Skip to main content
SpringerLink
Log in

Oral Preneoplasia and Chemoprevention of Squamous Cell Carcinoma of the Head and Neck

  • Chapter
Head and Neck Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 114))

  • 295 Accesses

Conclusions

Micronutrients and phytochemicals modulate genetic pathways of carcinogenesis and inhibit the initiation and progression of SCCHN. These compounds may have a role in the prevention of cancer in high-risk populations, such as tobacco smokers, as well as in the prevention of disease progression or relapse. Clinical studies investigating the use of these agents in the prevention ofSCCHN should be a high priority.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Greenlee, RT, Hill-Harmon, MB, Murray, T, and Thun, M. Cancer statistics, 2001. CA Cancer J Clin, 51:15–36, 2001.

    Article  PubMed  CAS  Google Scholar 

  2. Ries, L. A. G., C. L. Kosary, et al. SEER Cancer Statistics Review, 1973–1996, National Cancer Institute, 1999.

    Google Scholar 

  3. Swango, P. A. Cancer of the oral cavity and pharynx in the United States: an epidemilogic overview. J Public Health Dent 56(6): 309–318, 1996.

    PubMed  CAS  Google Scholar 

  4. Schantz, SP, Harrison, LB, and Forastiere, AA. Tumors of the nasal cavity and paranasal sinuses, nasopharynx, oral cavity, and oropharynx. VT DeVita, S Hellman, SA Rosenberg, eds., Cancer: Principles and Practice of Oncology. Lippincott Williams & Wilkins, NY, 797–860, 2001.

    Google Scholar 

  5. Wynder, E. L., M. H. Mushinski, et al. Tobacco and alcohol consumption in relation to the development of multiple primary cancers. Cancer 40(4 Suppl): 1872–8, 1977.

    PubMed  CAS  Google Scholar 

  6. Horowitz, A. M., H. S. Goodman, et al. The need for health promotion in oral cancer prevention and early detection. J Public Health Dent 56(6): 319–30, 1996.

    PubMed  CAS  Google Scholar 

  7. Devesa, S. S., W. J. Blot, et al. Cohort trends in mortality from oral, esophageal, and laryngeal cancers in the United States [see comments]. Epidemiology 1(2): 116–21, 1990.

    PubMed  CAS  Google Scholar 

  8. Gillison, M. L., W. M. Koch, et al. Human papillomavirus in head and neck squamous cell carcinoma: are some head and neck cancers a sexually transmitted disease? CurrOpin Oncol 11:191–199, 1999.

    CAS  Google Scholar 

  9. Yu MC, H. B. Nasopharyngeal Cancer. Cancer Epidemiology and Prevention. F. J. Schottenfeld D. New York, Oxford University Press: 603–618, 1996.

    Google Scholar 

  10. Potter, J. D., A. Chavez, et al. (1997). Food, nutrition and the prevention of cancer: a global perspective. Washington DC, World Cancer Research Fund/American Institute of Cancer Research.

    Google Scholar 

  11. Update January 1992: the American Cancer Society guidelines for cancer-related check-up. (1992). CA-Cancer J Clin 42: 44–45.

    Google Scholar 

  12. Slaughter, DP, Southwick, HW, Smejkal, W. Field cancerization in oral stratified squamous epithelium: Clinical implications of multicentric origin. Cancer, 6:963–968,1953.

    PubMed  CAS  Google Scholar 

  13. Lippman, SM and Hong, WK. Not yet standard: Retinoids versus second primary tumors. J Clin Oncol, 11:1204–1207,1993.

    PubMed  CAS  Google Scholar 

  14. Lee, JJ, Hong, WK, Hittelman, WN, et al. Predicting cancer development in oral leukoplakia: Ten years of translational research. Clin Cancer Res, 6:1702–1710, 2000.

    PubMed  CAS  Google Scholar 

  15. Hong, WK, Endicott, J, Itri, LM, et al. 13-cis-retinoic acid in the treatment of oral leukoplakia. N Eng J Med, 315:1501–1505, 1986.

    Article  CAS  Google Scholar 

  16. Lippman, SM, Batsakis, JG, Toth, BB, et al. Comparison of low-dose isotretinoin with beta carotene to prevent oral carcinogenesis. N Eng J Med, 328:15–20, 1993.

    CAS  Google Scholar 

  17. Garewal, HS, Katz, RV, Meyskens, F, et al. Beta-carotene produces sustained remissions in patients with oral leukoplakia. Arch Otolaryngol Head Neck Surg, 125:1305–1310, 1999.

    PubMed  CAS  Google Scholar 

  18. Waldron CA, Shafer WG: Leukoplakia revisited. A clinico-pathologic study of 3, 256 leukoplakias. Cancer 36:1386–1392,1968.

    Google Scholar 

  19. Mashberg A. Erythroplakia: the earliest sign of asymptomatic oral cancer. J Am Dent Assoc 96:615–620,1978.

    PubMed  CAS  Google Scholar 

  20. Shafer WG, Waldron CA. Erythroplakia of the oral cavity. Cancer 36:1021–1028, 1975.

    PubMed  CAS  Google Scholar 

  21. Crissman JD, Zarbo RJ: Dysplasia, in situ carcinoma and progress to invasive squamous cell carcinoma of the upper aerodigestive tract. Am J Surg Pathol 13(Suppl):5–16, 1989.

    PubMed  Google Scholar 

  22. Hsu, T.C., Spitz, M.R., and Schantz, S.P. (1991). Mutagen sensitivity: A biological marker of cancer susceptibility. Cancer Epidemiol. Biomarkers Prev. 1, 83–89.

    PubMed  CAS  Google Scholar 

  23. Hsu, T.C. (1983). Genetic instability in the human population: a working hypothesis. Hereditas 98, 1–9.

    PubMed  CAS  Google Scholar 

  24. Hsu, T.C., Johnston, D.A., Cherry, L.M., Ramkisson, D., Schantz, S.P., Jessup, J.M., Winn, R.J., Shirley, L., and Furlong, C. (1989). Sensitivity to genotoxic effects of bleomycin in humans: Possible relationship to environmental carcinogenesis. Int. J. Cancer 43, 403–09.

    PubMed  CAS  Google Scholar 

  25. Schantz, S.P., Spitz, M.R., and Hsu, T.C. (1990). Mutagen sensitivity in head and neck cancer patients: a biologic marker for risk of multiple primary malignancies. J. Natl. Cancer Inst. 82, 1773–1775.

    PubMed  CAS  Google Scholar 

  26. Spitz, M.R., Fueger, J.J., Halabi, S., Schantz, S.P., Sample, D., and Hsu, T.C. (1993). Mutagen sensitivity in upper aerodigestive tract cancer: A case-control analysis. Cancer Epidemiol. Biomarkers Prev. 2, 329–333.

    PubMed  CAS  Google Scholar 

  27. Cloos, J., Braakhuis, B.J.M., Steen, I., Copper, M.P., DeVries, N., Nauta, J.J.P. and Snow, G.P. (1994). Increased mutagen sensitivity in head-and-neck squamous-cell carcinoma patients, particularly those with multiple primary tumors. Int. J. Cancer. 56, 816–819.

    PubMed  CAS  Google Scholar 

  28. Trizna, Z., Schantz, S.P., and Hsu, T.C. (1991). Effects of N-acetyl-L-cysteine and ascorbic acid on mutagen-induced chromosomal sensitivity in patients with head and neck cancers. Am. J. Surg. 162, 294–298.

    Article  PubMed  CAS  Google Scholar 

  29. Pohl, H., and Reidy, J. (1989). Vitamin C intake influences the bleomycin-induced chromosome damage assay: Implications for detection of cancer susceptibility and chromosome breakage syndromes. Mutat. Res. 224, 247–252.

    PubMed  CAS  Google Scholar 

  30. Trizna, Z., Hsu, T.C., and Schantz, S.P. (1992). Protective effects of vitamin E against bleomycin-induced genotoxicity in head and neck cancer patients in vitro. Anticancer Res. 2, 325–328.

    Google Scholar 

  31. Shamberger, R.L., Baughman, F.F., Kalchert, S.L., et al. (1973). Carcinogen-induced chromosomal breakage decreased by antioxidants. Proc. Natl. Acad. Sci. USA 70, 1461–1463.

    PubMed  CAS  Google Scholar 

  32. LaVecchia, C., Negri, E., D’Avanzo, B., Franchesci, S., Decarli, A., and Boyle, P. Dietary indicators of laryngeal cancer risk. Cancer Res., 50:4497–4500, 1990.

    CAS  Google Scholar 

  33. Block, G., Patterson, B., and Subar, A. (1992). Fruits, vegetables, and cancer prevention: A review of epidemiological evidence. Nutr. Cancer 18, 1–29.

    PubMed  CAS  Google Scholar 

  34. Kucuk, O., Pung, A., Franke, A., Custer, L., Wilkens, L., LeMarchand, L., Higuchi, C., Cooney, R., and Hsu, T.C. (1995). Variability ofmutagen sensitivity in healthy adults: Correlations with plasma nutrient levels. Cancer Epidemiol. Biomarkers Prev. 4,217–221.

    CAS  Google Scholar 

  35. Monget, A. L., Galan, P., Preziosi, P., Keller, H., Bourgeois, C., Arnaud, J., Favier, A., and Hercberg, S. (1996). Micronutrient status in elderly people. Int. J. Vit. Nutr. Res. 66,71–76.

    CAS  Google Scholar 

  36. Donma, M. M., Donma, O., and Tas, M. A. (1993). Hair zinc and copper concentrations and zinc:copper ratios in pediatric malignancies and healthy children from southeastern Turkey. Biol. Trace Element Res. 36, 51–63.

    CAS  Google Scholar 

  37. Negri, E., Franceschi, S., Bosetti, C., Levi, F., Conti, E., Parpinel, M., and La Vecchia, C. (2000). Selected micronutrients and oral and pharyngeal cancer. Int. J. Cancer 86, 122–127.

    Article  PubMed  CAS  Google Scholar 

  38. Alhasan, S. A., Pietrasczkiwicz, H., Alonso, M. D., Ensley, J., and Sarkar, F. H. (1999). Genistein-induced cell cycle arrest and apoptosis in a head and neck squamous cell carcinoma cell line. Nutr. Cancer 34,12–19.

    Article  PubMed  CAS  Google Scholar 

  39. Alhasan, S. A., Ensley, J. F., and Sarkar, F. H. (2000). Genistein induced molecular changes in a squamous cell carcinoma of the head and neck cell line. Int. J. Oncol. 16, 333–338.

    PubMed  CAS  Google Scholar 

  40. Pamuk, E. R., Byers, T., Coates, R. J., Vann, J. W., Sowell, A. L., Gunter, E. W., and Glass, D. (1994). Effects of smoking on serum nutrient concentrations in African-American women. Am. J. Clin. Nutr. 59, 891–895.

    PubMed  CAS  Google Scholar 

  41. Ross, M. A., Crosley, L. K., Brown, K. M., Duthie, S. J., Collins, A. C., Arthur, J. R., and Duthie, G.G. (1995). Plasma concentrations of carotenoids and antioxidant vitamins in Scottish males: influences of smoking. Eur. J. Clin. Nutr. 49, 861–865.

    PubMed  CAS  Google Scholar 

  42. Pakrashi, A., and Chatterjee, S. (1995). Effect of tobacco consumption on the function ofmale accessory sex glands, Int. J. Androl. 18, 232–236.

    PubMed  CAS  Google Scholar 

  43. Faruque, M. O., Khan, M. R., Rahman, M. M., and Ahmed, F. (1995). Relationship between smoking and antioxidant micronutrient status. Br. J. Nutr. 73, 625–632.

    Article  PubMed  CAS  Google Scholar 

  44. Albanes, D., Heinonen, O. P., Taylor, P. R., Virtamo, J., Edwards, B. K., Rautalahti, M., Hartman, A. M., Palmgren, J., Freedman, L. S., Haapakoski, J., Barrett, M. J., Pietinen, P., Malila, N., Tala, E., Liippo, K., Salomaa, E. R., Tangrea, J. A., Teppo, L., Askin, F. B., Taskinen, E., Erozan, Y., Greenwald, P, Huttunen, J. K. (1996). Alpha-Tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study compliance. J. Natl. Cancer inst. 88, 1560–1570.

    PubMed  CAS  Google Scholar 

  45. Palozza, P., Luberto, C., Calviello, G., Ricci, P., and Bartoli, G.M. (1997). Antioxidant and prooxidant role of beta-carotene in murine normal and tumor thymocytes: effects of oxygen partial pressure. Free Rad. Biol. Med. 22, 1065–1073.

    Article  PubMed  CAS  Google Scholar 

  46. Wang, X.D., Liu, C., Branson, R.T., Smith, D.E., Krinsky, N.I., and Russell, M. (1999). Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke. J. Natl. Cancer Inst. 91, 60–66.

    PubMed  CAS  Google Scholar 

  47. Tsubono, Y., Tsugane, S., and Gey, K. F. (1996). Differential effects of cigarette smoking and alcohol consumption on the plasma levels of carotenoids in middle aged Japanese men. Jap. J. Res. 87, 563–569.

    CAS  Google Scholar 

  48. Brady, W. E., Mares-Perlman, J. A., Bowen, P., and Stacewicz-Sapuntzakis, M. (1996). Human serum carotenoid concentrations are related to physiologic and lifestyle factors. J. Nutrition 126, 129–137.

    CAS  Google Scholar 

  49. Lecomte, E., Grolier, P., Herbeth, B., Pirollet, P., Musse, N., Paille, F., Braesco, V., Siest, G., and Artur, Y. (1994). The relationship of alcohol consumption to serum carotenoid and retinol levels. Effects of withdrawal. Int. J. Vit. Nutr. Res. 64, 170–175.

    CAS  Google Scholar 

  50. Leo, M. A., Seitz, H. K., Maier, H., and Lieber, C. S. (1995). Carotenoid, retinoid and vitamin E status of the oropharyngeal mucosa in the alcoholics. Alcohol & Alcoholism 30, 163–170.

    CAS  Google Scholar 

  51. Goodwin, W. J., and Torres, J. (1984). The value ofprognostic nutritional index in the management of patients with carcinoma of the head and neck. Otolaryngol. Head Neck Surg. 6, 932–937.

    Google Scholar 

  52. Brooks, G. B. (1985). Nutritional status-a prognostic indicator in head and neck cancer. Otolaryngol. Head Neck Surg. 93, 69–74.

    Google Scholar 

  53. Williams, E. F., and Meguid, M. M. (1989). Nutritional concepts and considerations in head and neck surgery. Head Neck Surg. 11, 393–399.

    Google Scholar 

  54. Bassett, M. R., and Dobie, R. A. (1983). Patterns ofnutritional deficiency in head and neck cancer. Otolaryngol. Head Neck Surg. 91, 119–125.

    PubMed  CAS  Google Scholar 

  55. Hooley, R., Levine, H., Flores, T.C., Wheeler, T., and Steiger, E. (1983). Predicting postoperative complications using nutritional assessment. Arch. Otolaryngol. 109, 83–85.

    Google Scholar 

  56. Sobol, S. M., Conoyer, J. M., and Sessions, D. G. (1979). Enteral and parenteral nutrition in patients with head and neck cancer. Ann. Otolaryngol. 88, 495–501.

    CAS  Google Scholar 

  57. Mullen, J. L., Gertner, M. H., Buzby, G.P., Goodhart, G.L., and Rosato, E. F. (1979). Implications of malnutrition in the surgical patient. Arch. Surg. 114, 121–125.

    PubMed  CAS  Google Scholar 

  58. Buzby, G. P., Mullen, J. L., Matthews, D. C.; Hobbes, C. I., and Rosato, E. F. (1980). Prognostic nutritional index in gastrointestinal surgery. Am. J. Surg. 139, 160–167.

    Article  PubMed  CAS  Google Scholar 

  59. Olmedilla, B., Granado, F., Blanco, I., and Rojas-Hidalgo, E. (1996). Evaluation of retinol, alpha-tocopherol, and carotenoids in serum of men with cancer of the larynx before and after commercial enteral formula feeding. J. Parenteral Enteral Nutr. 20, 145–149.

    CAS  Google Scholar 

  60. Prasad, A. S. (1993). Biochemistry of zinc. Plenum Press, New York.

    Google Scholar 

  61. Faber, M., Coudray, C., Hida, H., Mousseau, M., and Favier, A. (1995). Lipid peroxidation products, and vitamin and trace element status in patients with cancer before and after chemotherapy, including Adriamycin. A preliminary study. Biol. Trace Element Res. 47, 117–123.

    CAS  Google Scholar 

  62. Torii, M., Ito, H., and Suzuki, T. (1992). Lipid peroxidation and myocardial vulnerability in hypertrophied SHR myocardium. Exp. Mol. Pathol. 57, 29–38.

    Article  PubMed  CAS  Google Scholar 

  63. Backstrom, I., Funegard, U., Andersson, I., Franzen, L., and Johansson, I. (1995). Dietary intake in head and neck irradiated patients with permanent dry mouth symptoms. Oral Oncol. Eur. J. Cancer 31B, 253–257.

    CAS  Google Scholar 

  64. Warth, J. A., Prasad, A. S., Zwas, F., and Frank, R. N. (1981). Abnormal dark adaptation in sickle cell anemia. J. Lab. Clin. Med. 98, 189–194.

    PubMed  CAS  Google Scholar 

  65. Koch H: Biochemical treatment of precancerous oral lesions; the effectiveness of various analogues of retinoic acid. JMaxillofac Surg 6:59–63, 1978

    CAS  Google Scholar 

  66. Hong WK, Endicott J, Itri LM, et al: 13-cis-retinoic acid in the treatment of oral leukoplakia. NEnglJ Med 315:1501–1505, 1986

    CAS  Google Scholar 

  67. Condero AA, Allevato MAJ, Barclay CA, et al: Treatment of lichen planus and leukoplakia with the oralretinoid Rol0-0359. In: Orfanos CE, et al, eds. Retinoids. Basel: Springer-Verlag, 1981:273–278

    Google Scholar 

  68. Shah JP, Strong EW, DeCrosse JJ, et al: Effect of retinoids on leukoplakia. Am J Surg 146:466–470,1983

    PubMed  CAS  Google Scholar 

  69. Wald NJ, Boreham J, Hayward JL, Bulbrook RD. Plasma retinol, beta-carotene and vitamin E levels in relation to the future risk of breast cancer. Br J Cancer 49:321–324,1984.

    PubMed  CAS  Google Scholar 

  70. Stahelin HB, Rosel F, Buess E, Brubacher G. Cancer, vitamins and plasma lipids: prospective Basel study. JNatl Cancer Inst 73:1463–1468, 1984.

    CAS  Google Scholar 

  71. Salonen JT, Salonen R, Lapapetelaianean R, Alfthan G, Puska P. Risk of cancer in relation to serum concentrations of selenium and vitamins A and E: matched case-control analysis of prospective data. BrMed J 290:417–420, 1985.

    CAS  Google Scholar 

  72. Benner SE, Winn RW, Lippman SM, et al. Regression of oral leukoplakia with alpha-tocopherol: a community clinical oncology program chemoprevention study. J Natl Cancer Inst 85:44–47, 1993.

    PubMed  CAS  Google Scholar 

  73. Shklar G, Schwartz J, Trickler D and Reid S. Regression of experimental cancer by oral administration of combined alpha-tocoperol and beta-carotene. Nutr Cancer 12:321–325, 1989.

    Article  PubMed  CAS  Google Scholar 

  74. Suda D, Schwartz J and Shklar G. GGT reduction in beta-carotene inhibition of hamster buccal pouch carcinogenesis. Eur J Cancer Clin Oncol 23:43–46, 1987.

    Article  PubMed  CAS  Google Scholar 

  75. Nomura AM, Stemmermann GM, Heilbrun LK et al. Serum vitamin levels and risk of cancer of specific sites in men of Japanese ancestry in Hawaii. Cancer Res 45:2369–2372, 1983.

    Google Scholar 

  76. Peto R, Doll R, Buckley JD, Sporn MB. Can dietary beta-carotene materially reduce human cancer rates? Nature 290:201–208, 1981.

    Article  PubMed  CAS  Google Scholar 

  77. Omenn GS, Goodman G, Rosenstock L, Barnhart S, Lund B, Thornquist M, Feigl P. Cancer chemoprevention with vitamin A and beta-carotene in populations at high risk for lung cancer. In Cerurti PA, Nygaard OF, Simic M (eds), 1987, pp. 279–283.

    Google Scholar 

  78. Hennekens CH. Beta-carotene and chemoprevention of cancer. In Cerutti PA, Nygaard OF, Simic MG (eds), 1987, pp. 269–277, 1987.

    Google Scholar 

  79. Ziegler RG. A review of the epidemiologic evidence that carotenoids reduce the risk of cancer. J Nutr 119:116–122, 1988.

    Google Scholar 

  80. Neiman C, Obbink HJR. The biochemistry and pathology of hypervitaminosis A. VitamHorm 12:69–99, 1954.

    Google Scholar 

  81. Hennekens CH, Mayrent SL, Willett W. Vitamin A, Carotenoids, and Retinoids. Cancer 58:1837–1841, 1986.

    PubMed  CAS  Google Scholar 

  82. Kaugars GE, Silverman S Jr, Lovas JGL, Brandt RB, Riley WT, Dao Q, Singh VN, Gallo J. A clinical trial of antioxidant supplements in the treatment of oral leukoplakia. Oral Surg Oral Med Oral Pathol 78:462–468,1994.

    PubMed  CAS  Google Scholar 

  83. Malaker K, Anderson BJ, Beecroft WA, Hodson DI. Management of oral mucosal dysplasia with beta-carotene and cis-retinoic acid: a pilot crossover study. Cancer Detect Prev 15:335–340, 1991.

    PubMed  CAS  Google Scholar 

  84. Toma S, Benso S, Albanese E, Palumbo R, Nicolo G, Mangiante P, Response of oral leukoplakia to beta-carotene treatment. In: Vitamins and Cancer Prevention. Baton Rouge: Louisiana State University Press; 1991.

    Google Scholar 

  85. Garewal HS, Katz RV, Meyskens F, Pitcock J, Morse D, Friedman S, Peng Y, Pendrys DG, Mayne S, Alberts D, Kiersch T, Graver E. Beta-carotene produces sustained remissions in patients with oral leukoplakia: results of a multicenter prospective trial. Arch Otolaryngol Head Neck Surg. 125(12): 1305–10, 1999.

    PubMed  CAS  Google Scholar 

  86. Garewal HS. Potential role of beta-carotene in prevention of oral cancer. Am J Clin Nutr 53:2948–2978, 1991.

    Google Scholar 

  87. Garewal HS, Meyskens FL, Jr., Killen D, Reeves D, Kiersch TA, Elletson H, Strosberg A, King D, Steinbronn K. Response of oral leukoplakia to beta-carotene. J Clin Oncol 8:1715–1720, 1990.

    PubMed  CAS  Google Scholar 

  88. Stich HF, Rosin MP, Hornby AP, Matthew B, Sankaranarayana R, Nair MK. Remission of oral leukoplakias and micronuclei in tobacco/betel quid chewers treated with beta-carotene and with beta-carotene plus vitamin A. Int J Cancer 42:195–199, 1988.

    PubMed  CAS  Google Scholar 

  89. Lippman SM, Batsakis JG, Toth BB, et al. Comparison of low-dose isotretinoin with beta-carotene to prevent oral carcinogenesis. N Engl J Med 328:15–20,1993.

    Article  PubMed  CAS  Google Scholar 

  90. The Alpha-tocopherol and Beta-carotene Cancer Prevention Study Group. The effect of vitamin E and beta-carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 330:1029–1035, 1994.

    Google Scholar 

  91. Stahelin HB, Gey KF, Eichholzer M, Ludin E. Beta-carotene and cancer prevention: The Basel study. Am J Clin Nutr 53:2658–2698, 1991.

    Google Scholar 

  92. Knekt P, Aromaa A, Maatela J, Aaran R-K, Nikkari T, Hakama M, Hakulinen T, Peto R, Teppo L. Vitamin E and cancer prevention. Am J Clin Nutr 53:2838–286S, 1991.

    Google Scholar 

  93. de Vries N, Snow GB. Relationship of Vitamins A and E and beta-carotene serum levels to head and neck cancer patients with and without second primary tumors. Eur Arch Otorhinolaryngol 247:368–370, 1990.

    Article  PubMed  Google Scholar 

  94. Krinsky NI. Effects of carotenoids in cellular and animal systems. Am J Clin Nutr 53:2388–2468, 1991.

    Google Scholar 

  95. Shklar G. Oral mucosal carcinogenesis inhibition by Vitamin E. J Natl Cancer Inst. 68:791–797, 1982.

    PubMed  CAS  Google Scholar 

  96. Schreinemachers, DM and Everson, RB. Aspirin use and lung, colon, and breast cancer incidence in a prospective study. Epidemiol, 5:138–146, 1994.

    CAS  Google Scholar 

  97. Beazer-Barclay, Y, Levy, DB, Moser, AR, et al. Sulindac suppresses tumorigenesis in the Min mouse. Carcinogenesis, 17:1757–1760, 1996.

    PubMed  CAS  Google Scholar 

  98. Harris, RE, Alshafie, GA, Abou-Issa, H, et al. Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor. Cancer Res, 60:2101–2103, 2000.

    PubMed  CAS  Google Scholar 

  99. Rao, KV, Detrisac, CJ, Steele, VE, et al. Differential activity of aspirin, ketoprofen and sulindac as cancer chemopreventive agents in the mouse urinary bladder. Carcinogenesis, 17:1435–1438, 1996.

    PubMed  CAS  Google Scholar 

  100. Jalbert, G and Castonguay, A. Effects of NSAIDs on NNK-induced pulmonary and gastric tumorigenesis in A/J mice. Cancer Lett, 66:21–28, 1992.

    Article  PubMed  CAS  Google Scholar 

  101. Steinbach, G, Lynch, PM, Phillips, RKS, et al. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Eng J Med, 342:1946–52, 2000.

    CAS  Google Scholar 

  102. He, T-C, Chan, TA, Vogelstein, B, et al. PPAR-gamma is an APC-regulated target of nonsteroidal anti inflammatory drugs. Cell, 99:335–345, 1999.

    Article  PubMed  CAS  Google Scholar 

  103. Shureiqi, I, Chen, D, Lotan, R, et al. 15-Lipoxygenase-l mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells. Cancer Res, 60:6846–6850, 2000.

    PubMed  CAS  Google Scholar 

  104. Sohm J-W, Mao, Y, Kim, M-G, et al. Cyclic GMP mediates apoptosis induced by sulindac derivatives via activation of c-Jun NH2-terminal kinase 1. Clin Cancer Res, 6:4136–4141, 2000.

    Google Scholar 

  105. Lehmann, JM, Lenhard, JM, Oliver, BB, et al. Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem, 272:3406–3410, 1997.

    PubMed  CAS  Google Scholar 

  106. Chang, T-S and Szabo, E. Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor-gamma in non-small cell lung cancer. Cancer Res, 60:1129–1138, 2000.

    PubMed  CAS  Google Scholar 

  107. Sarraf, P., Mueller, E., Jones, D., et al. Differentiation and reversal of malignant changes in colon cancer through PPAR-gamma. Nat. Med., 4: 1046–1052, 1998.

    Article  PubMed  CAS  Google Scholar 

  108. Mueller, E., Sarraf, P., Tontonoz, P., et al. Terminal differentiation of human breast cancer through PPAR-gamma. Mol. Cell, 1:465–470, 1998.

    Article  PubMed  CAS  Google Scholar 

  109. Silver, R and Ondrey, F. Functional RXR alpha mediated PPAR activation decreases upper aerodigestive squamous cell cancer (SCCA) proliferation. Proc AACR, 2001.

    Google Scholar 

  110. Inoue, H, Tanabe, T, and Umesono, K. Feedback control of cyclooxygenase-2 expression through PPAR-gamma. J Biol Chem, 275:28028–28032, 2000.

    PubMed  CAS  Google Scholar 

  111. Ondrey, FG. Arachidonic acid metabolism: A primer for head and neck surgeons. Head & Neck, 20:334–349, 1998.

    Article  CAS  Google Scholar 

  112. Chan, G, Boyle, JO, Yang, EK, et al. Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck. Cancer Res, 59:991–994, 1999.

    PubMed  CAS  Google Scholar 

  113. Tanaka, T, Nishikawa, A, Mori, Y, et al. Inhibitory effects of non-steroidal anti-inflammatory drags, piroxicam and indomethacin on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male ACI/N rats. Cancer Lett, 48:177–182, 1989.

    Article  PubMed  CAS  Google Scholar 

  114. Prasad, A. S., Beck, F. W. J., Grabowski, S. M., Kaplan. J. and Mathog, R. H. (1997). Zinc deficiency: Changes in cytokine production and T-cell subpopulations in patients with head and neck cancer and in non-cancer subjects. Proc. Asso. Am. Physicians 109, 68–77.

    CAS  Google Scholar 

  115. Mocchegiani, E., Veccia, S., Ancarani, F., Scalise, G., and Fabris, N. (1995). Benefit of oral zinc supplementation as an adjunct to zidovudine (AZT) therapy against opportunistic infections in AIDS. Int. J. Immunopharmacol. 17, 719–727.

    PubMed  CAS  Google Scholar 

  116. Abdulla, M., Biorklund, A., Mathur, A., and Wallenius, K. (1979). Zinc and copper levels in whole blood and plasma from patients with squamous cell carcinomas of head and neck. J. Surg. Oncol. 12, 107–113.

    PubMed  CAS  Google Scholar 

  117. Garofalo, J. A., Erlandson, E., Strong, E. W., Lesser, M., Gerold, F., Spiro, R., Schwartz, M., and Good, R. A. (1980). Serum zinc, serum copper, and the Cu/Zn ratio in patients with epidermoid cancers of the head and neck. J. Surg. Oncol. 15, 381–386.

    PubMed  CAS  Google Scholar 

  118. Wacker, WEC. 1976. Role of zinc in wound healing: A critical review. 1976. In: Prasad AS (Ed). Trace Elements in Human Health and Disease, Vol. I. New York, Academic Press, pp 107–113.

    Google Scholar 

  119. Strain, W. H., Pories, W. J., and Hinshaw, J. R. (1960). Zinc studies in skin repair. Surg. Forum 11, 291–292.

    Google Scholar 

  120. Pories, W. J., and Strain, W. H. (1966). Zinc and wound healing. In: “Zinc Metabolism” (A. S. Prasad, Ed.), pp. 378–394. Charles C Thomas, Springfield, IL.

    Google Scholar 

  121. Fernandez-Madrid, F., Prasad, A. S., and Oberleas, D. (1973). Effect of zinc deficiency on nucleic acid, collagen and non-collagenous protein of the connective tissue. J. Lab. Clin. Med. 82, 951–961.

    PubMed  CAS  Google Scholar 

  122. Prasad, A. S., Beck, F. W. J, Doerr, T. D., Shamsa, F. H., Penny, H. S., Marks, S. C., Kaplan, J., Kucuk, O., and Mathog, R. H. (1998). Nutritional status of head and neck cancer patients; zinc deficiency and cell mediated immune functions. J. Am. Coll. Nutr. 5, 409–418.

    Google Scholar 

  123. Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L. Jr, Valanis, B., Williams, J. H. Jr, Barnhart, S., Cherniack, M. G., Brodkin, C. A., and Hammar, S. (1996). Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial. J. Natl. Cancer Inst. 88, 1550–1559.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan

    Omer Kucuk MD (FACN)

Authors
  1. Omer Kucuk MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Evanston Northwestern Healthcare, Evanston, IL

    Brockstein Bruce M.D.  & Masters Gregory M.D.  & 

  2. Robert H. Lurie Cancer Center of Northwestern University, Feinberg School of Medicine, Chicago, IL

    Brockstein Bruce M.D.  & Masters Gregory M.D.  & 

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Kluwer Academic Publishers

About this chapter

Cite this chapter

Kucuk, O. (2004). Oral Preneoplasia and Chemoprevention of Squamous Cell Carcinoma of the Head and Neck. In: Bruce, B., Gregory, M. (eds) Head and Neck Cancer. Cancer Treatment and Research, vol 114. Springer, Boston, MA. https://doi.org/10.1007/0-306-48060-3_3

Download citation

  • DOI: https://doi.org/10.1007/0-306-48060-3_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4020-7336-6

  • Online ISBN: 978-0-306-48060-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation