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Monitoring HIV-1 Subtype Distribution

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AIDS in Africa

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Conclusion

The global HIV epidemic is extremely heterogeneous and dynamic in nature, embracing several epidemics specific to different geographic locations and populations, as evidenced in Africa. Although the degree of surveillance for HIV-1 strains has increased in recent years, more information is needed. Both the current incidence and the current distribution of HIV subtypes need to be better established. Only with these data, will it be possible to track changes in subtype distribution over time and detect the introduction of novel subtypes or CRFs into populations. This information is vital to delineating the historical and dynamic details of the epidemic. Subtype and strain surveillance is necessary to monitor the emergence of new subtypes and strains that may be naturally resistant to antiretroviral drugs. Finally, knowing the distribution of HIV-1 strains will likely be relevant for vaccine development.

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Authors and Affiliations

  1. Département de Microbiologie Médicale et Moléculaire, Université François Rabelais, Tours, France

    Francis R. Barin & Jean-Christophe Plantier

  2. Laboratoire Retrovirus, IRD, Montpellier, France

    Coumba Toure-Kane & Martine Peeters

  3. Hôpital Le Dantec, Dakar, Senegal

    Coumba Toure-Kane

  4. Laboratoire de Virologie, CHU Charles Nicolle, Rouen, France

    Jean-Christophe Plantier

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  1. Francis R. Barin
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  2. Coumba Toure-Kane
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  3. Jean-Christophe Plantier
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  4. Martine Peeters
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Editors and Affiliations

  1. Harvard AIDS Institute Mary Woodard Lasker Professor of Health Sciences Harvard University, Boston, Massachusetts, USA

    Max Essex DVM, PhD (Chairman) & Richard G. Marlink MD (Senior Research and Executive Director) (Chairman) &  (Senior Research and Executive Director)

  2. Laboratory of Bacteriology and Virology CHU Le Dantec, Université Cheikh Anta Diop, Dakar, Senegal

    Souleymane Mboup PharmD, PhD (Professor of Microbiology) (Professor of Microbiology)

  3. Department of Immunology and Infectious Diseases and the Harvard AIDS Institute, Harvard School of Public Health, Boston, Massachusetts, USA

    Phyllis J. Kanki DVM, DSc (Professor of Immunology and Infectious Diseases) & Molly Holme (Professor of Immunology and Infectious Diseases) & 

  4. Department of Nursing Education University of Botswana, Gaborone, Botswana

    Sheila D. Tlou PhD (Associate Professor) (Associate Professor)

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Barin, F.R., Toure-Kane, C., Plantier, JC., Peeters, M. (2002). Monitoring HIV-1 Subtype Distribution. In: Essex, M., Mboup, S., Kanki, P.J., Marlink, R.G., Tlou, S.D., Holme, M. (eds) AIDS in Africa. Springer, Boston, MA. https://doi.org/10.1007/0-306-47817-X_9

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