Skip to main content
SpringerLink
Log in
Book cover

Structure-Function Relationships of Human Pathogenic Viruses pp 89–107Cite as

Marburg Virus Replication and Nucleocapsid Formation: Different Jobs, Same Players

  • Chapter

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Becker, S., and Mühlberger, E. (1999). Co-and posttranslational modifications and functions of Marburg virus proteins. Curr Top Microbiol Immunol 235, 23–34.

    PubMed  CAS  Google Scholar 

  • Becker, S., Huppertz, S., Klenk, H. D., and Feldmann, H. (1994). The nucleoprotein of Marburg virus is phosphorylated. J Gen Virol 75(Pt 4), 809–18.

    PubMed  CAS  Google Scholar 

  • Becker, S., Klenk, H.-D., and Mühlberger, E. (1996). Intracellular transport and processing of the Marburg virus surface protein in vertebrate and insect cells. Virology 225(1), 145–55.

    Article  PubMed  CAS  Google Scholar 

  • Becker, S., Rinne, C., Hofsäss, U., Klenk, H.-D., and Mühlberger, E. (1998). Interactions of Marburg virus nucleocapsid proteins. Virology 249(2), 406–17.

    Article  PubMed  CAS  Google Scholar 

  • Becker, S., Spiess. M., and Klenk, H. D. (1995). The asialoglycoprotein receptor is a potential liver-specific receptor for Marburg virus. J Gen Virol 76(Pt 2), 393–9.

    PubMed  CAS  Google Scholar 

  • Bukreyev, A. A., Volchkov, V. E., Blinov, V. M., Dryga, S. A., and Netesov, S. V. (1995). The complete nucleotide sequence of the Popp (1967) strain of Marburg virus: a comparison with the Musoke (1980) strain. Arch Virol 140(9), 1589–600.

    Article  PubMed  CAS  Google Scholar 

  • Chan, S. Y., Empig. C. J., Welte, F. J., Speck, R. F., Schmaljohn, A., Kreisberg, J. F., and Goldsmith, M. A. (2001). Folate receptor-α is a cofactor for cellular entry by Marburg and Ebola virues. Cell 106, 117–126.

    Article  PubMed  CAS  Google Scholar 

  • Chenik, M., Chebli, K., Gaudin, Y., and Blondel, D. (1994). In vivo interaction of rabies virus phosphoprotein (P) and nucleoprotein (N): existence of two N-binding sites on P protein. J Gen Virol 75(Pt 11), 2889–96.

    PubMed  CAS  Google Scholar 

  • Collins, P. L., Hill, M. G., Cristina, J., and Grosfeld, H. (1996). Transcription elongation factor of respiratory syncytial virus, a nonsegmented negative-strand RNA virus. Proc Natl Acad Sci U S A 93(1), 81–5.

    Article  PubMed  CAS  Google Scholar 

  • Conzelmann, K. K. (1996). Genetic manipulation of non-segmented negative-strand RNA viruses. J Gen Virol 77(Pt 3), 381–9.

    PubMed  CAS  Google Scholar 

  • Davis, N. L., Arnheiter, H., and Wertz, G. W. (1986). Vesicular stomatitis virus N and NS proteins form multiple complexes. J Virol 59(3), 751–4.

    PubMed  CAS  Google Scholar 

  • Davis, N. L., Arnheiter. H., and Wertz., G. W. (1986). Vesicular stomatitis virus N and NS proteins form multiple complexes. J Virol 59(3), 751–4.

    PubMed  CAS  Google Scholar 

  • Davis, R. J. (1993). The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 268(20), 14553–6.

    PubMed  CAS  Google Scholar 

  • Egelman, E. H., Wu, S. S., Amrein, M., Portner, A., and Murti, G. (1989). The Sendai virus nucleocapsid exists in at least four different helical states. J Virol 63(5), 2233–43.

