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S-Nitrosylated Polyethylene Glycol-conjugated Hemoglobin Derivative as a Candidate Material for Oxygen Therapeutics

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Polymer Drugs in the Clinical Stage

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 519))

Conclusion

We have developed a new Hb derivative that can deliver and release oxygen and NO-group molecules in the periphery. This product might be a valuable oxygen carrier as a tool for oxygen therapeutics.

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References

  1. Nakai K, Sakuma I, Satoh H, Kitabatake A. Vascular activities of hemoglobin-based oxygen carriers: relationship between vasoconstrictive activity and endothelial permeability. In: Kitabatake A, Sakuma I. (eds). Recent Advances in Nitric Oxide Research. Tokyo: Springer-Verlag Tokyo; 1998. p. 33–45.

    Google Scholar 

  2. Jia L, Bonaventura C, Bonaventura J, Stamler J. S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control. Nature 1996; 380:221–226.

    Article  PubMed  CAS  Google Scholar 

  3. Stamler JS, Jia L, Eu JP, McMahon TJ, Demchenko IT, Bonaventura J, et al. Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. Science 1997; 276:2034–3037.

    Article  PubMed  CAS  Google Scholar 

  4. Pawloski JR, Swaminathan RV, Stamler JS. Cell-free and erythrocytic S-nitrosohemoglobin inhibits human platelet aggregation. Circulation 1998; 97:263–267.

    PubMed  CAS  Google Scholar 

  5. Nakai K, Hiroko T, Yasukohchi T, Sakuma I, Fujii S, Yoshioka M, et al. Preparation and characterization of SNO-PEG-hemoglobin as a candidate for oxygen transporting material. Int J Artif Organs 2001; 24:322–328.

    PubMed  CAS  Google Scholar 

  6. Akaike T, Inoue K, Okamoto T, Nishino H, Otagiri M, Fujii S, et al. Nanomolar quantification and identification of various nitrosothiols by high performance liquid chromatography coupled with flow reactors of metals and Griess reagent. J Biochem 1997; 122:459–466.

    PubMed  CAS  Google Scholar 

  7. Keipert PE, Gonzales A, Gomez CL, MacDonald VW, Hess JR, Winslow RM. Acute changes in systemic blood pressure and urine output of conscious rats following exchange transfusion with diaspirin-crosslinked hemoglobin solution. Transfusion 1993; 33:701–708.

    Article  PubMed  CAS  Google Scholar 

  8. Rioux F, Petitclerc E, Audet R, Drapeau G, Fielding RM, Marceau F. Recombinant human hemoglobin inhibits both constitutive and cytokine-induced nitric oxide-mediated relaxation of rabbit isolated aortic rings. J Cardiovasc Pharmacol 1994; 24:229–237.

    Article  PubMed  CAS  Google Scholar 

  9. Nakai K, Ohta T, Sakuma I, Akama K, Kobayashi Y, Tokuyama S, et al. Inhibition of endothelium-dependent relaxation by hemoglobin in rabbit aortic strips: Comparison between acellular hemoglobin derivatives and cellular hemoglobins. J Cardiovasc Pharmacol 1996; 28:115–123.

    PubMed  CAS  Google Scholar 

  10. Hoshi Y, Hazeki O, Kakihana Y, Tamura M. Redox behavior of cytochrome oxidase in the rat brain measured by near-infrared spectroscopy. J Appl Physiol 1997; 83:1842–8.

    PubMed  CAS  Google Scholar 

  11. Matsushita M, Yabuki A, Chen J, Takahashi T, Harasaki H, Malchesky PS, et al. Renal effects of a pyridoxalated-hemoglobin-polyoxyethylene conjugate solution as a blood substitute in exchange transfusions. Trans. Am. Soc. Artif. Intern. Organs 1988; 34:280–283.

    CAS  Google Scholar 

  12. Xu L, Eu JP, Meissner G, Stamler JS. Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation. Science 1998; 279:234–237.

    PubMed  CAS  Google Scholar 

  13. Ikebe N, Akaike T, Miyamoto Y, Hayashida K, Yoshitake J, Ogawa M, et al. Protective effect of S-nitrosylated al-protease inhibitor on hepatic ischemia-reperfusion injury. J Pharamacol Exp Ther 2000; 295:904–911.

    CAS  Google Scholar 

  14. Marshall HE, Stamler JS. Inhibition of NF-kB by S-nitrosylation. Biochemistry 2001; 40:1688–1693.

    PubMed  CAS  Google Scholar 

  15. Li X, Rose G, Dongre N, Pan H-L, Tobin JR, Eisenach JC. S-nitroso-l-cysteine releases norepinephrine in rat spinal synaplosomes. Brain Res 2000; 872:301–307.

    Article  PubMed  CAS  Google Scholar 

  16. Ramachandran N, Root P, Jiang XM, Hogg PJ, Mutus B. Mechanism of transfer of NO from extracellular S-nitrosothiols into the cytosol by cell-surface protein disulfide isomerase. Proc Natl Acad Sci USA 2001; 97:9539–9544.

    Google Scholar 

  17. Liu L, Hausladen A, Zeng M, Que L, Heitman J, Stamler JS. A metabolic enzyme for S- nitrosothiol conserved from bacteria to humans. Nature 2001; 410:490–494.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Environmental Health Sciences, Tohoku University Graduate School of Medicine, Aoba, Sendai

    Kunihiko Nakai & Hiroshi Satoh

  2. Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita-15 Nishi-7, Sapporo, Japan

    Ichiro Sakuma, Takeshi Sugawara & Akira Kitabatake

  3. Department of Pharmacology, Hokkaido University Graduate School of Medicine, Kita-15 Nishi-7, Sapporo, Japan

    Hiroko Togashi & Mitsuhiro Yoshioka

Authors
  1. Kunihiko Nakai
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  2. Ichiro Sakuma
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  3. Hiroko Togashi
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  4. Mitsuhiro Yoshioka
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  5. Takeshi Sugawara
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  6. Hiroshi Satoh
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  7. Akira Kitabatake
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Editor information

Editors and Affiliations

  1. Kumamoto University School of Medicine, Kumamoto, Japan

    Hiroshi Maeda

  2. University of Nebraska Medical Center, Omaha, Nebraska

    Alexander Kabanov

  3. University of Tokyo, Tokyo, Japan

    Kazunori Kataoka

  4. Tokyo Women’s Medical College, Tokyo, Japan

    Teruo Okano

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© 2004 Kluwer Academic Publishers

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Nakai, K. et al. (2004). S-Nitrosylated Polyethylene Glycol-conjugated Hemoglobin Derivative as a Candidate Material for Oxygen Therapeutics. In: Maeda, H., Kabanov, A., Kataoka, K., Okano, T. (eds) Polymer Drugs in the Clinical Stage. Advances in Experimental Medicine and Biology, vol 519. Springer, Boston, MA. https://doi.org/10.1007/0-306-47932-X_13

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  • DOI: https://doi.org/10.1007/0-306-47932-X_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-47471-2

  • Online ISBN: 978-0-306-47932-8

  • eBook Packages: Springer Book Archive

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