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The Sepsis Text pp 271–284Cite as

Cytopathic Hypoxia

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Conclusion

Several lines of evidence support the notion that cellular energetics are deranged in sepsis, not (just) on the basis of inadequate tissue perfusion, but rather because of impaired mitochondrial respiration and/or coupling. These findings suggest the possibility that organ dysfunction in sepsis may occur on the basis of cytopathic hypoxia. If this concept is correct, then the therapeutic implications are enormous. Efforts to improve outcome in septic patients by monitoring and manipulating cardiac output, systemic oxygen delivery, and regional blood flow would seem unlikely to have a major impact on outcome. Instead, our focus should be on developing pharmacological strategies to restore normal mitochondrial function and cellular energetics.

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Authors
  1. Mitchell P. Fink
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme University Hospital, Brussels, Belgium

    Jean-Louis Vincent M.D.

  2. Service de Réanimation Polyvalente, Hôpital Saint-Joseph, Paris, France

    Jean Carlet M.D.

  3. Division of Infectious Diseases, The Memorial Hospital of Rhode Island, Pawtucket, RI

    Steven M. Opal M.D.

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© 2002 Kluwer Academic Publishers

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Fink, M.P. (2002). Cytopathic Hypoxia. In: Vincent, JL., Carlet, J., Opal, S.M. (eds) The Sepsis Text. Springer, Boston, MA. https://doi.org/10.1007/0-306-47664-9_15

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  • DOI: https://doi.org/10.1007/0-306-47664-9_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-7923-7620-0

  • Online ISBN: 978-0-306-47664-8

  • eBook Packages: Springer Book Archive

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