholar 

  5. Lefebvre, JL, Chevalier, D, Luboinski, B, et al. Larynx preservation in pyriform sinus cancer: Preliminary results of a European Organization for research of cancer phase II trial. J Natl Cancer Inst 1996; 88:890–899.

    PubMed  CAS  Google Scholar 

  6. Forastiere AA, Berkey B, Maor M, et al. Phase III trial to preserve the larynx: Induction chemotherapy and radiotherapy versus concomitant chemoradiotherapy versusu radiotherapy alone, Intergroup trial R91-11. Proc ASCO 2001;20:abstract 4.

    Google Scholar 

  7. Ku KK, Pajak TF, Trotti A, et al. A radiation therapy oncolgy group (RTOG) phase III randomized study to compare hyperfractionated and two variants of accelerated fractionation to standard fractionated radiotherapy for head and neck squamous cell carcinomas: First report of RTOG 9003. Int J Radiation Oncology Biol Phys 2000;48:7–16.

    Google Scholar 

  8. Merlano M, Benasso M, Corvo R, et al. Five-year update of a randomized trial of alternating radiotherapy and chemotherapy compared with radiotherapy alone in treatment of unresectable squamous cell carcinoma of the head and neck. J Natl Cancer Inst 1996;88:583–589.

    PubMed  CAS  Google Scholar 

  9. Roh HD, Boucher Y, Kalnicki S, et al: Interstitial hypertension in carcinoma of uterine cervix in patients: Possible correlation with tumor oxygenation and radiation response. Cancer Res 1991; 51:6695

    PubMed  CAS  Google Scholar 

  10. Bush RS, Jenkin RDT, Alh WEC et al: Definitive evidence for hypoxic cells influencing cure in cancer therapy. Br J Cancer 1978; 38(suppl 3):302

    Google Scholar 

  11. Weichselbaum RR, Little JB: Repair of potentially legal x-ray damage and possible applications to clinical radiotherapy. Int J Radiat Oncol Biol Phys 1993; 9:91

    Google Scholar 

  12. Kinsella TJ: Radiosensitization and cell kinetics: Clinical implications for s-phase-specific radiosensitizers. Semin Oncol 1992; 19(suppl 9):41

    PubMed  CAS  Google Scholar 

  13. Laramore GB, Scott CB, Al-Sarraf M, et al. Adjuvant chemotherapy for resectable squamous cell carcinomas of the head and neck: report on Intergroup study 0034. Int J Radiat Oncol Biol Phys 1992;23:705–713.

    PubMed  CAS  Google Scholar 

  14. Paccagnella A, Orlando A, Marchiori C, et al. Phase III trial of initial chemotherapy in stage III or IV head and neck cancers: a study by the Gruppodidi Studio SUI Tumori Della Testa E Del Collo. J Natl Cancer Inst 1994;86:265–272.

    PubMed  CAS  Google Scholar 

  15. Schuller DE, Laramore G, Al-Sarraf M, Jacobs J, Pajak T. Combined therapy for resectable head and neck cancer. A phase III intergroup study. Arch Otolaryngol Head Neck Surg 1989;115:364–368.

    PubMed  CAS  Google Scholar 

  16. Head and Neck Contracts Program. Adjuvant chemotherapy for advanced head and neck squamous carcinoma. Final report of the head and neck contracts program. Cancer 1987;60:301–311

    Google Scholar 

  17. Adelstein DJ, Lavertu P, Saxton JP et al. Mature results of a phase III randomized trial comparing concurrent chemoradiotherapy with radiation therapy alone in patients with stage III and IV squamous cell carcinoma of the head and neck. Cancer 2000;88:876–883.

    Article  PubMed  CAS  Google Scholar 

  18. Adelstein DJ, Saxton JP, Lavertu P, et al. Maximizing local control and organ preservation in advanced squamous cell head and neck cancer (SCHNC) with hyperfractionated radiation (HRT) and concurrent chemotherapy. Proc ASCO 2001;20:224a, abstract 893.

    Google Scholar 

  19. Wendt TG, Grabenbauer GG, Rodel CM. Simultaneous radiotherapy versus radiotherapy alone in advanced head and neck cancer: A randomized multicenter study. J Clin Oncol 16:1318–1324

    Google Scholar 

  20. Brizel DM, Albers ME, Fisher R, et al. Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer. N Engl J Med 1998;338:1798–1804.

    Article  PubMed  CAS  Google Scholar 

  21. Jeremic B, Shibamoto Y, Milicic B, et al. Hyperfractionated radiation therapy with or without concurrent low dose cisplatin in locally advanced squamous cell carcinoma of the head and neck: A prospective randomized trial. J Clin Oncol 2000;18:1458–1464

    PubMed  CAS  Google Scholar 

  22. Calais G, Alfonsi M, Bardet E et al. Randomized trial of radiation versus concomitant chemotherapy and radiation for advanced-stage oropharynx carcinoma, J Natl Cancer Inst 1999; 15:2081–2086.

    Google Scholar 

  23. Vokes EE, Kies M, Haraf DJ, et al. Concomitant chemoradiotherapy as primary therapy for locoregionally advanced head and neck cancer. J Clin Oncol 2000; 18:1652–1661.

    PubMed  CAS  Google Scholar 

  24. Kies MS, Haraf DJ, Rosen F, et al. Concomitant infusional paclitaxel and fluorouracil, oral hydroxyurea, and hyperfractionated radiation for locally advanced squamous head and neck cancer. J Clin Oncol 2001;19:1961–1969.

    PubMed  CAS  Google Scholar 

  25. Rosen FR, Haraf DJ, Brockstein B, et al. Multicenter randomized phase II study of 1-hour infusion paclitaxel, fluorouracil and hydroxyurea with concomitant hyperfractionated radiotherapy (2XRT) with or without erythropoietin for advanced head and neck cancer. Proc ASCO 2001;20:226a, abstract 902

    Google Scholar 

  26. Glicksman AS, Wanebo HJ, Slotman G, et al. Concurrent platinum based chemotherapy and hyperfractionated radiotherapy with late intensification in advanced head and neck cancer. Int J Radiat Oncol Biol Phys 1997;39:721–729.

    Article  PubMed  CAS  Google Scholar 

  27. Leyvraz, S, Pasche, P, Bauer, J, et al. Rapidly alternating chemotherapy and hyperfractionated radiotherapy in the management of locally advanced head and neck carcinoma; Four year results of a phase I/II study. J Clin Oncol 1994; 12:1876.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Evanston Northwestern Healthcare, Evanston, IL

    Bruce Brockstein M.D.

  2. Northwestern University, Chicago, IL

    Bruce Brockstein M.D.

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  1. Bruce Brockstein M.D.
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Editors and Affiliations

  1. Evanston Northwestern Healthcare, Evanston, IL

    Brockstein Bruce M.D.  & Masters Gregory M.D.  & 

  2. Robert H. Lurie Cancer Center of Northwestern University, Feinberg School of Medicine, Chicago, IL

    Brockstein Bruce M.D.  & Masters Gregory M.D.  & 

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© 2004 Kluwer Academic Publishers

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Brockstein, B. (2004). Organ Preservation for Advanced Head and Neck Cancer Concomitant Chemoradiation. In: Bruce, B., Gregory, M. (eds) Head and Neck Cancer. Cancer Treatment and Research, vol 114. Springer, Boston, MA. https://doi.org/10.1007/0-306-48060-3_9

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  • DOI: https://doi.org/10.1007/0-306-48060-3_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4020-7336-6

  • Online ISBN: 978-0-306-48060-7

  • eBook Packages: Springer Book Archive

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