Conclusion
Despite the plethora of physiological monitoring commonly available in the ICU there remain some challenges in the avoidance of hypovolemia in sepsis. Interpretation of physiological data assumes a reference point of normality or acceptability. Normality is a statistical concept from which ‘acceptable’ cannot be derived for the individual. Avoiding hypovolemia in sepsis requires a high degree of suspicion and a ‘try it and see’ approach with corrective treatment. The fluid challenge approach provides a safe method of confirming or refuting the diagnosis while titrating appropriate volume replacement.
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Webb, A.R. (2002). Fluid Administration. In: Vincent, JL., Carlet, J., Opal, S.M. (eds) The Sepsis Text. Springer, Boston, MA. https://doi.org/10.1007/0-306-47664-9_22
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