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The Brain in Sepsis

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The Sepsis Text

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Conclusion

Septic encephalopathy is an early manifestation of sepsis. At times it can be profound and patients with septic encephalopathy have a higher mortality than those without. Its pathogenesis is uncertain but it has the hallmarks of a global metabolic brain injury and even if severe it appears to be reversible. Nevertheless some preliminary animal work suggests that neuronal injury does occur but it remains to be seen if significant damage occurs in humans. Studies considering long term neurological or neuro-psychiatric sequelae are required.

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Authors
  1. Barbara Philips
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  2. David Bennett
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme University Hospital, Brussels, Belgium

    Jean-Louis Vincent M.D.

  2. Service de Réanimation Polyvalente, Hôpital Saint-Joseph, Paris, France

    Jean Carlet M.D.

  3. Division of Infectious Diseases, The Memorial Hospital of Rhode Island, Pawtucket, RI

    Steven M. Opal M.D.

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© 2002 Kluwer Academic Publishers

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Philips, B., Bennett, D. (2002). The Brain in Sepsis. In: Vincent, JL., Carlet, J., Opal, S.M. (eds) The Sepsis Text. Springer, Boston, MA. https://doi.org/10.1007/0-306-47664-9_36

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  • DOI: https://doi.org/10.1007/0-306-47664-9_36

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-7923-7620-0

  • Online ISBN: 978-0-306-47664-8

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