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Immune Effectors Important in Protective Resistance

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The Filaria

Part of the book series: World Class Parasites ((WCPA,volume 5))

Abstract

This chapter describes immune effector mechanisms against the different developmental stages of filarial nematodes in humans and animal models of filarial infection. Over the last few years, significant insight has been gained from work using laboratory mice with engineered genetic defects leading to lack of immune cell subsets or cytokine responses. These data have provided evidence that both T helper 1 and T helper 2 responses as well as pathways of the innate system are essential for parasite containment. As data from animal and human studies reveal, these pathways are counterregulated by suppressor responses involving recently described regulatory T cells.

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  1. Department of Helminthology, Bernhard Nocht Institute of Tropical Medicine, Hamburg, Germany

    Achim Hoerauf

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© 2002 Kluwer Academic Publishers

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Hoerauf, A. (2002). Immune Effectors Important in Protective Resistance. In: The Filaria. World Class Parasites, vol 5. Springer, Boston, MA. https://doi.org/10.1007/0-306-47661-4_10

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  • DOI: https://doi.org/10.1007/0-306-47661-4_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4020-7038-9

  • Online ISBN: 978-0-306-47661-7

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