Skip to main content
SpringerLink
Log in

Expression Strategy and Functions of the Filoviral Glycoproteins

  • Chapter
Structure-Function Relationships of Human Pathogenic Viruses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Anderson, E.D., Thomas, L., Haytlick, J.S., and Thomas, G., 1993, Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant. J. Biol. Chem. 268: 24887–24891

    PubMed  CAS  Google Scholar 

  • Becker, S., Klenk, H.-D., and Mühlberger, E., 1996, Intracellular transport and processing of the Marburg virus surface protein in vertebrate and insect cells. Virology 225: 145–155

    Article  PubMed  CAS  Google Scholar 

  • Becker, S., Spiess, M., and Klenk, H.-D., 1995, The asialoglycoprotein receptor is a potential liver-specific receptor for Marburg virus. J. Gen. Virol. 76: 393–399

    Article  PubMed  CAS  Google Scholar 

  • Bukreyev A.A., Volchkov, V.E., Blinov, V.M., Dryga, S.A., and Netesov, S.V., 1995, The complete nucleotide sequence of the Popp (1967) strain of Marburg virus: A comparison with the Musoke (1980) strain. Arch. Virol. 140: 1589–1600

    Article  PubMed  CAS  Google Scholar 

  • Bullough, P.A., Hughson, F.M., Skehel, J.J. and Wiley, D.C., 1994, Structure of influenza haemagglutmin at the pH of membrane fusion. Nature 371: 37–43

    Article  PubMed  CAS  Google Scholar 

  • Burton, D.R., and Parren P.W.H.I., 2000, Fighting the Ebola virus. Nature 408: 527–528

    Article  PubMed  CAS  Google Scholar 

  • Bwaka, M.A., Bonnet, M.J., Calain, P., Colebunders, R., De Roo, A., Guimard, Y., Katwiki, K.R., Kibadi, K., Kipasa, M.A., Kuvula, K.J., Mapanda, B.B., Massamba, M., Mupapa, K.D., Muyembe-Tamfum, J.J., Ndaberey, E., Peters, C.J., Rollin, P.E., Van den Enden, E., and Van den Enden E., 1999, Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients. J. Infect. Dis. 179 Suppl 1: 1–7

    Google Scholar 

  • Cattaneo, R., Kaelin, K., Baczko K., and Billeter, M A., 1989, Measles virus editing provides an additional cysteine-rich protein. Cell 56: 759–764

    Article  PubMed  CAS  Google Scholar 

  • Chan, D.C., Fass, D., Berger, J.M., and Kim, P.S., 1997, Core structure of gp41 from the HIV enevelope glycoprotein. Cell 89: 263–273

    Article  PubMed  CAS  Google Scholar 

  • Chan, S.Y., Empig, C.J., Welte, F.J., Speck, R.F., Schmaljohn, A., Kreisberg, J.F., and Goldsmith, M.A., 2001, Folate receptor-alpha is a cofactor for cellular entry by Marburg and Ebola viruses. Cell 106: 117–126

    Article  PubMed  CAS  Google Scholar 

  • Chan, S.Y., Ma, M.C., and Goldsmith, M.A., 2000a. Differential induction of cellular detachment by envelope glycoproteins of Marburg and Ebola (Zaire) viruses. J. Gen. Virol. 81: 2155–2159

    PubMed  CAS  Google Scholar 

  • Chan, S.Y., Speck, R.F., Ma, M.C., and Goldsmith, M.A., 2000b, Distinct mechanisms of entry by envelope glycoproteins of Marburg and Ebola (Zaire) viruses. J. Virol. 74: 4933–4037

    PubMed  CAS  Google Scholar 

  • Feldmann H., Mühlberger, E., Randolf, A., Will, C., Kiley, M.P., Sanchez, A. and Klenk, H.-D., 1992, Marburg virus, a filovirus: messenger RNAs, gene order, and regulatory elements of the replication cycle. Virus Res. 24: 1–19

    Article  PubMed  CAS  Google Scholar 

  • Feldmann, H. and Kiley, M.P., 1999, Classification, structure, and replication of filoviruses. In: Marburg and Ebola viruses, Klenk, H.D., ed.; Springer Verlag; Curr. Top. Microbiol. Immunol. 235: 1–21

    Google Scholar 

  • Feldmann, H., Bugany, H., Mahner, F., Klenk, H.-D., Drenckhahn, D. and Schnittler, H.-J., 1996, Filovirus-induced endothelial leakage triggered by infected monocytes/macrophages. J. Virol. 70: 2208–2214

    PubMed  CAS  Google Scholar 

  • Feldmann, H., Nichol, S.T., Klenk, H.-D., Peters, C.J., and Sanchez, A., 1994, Characterization of filoviruses based on differences in structure and antigenicity of the virion glycoprotein. Virology 199: 469–473

    Article  PubMed  CAS  Google Scholar 

  • Feldmann, H., Will, C., Schikore, M., Slenczka, W., and Klenk, H.-D., 1991, Glycosylation and oligomerization of the spike protein of Marburg virus. Virology 182: 353–356

    Article  PubMed  CAS  Google Scholar 

  • Feng, Y., Broder, C.C., Kennedy, P.E., and Berger, E.A., 1996. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science, 272: 872–877

    PubMed  CAS  Google Scholar 

  • Fisher-Hoch S.P, and Brammer L, 1992, Pathogenic potential of filoviruses: role of geographic origin of primate host and virus strain, J. Infect. Dis., 166: 753–63

    PubMed  CAS  Google Scholar 

  • Fisher-Hoch, S.P., Platt, G.S., Neild, G.H., Southee, T., Baskerville, A., Raymond, R.T., Lloyd, G., and Simpson, D.I.H., 1985, Pathophysiology of shock and hemorrhage in a fulminating viral infection (Ebola). J. Infect. Dis., 152: 887–894

    PubMed  CAS  Google Scholar 

  • Freed, E., Myers, D., and Risser, R., 1990, Characterization of the fusion domain of the human immunodeficiency virus type 1 envelope glycoprotein gp41. Proc. Natl. Acad. Sci. USA 87: 4650–4654

    PubMed  CAS  Google Scholar 

  • Funke, C., Becker, B., Dartsch, H., Klenk, H.-D., and Mühlberger, E., 1995, Acylation of the Marburg virus glycoprotein. Virology 208: 289–297

    Article  PubMed  CAS  Google Scholar 

  • Gallaher, W.R., 1996, Similar structural models of the transmembrane proteins of Ebola and avian sarcoma viruses. Cell (Letter) 85: 477–478

    CAS  Google Scholar 

  • Geisbert TW, Jahrling PB, Hanes MA, and Zack PM, 1992, Association of Ebola-related Reston virus particles and antigen with tissue lesions of monkeys imported to the United States. J. Comp Path 106: 137–152

    Article  PubMed  CAS  Google Scholar 

  • Geisbert, T.W., and Jahrling, P.B., 1995, Differentiation of filoviruses by electron microscopy. Virus Res. 39: 129–150

    Article  PubMed  CAS  Google Scholar 

  • Geyer, H., Will, C., Feldmann, H., Klenk, H.-D., and Geyer, R., 1992, Carbohydrate structure of Marburg virus glycoprotein. Glycobiology 2: 299–312

    PubMed  CAS  Google Scholar 

  • Gupta, M., Mahanty, S., Ahmed, R., and Rollin, P.E., 2001a, Monocyte-derived human macrophages and peripheral blood mononuclear cells infected with ebola virus secrete MIP-1alpha and TNF-alpha and inhibit poly-IC-induced IFN-alpha in vitro. Virology 284: 20–25

    Article  PubMed  CAS  Google Scholar 

  • Gupta, M., Mahanty, S., Bray, M., Ahmed, R., and Rollin, P.E., 2001b, Passive transfer of antibodies protect immunocompetent and immunodeficient mice against lethal Ebola virus infection without complete inhibition of viral replication. J. Virol. 75: 4649–4654

    Article  PubMed  CAS  Google Scholar 

  • Hevey, M., Negley, D., Geisbert, J., Jahrling, P., and Schmaljohn, A., 1998, Antigenicity and vaccine potential of Marburg virus glycoprotein expressed by baculovirus recombinants. Virology 239: 206–216

    Google Scholar 

  • Horikami, S.M., and Moyer, S.A., 1991, Synthesis of leader RNA and editing of the P mRNA during transcription by purified measles virus. J. Virol. 65: 5342–5347

    PubMed  CAS  Google Scholar 

  • Ignatyev G.M., 1999, Immune response to filovirus infections. In: Marburg and Ebola viruses, Klenk, H.D., ed.; Springer Verlag; Curr. Top. Microbiol. Immunol. 235: 205–217

    Google Scholar 

  • Ito, H., Watanabe, S., Sanchez, A., Whitt, M.A. and Kawaoka, Y., 1999, Mutational analysis of the putative fusion domain of Ebola virusgly, coprotein. J. Virol. 73: 8907–8912

    PubMed  CAS  Google Scholar 

  • Ito, H., Watanabe, S., Takada, A., and Kawaoka, Y., 2001, Ebola virus glycoprotein: proteolytic processing, acylation, cell tropism, and detection of neutralizing antibodies. J. Virol. in press.

    Google Scholar 

  • Joshi, S.B., Dutch, R.E., and Lamb, R.A., 1998, A core trimer of the paramyxovirus fusion protein: parallels to influenza virus hemagglutinin and HIV-1 gp41. Virology 248: 20–34

    Article  PubMed  CAS  Google Scholar 

  • Kawaoka, Y., Yamnikova, S., Chambers, T.M., Lvov, D.K., and Webster, R.G., 1990, Molecular characterization of a new hemagglutinin, subtype H14, of influenza A virus. Virology 179: 759–767

    Article  PubMed  CAS  Google Scholar 

  • Kindzelskii, A.L., Yang, Z., Nabel, G.J., Todd III, R.F., and Petty, H.R., 2000, Ebola virus secretory glycoprotein (sGP) diminishes FcRIIIB-to-CR3 proximity on neutrophils. J. Immunol. 164: 953–958

    PubMed  CAS  Google Scholar 

  • Klenk, H.-D., 2000, Will we have and why do we need an Ebola vaccine? Nature Med. 6: 1322–1323

    PubMed  CAS  Google Scholar 

  • Klenk, H.-D., and Garten, W., 1994a, Activation cleavage of viral spike proteins by host proteases. In Cellular Receptors for Animal Viruses E. (Wimmer ed.), Cold Spring Harbor Laboratory Press, pp241–280

    Google Scholar 

  • Klenk, H.-D., and Garten, W., 1994b, Host cell prateases controlling virus pathogenicicty. Trends in Microbiol. 2: 39–43

    CAS  Google Scholar 

  • Klenk, H.-D., and Rott, R., 1988. The molecular biology of Influenza virus pathogenicity. Adv. Virus Res. 34: 247–281

    PubMed  CAS  Google Scholar 

  • Kondo, K., Bando, H., Tsurudome, M., Kawano, M., Nishio, M., and Ito, Y., 1990, Sequence analysis of the phosphoprotein (P) genes of human parainfluenza type 4A and 4B viruses and RNA editing at transcript of the P genes: the number of G residues added is imprecise. Virology 178: 321–326

    Article  PubMed  CAS  Google Scholar 

  • Leroy, H.M., Baize, S., Volchkov, V.E., Fisher-Hoch, S.P., Georges-Courbot, M.C., Lansoud-Soukate, J., Capron, M., Debre, P., McCormick, J.B., and Georges, A. J., 2000, Human asymptomatic Ebola infection and strong inflammatory response. Lancet 355: 2210–2215

    Article  PubMed  CAS  Google Scholar 

  • Malashkevich, V. N., Schneider, B.J., McNally, M.L., Milhollen, M.A., Pang, J.X., and Kim, P.S., 1999, Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution. Proc. Natl. Acad. Sci. USA 96: 2662–2667

    Article  PubMed  CAS  Google Scholar 

  • Mariyankova, R.F., Giushakowa, S.E., Pyzhik, H.V., and Lukashevich, I.S., 1993, Marburg virus penetration into eukaryotic cells. Vopr. Virusol 2: 74–76

    Google Scholar 

  • Maruyama, T., Buchmeier, M.J., Parren. P.W.H.I., and Burton, D.R., 1998. Ebola virus, neutrophils and antibody specificity. Science 282: 845a

    Article  Google Scholar 

  • Maruyama, T., Rodriguez, L.L., Jahrling, P.B., Sanchez, A., Khan, A.S., Nichol, S.T., Peters, C.J., Parren, P.W., and Burton, D.R., 1999, Ebola virus can be effectively neutralized by antibody produced in natural human infection. J. Virol. 73: 6024–6030

    PubMed  CAS  Google Scholar 

  • Matsuoka, Y., Curran, J., Pelet, T., Kolakofsky, D., Ray, R., and Compans, R.W., 1991, The P gene of human parainfluenza virus type 1 encodes P and C proteins but not a cysteine rich V protein. J. Virol. 65: 3406–3410

    PubMed  CAS  Google Scholar 

  • Molloy, S.S., Thomas, L., van Slyke, J.K., Stenberg, P.E., and Thomas, G., 1994, Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface. EMBO J 13: 18–33

    PubMed  CAS  Google Scholar 

  • Moss, B., 1990. Regulation of vaccinia virus transcription. Annu.Rev.Biochem., 59: 661–688

    Article  PubMed  CAS  Google Scholar 

  • Mupapa, K.D., Massamba, M., Kibadi, K., Kuvula, K., Bwaka, A., Kipasa, M., Colebunders, R., and Muyembe-Tamfum, J.J., 1999, Treatment of Ebola hemorrhagic fever with blood transfusions from convalescent patients. J. Infect. Dis. (Suppl. 1) 179: S18–S23

    PubMed  Google Scholar 

  • Murphy, F.A., van der Groen, G., Whitfield, S.G., and Lange, J.V., 1978, Ebola and Marburg virus morphology and taxonomy. In: Ebola Virus Haemorrhagic Fever (Pattyn, S.R., ed), Elsevier/North-Holland, Amsterdam, pp61–82

    Google Scholar 

  • Ohgimoto, S., Bando, H., Kawano, M., Okamoto, K., Kondo, K., Tsurudome, M., Nishio, M., and Ito, Y., 1990, Sequence analysis of P gene of human parainfluenza type 2 virus: P and cysteinerich proteins are translated by two mRNAs that differ by two nontemplated G residues. Virology 177: 116–123

    Article  PubMed  CAS  Google Scholar 

  • Paterson RG., and Lamb R.A., 1990, RNA editing by G-nucleotide insertion in mumps virus P-gene mRNA transcripts. J. Virol. 64: 4137–4145

    PubMed  CAS  Google Scholar 

  • Pelet T., Curran, J., and Kolakofsky, D., 1991, The P gene of bovine parainfluenza virus 3 expresses all three reading frames from a single mRNA editing site. EMBO J 10: 443–448

    PubMed  CAS  Google Scholar 

  • Peters, C.J., Sanchez, A., Rollin, P.E., Ksiazek, T.G., and Murphy, F.A., 1996, Filoviridae: Marburg and Ebola viruses, In Virology (B. N. Fields, D. M. Knipe, et al., eds.), Raven Press, Philadelphia, 3rd edn., pp1161–1176

    Google Scholar 

  • Peters, C.J. and LeDuc, J.W., 1999, Ebola: The virus and the disease. J. Infect. Dis. (Suppl. 1) 179: 1–288

    Google Scholar 

  • Pushko, P., Bray, M., Ludwih, G.V., Parker, M., Schmaljohn, A., Sanchez, A., Jahrling, P.B., and Smith, J.F., 2000, Recombinant RNA replicons derived from attenuated Venezuelan equine encephalitis virus protect guinea pigs and mice from Ebola hemorrhagic fever virus. Vaccine 19: 142–153

    Article  PubMed  CAS  Google Scholar 

  • Ruiz-Agüello, M.B., Goni, F.M., Pereira, F.B. and Nieva, J.L., 1998, Phosphatidylinositol-dependent membrane fusion induced by a put,ative fusogenic sequence of Ebola virus. Virol. 72: 1775–1781

    Google Scholar 

  • Ryabchikova, E., Kolesnikova, L.V., and Luchko, S.V., 1999, An analysis of features of pathogenesis in two animal models of Ebolka virus infection. J. Infect. Dis. (Suppl. 1) 179: 199–202

    Google Scholar 

  • Sanchez, A., Kiley, M.P., Holloway, B.P., and Auperin, D.D., 1993, Sequence analysis of the Ebola virus genome: organization, genetic elements, and comparison with the genome of Marburg virus. Virus Res. 29: 215–240

    Article  PubMed  CAS  Google Scholar 

  • Sanchez, A., Trappier, S.G., Mahy, B.W.J., Peters, C.J., and Nichol, S.T., 1996, The virion glycoprotein of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing. Proc Natl. Acad. Sci. USA 93: 602–3607

    Google Scholar 

  • Sanchez, A., Trappier, S.G., Ströher, U., Nichol, S.T., Bowen, M.D., and Feldmann H., 1998a, Variation in the glycoprotein and VP35 genes of Marburg virus strains. Virology 240: 1038–146

    Article  Google Scholar 

  • Sanchez, A., Yang, Z.Y., Xu, L., Nabel, G.J., Crews, T., and Peters, C.J., 1998b, Biochemical analysis of the secreted and virion glycoproteins of Ebola virus. J. Virol. 72: 6442–6447

    PubMed  CAS  Google Scholar 

  • Schäfer, W., Stroh, A., Berghöfer, S., Seiler, J., Vey, M., Kruse, M.L., Kern, H.F., Klenk, H.-D., and Garten, W., 1995, Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin. EMBO J. 14: 2424–2435

    PubMed  Google Scholar 

  • Schnittler, H.J., and Feldmann, H., 1999, Molecular pathogenesis of filovirus infections: role of macrophages and endothelial cells. In: Marburg and Ebola viruses, Klenk, H.D., ed.; Springer Verlag; Curr. Top. Microbiol. Immunol. 235: 175–204

    Google Scholar 

  • Seidah, N.G., Hamelin, J., Mamarbachi, M., Dong, W., Tadro, H., Mbikay, M., Chretien, M., and Day, R., 1996, cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases. Proc. Natl. Acad. Sci. USA 93: 3388–3393

    Article  PubMed  CAS  Google Scholar 

  • Skehel, J.J., Bayley, P.M., Brown, E.B., Martin, S.R., Waterfield, M.D., White, J.M., Wilson, I.A., and Wiley, D.C., 1982, Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion. Proc. Natl. Acad. Sci. USA 79: 968–972

    PubMed  CAS  Google Scholar 

  • Southern, J.A., Precious, B., and Randall, R.E., 1990, Two nontemplated nucleotide additions are required to generate the P mRNA of parainfluenza virus type 2 since the genome encodes protein V. Virology 177: 388–390

    Article  PubMed  CAS  Google Scholar 

  • Sullivan N.J., Sanchez, A., Rollin, P.E., Yang, Z., and Nabel G.J., 2000, Development of a preventive vaccine for Ebola virus infection in primates. Nature 408: 605–609

    PubMed  CAS  Google Scholar 

  • Takada, A., Robison, C., Goto, H., Sanchez, A., Murti, K. G., Whitt, M.A., and Kawaoka, Y., 1997, A system for functional analysis of Ebola virus glycoprotein. Proc. Natl. Acad. Sci. USA 94: 14764–14769

    PubMed  CAS  Google Scholar 

  • Takada, A., Watanabe, S., Ito, H., Okazaki, K., Kida, H., and Kawaoka, Y., 2000, Downregulation of betal integrins by Ebola virus glycoprotein: implication for virus entry. Virology 278: 20–26

    Article  PubMed  CAS  Google Scholar 

  • Takeuchi, K., Tanabayashi, K., Hishiyama, M., Yamada, Y. K., Yamada, A., and Sugiura, A., 1990, Detection and characterization of mumps virus V protein. Virology, 178: 247–253

    Article  PubMed  CAS  Google Scholar 

  • Thomas, S.M., Lamb, R.A., and Paterson, R.G., 1988, Two mRNA’s that differ by two nontemplated nucleotides encode the amino coterminal proteins P and V of the paramyxovirus SV5. Cell 54: 891–902

    PubMed  CAS  Google Scholar 

  • van der Groen, G., Webb, P., Johnson, K., Lange, J., Linsday, L., and Elliott, L., 1978, Growth of Lassa and Ebola viruses in different cell lines. In Ebola virus haemorrhagic fever (Pattyn, S.R., ed), Elsevier/North-Holland Biomedical Press, Amsterdam, The Netherlands, pp225–260

    Google Scholar 

  • van Regenmortel, M.H.V., Fauquet, C.M., Bishop, D.H.L., Carstens, E.B., Estes, M.K., Lemon, S.M., Maniloff, J., Mayo, M.A., McGeoch, D.J., Pringle, C.R., and Wickner, R.B., 2000, Virus Taxonomy: The Classification and Nomenclature of Viruses. The Seventh Report of the International Committee on Taxonomy of Viruses (book). Virus Taxonomy, VIIth report of the ICTV. Academic Press, San Diego, pp1167

    Google Scholar 

  • Vanderzanden, L., Bray, M., Fuller, D., Roberts, T., Custer, D., Spik, K., Jahrling, P., Huggins, J., Schmaljohn, A., and Schmaljohn, C., 1998, DNA vaccines expressing either the GP or NP genes of Ebola virus protect mice from lethal challenge. Virology 246: 134–144

    Article  PubMed  CAS  Google Scholar 

  • Vey, M., Schäfer, W., Reis, B., Ohuchi, R., Britt, W., Garten, W., Klenk, H.-D., and Radsak, K., 1995, Proteolytic processing of human cytomegalovirus glycoprotein B (gpUL55) is mediated by the human endoprotease furin. Virology 206: 746–749

    Article  PubMed  CAS  Google Scholar 

  • Vidal, S., Curran, J., and Kolakofsky, D., 1990a, Editing of the Sendai virus P/C mRNA by G insertion occurs during mRNA synthesis via a virus encoded activity. J Virol. 64: 239–246

    PubMed  CAS  Google Scholar 

  • Vidal, S., Curran, J., and Kolakofsky, D., 1990b, A stuttering model for paramyxovirus P mRNA editing. The EMBO J 9: 2017–2022

    CAS  Google Scholar 

  • Villinger, F., Rollin, P.E., Brar, S.S., Chikkala, N.F., Winter, J., Sundstrom, J.B., Zaki, S.R., Swanepoel, R., Ansari, A.A., and Peters, C.J., 1999, Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection. J Infect Dis. (Suppl 1) 179: 188–191

    Google Scholar 

  • Volchkov, V.E., 1999, Processing of the Ebola virus glycoprotein. In Marburg and Ebola viruses (Klenk, H.-D., ed.), 235, Springer-Verlag Berlin Heidelberg, pp35–47

    Google Scholar 

  • Volchkov, V.E., Becker, S., Volchkova, V.A., Ternovoj, V.A., Kotov, A.N., Netesov, S.V., and Klenk, H.-D., 1995, GP mRNA of Ebola virus is edited by the Ebola virus polymerase and by T7 and vaccinia virus polymerases. Virology 214: 421–430

    Article  PubMed  CAS  Google Scholar 

  • Volchkov, V.E., Blinov, V.M., and Netesov, S.V. 1992, The envelope glycoprotein of bola virus contains an immunosuppressive-like domain s,imilar to oncogenic etroviruses. FEBS Lett. 305:181–184

    Article  PubMed  CAS  Google Scholar 

  • Volchkov, V.E., Chepurnov, A.A., Volchkove, V.A., Ternovoj, V.A., and Klenk, H.-D., 2000a, Molecular characterization of guinea-pig-adapted variants of Ebola virus. Virology 277: 147–155

    Article  PubMed  CAS  Google Scholar 

  • Volchkov, V.E., Feldmann, H., Volchkova, V.A., and Klenk, H.-D., 1998a, Processing of the Ebola virus glycoprotein by the proprotein convertase furin. Proc. Natl. Acad. Sci. USA 95: 5762–5767

    Article  PubMed  CAS  Google Scholar 

  • Volchkov, V.E., Volchkova, V.A., Mühlberger, E., Kolesnikova, L.V., Weik, M., Dolnik, O., and Klenk, H.-D., 2001, Recovery of infectious Ebola virus from cDNA: transcriptional RNA editing of the GP gene controls viral cytotoxicity. Science 291: 1965–1969

    Article  PubMed  CAS  Google Scholar 

  • Volchkov, V.E., Volchkova, V.A., Slenczka, W., Klenk, H.-D. and Feldmann, H., 1998b, Release of viral glycoproteins during Ebola virus infection. Virology, 245: 110–119

    Article  PubMed  CAS  Google Scholar 

  • Volchkov, V.E., Volchkova, V.A., Strher, U., Cieplik, M., Becker, S., Dolnik, O., Garten, W., Klenk, H. D., and Keldmann, H., 2000b, Proteolytic processing of Marburg virus glycoprotein. Virology 268: 1–6

    Article  PubMed  CAS  Google Scholar 

  • Volchkova, V.A., Feldmann, H., Klenk, H.-D., and Volchkov, V.E., 1998, The nonstructural small glycoprotein of Ebola virus is secreted as an antiparallel-orientated homodimer. Virology 250: 408–414

    Article  PubMed  CAS  Google Scholar 

  • Volchkova, V., Klenk, H.-D., and Volchkov, V., 1999, Delta-peptide is the carboxy-terminal cleavage fragment of the nonstructural small glycoprotein sGP of Ebola virus. Virology 265: 64–171

    Article  CAS  Google Scholar 

  • Watanabe, S., Takada, A., Watanabe, T., Ito, H., Kida, H., and Kawaoka, Y., 2000, Functional importance of the coiled-coil of the Ebola virus glycoprotein. J. Virol. 74: 10194–10201

    Article  PubMed  CAS  Google Scholar 

  • Weissenhorn, W., Calder, L.J., Wharton, S.A., Skehel, J.J., and Wiley, D.C. 1998a, The central structural feature of the membrane fusion protein subunit from the Ebola virus glycoprotein is a long triple-stranded coiled coil. Proc. Natl. Acad. Sci. USA 95: 6032–6036

    Article  PubMed  CAS  Google Scholar 

  • Weissenhorn, W., Carfi, A., Lee, K.H., Skehel, J.J., and Wiley, D.C., 1998b, Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glyeoprotcin ectodomain. Mol. Cell 2: 605–616

    Article  PubMed  CAS  Google Scholar 

  • Weissenhorn, W., Dessen, A., Harrison, S.C., Skehel, J.J., and Wiley, D.C., 1997, Atomic structure of the ectodomain from HIV-1 gp41. Nature 387: 426–430

    Article  PubMed  CAS  Google Scholar 

  • Will, C., Mühlberger, E., Linder, D., Slenczka, W., Klenk, H.-D., and Feldmann, H., 1993, Marburg virus gene 4 encodes the virion membrane protein, a type I transmembrane glycoprotein. J Virol. 67: 1203–1210

    PubMed  CAS  Google Scholar 

  • Wilson, J.A., Hevey, M., Bakken, R., Guest, S., Bray, M., Schmaljohn, A.L., and Hart, M.K., 2000, Epitopes involved in antibody-mediated protection from Ebola virus. Science 287: 1664–1666

    Article  PubMed  CAS  Google Scholar 

  • Wise, R.J., Barr, P.J., Wong, P.A., Kiefer, M., Brake, A.J., and Kaufman, R.J., 1990, Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site. Proc. Natl. Acad. Sci. USA 87: 9378–9382

    PubMed  CAS  Google Scholar 

  • Wool-Levis, R.J., and Bates, P., 1998, Characterization of Ebola virus entry by using pseudotyped viruses: identification of receptor-deficient cell lines. J. Viral. 72: 3155–3160

    Google Scholar 

  • Wool-Levis, R.J. and Bates, P., 1999, Endoproteolytic processing of the Ebola virus envelope glycoprotein: cleavage is not required for function. J. Virol 73: 1419–1426

    Google Scholar 

  • Xu, L., Sanchez, A., Yang, Z.Y., Zaki, S.R., Nabel, E.G., Nichol, S.T., and Nabel, G.J., 1998, Immunization for Ebola virus infection. Nature Med 4: 37–42

    PubMed  CAS  Google Scholar 

  • Yang, Z., Delgado, R., Xu, L., Todd, R.F., Nabel, E.G., Sanchez, A., and Nabel, G.J., 1998, Distinct cellular interactions of secreted and transmembrane Ebola virus glycoproteins. Science 279: 1034–1036

    Article  PubMed  CAS  Google Scholar 

  • Yang, Z., Duckers, H. J., Sullivan, N., Sanchez, A., Nabel, E.G., and Nabel, G.J., 2000, Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury. Nature Med 6: 86–889

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biologie des Filovirus, Claude Bernard University Lyon, 1, 21, Avenue Tony, Gamier, 69007, France

    Viktor E. Volchkov

  2. Canadian Science Centre for Human and Animal Health, 1015 Arlington Street, Winnipeg, Manitoba, R3E 3R2, Canada

    Heinz Feldmann

Authors
  1. Viktor E. Volchkov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Heinz Feldmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Microscopy and Imaging Center Department of Biology Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas

    Andreas Holzenburg

  2. Institut für Klinische and Molekulare Virologie, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany

    Elke Bogner

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Volchkov, V.E., Feldmann, H. (2002). Expression Strategy and Functions of the Filoviral Glycoproteins. In: Holzenburg, A., Bogner, E. (eds) Structure-Function Relationships of Human Pathogenic Viruses. Springer, Boston, MA. https://doi.org/10.1007/0-306-47650-9_9

Download citation

  • DOI: https://doi.org/10.1007/0-306-47650-9_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46768-4

  • Online ISBN: 978-0-306-47650-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation