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Effect of Infection on Lipoproteins and the Coagulation System

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Part of the book series: Emerging Infectious Diseases of the 21st Century ((EIDC,volume 1))

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References

  1. Stamler, M., Wentworth, D., & Neaton, J. D. for the MRFIT Research Group (1986) Is the relationship between serum cholesterol and the risk of premature death from coronary heart disease continuous or graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT), JAMA, 256, 2823–2828.

    Article  PubMed  CAS  Google Scholar 

  2. Kwiterovitch, P. O. (1998) State of the art update and review: clinical trials of lipid-lowering agents, Am. J. Cardiol., 82, 3u–17u.

    Google Scholar 

  3. Long Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group (1998) Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels, N. Engl. J. Med., 339, 1349–1357.

    Google Scholar 

  4. Bradley, W. A., & Gianturco, S. H. (1994) Triglyceride-rich lipoprotein and atherosclerosis: pathophysiological considerations, J. Intern. Med. Suppl, 736, 33–39.

    PubMed  CAS  Google Scholar 

  5. Rader, D. J., & Rosas, S. (2000) Management of selected lipid abnormalities: hypertriglyceridemia, low HDL cholesterol, lipoprotein (a), in thyroid and renal diseases, and post-transplantation, Med. Clin. North Am., 84,43–61.

    Article  PubMed  CAS  Google Scholar 

  6. Goldbourt, U, Yeari, S., & Medalie, J. H. (1997) Isolated low HDL cholesterol as a risk factor for coronary heart disease mortality: a 21 year follow-up of 8000 men, Arterioscler. Thromb. Vasc. Biol., 17, 107–113

    PubMed  CAS  Google Scholar 

  7. Goldbourt, U., Behar, S., Reicher-Reiss, H., Agmon, J., Kaplinsky, E., Graff, E., Kishon, Y., Caspi, A., Weisbort, J., & Mandezulig, L. (1993) Rationale and design of a secondary prevention trial of increasing serum high-density lipoprotein cholesterol and reducing triglycerides in patients with clinically manifest atherosclerotic heart disease (The Bezafibrate Infarction Prevention Trial), Am. J. Cardiol., 71, 909–915.

    Article  PubMed  CAS  Google Scholar 

  8. Rubins, H. B., Robins, S. J., Iwane, M. K., Boden, W. E., Elam, M. B., Fye, L. L., Gorden, D. J., Schaefer, E. J., Schectman, G., & Wittes, J. T. (1993) Rationale and design of the Department of Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial (HIT) for secondary prevention of coronary artery disease in men with low high-density lipoprotein cholesterol and desirable lowdensity lipoprotein cholesterol, Am. J. Cardiol., 71, 45–52.

    Article  PubMed  CAS  Google Scholar 

  9. Gabay, C., & Kushner, I. (1999) Acute-phase proteins and other systemic response to inflammation, N. Engl. J. Med., 340, 448–454.

    Article  PubMed  CAS  Google Scholar 

  10. Mak, T. W., & Ferrick, D. A. (1998) The γδl-cell bridge: linking innate and acquired immunity. Nat. Med., 4, 764–765.

    Article  PubMed  CAS  Google Scholar 

  11. Tilg, H., Dinarello, G. A., & Mier, J. W. (1997) IL-6 and APPS: anti-inflammatory and immunosuppressive mediators, Immunol. Today, 18, 428–432.

    Article  PubMed  CAS  Google Scholar 

  12. Khovidhunkit, W., Memon, R. A., Feingold, K. R., & Grunfeld, C. (2000) Infection and inflammation-induced proatherogenic changes of lipoproteins, J. Infect. Dis., 181(Suppl. 3), S462–472.

    Google Scholar 

  13. Gallin, J. I., Kaye, D., & O’Leary, W. M. (1969) Serum lipids in infection, N. Engl. J. Med., 281, 1081–1086.

    Article  PubMed  CAS  Google Scholar 

  14. Grunfield, C., Pang, M., Doerrler, W., Shingenaga, J. K., Jensen, P., & Feingold, K. R. (1992) Lipids, lipoproteins, triglyceride clearance and cytokines in human immunodeficiency virus infection and the acquired immunodeficiency syndrome, J. Clin. Endocrinol. Metab., 74, 1045–1052.

    Google Scholar 

  15. Memon, R. A., Grunfeld, C., Moser, A. H., & Feingold, K. R. (1993) Tumor necrosis factormediates the effects of endotoxin in cholesterol and triglyceride metabolism in mice, Endocrinology, 132, 2246–2253.

    Article  PubMed  CAS  Google Scholar 

  16. Memon, R. A., Feingold, K. R., Moser, A. H., Doerrler, W., Adi, S., Dinarello, C. A., & Grunfeld, C. (1992) Differential effects of interleukin-I and tumour necrosis factor on ketogenesis, Am. J. Physiol., 262, E301–E309.

    Google Scholar 

  17. Feingold, K. R., Staprans, I., Memon, R. A., Moser, A. H., Shigenaga, J. K., Doerrler, W., & Dinarello, C. A. (1992) Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance, Lipid Res., 33, 1765–1776.

    CAS  Google Scholar 

  18. Nonogaki, K., Moser, A. H., Pan, X. M., Staprans, I., Grunfeld, C., & Feingold, K. R. (1995) Lipoteichoic acid stimulates lipolysis and hepatic triglyceride secretion in rats in vivo, J. Lipid Res., 36, 1987–1995.

    PubMed  CAS  Google Scholar 

  19. Hardardóttir, I., Sipe, J., Moser, A. H., Fielding, C. J., Feingold, K. R., & Grünfeld, C. (1997) LPS and cytokines regulate extra hepatic mRNA levels of apolipoproteins during the acute phase response in Syrian hamsters, Biochem. Biophys. Acta, 1344, 210–222.

    PubMed  Google Scholar 

  20. Feingold, K. R., Soued, M., Serio, M. K., Moser, A. H., Dinarello, C. A., & Grünfeld, C. (1989) Multiple cytokines stimulate hepatic lipid synthesis in vivo, Endocrinology, 125, 267–274.

    Article  PubMed  CAS  Google Scholar 

  21. Redgrave, T. G., Rakic, V., Mortimer, B. C., & Mamo, J. C. (1992) Effects of sphingomyelin and phosphatidylcholine acyl chains on the clearance of triacylglycerol-rich lipoproteins from plasma. Studies with lipid emulsions in rats, Biochem. Biophys. Acta, 1126, 65–72.

    PubMed  CAS  Google Scholar 

  22. Memon, R. A., Staprans, I., Noor, M., Holleran, W. M., Uchida, Y., Moser, A. H., Feingold, K. R., & Grunfeld, C. (2000) Infection and inflammation induce LDL oxidation in vivo, Arterioscler. Thromb. Vasc. Biol., 20, 1536–1542.

    PubMed  CAS  Google Scholar 

  23. Chait, A., Bragg, R. L., Tribble, D. L., & Krauss, R. M. (1993) Susceptibility of small, dense, low-density lipoproteins to oxidative modification in subjects with the atherogenic lipoprotein phenotype, pattern B, Am. J. Med., 94, 350–356.

    Article  PubMed  CAS  Google Scholar 

  24. Hurt-Cumejo, E., Camejo, G., Rosengren, B., Lopez, F., Wiklund, O., & Bondjers, G. (1990) Differential uptake of proteoglycan-selected subtractions of low density lipoprotein by human macrophages, J. Lipid Res., 31, 1387–1398.

    Google Scholar 

  25. Nigon, F., Lesnik, P., Rouis, M., & Chapman, M. J. (1991) Discrete subspecies of human low density lipoproteins are heterogenous in their interaction with the cellular LDL receptor, J. Lipid Res., 32,1741–1753.

    PubMed  CAS  Google Scholar 

  26. Feingold, K. R., Krauss, R. M., Pang, M., Doerrler, W., Jensen, P., & Grunfeld, C. (1993) The hypertriglyceridemia of acquired immunodeficiency syndrome is associated with an increased prevalence of low density lipoprotein subclass pattern B, J. Clin. Endocrinol. Metab., 76, 1423–1427.

    Article  PubMed  CAS  Google Scholar 

  27. Feingold, K. R., Hardardottir, L, Memon, R., Krul, E. J., Moser, A. H., Taylor, J. M., & Grunfeld, C. (1993) Effect of endotoxin on cholesterol biosynthesis and distribution in serum lipoproteins in Syrian hamsters, J. Lipid Res., 34, 2147–2158.

    PubMed  CAS  Google Scholar 

  28. Memon, R. A., Holleran, W. M, Moser, A. H., Seki, T., Uchida, Y., Fuller, J., Shingenaga, J. K., Grunfeld, C., & Feingold, K. R. (1998) Endotoxin and cytokines increase hepaticsphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin, Arterioscler. Thromb. Vasc. Biol., 18, 1257–1265.

    PubMed  CAS  Google Scholar 

  29. Schissel, S. L., Tweedie-Hardman, J., Rapp, J. H., Graham, G., Williams, K. J., & Tabas, I. (1996) Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins, J. Clin. Invest., 98, 1455–1464.

    PubMed  CAS  Google Scholar 

  30. Xu, X. X., & Tabas, I. (1991) Sphingomyelinase enhances low density lipoprotein uptake and ability to induce cholesteryl ester accumulation in macrophages, J. Biol. Chem., 266, 24849–24858.

    PubMed  CAS  Google Scholar 

  31. Memon, R. A., Holleran, W. M., Uchida, Y., Moser, A. H., Ichikawa, S., Hirabayashi, Y., Grunfeld, C., & Feingold, K. R. (1999) Regulation of glycosphingolipid metabolism in liver during the acute phase response, J. Biol. Chem., 274, 19707–19713.

    Article  PubMed  CAS  Google Scholar 

  32. Mukhin, D. N., Chao, F. F., & Kruth, H. S. (1995) Glycosphingolipid accumulation in the aortic wall is another feature of human atherosclerosis, Arterioscler. Thromb. Vasc. Biol., 15, 1607–1615.

    PubMed  CAS  Google Scholar 

  33. Imaizumi, T. A., Stafforini, D. M., Yamada, Y., McIntyre, T. M., Prescott, S. M., & Zimmerman, G. A. (1995) Platelet-activating factor: a mediator for clinicians, J. Intern. Med., 238, 5–20.

    Article  PubMed  CAS  Google Scholar 

  34. Quinn, M. T., Parthasarathy, S., & Steinberg, D. (1988) Lipophosphatidylcholine: a chemotactic factor for human monocytes and its potential role in atherogenesis, Proc. Natl. Acad. Sci. USA., 85, 2805–2809.

    PubMed  CAS  Google Scholar 

  35. Kugiyama, K., Kerns, S. A., Morrisett, J. D, Roberts, R., & Henry, P. D. (1990) Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoprotein, Nature, 344, 160–162.

    Article  PubMed  CAS  Google Scholar 

  36. Leitinger, N., Watson, A. D., Hama, S. Y., Ivandic, B., Qiao, J. H., Huber, J., Faull, F. K., Grass, D. S., Navab, M., Fogelman, A. M., de Beer, F. C., Lusis, A. J., & Berlinger, J. A. (1999) Role of Group II secretory phospholipase A2 in atherosclerosis. 2. Potential involvement of biologically active oxidized phospholipids, Arterioscler. Thromb. Vasc. Biol., 19, 1291–1298.

    PubMed  CAS  Google Scholar 

  37. Ivandic, B., Castellani, L. W., Wang, X., P., Qiao, J. H., Mehrabian, M., Navab, M., Fogelman, A. M., Grass, D. S., Swanson, M. E., de Beer, M. C., de Beer, F., & Lusis, A. J. (1999) Role of Group II secretory phospholipase A2 in atherosclerosis. 1. Increased atherogenesis and altered lipoproteins in transgenic mice expressing Group IIa phospholipase A2, Arterioscler. Thromb. Vasc. Biol., 19, 1284–1290.

    PubMed  CAS  Google Scholar 

  38. Auerbach, B. J., & Parks, J. S. (1989) Lipoprotein abnormalities associated with lipopolysaccharide-induced lecithin: cholesterol acyltransferase and lipase deficiency, J. Biol.Chem., 264, 10264–10270.

    PubMed  CAS  Google Scholar 

  39. Ettinger, W. H., Miller, L. D., Albers, J. J., Smith, T. K, & Parks, J. S. (1990) Lipopolysaccharide and tumour necrosis factor cause a fall in plasma concentration of lecithin: cholesterol acyltransferase in cynomologus monkeys, J. Lipid Res., 31, 1099–1107.

    PubMed  CAS  Google Scholar 

  40. Ly, H., Francone, O. L., Fielding, C. J., Shigenaga, J. K., Moser, A. H., Grunfeld, C., & Feingold, K. R. (1995) Endotoxin and TNF lead to reduced plasma LCAT activity and decreases hepatic LCAT mRNA levels in Syrian hamsters, J. Lipid. Res., 36, 1254–1263.

    PubMed  CAS  Google Scholar 

  41. Hardardottir, I., Moser, A. H., Fullerr, J., Fielding, C., Feingold, K., & Grunfeld, C. (1996) Endotoxin and cytokines decreases serum levels and extra hepatic protein and mRNA levels of cholesteryl ester transfer protein in Syrian hamsters, J. Clin. Invest., 97, 2585–2592.

    PubMed  CAS  Google Scholar 

  42. Feingold, K. R., Memon, R. A., Moser, A. H., Shigenga, J. K., & Grunfeld, C. (1999) Endotoxin and interleukin-1 decrease hepatic lipase mRNA, Atherosclerosis, 142, 379–387.

    Article  PubMed  CAS  Google Scholar 

  43. Khovidhunkit, W., Memon, R. A., Shigenaga, J. K., Pang, M., Schambelan, M., Mulligan, K., Feingold, K. R., & Grunfeld, C. (1999) Plasma platelet-activating factor acetylhydrolase activity in human immunodeficiency virus infection and the acquired immunodeficiency syndrome, Metab. Clin. Exp., 48, 1524–1531.

    PubMed  CAS  Google Scholar 

  44. Feingold, K. R., Memon, R. A., Moser, A. H., & Grunfeld, C. (1998) Paraoxanase activity in the serum and hepatic mRNA levels decrease during the acute phase response, Atherosclerosis, 139, 307–315.

    Article  PubMed  CAS  Google Scholar 

  45. Van Lenten, B. J., Hama, S. Y., de Beer, F. C., Stafforini, D. M., McIntyre, T. M., Prescott, S. M., La Du, B. N., Fogelman, A. M., & Navab, M. (1995) Antiinflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell co-cultures, J. Clin. Invest., 96, 2758–2767.

    PubMed  Google Scholar 

  46. Shih, D. M., Gu, L, Xia, Y. R., Navab, M., Li, W. F., Hama, S., Castellani, L. W., Furlong, C. E., Costa, L. G., Fogelman, A. M., & Lusis, A. J. (1998) Mice lacking paraoxanase are susceptible to organophosphate toxicity and atherosclerosis, Nature, 394, 284–287.

    PubMed  CAS  Google Scholar 

  47. Kunitake, S. T., Jarvis, M. F., Hamilton, R. L., Kane, J. P. (1992) Binding of transition metals by apolipoprotein A-1-containing plasma lipoproteins: inhibition of oxidation of low density lipoproteins, Proc. Natl. Acad. Sci. USA, 89, 6993–6997.

    PubMed  CAS  Google Scholar 

  48. Ehrenwald, E., Chisolm, G. M., & Fox, P. L. (1994) Intact human ceruloplasmin oxidatively modifies low density lipoprotein, J. Clin. Invest, 93, 14493–14501.

    Google Scholar 

  49. Manttari, M., Manninen, V, Huttunen, J. K., Palosuo, T., Ehnholm, C., Heinonen, O. P., & Frick, M. H. (1994) Serum ferritin and ceruloplasmin as coronary risk factors, Eur. Heart J., 15, 1599–1603.

    PubMed  CAS  Google Scholar 

  50. Oram, J. F, & Yokoyama, S. (1996) Apolipoprotein-mediated removal of cellular cholesterol and phospholipids, J. Lipid Res., 37, 2473–2491.

    PubMed  CAS  Google Scholar 

  51. Rothblat, G. H., de la Llera-Moya, M., Atger, V., Kellner-Weiber, G., Williams, D. L., & Phillips, M. C. (1999) Cells cholesterol efflux: integration of old and new observations provides new insights, J. Lipids Res., 40, 781–796.

    CAS  Google Scholar 

  52. Lawn, R. M., Wade, D. P., Garvin, M. R., Wang, X., Schwartz, K., Porter, J. G., Seilhamer, J. J., Vaughan, A. M., & Oram, J. F. (1999) The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway, J. Clin. Invest., 104, R25–31.

    Google Scholar 

  53. Jiang, X. C., Bruce, C., Mar, J., Lin, M., Yi, Y., Francome, O. L., & Tall, A. R. (1999) Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels, J. Clin. Invest., 103, 907–914.

    PubMed  CAS  Google Scholar 

  54. Johnson, W. I, Bamberger, M. J., Latta, R. A., Rapp, P. E., Phillips, M. C., & Rothblat, G. H. (1986) The bidirectional flux of cholesterol between cells and lipoproteins. Effect of phospholipid depletion of high density lipoprotein, J. Biol. Chem., 261, 5766–5776.

    PubMed  CAS  Google Scholar 

  55. Kisilevsky, R., & Subrahmanyan, L. (1992) Serum amyloid A changes high density lipoproteins cellular affinity: a clue to serum amyloid A’s principal function, Lab. Invest., 66, 778–785; [Erratum] 1992, 67, 151.

    PubMed  CAS  Google Scholar 

  56. Moulson, C. L., & Millis, A. J. (1999) Clusterin (apoJ) regulates vascular smooth muscle cell differentiation in vitro, J. Cell Physiol., 180, 355–364.

    Article  PubMed  CAS  Google Scholar 

  57. Mannusic, P. M. (1981) The Rokitanski-Duguid project [Letter], Thromb. Haemost., 45, 300.

    Google Scholar 

  58. Neimetz, J. (1972) Coagulant activity of leucocytes. Tissue factor activity, J. Clin. Invest., 51, 307–313.

    Google Scholar 

  59. Colucci, M., Balconi, G., Lorenzet, R., Pietra, A., Locati, D., Donati, M. B,, & Semeraro, N. (1983) Cultured humanendothelial cells generate tissue factor in response to endotoxin, J. Clin. Invest., 71, 1893–1896.

    PubMed  CAS  Google Scholar 

  60. Smith, E. B. (1994) Fibrin deposition and fibrin degradation products in atherosclerotic plaques, Thromb. Res., 74, 329–335.

    Google Scholar 

  61. Penn, M. S., Chisolm, G. M., & Schwartz, S. M. (1990) Visualization and quantification of transmural concentration profiles of macromolecules across the arterial wall, Circ. Res., 67, 11–22.

    PubMed  CAS  Google Scholar 

  62. Bini, A., Fenoglio, J. J. Jr., Mesa-Tejada, R., Kudryk, R., & Kaplan, K. L. (1989) Identification and distribution of fibrinogen, fibrin and fibrin(ogen) degradation products in atherosclerosis. Use of monoclonal antibodies, Arteriosclerosis, 9, 109–121.

    PubMed  CAS  Google Scholar 

  63. Shekhonin, B. V, Tararak, E. M., Samokhin, G. P., Mitkevich, O. V, Mazurov, A. V, Vinogradov, D. V, Vlasik, T. N., Kalantarov, G. E, & Koteliansky, V E. (1990) Visualization of apo B, fibrinogen/fibrin and fibronectin in the intima of normal human aorta and large arteries during atherosclerosis, Atherosclerosis, 82, 213–226.

    Article  PubMed  CAS  Google Scholar 

  64. Taubman, M. B., Fallon, J. T., Schecter, A. D., Giesen, P., Mendlowitz, M., Fyfe, B. S., Marmur, J. D., & Nemerson, Y. (1997) Tissue factor in the pathogenesis of atherosclerosis, Thromb. Haemost., 78, 200–204.

    PubMed  CAS  Google Scholar 

  65. Fisher, M., Sacoolidge, J. C., & Taylor, C. R. (1987) Patterns of fibrin deposits in carotid artery plaques, Angiology, 38, 393–399.

    PubMed  CAS  Google Scholar 

  66. Yee, K.O., Ikari, Y., & Schwartz, S. M. (2001) An update of the Grützbalg hypothesis: the role of thrombosis and coagulation in atherosclerotic progression, Thromb. Haemost., 85, 207–217.

    PubMed  CAS  Google Scholar 

  67. Valenzuela, R., Shianoff, J. R., DiBello, P. M., Urbanic, D. A., Anderson, J. M., Matsueda, G. R., & Kudryk, B. J. (1992) Immunoelectrophorectic and immuno-histochemical characterization of fibrinogen derivatives in atherosclerotic aortic intimas and vascular prosthesis pseudointimas, Am. J. Pathol, 141, 861–880.

    PubMed  CAS  Google Scholar 

  68. Fuster, V (1996) Elucidation of the role of plaque instability and rupture in acute coronary events, Am. J.Cardiol., 76, 24C–33C.

    Google Scholar 

  69. Giesen, P. L., Rauch, U., Bohrmann, B., Kling, D., Roque, M., Fallon, J. T., Badimon, J. J., Himber, J., Riederer, M. A., & Nemerson, Y. (1999) Blood borne tissue factor: another view of thrombosis, Proc. Natl. Acad. Sci. USA, 96, 2311–2315.

    Article  PubMed  CAS  Google Scholar 

  70. Falk, E., Shah, P. K., & Fuster, V (1995) Coronary plaque disruption, Circulation, 92, 657–671.

    PubMed  CAS  Google Scholar 

  71. Davies, M. J. (1992) Anatomic features in victims of sudden death. Coronary artery pathology, Circulation, 85(Suppl. 1), 119–124.

    Google Scholar 

  72. Schonbeck, U., Mach, F., Sukhova, G. R., Atkinson, E., Levesque, E., Herman, M., Graber, P., Bassett, P., & Libby, P. (1999) Expression of stromelysin-3 in atherosclerotic lesions: regulation via CD40-CD40 ligand signaling in vitro and in vivo, J. Exp. Med., 189, 843–853.

    Article  PubMed  CAS  Google Scholar 

  73. Hazen, S. L., Hsu, F. F., Gaut, J. P., Crowley, J. R., & Heinecke, J. W. (1999) Modification of proteins and lipids by myeloperoxidase, Methods Enzymol., 300, 88–105.

    PubMed  CAS  Google Scholar 

  74. Desrochers, P. E., Mookhtiar, K., Van Wort, H. E., Hasty, K. A., & Weiss, S. J. (1992) Proteolytic inactivation of alpha 1-proteinase inhibitor and alpha-1 antichymotrypsin by oxidatively activated human neutrophil metalloproteinase-S, J. Biol. Chem., 267, 5005–5012.

    PubMed  CAS  Google Scholar 

  75. Bennett, M. R., Evan, G. I., & Schwartz, S. M. (1995) Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques, J. Clin. Invest., 95, 2266–2274.

    PubMed  CAS  Google Scholar 

  76. Geng, Y. J., Henderson, L. E., Levesque, E. B., Muszynski, M., & Libby, P. (1997) Fas is expressed in human atherosclerotic intima and promotes apoptosis of cytokine-primed human vascular smooth muscle cells, Arterioscler. Thromb. Vasc. Biol., 17, 2200–2208.

    PubMed  CAS  Google Scholar 

  77. Kiener, P. A., Davis, P. M., Starling, G. C., Mehlin, C., Klebanoff, S. J., Ledbetter, J. A., & Lilies, W. C. (1997) Differential induction of apoptosis by Fas-Fas ligand interactions in human monocytes and macrophages, J. Exp. Med., 185, 1511–1516.

    Article  PubMed  CAS  Google Scholar 

  78. Arbustini, E., Grasso, M., Diegoli, M., Morbini, P., Aguzzi, A., Fasani, R., & Specchia, G. (1993) Coronary thrombosis in non-cardiac death, Coron. Artery. Dis., 4, 751–759.

    PubMed  CAS  Google Scholar 

  79. Farb, A., Burke, A. P., Tang, A. L., Liang, Y. H., Mannan, P., Smialek, J., & Virmani, R. (1996) Coronary plaque erosion without rupture into a lipid core: a frequent cause of coronary thrombosis in sudden coronary death, Circulation, 93, 1354–1363.

    PubMed  CAS  Google Scholar 

  80. Farb, A., Tang, A. L., Burke, A. P., Sessums, L., Liang, Y., & Virmani, R. (1995) Sudden coronary death. Frequency of active coronary lesions, inactive coronary lesions, and myocardial infarction, Circulation, 92, 1701–1709.

    PubMed  CAS  Google Scholar 

  81. Burke, A. P., Farb, A., Malcom, G. T, Liang, Y. H., Smialek, J., & Virmani, R. (1997) Coronary risk factors and plaque morphology in men with coronary disease who died suddenly [see comments], N. Engl. J. Med., 336, 1276–1282.

    PubMed  CAS  Google Scholar 

  82. Flynn, P. D., Byrne, C. D., Baglin, T. P., Weissberg, P. L., & Bennett, M. R. (1997) Thrombin generation by apoptotic vascular smooth muscle cells, Blood, 89, 4378–4384.

    PubMed  CAS  Google Scholar 

  83. Bombeli, T., Karsan, A., Tait, J. F., & Harlan, J. M. (1997) Apoptotic vascular endothelial cells become procoagulant, Blood, 89, 2429–2442.

    PubMed  CAS  Google Scholar 

  84. Rauch, U., Osende, J. I., Fuster, V., Badimon, J. J., Fayad, Z., & Cheseboro, J. H. (2001) Thrombus formation on atherosclerotic plaques: pathogenesis and clinical consequences, Ann. Intern. Med., 134, 224–238.

    PubMed  CAS  Google Scholar 

  85. Fernandez-Ortiz, A., Badimon, J. J., Falk, E., Fuster, V., Meyer, B., Mailhac, A., Weng, D., Shah, P. K., & Badimon, L. (1994) Characterization of the relative thrombogenicity of atherosclerotic plaque components: Implications for consequences of plaque rupture, J. Am. Coll. Cardiol., 23, 1562–1569.

    Article  PubMed  CAS  Google Scholar 

  86. Felton, C. V., Crook, D., Davies, M. J., & Oliver, M. F. (1997) Relation of plaque lipid composition and morphology to the stability of human aortic plaques, Arterioscler. Thromb. Vasc. Biol., 17, 1337–1345.

    PubMed  CAS  Google Scholar 

  87. Moreno, P. R., Falk, E., Palacios, I. F., Newell, J. B., Fuster, V., & Fallon, J. T. (1994) Macrophage infiltration in acute coronarysyndromes. Implications for plaque rupture, Circulation, 90, 775–778.

    PubMed  CAS  Google Scholar 

  88. Turritto, V.T., & Hall, C. L. (1998) Mechanical factors affecting hemostasis and thrombosis, Thromb. Res., 92, S25–S31.

    Google Scholar 

  89. Badimon, L., & Badimon, J. J. (1989) Mechanisms of arterial thrombosis in nonparallel streamlines. Platelet thrombi grow on the apex of stenotic severely injured vessel wall. Experimentalstudy in the pig model, J. Clin. Invest, 84, 1134–1144.

    PubMed  CAS  Google Scholar 

  90. Loscalzo, J. (1990) Lipoprotein(a). A unique risk factor for atherothrombotic disease, Arteriosclerosis, 10, 672–679.

    PubMed  CAS  Google Scholar 

  91. Brook, J. G., & Aviram, M. (1988) Platelet lipoprotein interactions, Semin. Thromb. Hemostat., 14, 258–265.

    CAS  Google Scholar 

  92. Rauch, U., Osende, J. I., Chesebro, J. H., Fuster, V., Vorcheimer, D. A., Harris, K., Sandler, D. A., Fallon, J. T., Jayaraman, S., & Badimon, J. J. (2000) Statins and cardiovascular disease: the multipleeffects of lipid-lowering therapy by statins, Atherosclerosis, 153, 181–189.

    Article  PubMed  CAS  Google Scholar 

  93. Miller, G. J. (1992) Hemostasis and cardiovascular risk. The British and European experience, Arch. Pathol. Lab. Med., 116, 1318–1321.

    PubMed  CAS  Google Scholar 

  94. Meigs, J. B., Mittleman, M. A., Nathan, D. M, Tofler, G. H., Singer, D. E., Murphy-Sheehy, P. M., Lipinska, I., D’Agostino, R. B., & Wilson, P. W. (2000) Hyperinsulinemia, hyperglycemia and impaired hemostasis: The Framingham offspring study, JAMA, 283, 221–228.

    Article  PubMed  CAS  Google Scholar 

  95. Matsuda, T., Morishita, E., Jokaji, H., Asakura, H., Saito, M., Yoshida, T., & Takemoto, K. (1996) Mechanism on disorders of coagulation and fibrinolysis in diabetes, Diabetes, 45(Suppl. 3), S109–S110.

    PubMed  CAS  Google Scholar 

  96. Tschoepe, E., Rauch, U., & Schwippert, B. (1997) Platelet-leucocytes cross-talk in diabetes mellitus, Horm. Metab. Res., 29, 631–635.

    Article  PubMed  CAS  Google Scholar 

  97. Rauch, U, Schwippert, B., Schultheiss, H. P., & Tschoepe, D. (1998) Platelet activation in diabetic microangiopathy, Platelets, 9, 237–240.

    CAS  PubMed  Google Scholar 

  98. Buzzan, M., Gruden, G., Stella, S., Vaccarino, A., Tamponi, G., Olivetti, C., Giunti, S., & Carvallo-Perin, P. (1998) Microalbuminuria in IDDM is associated with increasing expression of monocyte procoagulant activity, Diabetologia, 41, 767–771.

    Google Scholar 

  99. Rao, A. K., Chouhan, V., Chen, X., Sun, L., & Boden, G. (1999) Activation of the tissue factor pathway of blood coagulation during prolonged hyperglycemia in young healthy men, Diabetes, 48, 1156–1161.

    PubMed  CAS  Google Scholar 

  100. Levi, M., & ten Cate, H. (1999) Disseminated intravascular coagulation, N. Engl. J. Med., 341, 586–592.

    Article  PubMed  CAS  Google Scholar 

  101. Faust, S. N., Heyderman, R. S., & Levin (2000) Disseminated intravascular coagulation and purpura fulminans secondary to infection. Baillieres Best Pract. Res. Clin. Haematol., 13, 179–197.

    CAS  Google Scholar 

  102. Libby, P., & Simon, D. I. (2001) Inflammation and thrombosis. The clot thickens, Circulation, 103, 1718–1720.

    PubMed  CAS  Google Scholar 

  103. Esmon, C. T., Ding, W., Yasuhiro, K., Gu, J. M., Ferrell, G., Regan, L. M., Stearns-Kurosawa, D. J., Kurosawa, S., Mather, T., Laszik, Z., & Esmon, N. L. (1997) The protein C pathway: new insights, Thromb. Haemostat., 78, 70–74.

    CAS  Google Scholar 

  104. Alberio, L., Lämmle, B., & Esmon, C. T. (2001) Protein C replacement in severe meningococcemia: rationale and clinical experience, Clin. Infect. Dis., 32, 1338–1346.

    Article  PubMed  CAS  Google Scholar 

  105. Ulevitch, R. J., & Tobias, P. S. (1995) Receptor-dependent mechanisms of cell stimulation of bacterial endotoxin, Annu. Rev. Immunol., 13, 437–457.

    Article  PubMed  CAS  Google Scholar 

  106. Brandtzaeg, P., Mollness, T. E., & Kierulf, P. (1989) Complement activation and endotoxin levels in systemic meningococcal disease, J. Infect. Dis., 160, 58–65.

    PubMed  CAS  Google Scholar 

  107. Bauer, K. A., ten Cate, H., Barzegar, S., Spriggs, D. R., Sherman, M. L., & Rosenberg, R. D. (1989) Tumour necrosis factor infusions have a procoagulant effect on the hemostasis mechanisms of humans, Blood, 74, 165–172.

    PubMed  CAS  Google Scholar 

  108. Van Deventer, S. J., Buller, H. R., ten Cate, J. W., Aarden, L. A., Hack, C. E., & Sturk, A. (1990) Experimentalendotoxemia in humans: analysis of cytokines release and coagulation,fibrinolytic and complement pathways, Blood, 76, 2520–2526.

    PubMed  Google Scholar 

  109. Edgington, T. S., Mackman, N., Brand, K., & Ruf, W. (1991) The structural biology of expression and function of tissue factor, Thromb. Haemost., 66, 67–79.

    PubMed  CAS  Google Scholar 

  110. Moore, K. L., Andreoli, S. P., Esmon, N. L, Esmon, C. T., & Bang, N. U. (1987) Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro, J. Clin. Invest., 79,124–130.

    PubMed  CAS  Google Scholar 

  111. Sims, P. J., Wiedmer, T., Esmon, C. T., Weiss, H. J., & Shattil, S. J. (1989) Assembly of platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane: studies in Scott syndrome-an isolated defect in platelet procoagulant activity, J. Biol. Chemo., 264, 17049–17057.

    CAS  Google Scholar 

  112. Nieuwland, R., Berckmans, R. J., McGregor, S., Boing, A. N., Romijn, F. P., Westendorp, R. G., Hack, C. E., & Sturk, A. (2000) Cellular origin and procoagulant properties of microparticles in meningococcal sepsis, Blood, 95, 930–935.

    PubMed  CAS  Google Scholar 

  113. Neissen, R. W., Lamping, R. J., Jansen, P. M., Prins, M. N., Peters, M., Taylor, F. B., de Vijlder, J. J., ten Cate, J. W, Hack, C. E., & Sturk, A. (1997) Antithrombin acts as a negative acute phase protein as established with studies on Hep G2 cells and in baboons, Thromb. Haemost., 78, 1088–1092.

    Google Scholar 

  114. Moore, K. L., Esmon, C. T., & Esmon, N. L. (1998) Tumour necrosis factor leads to internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture, Blood, 73, 159–165.

    Google Scholar 

  115. Boehme, M. W., Deng, Y., Raeth, U., Bierhaus, A., Ziegler, R., Stremmel, W., & Nawroth, P. P. (1996) Release of thrombomodulinfrom endothelial cells by concerted action of TNF-alpha and neutrophils: in vivo and in vitro studies, Immunology, 87, 134–140.

    PubMed  CAS  Google Scholar 

  116. Glaser, C. B., Morser, J., Clarke, J. H., Blasko, E., McLean, K., Kuhn, I., Chang, R. J., Lin, J. H., Vilander, L., & Andrews, W. H. (1992) Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity: a potential rapid mechanism for modulation of coagulation, J. Clin. Invest., 90, 2565–2573.

    PubMed  CAS  Google Scholar 

  117. Dahbäck, B. (1991) Protein S and C4b-binding protein: components involved in the regulation of the protein C anticoagulated system, Thromb. Haemost., 66, 49–61.

    Google Scholar 

  118. Heeb, M. J., & Griffin, J. H. (1988) Physiologic inhibition of human activated protein C by alpha 1-antitrypsin, J. Biol. Chem., 263, 11613–11616.

    PubMed  CAS  Google Scholar 

  119. Colucci, M., Paramo, J. A., & Collen, D. (1985) Generation in plasma of a fastacting inhibitor of plasminogen activator in response to endotoxin stimulation, J. Clin. Invest., 75, 818–824.

    PubMed  CAS  Google Scholar 

  120. Bizios, R., Lai, L., Fenton, J. W., & Malik, A. B. (1986) Thrombin-induced chemotaxis and aggregation of neutrophils, J. Cell Physiol., 128, 485–490.

    Article  PubMed  CAS  Google Scholar 

  121. Prescott, S. M., Zimmerman, G. A., & McIntyre, T. M. (1984) Human endothelial cells in culture produce platelet activating factor (l-alkyl-2-acetyl-sn-glkycero-3-phosphocholine) when stimulated with thrombin, Proc. Natl. Acad. Sci. USA, 81, 3534–3538.

    PubMed  CAS  Google Scholar 

  122. Bar-Shavit, R., Kahn, A., Wilner, G. D., & Fenton, J. W. D. (1983) Monocyte chemotaxis: stimulation by specificexosite region in thrombin, Science, 220, 728–731.

    PubMed  CAS  Google Scholar 

  123. Johnson, K., Choi, Y., De Groot, E., Samuels, I., Creasey, A., & Aarden, L. (1998) Potential mechanisms for a proinflammatory vascular cytokine response to coagulation activation, J. Immunol., 160, 5130–5135.

    PubMed  CAS  Google Scholar 

  124. Kaplanski, G., Fabrigoule, M., Boulay, V., Dinarello, C. A., Bongrand, P., Kaplanski, S., & Farnarier, C. (1997) Thrombin induces endothelial Type II activation in vitro: IL-1 and TNF-alpha-independent IL-8 secretion and E-selectin expression, J. Immunol., 158, 5435–5441.

    PubMed  CAS  Google Scholar 

  125. Aiura, K., Clark, B. D., Dinarello, C. A., Margolis, N. A., Kaplanski, G., Burke, J. F., Tompkins, R. G., & Gelfand, J. A. (1997) Interaction with autologous platelets multiplies interleukin-1-and tumour necrosis factor production in mononuclear cells, J. Infect Dis., 175, 123–129.

    PubMed  CAS  Google Scholar 

  126. Kaplanski, G., Porat, R., Aiura, K., Erban, J. K., Gelfand, J. A., & Dinarello, C. A. (1993) Activated platelets induce endothelial secretion of interleukin-8 in vitro via an interleukin-1 mediated event, Blood, 81, 2492–2495.

    PubMed  CAS  Google Scholar 

  127. Cirino, G., Cicala, C., Bucci, M., Sorrentino, L., Ambrosini, G., De Dominicis, G., & Altier, D. C. (1997) Factor Xa as an interface between coagulation and inflammation: molecular mimicry of factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo, J. Clin. Invest., 99, 2446–2451.

    PubMed  CAS  Google Scholar 

  128. Taylor, F. B., Jr., Chang, A., Esmon, C. T, D’Angelo, A., Vigano-D’Angelo, S., & Blick, K. E. (1987) Protein C-prevents the coagulatopathic and lethal effects of Escherichia coli infusion in the baboon, J. Clin. Invest., 79, 918–925.

    Article  PubMed  CAS  Google Scholar 

  129. Roback, M. G., Stack, A. M., Thomspon, C., Brugnara, C., Schwarz, H. P., & Salidino, R. A. (1998) Activated protein C concentrate for the treatment of meningococcal endotoxin shock in rabbits, Shock, 9, 138–142.

    PubMed  CAS  Google Scholar 

  130. Gray, S. T., & Hancock, W. W. (1996) A physiologic anti-inflammatory pathway based on thrombomodulin expression and generation of activated protein C by human mononuclear phagocytes, J. Immunol., 156, 2256–2263.

    Google Scholar 

  131. Brand, K., Fowler, B. J., Edgington, T. S., & Mackman, N. (1991) Tissue factor mRNA in THP-1 monocytic cells is regulated at both transcriptional and post-transcriptional levels in response to lipopolysaccharide, Mol. Cell Biol., 11, 4732–4738.

    PubMed  CAS  Google Scholar 

  132. Wilcox, J. N,, Smith, K. M., Schwartz, S. M., & Gordon, D. (1989) Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque, Proc. Natl. Acad. Sci. USA, 86, 2839–2843.

    PubMed  CAS  Google Scholar 

  133. Mach, F., Schonbeck, U., Bonnefoy, J. Y., Pober, J. S., & Libby, P. (1997) Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of CD40: induction of collagenase stromelysin and tissue factor, Circulation, 96, 396–399.

    PubMed  CAS  Google Scholar 

  134. Mach, F., Schonbeck, U., Sukhova, G. K., Bourcier, T., Bonnefoy, J. Y., Pober, J. S., & Libby, P. (1997) Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis, Proc. Natl. Acad. Sci. USA, 94, 1931–1936.

    Article  PubMed  CAS  Google Scholar 

  135. Abi-Younes, S., Sauty, A., Mach, F., Sukhova, G. K., Libby, P., & Luster, A. D. (2000) The stromal cell-derived factor-1 chemokine is a potent platelet agonist highly expressed in atherosclerotic plaques, Circ. Res., 86, 131–138.

    PubMed  CAS  Google Scholar 

  136. Henn, V., Slupsky, J. R., Grafe, M., Anagnostopoulos, I., Forster, R., Muller-Berghaus, G., & Kroczek, R. A. (1998) CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells, Nature, 391, 591–594.

    PubMed  CAS  Google Scholar 

  137. Ott, I., Neumann, F. J., Gawaz, M., Schmitt, M., & Schomig, A. (1996) Increased neutrophil-platelet adhesion in patients with unstable angina [see comments], Circulation, 94, 1239–1246.

    PubMed  CAS  Google Scholar 

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(2003). Effect of Infection on Lipoproteins and the Coagulation System. In: Fong, I.W. (eds) Infections and the Cardiovascular System: New Perspectives. Emerging Infectious Diseases of the 21st Century, vol 1. Springer, Boston, MA. https://doi.org/10.1007/0-306-47926-5_4

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