    PubMed  CAS  Google Scholar 

  • Elliott, L.H., Kiley, M.P., and McCormick, J. B. (1985). Descriptive analysis of Ebola virus proteins. Virology 147(1), 169–76.

    Article  PubMed  CAS  Google Scholar 

  • Feldmann, H., Bugany, H., Mahner, F., Klenk, H. D., Drenckhahn, D., and Schnittler, H. J. (1996). Filovirus-induced endothelial leakage triggered by infected monocytes/macrophages. J Virol 70(4), 2208–14.

    PubMed  CAS  Google Scholar 

  • Feldmann, H., Muhlberger, E., Randolf, A., Will, C., Kiley, M. P., Sanchez, A., and Klenk, H. D. (1992). Marburg virus, a filovirus: messenger RNAs, gene order, and regulatory elements of the replication cycle. Virus Res 24(1), 1–19.

    Article  PubMed  CAS  Google Scholar 

  • Feldmann, H., Will, C., Schikore, M., Slenczka, W., and Klenk, H. D. (1991). Glycosylation and oligomerization of the spike protein of Marburg virus. Virology 182(1), 353–6.

    Article  PubMed  CAS  Google Scholar 

  • Fisher-Hoch, S. P., and McCormick, J. B. (1999). Experimental filovirus infections. Curr Top Microbiol Immunol 235, 117–43.

    PubMed  CAS  Google Scholar 

  • Fooks, A. R., Stephenson, J. R., Warnes, A., Dowsett, A. B., Rima, B. K., and Wilkinson, G. W. (1993). Measles virus nucleocapsid protein expressed in insect cells assembles into nucleocapsid-like structures. J Gen Virol 74(Pt 7), 1439–44.

    PubMed  CAS  Google Scholar 

  • Garcia, J., Ciarcia-Barreno, B., Vivo. A., and Melero. J. A. (1993). Cytoplasmic inclusions of respiratory syncytial virus-infeeted cells: formation of inclusion bodies in translected cells that coexpress the nucleoprotein. the phosphoprotein, and the 22K protein. Virology 195(1), 243–7.

    PubMed  CAS  Google Scholar 

  • Garcia-Barreno, B., Delgado. T., and Melero. J. A. (1996). Identification of protein regions involved in the interaction of human respiratory syncytial virus phosphoprotein and nucleoprotein: significance for nucleocapsid assembly and formation of cytoplasmic inclusions. J Virol 70(2), 801–8.

    PubMed  CAS  Google Scholar 

  • Gear, J. S., Cassel, G. A., Gear, A. J., Trappler, B., Clausen, L., Meyers, A. M., Kew, M. C., Bothwell, T. H., Sher, R., Miller, G. B., Schneider, J., Koornhof, H. J., Gomperts, E. D., Isaacson, M., and Gear, J. H. (1975). Outbreak of Marburg virus disease in Johannesburg. Br Med J 4(5995), 489–93.

    Article  PubMed  CAS  Google Scholar 

  • Geisbert, T. W., and Jaax, N. K. (1998). Marburg hemorrhagic fever: report of a case studied by immunohistochemistry and electron microscopy. Ultrastruct Pathol 22(1), 3–17.

    Article  PubMed  CAS  Google Scholar 

  • Geishert, T. W., and Jahrling, P. B. (1995). Differentiation of filoviruses by electron microscopy. Virus Res 39(2–3), 129–50.

    Google Scholar 

  • Gombart, A. F., Hirano, A., and Wong, T. C. (1995). Nucleoprotein phosphorylated on both serine and threonine is preferentially assembled into the nucleocapsids of measles virus. Virus res 37, 63–73.

    Article  PubMed  CAS  Google Scholar 

  • Horikami, S. M., Curran, J., Kolakofsky, D., and Moyer, S. A. (1992). Complexes of Sendai virus NP-P and P-L proteins are required for defective interfering particle genome replication in vitro. J Virol 66(8), 4901–8.

    PubMed  CAS  Google Scholar 

  • Hsu, C. H., and Kingsbury, D. W. (1982). Topography of phosphate residues in Sendai virus proteins. Virology 120(1), 225–34.

    Article  PubMed  CAS  Google Scholar 

  • Huber, M., Cattaneo, R., Spielhofer, P., Orvell, C., Norrby, E., Messerli, M., Perriard, J. C., and Billeter, M. A. (1991). Measles virus phosphoprotein retains the nucleocapsid protein in the cytoplasm. Virology 185(1), 299–308.

    Article  PubMed  CAS  Google Scholar 

  • Iseni, F., Barge, A., Baudin, F., Blondel, D., and Ruigrok, R. W. (1998). Characterization of rubies virus nucleocapsids and recombinant nucleocapsid-like structures. J Gen Virol 79(Pt 12), 2909–19.

    PubMed  CAS  Google Scholar 

  • Kawai, A., Anzai, J., Honda, Y., Morimoto, K., Takeuchi, K., Kohno, T., Wakisaka, K., Goto, H., and Minamoto, N. (1997). Monoclonal antibody #5-2-26 recognizes the phosphatase-sensitive epitope of rabies virus nucleoprotein. Microbiol Immunol 41(1), 33–42.

    PubMed  CAS  Google Scholar 

  • Kolesnikova, L., Mühlberger, E., Ryabchikova, E., and Becker, S. (2000). Ultrastructural organization of recombinant Marburg virus nucleoprotein: comparison with Marburg virus inclusions. J Virol 74(8), 3899–904.

    Article  PubMed  CAS  Google Scholar 

  • Liston, P., Batal, R., DiFlumeri, C., and Briedis, D. J. (1997). Protein interaction domains of the measles virus nucleocapsid protein (NP). Arch Virol 142(2), 305–21.

    Article  PubMed  CAS  Google Scholar 

  • Lötfering, B., E, M. h., Tamura, T., Klenk, H. D., and Becker, S. (1999). The nucleoprotein of Marburg virus is target for multiple cellular kinases. Virology 255(1), 50–62.

    PubMed  Google Scholar 

  • Luytjes, W., Krystal, M., Enami, M., Pavin, J. D., and Palese, P. (1989). Amplification, expression, and packaging of foreign gene by influenza virus. Cell 59(6), 1107–13.

    Article  PubMed  CAS  Google Scholar 

  • Martini, G. A. (1971). Marburg virus disease. Clinical syndrome. In “Marburg virus disease” (G. A. Martini, and R. Siegert, Eds.), pp. 1–9. Springer, Berlin, Heidelberg, New York.

    Google Scholar 

  • Martini, G. A. (1971). Marburg virus disease. Clinical syndrome. In “Marburg virus disease” (G. A. Martini, and R. Siegert, Eds.), pp. 1–9. Springer, Berlin, Heidelberg, New York.

    Google Scholar 

  • Masters, P. S., and Banerjee, A. K. (1988). Resolution of multiple complexes of phosphoprotein NS with nucleocapsid protein N of vesicular stomatitis virus. J Virol 62(8), 2651–7.

    PubMed  CAS  Google Scholar 

  • Meric, C., Spehner, D., and Mazarin, V. (1994). Respiratory syncytial virus nucleocapsid protein (N) expressed in insect cells forms nucleocapsid-like structures. Virus Res 31(2), 187–201.

    Article  PubMed  CAS  Google Scholar 

  • Mühlberger, E., Lotfering, B., Klenk, H.-D., and Becker, S. (1998). Three of the four nucleocapsid proteins of Marburg virus, NP, VP35, and L, are sufficient to mediate replication and transcription of Marburg virus-specific monocistronic minigenomes. J Virol 72(11), 8756–64.

    PubMed  Google Scholar 

  • Mühlberger, E., Sanchez, A., Randolf, A., Will, C., Kiley, M. P., Klenk, H. D., and Feldmann, H. (1992). The nucleotide sequence of the L gene of Marburg virus, a filovirus: homologies with paramyxoviruses and rhabdoviruses. Virology 187(2), 534–47.

    PubMed  Google Scholar 

  • Mühlberger, E., Trommer, S., Funke, C., Volchkov, V., Klenk, H.-D., and Becker, S. (1996). Termini of all mRNA species of Marburg virus: sequence and secondary structure. Virology 223(2), 376–80.

    PubMed  Google Scholar 

  • Muhlberger, E., Weik, M., Volchkov, V. E., Klenk, H.-D., and Becker, S. (1999). Comparison of the transcription and replication strategies of Marburg virus and Ebola vims by using artificial replication systems. J Virol 73(3), 2333–42.

    PubMed  CAS  Google Scholar 

  • Murphy, F. A., Simpson, D. I., Whitfield, S. G., Zlotnik, I., and Carter, G. B. (1971). Marburg virus infection in monkeys. Ultrastructural studies. Lab Invest 24(4), 279–91.

    PubMed  CAS  Google Scholar 

  • Muyembe-Tamfum, J.-J., Borchert, M., Swanepoel, R., Bausch, D. G., Tshioko, F. K., Campbell, P., Roth, C., Sleurs, H., Olinda, L. A., Libande, M., Colebunders, R., Rodier, G., Leirs, H., Zeller, H., Van der Sluyft, P., and Rollin, P. E. (2000). Symposium on Marburg and Ebola viruses, Marburg.

    Google Scholar 

  • Nishio, M., Tsurudome, M., Kawano, M., Watanabe, N., Ohgimoto, S., Ito, M., Komada, H., and Ito, Y. (1996). Interaction between nucleocapsid protein (NP) and phosphoprotein (P) of human parainfluenza virus type 2: one of the two NP binding sites on P is essential for granule formation. J Gen Virol 77(Pt 10), 2457–63.

    PubMed  CAS  Google Scholar 

  • Pattnaik, A. K., Ball, L. A., LeGrone, A. W., and Wertz, G. W. (1992). Infectious defective interfering particles of VSV from transcripts of a cDNA clone. Cell 69(6), 1011–20.

    Article  PubMed  CAS  Google Scholar 

  • Peters, D., Müller. G., and Slenczka, W. (1971). Morphology, development, and classification of the Marburg virus. In “Marburg virus disease”, pp. 68–83. Springer, Berlin, Heidelberg, New York.

    Google Scholar 

  • Rippey, J. J., Schepers, N. J., and Gear, J. H. (1984). The pathology of Marburg virus disease. S Afr Med J 66(2), 50–4.

    PubMed  CAS  Google Scholar 

  • Ryabchikova, E. I., Kolesnikova, L. V., and Netesov, S. V. (1999). Animal pathology of filoviral infections. Curr Top Microbiol Immunol 235, 145–73.

    PubMed  CAS  Google Scholar 

  • Ryabchikova, E, Strelets, L., Kolesnikova, L., Pyankov, O., and Sergeev, A. (1996). Respiratory Marburg virus infection in guinea pigs. Arch Virol 141(11), 2177–90.

    Article  PubMed  CAS  Google Scholar 

  • Ryan, K. W., Murti, K. G., and Portlier, A. (1990). Localization of P protein binding sites on the Sendai virus nucleocapsid. J Gen Virol 71(Pt 4), 997–1000.

    PubMed  CAS  Google Scholar 

  • Sanchez, A., Kiley, M. P., Klenk, H. D., and Feldmann, H. (1992). Sequence analysis of the Marburg virus nucleoprotein gene: comparison to Ebola virus and other non-segmented negative-strand RNA viruses. J Gen Virol 73(Pt 2), 347–57.

    PubMed  CAS  Google Scholar 

  • Sanchez, A., Kiley, M. P., Klenk, H. D., and Feldmann, H. (1992). Sequence analysis of the Marburg virus nucleoprotein gene: comparison to Ebola virus and other non-segmented negative-strand RNA viruses. J Gen Virol 73(Pt 2), 347–57.

    PubMed  CAS  Google Scholar 

  • Schnitller, H. J., Mahner, F., Drenckhahn, D., Klenk, H. D., and Feldmann, H. (1993). Replication of Marbuig virus in human endolhelial cells. A possible mechanism for the development of viral hemorrhagic disease. J Clin Invest 91(4), 1301–9.

    Google Scholar 

  • Schoehn, G., Iseni, F., Mavrakis, M., Blondel. D., and Ruigrok, R. W. (2001). Structure of recombinantrabies virus nucleoprotein-RNA complex and identification of the phosphoprotein binding site [In Process Citation]. J Virol 75(1), 490–8.

    Article  PubMed  CAS  Google Scholar 

  • Schwemmle, M., Salvatore, M., Shi, L., Richt, J., Lee, C. H., and Lipkin, W. I. (1998). Interactions of the borna disease virus P, N, and X proteins and their functional implications. J Biol (Chem 273(15), 9007–12

    CAS  Google Scholar 

  • Slenczka, W. G. (1999). The Marburg virus outbreak of 1467 and subsequent episodes. Curr Top Micrpbiol Immunol 235, 44–75.

    Google Scholar 

  • Sokol. F., and Clark, H. F. (1973) Phosphoproteins, structural components of rhabdoviruses. Virology 52(1), 246–63.

    Article  PubMed  CAS  Google Scholar 

  • Spehner, D., Drillien, R., and Howley, P. M. (1997) The assembly of the measles virus nucleoprotein into nucleocapsid-like particles is modulated by the phosphoprotein. I Virology 232(2), 260–8.

    CAS  Google Scholar 

  • Stille, W., and Böhle, E. (1971). Clinical course and prognosis of Marburg virus (green monkey) disease. In “Marburg virus disease” (G. A. Martini, and R. Siegert, Eds.), pp. 10–18. Springer, Berlin, Heidelberg, New York.

    Google Scholar 

  • Sutter, G., Ohlmann, M., and Erfle, V. (1995). Non-replicating vaccinia vector efficiently expresses bacteriophage T7 RNA polymerase. FEBS Lett 371(1), 9–12.

    Article  PubMed  CAS  Google Scholar 

  • Swanepoel, R., Smit, S., Burt, F. J., Rollin, P. E., Ksiazek, T. G., Bowen, M. D., Trappier, S. G., McMullan, L., Bausch, D. G., Zaki, S. R., and Nichol, S. T. (2000). Symposium on Marburg and Ebola viruses, Marburg.

    Google Scholar 

  • Will, C., Muhlberger, E., Linder, D., Slenczka, W., Klenk, H. D., and Feldmann, H. (1993). Marburg virus gene 4 encodes the virion membrane protein, a type I transmembrane glycoprotein. J Virol 67(3), 1203–10.

    PubMed  CAS  Google Scholar 

  • Zaki, S. R., and Goldsmith, C. S. (1999). Pathologic features of filovirus infections in humans. Curr Top Microbiol Immunol 235, 97–116.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Virologie, Philipps-Universität Marburg, Robert-Koch-Str. 17, 35037, Marburg, Germany

    Elke Mühlberger & Stephan Becker

Authors
  1. Elke Mühlberger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stephan Becker
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Microscopy and Imaging Center Department of Biology Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas

    Andreas Holzenburg

  2. Institut für Klinische and Molekulare Virologie, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany

    Elke Bogner

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Mühlberger, E., Becker, S. (2002). Marburg Virus Replication and Nucleocapsid Formation: Different Jobs, Same Players. In: Holzenburg, A., Bogner, E. (eds) Structure-Function Relationships of Human Pathogenic Viruses. Springer, Boston, MA. https://doi.org/10.1007/0-306-47650-9_4

Download citation

  • DOI: https://doi.org/10.1007/0-306-47650-9_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46768-4

  • Online ISBN: 978-0-306-47650-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation