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The Sepsis Text pp 645–664Cite as

The Gut in Sepsis

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References

  1. Evans WE, Darin JC. Effect of enterectomy in endotoxin shock. Surgery 1966; 60:1026–1029

    PubMed  CAS  Google Scholar 

  2. Meakins JL, Marshall JC. The gastrointestinal tract: the ‘motor’ of multiple organ failure. Arch Surg 1986; 121:197–201

    Google Scholar 

  3. Vallet B, Lebuffe G. The role of the gut in multiple organ failure. In Vincent JL (ed) Yearbook of intensive care and emergency medicine. Springer, Berlin, 1999 pp 539–546

    Google Scholar 

  4. Nieuwenhuijzen GA, Deitch EA, Goris RJ. Infection, the gut and the development of the multiple organ dysfunction syndrome. Eur J Surg 1996; 162:259–273

    PubMed  CAS  Google Scholar 

  5. Vallet B, Lund N, Curtis SE, et al. Gut and muscle tissue PO2 in endotoxemic dogs during shock and resuscitation. J Appl Physiol 1994; 76:793–800

    PubMed  CAS  Google Scholar 

  6. Mayer K, Temmesfeld-Wollbrück B, Friedland A, et al. Severe microcirculatory abnormalities elicited by E. coli hemolysin in the rabbit ileum mucosa. Am J Respir Crit Care Med 1999; 160:1171–1178

    PubMed  CAS  Google Scholar 

  7. Temmesfeld-Wollbrück B, Szalay A, Mayer K, et al. Abnormalities of gastric mucosal oxygenation in septic shock. Am J Respir Crit Care Med 1998;1586–1592

    Google Scholar 

  8. VanderMeer TJ, Wang H, Fink MP. Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock. Crit Care Med 1995, 23:1217–1226

    Google Scholar 

  9. Unno N, Menconi MJ, Smith M, et al. Hyperpermeability of intestinal epithelial monolayers is induced by NO: effect of low extracellular pH. Am J Physiol 1997; 272:G923–34

    PubMed  CAS  Google Scholar 

  10. Unno N, Wang H, Menconi MJ, et al. Inhibition of inducible nitric oxide synthase ameliorates endotoxin-induced gut mucosal barrier dysfunction in rats. Gastroenterology 1997; 113:1246–1257

    Article  PubMed  CAS  Google Scholar 

  11. Crouser ED, Julian MW, Dorinsky P. Ileal VO2-DO2 alterations induced by endotoxin correlate with severity of mitochondrial injury. Am J Respir Crit Care Med 1999; 160:1347–1353

    PubMed  CAS  Google Scholar 

  12. Wells CL, Maddaus M, Simmons RL. Proposed mechanisms for the translocation of intestinal bacteria. Rev Infectious Dis 1988; 10:958–979

    CAS  Google Scholar 

  13. Gannon B, Browning J, O’Brien P, Rogers P. Mucosal microvascular architecture of the fundus and body of human stomach. Gastroenterology 1984; 86:866–875

    PubMed  CAS  Google Scholar 

  14. Landow L, Andersen LW. Splanchnic ischemia and its role in multiple organ failure. Acta Anaesthesiol Scand 1994; 38:626–639

    PubMed  CAS  Google Scholar 

  15. Lundgren O. Physiology of the intestinal circulation. In: Marston A, Bulkley GB, Fiddian-Green RG, Haglund U (eds) Splanchnic Ischemia and Multiple Organ Failure. Edward Arnold, London, 1989 pp 29–40

    Google Scholar 

  16. Nelson DP, King CE, Dodd SL, et al. Systemic and intestinal limits of O2 extraction in the dog. J Appl Physiol 1987; 63:387–394

    PubMed  CAS  Google Scholar 

  17. Samsel RW, Schumacker PT. Systemic hemorrhage augments local O2 extraction in canine intestine. J Appl Physiol 1994; 77:2291–2298

    PubMed  CAS  Google Scholar 

  18. Salzman A, Wollert PS, Wang H, et al. Intraluminal oxygenation ameliorates ischemia/reperfusion-induced gut mucosal hyperpermeability in pigs. Circ Shock 1993; 40:37–46

    PubMed  CAS  Google Scholar 

  19. Salzman AL, Wang H, Wollert PS, et al. Endotoxin-induced ileal mucosal hyperpermeability in pigs: role of tissue acidosis. Am J Physiol 1994; 266:G633–G646

    PubMed  CAS  Google Scholar 

  20. Xu D, Qi L, Guillory D, et al. Mechanisms of endotoxin-induced intestinal injury in a hyperdynamic model of sepsis. J Trauma 1993; 34:676–683

    Article  PubMed  CAS  Google Scholar 

  21. Nelson DP, Samsel RW, Wood LDH, et al. Pathological supply dependence of systemic and intestinal O2 uptake during endotoxemia. J Appl Physiol 1988; 64:2410–2419

    PubMed  CAS  Google Scholar 

  22. Schumacker PT, Kazaglis J, Connolly HV, et al. Systemic and gut oxygen extraction during endotoxemia: role of nitric oxide synthesis. Am J Respir Crit Care Med 1995; 151:107–115

    PubMed  CAS  Google Scholar 

  23. Connolly HV, Maginniss LA, Schumacker PT. Transit time heterogeneity in canine small intestine: significance for oxygen transport. J Clin Invest 1997; 99:228–238

    Article  PubMed  CAS  Google Scholar 

  24. Drazenovic R, Samsel RW, Wylam ME, et al. Regulation of perfused capillary density in canine intestinal mucosa during endotoxemia. J Appl Physiol 1992; 72:259–265

    PubMed  CAS  Google Scholar 

  25. Whithworth PW, Cryer HM, Garrisson RN, et al. Hypoperfusion of the intestinal microcirculation without decreased cardiac output during live Escherichia coli in rats. Circ Shock 1989; 27:111–122

    Google Scholar 

  26. Vallet B. Regional capnometry. In Vincent JL (ed) Yearbook on Intensive Care and Emergency Medicine. Springer, Berlin, 1997 pp 669–676

    Google Scholar 

  27. Hasibeder W, Germann R, Wolf et al. Effects of short-term endotoxemia and dopamne on mucosal oxygenation in porcine jejunum. Am J Physiol 1996; 270:G667–G675

    PubMed  CAS  Google Scholar 

  28. Stehr A, Tugtekin IF, Matejovic M, et al. Effect of endotoxemia on microcirculation of the small bowel mucosa in pigs. Chir Forum 2000; 29:505–508

    Google Scholar 

  29. Ince C, Sinaasappel M. Microcirculatory oxygenation and shunting in sepsis and shock. Crit Care Med 1999; 27:1369–1377

    PubMed  CAS  Google Scholar 

  30. Navaratman RL, Morris SE, Traber DL, et al. Endotoxin (LPS) increases mesenteric vascular resistance (MVR) and bacterial translocation (BT). J Trauma 1990; 30:1104–1113

    Google Scholar 

  31. Theuer CJ, Wilson MA, Steeb GD, et al. Microvascular vasoconstriction and mucosal hypoperfusion of the rat small intestine during bacteremia. Circ Shock 1993; 40:61–68

    PubMed  CAS  Google Scholar 

  32. Neviére R, Mathieu D, Chagnon JL, et al. The contrasting effects of dobutamine and dopamine on gastric mucosal perfusion in septic patients. Am J Respir Crit Care Med 1996; 154:1684–1688

    PubMed  Google Scholar 

  33. Neviére R, Chagnon LJ, Vallet B, et al. Dobutamine improves gastro-intestinal mucosal blood flow in a porcine model of endotoxic shock. Crit Care Med 1997; 25:1371–1377

    PubMed  Google Scholar 

  34. Jutabha R, Poa L, Jensen DM. Stress ulceration in the critically ill. Curr Opin Crit Care 1995, 1:125–129

    Google Scholar 

  35. Nash J, Lambert L, Deakin M. Histamine H2-receptor antagonists in peptic ulcer disease. Evidence for a prophylactic use. Drugs 1994; 47:862–871

    PubMed  CAS  Google Scholar 

  36. Julou-Schaeffer G, Gray GA, Fleming I, Schott C, Parratt JR, Stoclet JC. Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway. Am J Physiol 1990; 259:H1038–H1043

    PubMed  CAS  Google Scholar 

  37. Parker JL, Keller RS, DeFily DV, et al. Coronary vascular smooth muscle function in E. coli endotoxemia in dogs. Am J Physiol 1991; 260:H832–H842

    PubMed  CAS  Google Scholar 

  38. Maginiss LA, Connolly H, Samsel RW, Schumacker PT. Adrenergic vasoconstriction augments tissue O2 extraction during reductions in O2 delivery. J Appl Physiol 1994; 76:1454–1461

    Google Scholar 

  39. Zhang H, Spapen H, Vincent JL. Effects of dobutamine and norepinephrine on oxygen availability in tamponade-induced stagnant hypoxia: a prospective, randomized, controlled study. Crit Care Med 1994; 22:299–305

    PubMed  CAS  Google Scholar 

  40. Vallet B. Vascular reactivity and tissue oxygenation. Intensive Care Med 1998; 24:3–11

    Article  PubMed  CAS  Google Scholar 

  41. Wang P, Ba ZF, Chaudry IH. Endothelium-dependent relaxation is depressed at the macro-and microcirculatory levels during sepsis. Am J Physiol 1995; 269:R988–R994

    PubMed  CAS  Google Scholar 

  42. Fink MP, Antonsson JB, Wang HL, et al. Increased intestinal permeability in endotoxic pigs. Mesenteric hypoperfusion as an etiologic factor. Arch Surg 1991; 126:211–218

    PubMed  CAS  Google Scholar 

  43. Fink MP. Cytopathic hypoxia: mitochondrial dysfunction as a potential mechanism contributing to organ failure in sepsis. In Sibbald WJ, Messmer K, Fink MP (eds) Tissue Oxygenation in Acute Medicine. Springer, Berlin, 1998 pp 128–137

    Google Scholar 

  44. Salzman AL, Menconi MJ, Unno N, et al. Nitric oxide dilates tight junctions and depletes ATP in cultured Caco-2BBe intestinal epithelial monolayers. Am J Physiol 1995; 268:G361–G373

    PubMed  CAS  Google Scholar 

  45. Tepperman BL, Brown JF, Whittle BJR. Nitric oxide synthase induction and intestinal viability in rats. Am J Physiol 1993; 265:G214–G218

    PubMed  CAS  Google Scholar 

  46. Brown GC, Cooper CE. Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Letters 1994; 356:295–298

    Article  PubMed  CAS  Google Scholar 

  47. King CJ, Tytgat S, Delude RL, et al. Ileal mucosal oxygen consumption is decreased in endotoxemic rats but is restored toward normal by treatment with aminoguanidine. Crit Care Med 1999; 27:2518–2524

    PubMed  CAS  Google Scholar 

  48. Kubes P. Nitric oxide modulates epithelial permeability in the feline small intestine. Am J Physiol 1992; 262:G1138–G1142

    PubMed  CAS  Google Scholar 

  49. Payne D, Kubes P. Nitric oxide donors reduce the rise in reperfusion-induced intestinal mucosal permeability. Am J Physiol 1994; 265:G189–G195

    Google Scholar 

  50. Kubes P. Ischemia-reperfusion in the feline small intestine: a role for nitric oxide. Am J Physiol 1993; 264:G143–G149

    PubMed  CAS  Google Scholar 

  51. Hutcheson IR, Whittle BJ, Bouhton-Smith NK. Role of nitric oxide in maintaining vascular integrity in endotoxin-induced intestinal damage in the rat. Br J Pharmacol 1990; 101:815–820

    PubMed  CAS  Google Scholar 

  52. Salzman AL. Endotoxic nitrosopenia. Intensive Care Med 1998; 24:1239–1241

    Article  PubMed  CAS  Google Scholar 

  53. Vallet B, Leclerc J. Endothelial cell dysfunction in septic shock. In Vincent JL (ed) Yearbook of Intensive Care and Emergency Medicine. Springer, Berlin, 1998 pp 133–142

    Google Scholar 

  54. Crouser ED, Julian MW, Weinstein DM, et al. Endotoxin-induced ileal mucosal injury and nitric oxide dysregulation are temporally dissociated. Am J Respir Crit Care Med 2000; 161:1705–1712

    PubMed  CAS  Google Scholar 

  55. Bersten AD, Hersch M, Cheung H, et al. The effect of various sympathomimetics on the regional circulations in hyperdynamic sepsis. Surgery 1992; 112:549–561

    PubMed  CAS  Google Scholar 

  56. Breslow MJ, Miller CF, Parker SD, Walman AT, Traystman RJ. Effect of vasopressors on organ blood flow during endotoxin shock in pigs. Am J Physiol 1987; 252:H291–H300

    PubMed  CAS  Google Scholar 

  57. Shepherd AP, Riedel GL, Maxwell LC, et al. Selective vasodilators redistribute intestinal blood flow and depress oxygen uptake. Am J Physiol 1984; 247:G377–G384

    PubMed  CAS  Google Scholar 

  58. Cain SM, Curtis SE. Systemic and regional oxygen uptake and lactate flux in endotoxic dogs resuscitated with dextran and dopexamine or dextran alone. Circ Shock 1992; 38:173–181

    PubMed  CAS  Google Scholar 

  59. Fink MP, Kaups KL, Wang H, et al. Maintenance of superior mesenteric arterial perfusion prevents increased intestinal mucosal permeablity in endotoxic pigs. Surgery 1991; 110:154–161

    PubMed  CAS  Google Scholar 

  60. Silverman HJ, Tuma P. Gastric tonometry in patients with sepsis: effects of dobutamine infusion and packed red blood cell transfusions. Chest 1992; 102:184–188

    PubMed  CAS  Google Scholar 

  61. Marik PE, Sibbald WJ. The effect of stored blood transfusion on oxygen delivery in patients with sepsis. JAMA 1993; 269:3024–3029

    Article  PubMed  CAS  Google Scholar 

  62. Silva E, DeBacker D, Creteur J, Vincent JL. Effects of vasoactive drugs on gastric intramucosal pH. Crit Care Med 1998; 26:1749–1758

    PubMed  CAS  Google Scholar 

  63. Reinhart K, Sakka SG, Meier-Hellmann A. Hemodynamic management of a patient with septic shock. Eur J Anaesthesiol 2000; 17:6–17

    Article  PubMed  CAS  Google Scholar 

  64. Smithies M, Yee TH, Jackson L et al. Protecting the gut and the liver in the critically ill: effects of dopexamine. Crit Care Med 1994; 22:789–795

    PubMed  CAS  Google Scholar 

  65. Gutierrez G, Clark C, Brown SD, et al. Effect of dobutamine on oxygen consumption and gastric mucosal pH in septic patients. Am J Respir Crit Care Med 1994; 150:324–329

    PubMed  CAS  Google Scholar 

  66. Creteur J, De Backer D, Vincent JL. A dobutamine test can disclose hepatosplanchnic hypoperfusion in septic patients. Am J Respir Crit Care Med 1999; 160:839–45

    PubMed  CAS  Google Scholar 

  67. Levy B, Bollaert PE, Lucchelli JP, et al. Dobutamine improves the adequacy of gastric mucosal perfusion in epinephrine-treated septic shock. Crit Care Med 1997; 25:1649–1654

    PubMed  CAS  Google Scholar 

  68. Levy B, Bollaert PE, Nace L, Charpentier C, Bauer PH, Larcan A. Comparison of norepinephrine and dobutamine to epinephrine for hemodynamics, lactate metabolism and gastric tonometric variables in septic shock. A prospective randomized study. Intensive Care Med 1997; 23:282–287

    Article  PubMed  CAS  Google Scholar 

  69. Duranteau J, Sitbon P, Teboul JL, et al. Effects of epinephrine, norepinephrine, or the combination of norepinephrine and dobutamine on gastric mucosa in septic shock. Crit Care Med 1999; 27:893–900

    PubMed  CAS  Google Scholar 

  70. Gutierrez G, Palizas F, Doglio G, et al. Gastric intramucosal pH as a therapeutic index of tissue oxygenation in critically ill patients. Lancet 1992; 339:195–199

    PubMed  CAS  Google Scholar 

  71. Porter JM, Sussman MS, Bulkley GB. Splanchnic vasospasm in circulatory shock in splanchnic ischemia and multiple organ failure. Marston A, Bulkley GB, Fiddian-Green RG et al. (eds) Splanchnic Ischemia and Multiple Organ Failure. CV Mosby, St Louis, 1989, pp 73–88

    Google Scholar 

  72. Carrol G, Synder J. Hyperdynamic severe intravascular sepsis depends on fluid administration in cyonomolgus monkey. Am J Physiol 1982; 243:R131–R141

    Google Scholar 

  73. Umans JG, Wylam ME, Samsel RW, et al. Effects of endotoxin in vivo on endothelial and smooth-muscle function in rabbit and rat aorta. Am Rev Repir Dis 1993; 148: 1638–1645

    CAS  Google Scholar 

  74. Fink MP. Systemic and splanchnic hemodynamic derangements in the sepsis syndrome. In: Marston A, Bulkley GB, Fiddian-Green RG, Haglund U (eds) Splanchnic Ischemia and Multiple Organ Failure. CV Mosby, St Louis, 1989 pp: 101–106

    Google Scholar 

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Authors
  1. Benoit Vallet
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Editors and Affiliations

  1. Department of Intensive Care, Erasme University Hospital, Brussels, Belgium

    Jean-Louis Vincent M.D.

  2. Service de Réanimation Polyvalente, Hôpital Saint-Joseph, Paris, France

    Jean Carlet M.D.

  3. Division of Infectious Diseases, The Memorial Hospital of Rhode Island, Pawtucket, RI

    Steven M. Opal M.D.

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© 2002 Kluwer Academic Publishers

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Vallet, B. (2002). The Gut in Sepsis. In: Vincent, JL., Carlet, J., Opal, S.M. (eds) The Sepsis Text. Springer, Boston, MA. https://doi.org/10.1007/0-306-47664-9_37

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  • DOI: https://doi.org/10.1007/0-306-47664-9_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-7923-7620-0

  • Online ISBN: 978-0-306-47664-8

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