Skip to main content

Seprase-DPPIV Association and Prolyl Peptidase and Gelatinase Activities of the Protease Complex

  • Chapter
Dipeptidyl Aminopeptidases in Health and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 524))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Birkedal-Hansen, H., Moore, W.G.I., Bodden, M.K., Windsor, L.J., Birkedal-Hansen, B., DeCarlo, A., and J.A. Engler, 1993, Matrix Metalloproteinases: A Review, Critical Reviews in Oral Biology and Medicine 4: 197.

    PubMed  CAS  Google Scholar 

  2. Martin, P., 1997, Wound healing-Aiming for perfect skin regeneration, Science 276: 75.

    Article  PubMed  CAS  Google Scholar 

  3. Chen, W.-T., 1979, Induction of spreading during fibroblast movement, J.Cell Biol 81: 684.

    Article  PubMed  CAS  Google Scholar 

  4. Young, P.K., and Grinnell, F., 1994, Metalloproteinase activation cascade after burn injury: A longitudinal analysis of the human wound environment, J. Invest. Dermatol. 103: 660.

    Article  PubMed  CAS  Google Scholar 

  5. Grinnell, F., and Zhu, M., 1994, Identification of neutrophil elastase as the proteinase in burn wound fluid responsible for degradation of fibronectin, J.Invest.Dermatol. 103: 155.

    Article  PubMed  CAS  Google Scholar 

  6. Chen, W.T., 1996, Proteases associated with invadapodia, and their role in degradation of extracellular matrix., Enzyme Protein 49: 59.

    PubMed  CAS  Google Scholar 

  7. Goldstein, L.A., Ghersi, G., Piñeiro-Sánchez, M.L., Salamone, M., Yeh, Y.Y., Flessate, D., and Chen, W.-T., 1997, Molecular cloning of seprase: A serine integral membrane protease from human melanoma, Biochimica et Biophysica Acta: Molecular Basis of Disease 1361: 11.

    Google Scholar 

  8. Pineiro-Sanchez, M.L., Goldstein, L.A., Dodt, J., Howard, L., Yeh, Y., Tran, H., Argraves, W.S., and Chen, W.-T., 1997, Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease. J.Biol.Chem. 272: 7595.

    PubMed  CAS  Google Scholar 

  9. Ghersi, G., Chen, W., Lee, E.W., and Zukowska, Z., 2001, Critical role of dipeptidyl peptidase IV in neuropeptide Y-mediated endothelial cell migration in response to wounding, Peptides 22: 453.

    Article  PubMed  CAS  Google Scholar 

  10. Heins, J., Welker, P., Schonlein, C., Born, J., Hartrodt, B., Neubert, K., Tsuru, D., and Barth, A., 1988, Mechanism of proline-specific proteinases: (I) substrate specificity of dipeptidyl peptidase IV from pig kidney and proline-specific endopeptidase from Flavobacterium meningosepticum., Biochim.Biophys.Acta 954: 161.

    PubMed  CAS  Google Scholar 

  11. Löster, K., Zeilinger, K., Schuppan, D., and Reutter, W., 1995, The cysteine-rich region of dipeptidyl peptidase IV (CD 26) is the collagen-binding site, Biochem.Biophys.Res.Commun. 217: 341.

    PubMed  Google Scholar 

  12. Abdel-Ghany, M., Cheng, H., Levine, R.A., and Pauli, B.U., 1998, Truncated dipeptidyl peptidase IV is a potent anti-adhesion and anti-metastasis peptide for rat breast cancer cells, Invasion Metastasis 18: 35.

    Article  PubMed  CAS  Google Scholar 

  13. Bermpohl, F., Löster, K., Reutter, W., and Baum, O., 1998, Rat dipeptidyl peptidase IV (DPP IV) exhibits endopeptidase activity with specificity for denatured fibrillar collegens, FEBS Lett 428: 152.

    Article  PubMed  CAS  Google Scholar 

  14. Morimoto, C., and Schlossman, S.F., 1994, CD26: A key costimulatory molecule on CD4 memory T cells, The Immunologist 2: 4.

    CAS  Google Scholar 

  15. Mueller, S.C., Ghersi, G., Akiyama, S.K., Sang, Q.X., Howard, L., Pineiro-Sanchez, M., Nakahara, H., Yeh, Y., and Chen, W.-T., 1999, A novel protease-docking function of integrin at invadopodia, J.Biol.Chem. 274: 24947.

    PubMed  CAS  Google Scholar 

  16. Monsky, W.L., Lin, C.-Y., Aoyama, A., Kelly, T., Mueller, S.C., Akiyama, S.K., and Chen, W.-T., 1994, A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells, Cancer Res. 54: 5702.

    PubMed  CAS  Google Scholar 

  17. Garin-Chesa, P., Old, L.J., and Rettig, W.J., 1990, Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers, Proc.Natl.AcadSci.USA 87: 7235.

    Article  CAS  Google Scholar 

  18. Ghersi, G., Dong, H., Goldstein, L.A., Yeh, Y., Hakkinen, L., Larjava, H.S., and Chen, W.-T., 2002, Regulation of fibroblast migration on collagenous matrix by a cell surface peptidase complex, J.Biol.Chem. 277: 29231.

    Article  PubMed  CAS  Google Scholar 

  19. Kelly, T., Yan, Y., Osborne, R.L., Athota, A.B., Rozypal, T.L., Colclasure, J.C., and Chu, W.S., 1998, Proteolysis of extracellular matrix by invadopodia facilitates human breast cancer cell invasion and is mediated by matrix metalloproteinases, Clinical & Experimental Metastasis 16: 501.

    Article  CAS  Google Scholar 

  20. Kelly, T., Kechelava, S., Rozypal, T.L., West, K.W., and Korourian, S., 1998, Seprase, a membrane-bound protease, is overexpressed by invasive ductal carcinoma cells of human breast cancers, Modern Pathology 11: 855.

    PubMed  CAS  Google Scholar 

  21. Chen, W.-T., 1989, Proteolytic activity of specialized surface protrusions formed at rosette contact sites of transformed cells, J.Exp.Zool. 251: 167.

    Article  PubMed  CAS  Google Scholar 

  22. Nakahara, H., Howard, L., Thompson, E.W., Sato, H., Seiki, M., Yeh, Y., and Chen, W.-T., 1997, Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion, Proc.Natl.Acad.Sci.U.S.A 94: 7959.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Kluwer Academic Publishers

About this chapter

Cite this chapter

Ghersi, G. et al. (2004). Seprase-DPPIV Association and Prolyl Peptidase and Gelatinase Activities of the Protease Complex. In: Back, N., Cohen, I.R., Kritchevsky, D., Lajtha, A., Paoletti, R. (eds) Dipeptidyl Aminopeptidases in Health and Disease. Advances in Experimental Medicine and Biology, vol 524. Springer, Boston, MA. https://doi.org/10.1007/0-306-47920-6_11

Download citation

  • DOI: https://doi.org/10.1007/0-306-47920-6_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-47717-1

  • Online ISBN: 978-0-306-47920-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics