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NMR Methods for Screening the Binding of Ligands to Proteins — Identification and Characterization of Bioactive Ligands

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Protein NMR for the Millennium

Part of the book series: Biological Magnetic Resonance ((BIMR,volume 20))

Abstract

It has been shown during recent years that NMR provides power ful tools for the screening and identification of bioactive ligand molecules. Depending on the experimental parameters employed, these novel techniques detect and characterize the binding of ligands to proteins via the observation of either protein resonances, or the ligand signals. Obviously, an intelligent combination of different experiments greatly enhances the options for screening compound libraries. This chapter summarizes the recent developments in the field.

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Authors and Affiliations

  1. Institute of Chemistry, Medical University of Luebeck, Luebeck, Germany

    Thomas Peters, Thorsten Biet & Lars Herfurth

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  1. Thomas Peters
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  2. Thorsten Biet
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Editors and Affiliations

  1. University of Alabama at Birmingham, Birmingham, Alabama

    N. Rama Krishna

  2. University of Denver, Denver, Colorado

    Lawrence J. Berliner

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© 2002 Kluwer Academic Publishers

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Peters, T., Biet, T., Herfurth, L. (2002). NMR Methods for Screening the Binding of Ligands to Proteins — Identification and Characterization of Bioactive Ligands. In: Krishna, N.R., Berliner, L.J. (eds) Protein NMR for the Millennium. Biological Magnetic Resonance, vol 20. Springer, Boston, MA. https://doi.org/10.1007/0-306-47936-2_10

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  • DOI: https://doi.org/10.1007/0-306-47936-2_10

  • Publisher Name: Springer, Boston, MA

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