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Advances in the Use of Naltrexone an Integration of Preclinical and Clinical Findings

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Recent Developments in Alcoholism

Part of the book series: Recent Developments in Alcoholism ((RDIA,volume 16))

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References

  • Akil, H., Watson, S.J., Young, E., Lewis, M.E., Khachaturian, H., & Walker, J.M. (1984). Endogenous opioids: biology and function. Annual Review of Neuroscience 7, 223–255.

    Article  PubMed  Google Scholar 

  • Altshuler, H.L., Phillips, P.E., & Feinhandler, D.A. (1980). Alteration of ethanol self-administration by naltrexone. Life Sciences 26(9), 679–688.

    Article  PubMed  Google Scholar 

  • Andersen, P.K., & Gill, R.D. (1982). Cox’s regression model for counting processes: a large sample study. Annals of Statistics 10, 1100–1120.

    Google Scholar 

  • Anton, R.F., Moak, D.H., Waid, L.R., Latham, P.K., Malcolm, R.J., & Dias, J.K. (1999). Naltrexone and cognitive behavioral therapy for the treatment of outpatient alcoholics: Results of a placebo-controlled trial. American Journal of Psychiatry 156(11), 1758–1764.

    PubMed  Google Scholar 

  • Anton, R., Moak, D.H., Latham, P.K., Waid, L.R., Malcolm, R.J., Dias, J.K., & Roberts, J.S. (2001). Posttreatment results of combining naltrexone with cognitive-behavior therapy for the treatment of alcoholism. Journal of Clinical Psychopharmacology 21(1), 72–77.

    Article  PubMed  Google Scholar 

  • Badia-Elder, N.E., Mosemiller, A.K., Elder, R.L., & Froehlich, J.C. (1999). Naloxone retards the expression of a genetic predisposition toward alcohol drinking. Psychopharmacology (Berl) 144(3), 205–212.

    Google Scholar 

  • Baker, T.B., Morse, E., & Sherman, J.E. (1987). The Motivation to Use Drugs: A Psychobiological Analysis of Urges. Lincoln, NE: University of Nebraska Press.

    Google Scholar 

  • Benjamin, D., Grant, E.R., & Pohorecky, L.A. (1993). Naltrexone reverses ethanol-induced dopamine release in the nucleus accumbens in awake, freely moving rats. Brain Research 621(1), 137–140.

    Article  PubMed  Google Scholar 

  • Bienkowski, P., Kostowski, W., & Koros, E. (1999). Ethanol-reinforced behavior in the rat: Effects of naltrexone. European Journal of Pharmacology 374(3), 321–327.

    PubMed  Google Scholar 

  • Bohn, M.J., Kranzler, H.R., Beazoglou, D., & Staehler, B.A. (1994). Naltrexone and brief counseling to reduce heavy drinking. American Journal on Addictions 2, 91–99.

    Google Scholar 

  • Brown, S.A., Vik, P.W., Patterson, T.L., Grant, I., & Schuckit, M.A. (1995). Stress, vulnerability and adult alcohol relapse. Journal of Studies on Alcohol 56(5), 538–545.

    PubMed  Google Scholar 

  • Cadoret, R.J., Cain, C.A., & Grove, W.M. (1980). Development of alcoholism in adoptees raised apart from alcoholic biologic relatives. Archives of General Psychiatry 37(5), 561–563.

    PubMed  Google Scholar 

  • Chick, J., Anton, R., Checinski, K., Croop, R., Drummond, D.C., Farmer, R., Labriola, D., Marshall, J., Moncrieff, J., Morgan, M.Y., Peters, T., & Ritson, B. (2000). A multicentre, randomized, double-blind, placebo-controlled trial of naltrexone in the treatment of alcohol dependence or abuse. Alcohol and Alcoholism 35(6), 587–593.

    Article  PubMed  Google Scholar 

  • Cotton, N.S. (1979). The familial incidence of alcoholism. Journal of Studies on Alcohol 40, 89–116.

    PubMed  Google Scholar 

  • Cowen, M.S., Rezvani, A.H., Jarrott, B., & Lawrence, A.J. (1999). Ethanol consumption by Fawn-Hooded rats following abstinence: Effect of naltrexone and changes in mu-opioid receptor density. Alcoholism: Clinical and Experimental Research 23(6), 1008–1014.

    Google Scholar 

  • Danks, J.A., Tortella, F.C., Long, J.B., Bykov, V., Jacobson, A.E., Rice, K.C., Holaday, J.W., & Rothman, R.B. (1988). Chronic administration of morphine and naltrexone upregulate[3H][D-Ala2, D-leu5]enkephalin binding sites by different mechanisms. Neuropharmacology 27(9), 965–974.

    Article  PubMed  Google Scholar 

  • Davidson, D., Swift, R., & Fitz, E. (1996). Naltrexone increases the latency to drink alcohol in social drinkers. Alcoholism: Clinical and Experimental Research 20(4), 732–739.

    Google Scholar 

  • Davidson, D., Palfai, T., Bird, C., & Swift, R. (1999). Effects of naltrexone on alcohol self-administration in heavy drinkers. Alcoholism: Clinical and Experimental Research 23(2), 195–203.

    Google Scholar 

  • De Waele, J.P., Papachristou, D.N., & Gianoulakis, C. (1992). The alcohol-preferring C57BL/6 mice present an enhanced sensitivity of the hypothalamic beta-endorphin system to ethanol than the alcohol-avoiding DBA/2 mice. Journal of Pharmacology & Experimental Therapeutics 261(2), 788–794.

    Google Scholar 

  • Di Chiara, G., & Imperato, A. (1988). Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proceedings of the National Academy of Sciences of the United States of America 85(14), 5274–5278.

    PubMed  Google Scholar 

  • Di Chiara, G., Acquas, E., & Carboni, E. (1992). Drug motivation and abuse: A neurobiological perspective. Annals of the New York Academy of Sciences 654, 207–219.

    PubMed  Google Scholar 

  • Farren, C.K., Catapano, D., & O’Malley, S. (1997). Sertraline with naltrexone vs naltrexone alone in the treatment of alcohol dependence. Alcoholism: Clinical and Experimental Research 21(suppl), 64A.

    Google Scholar 

  • Froehlich, J.C. (1995). Genetic factors in alcohol self-administration. Journal of Clinical Psychiatry 56 (Suppl 7), 15–23.

    PubMed  Google Scholar 

  • Froehlich, J.C. (1997). Physiology of opioid peptides. Alcohol Health and Research World 21, 132–136.

    PubMed  Google Scholar 

  • Froehlich, J.C., & Li, T.K. (1993). Recent developments in alcoholism: Opioid peptides. Recent Developments in Alcoholism 11, 187–205.

    PubMed  Google Scholar 

  • Froehlich, J.C., & Li, T.K. (1994). Opioid involvement in alcohol drinking. Annals of the New York Academy of Sciences 739, 156–167.

    PubMed  Google Scholar 

  • Froehlich, J.C., Harts, J., Lumeng, L., & Li, T.K. (1987). Naloxone attenuation of voluntary alcohol consumption. Alcohol and Alcoholism Suppl 1, 333–337.

    Google Scholar 

  • Froehlich, J.C., Harts, J., Lumeng, L., & Li, T.K. (1990). Naloxone attenuates voluntary ethanol intake in rats selectively bred for high ethanol preference. Pharmacology, Biochemistry and Behavior 35(2), 385–390.

    Article  Google Scholar 

  • Froehlich, J.C., Zweifel, M., Harts, J., Lumeng, L., & Li, T.K. (1991). Importance of delta opioid receptors in maintaining high alcohol drinking. Psychopharmacology 103(4), 467–472.

    Article  PubMed  Google Scholar 

  • Froehlich, J.C., Zink, R.W., Li, T.K., & Christian, J.C. (2000a). Analysis of heritability of hormonal responses to alcohol in twins: Beta-endorphin as a potential biomarker of genetic risk for alcoholism. Alcoholism: Clinical and Experimental Research 24(3), 265–277.

    Google Scholar 

  • Froehlich, J.C., Zink, R.W., & Rohrbach, K. (2000b). Preclinical medications development: Combining naltrexone with acamprosate produces enhanced suppression of alcohol drinking in alcoholpreferring (P) rats. Alcoholism: Clinical and Experimental Research 24, 78A.

    Google Scholar 

  • Gardell, L.R., Hubbell, C.L., & Reid, L.D. (1996). Naltrexone persistently reduces rats’ intake of a palatable alcoholic beverage. Alcoholism: Clinical and Experimental Research 20(3), 584–588.

    Google Scholar 

  • Gardell, L.R., Whalen, C.A., Chattophadyay, S., Cavallaro, C.A., Hubbell, C.L., & Reid, L.D. (1997). Combination of naltrexone and fluoxetine on rats’ propensity to take alcoholic beverage. Alcoholism: Clinical and Experimental Research 21(8), 1435–1439.

    Google Scholar 

  • Gianoulakis, C. (1990). Characterization of the effects of acute ethanol administration on the release of beta-endorphin peptides by the rat hypothalamus. European Journal of Pharmacology 180(1), 21–29.

    Article  PubMed  Google Scholar 

  • Gianoulakis, C. (1998). Alcohol seeking behavior: The roles of the hypothalamic-pituitary-adrenal axis and the endogenous opioid system. Alcohol Health and Research World 22, 202–210.

    PubMed  Google Scholar 

  • Gianoulakis, C., Hutchison, W.D., & Kalant, H. (1988). Effects of ethanol treatment and withdrawal on biosynthesis and processing of proopiomelanocortin by the rat neurointermediate lobe. Endocrinology 122(3), 817–825.

    Article  PubMed  Google Scholar 

  • Gianoulakis, C., Beliveau, D., Angelogianni, P., Meaney, M., Thavundayil, J., Tawar, V., & Dumas, M. (1989). Different pituitary beta-endorphin and adrenal cortisol response to ethanol in individuals with high and low risk for future development of alcoholism. Life Sciences 45(12), 1097–1109.

    Article  PubMed  Google Scholar 

  • Gianoulakis, C., De Waele, J.P., & Thavundayil, J. (1996). Implication of the endogenous opioid system in excessive ethanol consumption. Alcohol 13(1), 19–23.

    Article  PubMed  Google Scholar 

  • Gonzales, R.A., & Weiss, F. (1998). Suppression of ethanol-reinforced behavior by naltrexone is associated with attenuation of the ethanol-induced increase in dialysate dopamine levels in the nucleus accumbens. Journal of Neuroscience 18(24), 10663–10671.

    PubMed  Google Scholar 

  • Goodwin, D.W. (1985). Alcoholism and genetics. The sins of the fathers. Archives of General Psychiatry 42(2), 171–174.

    PubMed  Google Scholar 

  • Hayes, C.E., Cantorna, M.T., & DeLuca, H.F (1997). Vitamin D and multiple sclerosis. Proceedings of the Society for Experimental Biology and Medicine 216(1), 21–27.

    PubMed  Google Scholar 

  • Heinala, P., Alho, H., Kiianma, K., Lonnqvist, J., & Kuoppasalmi, K. (2001). Targeted use of naltrexone without prior detoxification in the treatment of alcohol dependence: A factorial doubleblind, placebo-controlled trial. Journal of Clinical Psychopharmacology 21(3), 287–292.

    Article  PubMed  Google Scholar 

  • Henry, J.L. (1982). Circulating opioids: Possible physiological roles in centralnervous function. Neuroscience and Biobehavioral Reviews 6(3), 229–245.

    Article  PubMed  Google Scholar 

  • Hersh, D., Van Kirk, J.R., & Kranzler, H.R. (1998). Naltrexone treatment of comorbid alcohol and cocaine use disorders. Psychopharmacology (Berl) 139(1–2), 44–52.

    Google Scholar 

  • Herz, A. (1997). Endogenous opioid systems and alcohol addiction. Psychopharmacology (Berl) 129(2), 99–111.

    Google Scholar 

  • Hesselbrock, V.M. (1995). The genetic epidemiology of alcoholism. In H. Begleiter & B. Kissin (eds.), The Genetics of Alcoholism. New York: Oxford University Press, pp. 17–39.

    Google Scholar 

  • Heyser, C.J., Schulteis, G., & Koob, G.F. (1997). Increased ethanol self-administration after a period of imposed ethanol deprivation in rats trained in a limited access paradigm. Alcoholism: Clinical and Experimental Research 21(5), 784–791.

    Google Scholar 

  • Heyser, C.J., Schulteis, G., Durbin, P., & Koob, G.F. (1998). Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats. Neuropsychopharmacology 18(2), 125–133.

    Article  PubMed  Google Scholar 

  • Heyser, C.J., Roberts, A.J., Schulteis, G., & Koob, G.F. (1999). Central administration of an opiate antagonist decreases oral ethanol self-administration in rats. Alcoholism: Clinical and Experimental Research, 23(9), 1468–1476.

    Google Scholar 

  • Holter, S.M., & Spanagel, R. (1999). Effects of opiate antagonist treatment on the alcohol deprivation effect in long-term ethanol-experienced rats. Psychopharmacology (Berl) 145(4), 360–369.

    Google Scholar 

  • Holter, S.M., Landgraf, R., Zieglgansberger, W., & Spanagel, R. (1997). Time course of acamprosate action on operant ethanol self-administration after ethanol deprivation. Alcoholism: Clinical and Experimental Research 21(5), 862–868.

    Google Scholar 

  • Hore, B.D. (1971). Factors in alcoholic relapse. British Journal of Addiction to Alcohol and Other Drugs 66(2), 89–96.

    PubMed  Google Scholar 

  • Hubbell, C.L., & Reid, L. (1990). Opioids modulate rats’ intakes of alcoholic beverages. In L. Reid (ed.), Opioids, Bulimia, and Alcohol Abuse and Alcoholism. New York: Springer-Verlag.

    Google Scholar 

  • Hubbell, C.L., Czirr, S.A., Hunter, G.A., Beaman, C.M., LeCann, N.C., & Reid, L.D. (1986). Consumption of ethanol solution is potentiated by morphine and attenuated by naloxone persistently across repeated daily administrations. Alcohol 3(1), 39–54.

    Article  PubMed  Google Scholar 

  • Hubbell, C.L., Marglin, S.H., Spitalnic, S.J., Abelson, M.L., Wild, K.D., & Reid, L.D. (1991). Opioidergic, serotonergic, and dopaminergic manipulations and rats’ intake of a sweetened alcoholic beverage. Alcohol 8(5), 355–367.

    Article  PubMed  Google Scholar 

  • Hurt, R.D., Sachs, D., Glover, E.D., Offord, K.P., Johnston, J.A., Dale, L.C., Khayrallah, M.A., Schroeder, D.R., Glover, P.N., Sullivan, C.R., Croghan, I.T., & Sullivan, P.M. (1997). A comparison of sustained-release bupropion and placebo for smoking cessation. The New England Journal of Medicine 337(17), 1195–1202.

    Article  PubMed  Google Scholar 

  • Hyytia, P., & Kiianmaa, K. (2001). Suppression of ethanol responding by centrally administered CTOP and naltrindole in AA and Wistar rats. Alcoholism: Clinical and Experimental Research 25(1), 25–33.

    Google Scholar 

  • Hyytia, P., & Sinclair, J.D. (1993). Responding for oral ethanol after naloxone treatment by alcoholpreferring AA rats. Alcoholism: Clinical and Experimental Research 17(3), 631–636.

    Google Scholar 

  • Hyytia, P., Ingman, K., Soini, S.L., Laitinen, J.T., & Korpi, E.R. (1999). Effects of continuous opioid receptor blockade on alcohol intake and up-regulation of opioid receptor subtype signalling in a genetic model of high alcohol drinking. Naunyn Schmiedebergs Archives of Pharmacology 360, 391–401.

    Google Scholar 

  • Iso, H., & Brush, F.R. (1991). Opposite effects of naltrexone on ETOH intake by Syracuse high and low avoidance rats. Alcohol 8(6), 443–448.

    Article  PubMed  Google Scholar 

  • Jaffe, A.J., Rounsaville, B., Chang, G., Schottenfeld, R.S., Meyer, R.E., & O’Malley, S.S. (1996). Naltrexone, relapse prevention, and supportive therapy with alcoholics: An analysis of patient treatment matching. Journal of Consulting and Clinical Psychology 64(5), 1044–1053.

    Article  PubMed  Google Scholar 

  • Jamensky, N.T., & Gianoulakis, C. (1997). Content of dynorphins and kappa-opioid receptors in distinctbrain regions of C57BL/6 and DBA/2 mice. Alcoholism: Clinical and Experimental Research 21(8), 1455–1464.

    Google Scholar 

  • Janal, M.N., Colt, E.W., Clark, W.C., & Glusman, M. (1984). Pain sensitivity, mood and plasma endocrine levels in man following long-distance running: Effects of naloxone. Pain 19(1), 13–25.

    Article  PubMed  Google Scholar 

  • Johnson, B.A., Ait-Daoud, N., & Prihoda, T.J. (2000). Combining ondansetron and naltrexone effectively treats biologically predisposed alcoholics: From hypotheses to preliminary clinical evidence. Alcoholism: Clinical and Experimental Research 24(5), 737–742.

    Google Scholar 

  • Johnson, B.A., O’Malley, S., Ciraulo, D.A., Roache, J.D., Chambers, R.A., Sarid-Segal, O., & Couper, D. (in press). Dose-ranging kinetics and safetyassessment of naltrexone and acamprosate both alone and combined in alcohol-dependent subjects. Journal of Clinical Psychopharmacology.

    Google Scholar 

  • Katner, S.N., & Weiss, B. (1999). Ethanol-associated olfactory stimuli reinstate ethanol-seeking behavior after extinction and modify extracellular dopamine levels in the nucleus accumbens. Alcoholism: Clinical and Experimental Research 23(11), 1751–1760.

    Google Scholar 

  • Katner, S.N., Kerr, T.M., & Weiss, F. (1996). Ethanolanticipation enhances dopamine efflux in the nucleus accumbens of alcohol-preferring (P) but not Wistar rats. Behavioral Pharmacology 7, 669–674.

    Google Scholar 

  • King, A.C., Volpicelli, J.R., Frazer, A., & O’Brien, C.P. (1997). Effect of naltrexone on subjective alcohol response in subjects at high and low risk for future alcohol dependence. Psychopharmacology (Berl) 129(1), 15–22.

    Google Scholar 

  • Koob, G.F. (1992). Neuralmechanisms of drug reinforcement. Annals of the New York Academy of Sciences 654, 171–191.

    PubMed  Google Scholar 

  • Koob, G.F., & Bloom, F.E. (1983). Behavioural effects of opioid peptides. British Medical Bulletin 39(1), 89–94.

    PubMed  Google Scholar 

  • Koob, G.F., Roberts, A.J., Schulteis, G., Parsons, L.H., Heyser, C.J., Hyytia, P., Merlo-Pich, E., & Weiss, F. (1998). Neurocircuitry targets in ethanol reward and dependence. Alcoholism: Clinical and Experimental Research 22(1), 3–9.

    Google Scholar 

  • Kornet, M., Goosen, C., & Van Ree, J.M. (1991). Effect of naltrexone on alcohol consumption during chronic alcohol drinking and after a period of imposed abstinence in free-choice drinking rhesus monkeys. Psychopharmacology 104(3), 367–376.

    Article  PubMed  Google Scholar 

  • Kornitzer, M., Boutsen, M., Dramaix, M., Thijus, J., & Gustavsson, G. (1995). Combined use of nicotine patch and gum in smoking cessation—a placebo-controlled clinical-trial. Preventive Medicine 24(1), 41–47.

    Article  PubMed  Google Scholar 

  • Kranzler, H., & Van Kirk, J. (2001). Efficacy of naltrexone and acamprosate for alcoholism treatment: A meta-analysis. Alcoholism: Clinical and Experimental Research 25(9), 1334–1341.

    Article  Google Scholar 

  • Kranzler, H.R., Tennen, H., Penta, C., & Bohn, M.J. (1997). Targeted naltrexone treatment of early problem drinkers. Addictive Behaviors 22(3), 431–436.

    Article  PubMed  Google Scholar 

  • Kranzler, H.R., Modesto-Lowe, V., & Nuwayser, E.S. (1998). Sustained-release naltrexone for alcoholism treatment: A preliminary study. Alcoholism: Clinical and Experimental Research 22(5), 1074–1079.

    Google Scholar 

  • Kranzler, H.R., Modesto-Lowe, V., Van Kirk, J., & J, D. (2000). Naltrexone vs. nefazodone for treatment of alcohol dependence. A placebo-controlled trial. Neuropsychopharmacology 22(5), 493–503.

    Article  PubMed  Google Scholar 

  • Krishnan-Sarin, S., Jing, S.L., Kurtz, D.L., Zweifel, M., Portoghese, P.S., Li, T.K., & Froehlich, J.C. (1995a). The delta opioid receptor antagonist naltrindole attenuates both alcohol and saccharin intake in rats selectively bred for alcohol preference. Psychopharmacology (Berl) 120(2), 177–185.

    Google Scholar 

  • Krishnan-Sarin, S., Portoghese, P.S., Li, T.K., & Froehlich, J.C. (1995b). The delta 2-opioid receptor antagonist naltriben selectively attenuates alcohol intake in rats bred for alcohol preference. Pharmacology, Biochemistry and Behavior 52(1), 153–159.

    Article  Google Scholar 

  • Krishnan-Sarin, S., Wand, G.S., Li, X.W., Portoghese, P.S., & Froehlich, J.C. (1998). Effect of mu opioid receptor blockade on alcohol intake in rats bred for high alcohol drinking. Pharmacology, Biochemistry and Behavior 59(3), 627–635.

    Article  Google Scholar 

  • Krystal, J.H., Cramer, J.A., Krol, W.F., Kirk, G.F., Rosenheck, R., & Veterans Affairs Naltrexone Cooperative Study 425 Group. (2001). Naltrexone in the treatment of alcohol dependence. New England Journal of Medicine 345, 1734–1739.

    Article  PubMed  Google Scholar 

  • Lawless, J.F., & Nadeau, J.C. (1995). Some simple robust methods for the analysis of recurrent events. Technometrics 37, 158–168.

    Google Scholar 

  • Le, A.D., Poulos, C.X., Quan, B., & Chow, S. (1993). The effects of selective blockade of delta and mu opiate receptors on ethanol consumption by C57BL/6 mice in a restricted access paradigm. Brain Research 630(1–2), 330–332.

    PubMed  Google Scholar 

  • Le, A.D., Poulos, C.X., Harding, S., Watchus, J., Juzytsch, W., & Shaham, Y. (1999). Effects of naltrexone and fluoxetine on alcohol self-administration and reinstatement of alcohol seeking induced by priming injections of alcohol and exposure to stress. Neuropsychopharmacology 21, 435–444.

    PubMed  Google Scholar 

  • Li, X.W., Li, T.K., & Froehlich, J.C. (1998). Enhanced sensitivity of the nucleus accumbens proenkephalin system to alcohol in rats selectively bred for alcohol preference. Brain Research 794(1), 35–47.

    PubMed  Google Scholar 

  • Litten, R.Z., & Fertig, J. (1996). Internationalupdate: New findings on promising medications. Alcoholism: Clinical and Experimental Research 20(8 Suppl), 216A–218A.

    Google Scholar 

  • Ludwig, A.M., Wikler, A., & Stark, L.H. (1974). The first drink: Psychobiological aspects of craving. Archives of General Psychiatry 30(4), 539–547.

    PubMed  Google Scholar 

  • Mason, B. (1999). Cognitive effects of naltrexone and acamprosate administered alone and in combination. Paper presented at the Scientific Meeting of the Research Society on Alcoholism, Santa Barbara, CA.

    Google Scholar 

  • McCaul, M.E., Wand, G.S., Eissenberg, T., Rohde, C.A., & Cheskin, L.J. (2000). Naltrexone alters subjective and psychomotor responses to alcohol in heavy drinking subjects. Neuropsychopharmacology 22(5), 480–492.

    Article  PubMed  Google Scholar 

  • McCullough, D.E., Mosemiller, A.K., Zhou, F.C., Portoghese, P.S., & Froehlich, J.C. (1998). Infusion of a delta opioid antagonist into the ventral tegmental area attenuates alcohol drinking in P rats. Alcoholism: Clinical and Experimental Research 22, 47A.

    Google Scholar 

  • McCullough, D., Mosemiller, A.K., Portoghese, P.S., & Froehlich, J.C. (1999). Infusion of a delta opioid receptor antagonist into the VTA produces early termination of alcohol drinking in P rats given scheduled access to alcohol. Alcoholism: Clinical and Experimental Research 23, 16A.

    Google Scholar 

  • McCullough, D., Portoghese, P.S., & Froehlich, J.C. (2000). Infusion of a delta opioid receptor antagonist into the nucleus accumbens reduces alcohol intake in alcohol preferring (P) rats. Alcoholism: Clinical and Experimental Research 24, 83A.

    Google Scholar 

  • McKinzie, D.L., Nowak, K.L., Yorger, L., McBride, W.J., Murphy, J.M., Lumeng, L., & Li, T.K. (1998). The alcohol deprivation effect in the alcohol-preferring P rat under free-drinking and operant access conditions. Alcoholism: Clinical and Experimental Research, 22(5) 1170–1176.

    Google Scholar 

  • Meyer, R.E. (2000). Craving: What can be done to bring the insights of neuroscience, behavioral science and clinical science into synchrony. Addiction 95 Suppl 2, S219–227.

    Google Scholar 

  • Monterosso, J.R., Flannery, B.A., Pettinati, H.M., Oslin, D.W., Rukstalis, M., O’Brien, C.P., & Volpicelli, J.R. (2001). Predicting treatment response to naltrexone: The influence of craving and family history. American Journal on Addictions 10, 258–268.

    PubMed  Google Scholar 

  • Monti, P.M., Rohsenow, D.J., Rubonis, A.V., Niaura, R.S., Sirota, A.D., Colby, S.M., & Abrams, D.B. (1993). Alcohol cue reactivity: Effects of detoxification and extended exposure. Journal of Studies on Alcohol 54(2), 235–245.

    PubMed  Google Scholar 

  • Monti, P.M., Rohsenow, D.J., Hutchison, K.E., Swift, R.M., Mueller, T.I., Colby, S.M., Brown, R.A., Gulliver, S.B., Gordon, A., & Abrams, D.B. (1999). Naltrexone’s effect on cue-elicited craving among alcoholics in treatment. Alcoholism: Clinical and Experimental Research 23(8), 1386–1394.

    Google Scholar 

  • Monti, P.M., Rohsenow, D.J., Swift, R., Gulliver, S.B., Colby, S.M., Mueller, T.I., Brown, R.A., Gordon, A., Abrams, D.B., Niaura, R.S., & Asher, M.K. (2001). Naltrexone and cue exposure with coping and communication skills training for alcoholics: Treatment process and 1-year outcomes. Alcoholism: Clinical and Experimental Research 25, 1634–1647.

    Google Scholar 

  • Morris, B.J., Millan, M.J., & Herz, A. (1988). Antagonist-induced opioid receptor upregulation. II. Regionally specific modulation of mu, delta and kappa binding sites in rat brain revealed by quantitative autoradiography. Journal of Pharmacology and Experimental Therapeutics 247(2), 729–736.

    PubMed  Google Scholar 

  • Morris, P.L.P., Hopwood, M., Whelan, G., Gardiner, J., & Drummond, E. (2001). Naltrexone for alcohol dependence: A randomized controlled trial. Addiction 96

    Google Scholar 

  • Moudy, A.M., Spain, J.W., & Coscia, C.J. (1985). Differential up-regulation of microsomal and synaptic membrane mu opioid receptors. Biochemical and Biophysical Research Communications 132(2), 735–741.

    Article  PubMed  Google Scholar 

  • Myers, R.D., & Lankford, M.F. (1996). Suppression of alcohol preference in high alcohol drinking rats: efficacy of amperozide versus naltrexone. Neuropsychopharmacology 14(2), 139–149.

    Article  PubMed  Google Scholar 

  • O’Malley, S.S. Naltrexone therapy: Predictors of adverse events, medication compliance and clinical treatment outcome. Symposium: Naltrexone treatment of alcoholism: Recent evidence from clinial research. Paper presented at the Research Society on Alcoholism Scientific Meeting, Santa Barbara, CA, July 1, 1999.

    Google Scholar 

  • O’Malley, S.S., Jaffe, A.J., Chang, G., Schottenfeld, R.S., Meyer, R.E., & Rounsaville, B. (1992). Naltrexone and coping skills therapy for alcohol dependence. A controlled study. Archives of General Psychiatry 49(11), 881–887.

    Google Scholar 

  • O’Malley, S.S., Jaffe, A.J., Rode, S., & Rounsaville, B.J. (1996). Experience of a “slip” among alcoholics treated with naltrexone or placebo. American Journal of Psychiatry 153(2), 281–283.

    Google Scholar 

  • O’Malley, S.S., Mattson, M.E., & The COMBINE Research Group. Design and rationale for COMBINE, a multi-study on combining medications and behavior interventions for alcohol dependence. Paper presented at the Research Society on Alcoholism Scientific Meeting, Denver, CO, June 25,2000.

    Google Scholar 

  • O’Malley, S.S., Krishnan-Sarin, S., Farren, C., Sinha, R., & Kreek, M.J. (2002). Naltrexone decreases craving and alcohol self-administration in alcohol dependent subjects and activates the hypothalamic-pituitary-adrenocorticol axis. Psychopharmacology 160, 19–29.

    Google Scholar 

  • Overstreet, D.H., Kampov-Polevoy, A.B., Rezvani, A.H., Braun, C., Bartus, R.T., & Crews, F.T. (1999). Suppression of alcohol intake by chronic naloxone treatment in P rats: Tolerance development and elevation of opiate receptor binding. Alcoholism: Clinical and Experimental Research 23(11), 1761–1771.

    Google Scholar 

  • Parkes, H., & Sinclair, J.D. (2000). Reduction of alcohol drinking and upregulation of opioid receptors by oral naltrexone in AA rats. Alcohol 21(3), 215–221.

    Article  PubMed  Google Scholar 

  • Phillips, T.J., Wenger, C.D., & Dorow, J.D. (1997). Naltrexone effects on ethanol drinking acquisition and on established ethanol consumption in C57BL/6J mice. Alcoholism: Clinical and Experimental Research 21(4), 691–702.

    Google Scholar 

  • Reid, L.D.(1996a). Endogenous opioids and alcohol dependence: Opioid alkaloids and the propensity to drink alcoholic beverages. Alcohol 13(1), 5–11.

    Google Scholar 

  • Reid, L.D., Gardell, L.R., Chattopadhyay, S., & Hubbell, C.L. (1996b). Periodic naltrexone and propensity to take alcoholic beverage. Alcoholism: Clinical and Experimental Research 20(8), 1329–1334.

    Google Scholar 

  • Rezvani, A.H., Overstreet, D.H., Mason, G.A., Janowsky, D.S., Hamedi, M., Clark, E., Jr., & Yang, Y. (2000). Combination pharmacotherapy: A mixture of small doses of naltrexone, fluoxetine, and a thyrotropin-releasing hormone analogue reduces alcohol intake in three strains of alcohol-preferring rats. Alcohol and Alcoholism 35(1), 76–83.

    Article  PubMed  Google Scholar 

  • Rodd-Henricks, Z.A., McKinzie, D.L., Murphy, J.M., McBride, W.J., Lumeng, L., & Li, T.K. (2000). The expression of an alcohol deprivation effect in the high-alcohol-drinking replicate rat lines is dependent on repeated deprivations. Alcoholism: Clinical and Experimental Research 24(6), 747–753.

    Google Scholar 

  • Rohsenow, D.J., & Monti, J. (1999). Does urge to drink predict relapse after treatment? Alcohol Research and Health 23, 225–232

    PubMed  Google Scholar 

  • Rothman, R.B., Bykov, V., Long, J.B., Brady, L.S., Jacobson, A.E., Rice, K.C., & Holaday, J.W. (1989). Chronic administration of morphine and naltrexone up-regulate mu-opioid binding sites labeled by [3H][D-Ala2,MePhe4,Gly-ol5]enkephalin: Further evidence for two mu-binding sites. European Journal of Pharmacology 160(1), 71–82.

    Article  PubMed  Google Scholar 

  • Rothman, R.B., Long, J.B., Bykov, V., Jacobson, A.E., Rice, K.C., & Holaday, J.W. (1990). Pretreatment of rats withthe irreversible mu-receptor antagonist, beta-FNA, fails to prevent naltrexone-induced upregulation of mu-opioid receptors. Neuropharmacology 29(9), 805–810.

    Article  PubMed  Google Scholar 

  • Rubio, G., Jimenez-Arriero, M.A., Ponce, G., & Palomo, T. (2001). Naltrexone versus acamprosate: One year follow-up of alcohol dependence treatment. Alcohol and Alcoholism 36(5), 419–425.

    Article  PubMed  Google Scholar 

  • Rukstalis, M.R., Stromberg, M.F., O’Brien, C.P., & Volpicelli, J.R. (2000). 6-beta-Naltrexol reduces alcohol consumption in rats. Alcoholism: Clinical and Experimental Research 24(10), 1593–1596.

    Google Scholar 

  • Salloum, I.M., Cornelius, J.R., Thase, M.E., Daley, D.C., Kirisci, L., & Spotts, C. (1998). Naltrexone utility in depressed alcoholics. Psychopharmacol Bulletin 34(1), 111–115.

    Google Scholar 

  • Schwarz-Stevens, K.S., Files, F.J., & Samson, H.H. (1992). Effects of morphine and naloxone on ethanol-and sucrose-reinforced responding in nondeprived rats. Alcoholism: Clinical and Experimental Research 16(4), 822–832.

    Google Scholar 

  • Seizinger, B.R., Bovermann, K., Maysinger, D., Hollt, V., & Herz, A. (1983). Differential effects of acute and chronic ethanol treatment on particular opioid peptide systems in discrete regions of rat brain and pituitary. Pharmacology, Biochemistry and Behavior 18 Suppl 1, 361–369.

    Google Scholar 

  • Sharpe, A.L., & Samson, H.H. (2001). Effect of naloxone on appetitive and consummatory phases of ethanol self-administration. Alcoholism: Clinical and Experimental Research 25(7), 1006–1011.

    Google Scholar 

  • Shelton, K.L., & Grant, K.A. (2001). Effects of naltrexone and Ro 15-4513 on a multiple schedule of ethanol and Tang self-administration. Alcoholism: Clinical and Experimental Research 25, 1576–1585.

    Google Scholar 

  • Sinclair, J.D. (1990). Drugs to decrease alcohol drinking. Annals of Medicine 22(5), 357–362.

    PubMed  Google Scholar 

  • Sinclair, J.D., & Senter, R.J. (1967). Increased preference for ethanol in rats following alcohol deprivation. Psychonomic Science 8, 11–12.

    Google Scholar 

  • Sinclair, J.D., Walker, S., & Jordan, W. (1973). Behavioral and physiological changes associated with various durations of alcohol deprivation in rats. Quarterly Journal of Studieson Alcohol 34(3), 744–757.

    Google Scholar 

  • Siviy, S.M., Calcagnetti, D.J., & Reid, L.D. (1982). A temporal analysis of naloxone’s suppressant effect on drinking. Pharmacology, Biochemistry and Behavior 16(1), 173–175.

    Article  Google Scholar 

  • Spanagel, R., & Holter, S.M. (2000). Pharmacological validation of a new animal model of alcoholism. Journal of Neural Transmission (Budapest) 107(6), 669–680.

    Google Scholar 

  • Spanagel, R., Holter, S.M., Allingham, K., Landgraf, R., & Zieglgansberger, W. (1996). Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat. Eur J Pharmacol, 305(1-3), 39–44.

    PubMed  Google Scholar 

  • Staiger, P.K., & White, J.M. (1991). Cue reactivity in alcohol abusers: Stimulus specificity and extinction of the responses. Addictive Behaviors 16(5), 211–221.

    Article  PubMed  Google Scholar 

  • Stewart, J., & de Wit, H. (1987). Reinstatement of drug-taking behavior as a method of assessing incentive motivational properties of drugs. In M.A. Bozarth (ed.), Methods of Assessing the Reinforcing Properties of Abused Drugs. New York: Springer-Verlag, pp. 211–227.

    Google Scholar 

  • Streeton, C., & Whelan, G. (2001). Naltrexone, a relapse prevention maintenance treatment of alcohol dependence: A meta-analysis of randomized clinical trials. Alcohol and Alcoholism 36(6), 544–552.

    Article  PubMed  Google Scholar 

  • Stromberg, M.F., Casale, M., Volpicelli, L., Volpicelli, J.R., & O’Brien, C.P. (1998a). A comparison of the effects of the opioid antagonists naltrexone, naltrindole, and beta-funaltrexamine on ethanol consumption in the rat. Alcohol 15(4), 281–289.

    Article  PubMed  Google Scholar 

  • Stromberg, M.F., Volpicelli, J.R., & O’Brien, C.P. (1998b). Effects of naltrexone administered repeatedly across 30 or 60 days on ethanol consumption using a limited access procedure in the rat. Alcoholism: Clinical and Experimental Research 22(9), 2186–2191.

    Google Scholar 

  • Stromberg, M.F., Mackler, S.A., Volpicelli, J.R., & O’Brien, C.P. (2001). Effect of acamprosate and naltrexone, alone or in combination, on ethanol consumption. Alcohol 23(2), 109–116.

    Article  PubMed  Google Scholar 

  • Swift, R.M., Whelihan, W., Kuznetsov, O., Buongiorno, G., & Hsuing, H. (1994). Naltrexone-induced alterations in human ethanol intoxication. American Journal of Psychiatry 151(10), 1463–1467.

    PubMed  Google Scholar 

  • Tempel, A., Gardner, E.L., & Zukin, R.S. (1985). Neurochemical and functional correlates of naltrexone-induced opiate receptor up-regulation. Journal of Pharmacology and Experimental Therapeutics 232(2), 439–444.

    PubMed  Google Scholar 

  • Verge, C.F., & Eisenbarth, G.S. (1996). Strategies for preventing type I diabetes mellitus. [see comments]. Western Journal of Medicine 164(3), 249–255.

    PubMed  Google Scholar 

  • Volpicelli, J.R., Davis, M.A., & Olgin, J.E. (1986). Naltrexone blocks the post-shock increase of ethanol consumption. Life Sciences 38(9), 841–847.

    Article  PubMed  Google Scholar 

  • Volpicelli, J.R., O’Brien, C.P., Alterman, A.I., & Hayashida, M. (1990). Naltrexone and the treatment of alcohol dependence: Initial observations. In L. Reid (ed.), Opioids, Bulimia, and Alcohol Abuse and Alcoholism. New York: Springer-Verlag, pp. 195–214.

    Google Scholar 

  • Volpicelli, J.R., Alterman, A.I., Hayashida, M., & O’Brien, C.P. (1992). Naltrexone in the treatment of alcohol dependence. Archives of General Psychiatry 49(11), 876–880.

    PubMed  Google Scholar 

  • Volpicelli, J.R., Watson, N.T., King, A.C., Sherman, C.E., & O’Brien, C.P. (1995). Effect of naltrexone on alcohol “high” in alcoholics. American Journal of Psychiatry 152(4), 613–615.

    PubMed  Google Scholar 

  • Volpicelli, J.R., Rhines, K.C., Rhines, J.S., Volpicelli, L.A., Alterman, A.I., & O’Brien, C.P. (1997). Naltrexone and alcohol dependence: Role of subject compliance. Archives of General Psychiatry 54, 737–742.

    PubMed  Google Scholar 

  • Wang, S.J. (2000). Statistical Consideration—exploration of multivariate failure time analysis method, an approach for alcohol treatment clinical trials. Paper presented at the Second Seattle Symposium in Biostatistics: Analysis of Correlated Data, Seattle, Washington.

    Google Scholar 

  • Weiss, F., Mitchiner, M., Bloom, F.E., & Koob, G.F. (1990). Free-choice responding for ethanol versus water in alcohol preferring (P) and unselected Wistar rats is differentially modified by naloxone, bromocriptine, and methysergide. Psychopharmacology 101(2), 178–186.

    Article  PubMed  Google Scholar 

  • Weiss, F., Hurd, Y.L., Ungerstedt, U., Markou, A., Plotsky, P.M., & Koob, G.F. (1992). Neurochemical correlates of cocaine and ethanol self-administration. Annals of the New York Academy of Sciences 654, 220–241.

    PubMed  Google Scholar 

  • Weiss, F., Lorang, M.T., Bloom, F.E., & Koob, G.F. (1993). Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: Genetic and motivational determinants. Journal of Pharmacology and Experimental Therapeutics 267(1), 250–258.

    PubMed  Google Scholar 

  • Widdowson, P.S., & Holman, R.B. (1992). Ethanol-induced increase in endogenous dopamine release may involve endogenous opiates. Journal of Neurochemistry 59(1), 157–163.

    PubMed  Google Scholar 

  • Wise, R.A. (1996). Neurobiology of addiction. Current Opinion in Neurobiology 6(2), 243–251.

    Article  PubMed  Google Scholar 

  • Wolffgramm, J., & Heyne, A. (1995). From controlled drug intake to loss of control: The irreversible development of drug addiction in the rat. Behavioural Brain Research 70(1), 77–94.

    Article  PubMed  Google Scholar 

  • Wolffgramm, J., Galli, G., Thimm, F., & Heyne, A. (2000). Animal models of addiction: Models for therapeutic strategies? Journal of Neural Transmission (Budapest) 107(6), 649–668.

    Google Scholar 

  • Zink, R.W., Rohrbach, K., & Froehlich, J.C. (1999). Preclinical medications development: Combining an opioid antagonist with a serotonin reuptake inhibitor produces enhanced suppression of alcohol drinking in alcohol preferring (P) rats. Alcoholism: Clinical and Experimental Research 23, 19A.

    Google Scholar 

  • Zukin, R.S., Sugarman, J.R., Fitz-Syage, M.L., Gardner, E.L., Zukin, S.R., & Gintzler, A.R. (1982). Naltrexone-induced opiate receptor supersensitivity. Brain Research 245(2), 285–292.

    PubMed  Google Scholar 

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  1. Yale University School of Medicine, New Haven, Connecticut, 06519

    Stephanie S. O’Malley

  2. Indiana University School of Medicine, Indianapolis, Indiana

    Janice C. Froehlich

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  1. New York University School of Medicine, New York, New York

    Marc Galanter

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O’Malley, S.S., Froehlich, J.C. (2002). Advances in the Use of Naltrexone an Integration of Preclinical and Clinical Findings. In: Galanter, M., et al. Recent Developments in Alcoholism. Recent Developments in Alcoholism, vol 16. Springer, Boston, MA. https://doi.org/10.1007/0-306-47939-7_17

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