Skip to main content
SpringerLink
Log in
Book cover

Structure-Function Relationships of Human Pathogenic Viruses pp 465–484Cite as

Cytomegalovirus Glycoproteins Interacting with MHC Class I Molecules and the MHC-encoded Peptide Transporter

  • Chapter

  • 203 Accesses

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ahmed, R. and Biron, C.A., 1999, Immunity to viruses. In: Fundamental Immunology, (W.E. Paul, ed.) Lippincott-Raven, Philadelphia; pp. 1295–1334

    Google Scholar 

  • Ahn, K., Angulo, A., Ghazal, P., Peterson, P. A., Yang, Y., and Friih, K., 1996b, Human cytomegalo virus inhibits antigen presentation by a sequential multistep process., Proc. Nad. Acad. Sci. USA 93:10990–10995

    CAS  Google Scholar 

  • Ahn, K., Gruhler, A., Galocha, B., Jones, T.R., Wiertz, E.J.H.J., Ploegh, H. L., Peterson, P. A., and Früh, K., 1997, The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP. Immunity 6: 613–621

    Article  PubMed  CAS  Google Scholar 

  • Ahn, K., Meyer, T.H., Uebel, S., Sempe, P., Djaballah, H., Yang, Y., Peterson, P.A., Früh, K., Tampe, R., 1996a, Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47. EMBO J 15:3247–3255

    PubMed  CAS  Google Scholar 

  • Bahram, S., Bresnahan, M., Geraghty, D.E. and Spies, T., 1994, A second lineage of mammalian major histocompatibility complex class I genes. Proc. Natl. Acad. Sci. USA 91:6259–6263

    PubMed  CAS  Google Scholar 

  • Beersma, M.F.C., Bijlmakers, M.J.E., and Ploegh, H.L., 1993, Cytomegalovirus downregulates HLA class I expression by reducing the stability of class I H chains. J. Immunol. 151:4455–4464

    PubMed  CAS  Google Scholar 

  • Benz, C. and Hengel, H., 2000, MHC class I-subversive gene functions of Cytomegalovirus and their regulation by interferons — an intricate balance. Virus Genes 21:39–47

    Article  PubMed  CAS  Google Scholar 

  • Benz, C., Reusch, U., Muranyi, W., Brune, W., Atalay, R., and Hengel, H., 2001, Efficient downregulation of major histocompatibilty complex class I molecules in human epithelial cells infected with Cytomegalovirus. J. Gen. Virol. 82: 2061–2070

    PubMed  CAS  Google Scholar 

  • Borrego, F., Ulbrecht, M., Weiss, E.H., Coligan, J.E., Brooks, A.G., 1998, Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis. J. Exp. Med. 187:813–818

    Article  PubMed  CAS  Google Scholar 

  • Braud, V.M., Allan, D.S., Wilson, D., McMichael, A.J., 1998a, TAP-and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide. Curr. Biol. 8:1–10

    Article  PubMed  CAS  Google Scholar 

  • Braud, V.M., Allan, D.S., O’Callaghan, C.A., Soderstrom, K., D’Andrea, A., Ogg, G.S., Lazetic, S., Young, N.T., Bell, J.I., Phillips, J.H., Lanier, L.L., McMichael, A.J., 1998b, HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature 391:795–799

    Article  PubMed  CAS  Google Scholar 

  • Chee, M. S,, Bankier, A.T., Beck, S., Bohni, R., Brown, C.M., Cerny, R., Horsnell, T., Hutchison, C.A. 3d, Kouzarides, T., Martignetti, J.A., Preddi, E., Satchwell, S.C., Tomlinson, P., Weston, K.M., Barrell, B.G., 1990, Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169. Curr. Top. Microbiol. Immunol. 154:125–169

    PubMed  CAS  Google Scholar 

  • Cosman, D., Müllberg, J., Sutherland, C.L., Chin, W., Armitage, R., Fanslow, W., Kubin, M., and Chalupny, n.J., 2001, ULBPs, novel MHC class I-related molelcules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 14:123–133

    Article  PubMed  CAS  Google Scholar 

  • Del Val, M., Hengel, H., Häcker, H., Hartlaub, U., Ruppert, T., Lucin, P. and Koszinowski, U. H., 1992, Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment. J. Exp. Med. 172:729–738

    Google Scholar 

  • Del Val, M., Münch, K., Reddehase, M.J., Koszinowski, U.H., 1989, Presentation of cytomegalovirus immediate-early antigens to cytolytic T lymphocytes is selectively blocked by viral genes expressed in the early phase. Cell 58:305–315

    PubMed  Google Scholar 

  • Früh, K., Ahn, K., Djaballah, H., Sempe, P., van Endert, P.M., Tampe, R., Peterson, P.A., Yang, Y. 1995, A viral inhibitor of peptide transporters for antigen presentation. Nature 375:415–418

    PubMed  Google Scholar 

  • Geginat, G., Ruppert, T., Hengel, H., Holtappels, R., and Koszinowski, U.H., 1997, IFN-γ is a prerequisite for optimal antigen processing of viral peptides in vivo. J. Immunol. 158:3303–3310

    PubMed  CAS  Google Scholar 

  • Gewurz, B.E., Wang, E.W., Tortorella, D., Schust, D.J., and Ploegh, H.L., 2001, Human cytomegalovirus US2 endoplasmic reticulum domain dictates association with major histocompatibility complex class I in a locus-specific manner. J. Virol. 75:5197–5204

    Article  PubMed  CAS  Google Scholar 

  • Groh, V., Bahrain, S., Bauer, S., Herman, A., Beauchamp, M., and Spies, T., 1996, Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc. Natl. Acad. Sci. USA 93: 12445–12450

    Article  PubMed  CAS  Google Scholar 

  • Heemels, M. T., and H. L. Ploegh. Generation, translocation, and presentation of MHC class I-restricted peptides. 1995. Annu. Rev. Biochem. 64:463–491.

    Article  PubMed  CAS  Google Scholar 

  • Heise, M., Connick, M., and Virgin, H.W., 1998, Murine cytomegalovirus inhibits interferon γ-induced antigen presentation to CD4 T cells by macrophages via regulation of expression of major histocompatibility complex class II-associated genes. J. Exp. Med. 187:1037–1046

    Article  PubMed  CAS  Google Scholar 

  • Hengel, H., Brune, W., and Koszinowski, U.H. 1998, Immune evasion by cytomegalovirus — survival strategies of a highly adapted opportunist. Trends Microbiol. 6:190–197

    Article  PubMed  CAS  Google Scholar 

  • Hengel, H., Eßlinger, C., Pool, J., Goulmy, E., and Koszinowski, U.H., 1995, Cytokines restore MHC class I complex formation and control antigen presentation in human cytomegalovirus-infected cells. J. Gen. Virol. 76:2987–2997

    PubMed  CAS  Google Scholar 

  • Hengel, H., Flohr, T., Hämmerling, G.H., Koszinowski, U.H., and Momburg, F., 1996, Human cytomegalovirus inhibits peptide translocation into the endoplasmic reticulum for MHC class I assembly. J. Gen. Virol. 77:2287–2296

    PubMed  CAS  Google Scholar 

  • Hengel, H., Koopmann, J.O., Flohr, T., Muranyi, W., Goulmy, E., Hämmerling, G.J., Koszinowski, U.H., and Momburg, F., 1997. A viral ER-resident glycoprotein inactivates the MHC-encoded peptide transporter. Immunity 6:623–632

    Article  PubMed  CAS  Google Scholar 

  • Hengel, H., and Koszinowski, U.H., 1997, Interference with antigen processing by viruses. Cur. Opin. Immunol., 9:470–476

    CAS  Google Scholar 

  • Hengel, H., Lucin, P., Jonjic, S., Ruppert, T., and Koszinowski, U.H., 1994, Restoration of cytomegalovirus antigen presentation by gamma interferon combats viral escape. J. Virol. 68:289–297

    PubMed  CAS  Google Scholar 

  • Hengel, H., Reusch, U., Geginat, G., Holtappels, R., Ruppert, T., Hellebrand, E., and Koszinowski, U.H., 2000, Macrophages escapeinhibition of major histocompatibility complex class I dependent antigen presentation by cytomegalovirus. J. Virol. 74:7861–7868

    Article  PubMed  CAS  Google Scholar 

  • Hengel, H., Reusch, U., Gutermann, A., Ziegler, H., Jonjic, S., Lucin, P., and Koszinowski U.H., 1999, Cytomegaloviral control of MHC class I function in the mouse. Immunol. Rev. 168:167–176

    PubMed  CAS  Google Scholar 

  • Hewitt, E.W., Sen Gupta, S. and Lehner P.J., 2001, The human cytomegalovirus gene product US6 inhibits ATP binding by TAP. EMBO J. 20:387–396

    Article  PubMed  CAS  Google Scholar 

  • Hill, A., Jugovic, P., York, I., Russ, G., Bennink, J., Yewdell, J., Ploegh, H., Johnson, D. 1995, Herpes simplex virus turns off the TAP to evade host immunity. Nature 375:411–415

    Article  PubMed  CAS  Google Scholar 

  • Huard, B., Früh, K., 2000, A role for MHC class I down-regulation in NK cell lysis of herpes virus-infected cells. Eur. J. Immunol. 30:509–515

    PubMed  CAS  Google Scholar 

  • Jones, T.R., Hanson, L.K., Sun, L., Slater, J.S., Stenberg, R.S. and Campbell, A.E., 1995, Multiple independent loci within the human cytomegalovirus unique short region down-regulate expression of major histocompatibility complex class I heavy chains. J. Virol. 69:4830–4841

    PubMed  CAS  Google Scholar 

  • Jones, T. R. and Muzithras, V. P., 1991, Fine mapping of transcripts expressed from the US6 gene family of human cytomegalovirus strain AD169. J. Virol. 65:2024–2036

    PubMed  CAS  Google Scholar 

  • Jones, T.R., and Sun, L., 1997, Human cytomegalovirus US2 destabilizes major histocompatibility complex class I heavy chains. J. Virol. 71:2970–2979

    PubMed  CAS  Google Scholar 

  • Jones, T.R., Wiertz, E.J.H.J., Sun, L., Fish, K., Nelson, J.A. and Ploegh, H.L., 1996, Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains. Proc. Natl. Acad. Sci. USA 93:11327–11333

    PubMed  CAS  Google Scholar 

  • Jonjic, S., Del Val, M., Keil, G.M., Reddehase, M.J. and Koszinowski, U.H., 1988, A nonstmctural viral protein expressed by a recombinant vaccinia virus protects against lethal cytomegalovirus infection. J. Virol. 62:1653–1658

    PubMed  CAS  Google Scholar 

  • Jonjic, S., Mutter, W., Weiland, F., Reddehase, M.J., and Koszinowski, U.H., 1989, Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes. J. Exp. Med 169:1199–1212

    Article  PubMed  CAS  Google Scholar 

  • Jonjic, S., Pavic, I., Polic, B., Crnkovic, I., Lucin, P., and Koszinowski, U.H., 1994, Antibodies are not essential for the resolution of primary cytomegalovirus infection but limit dissemination of recurrent virus. J. Exp. Med. 179:1713–1717

    Article  PubMed  CAS  Google Scholar 

  • Jun, Y., Kim, E., Jin, M., Sung, H.C., Han, H., Geraghty, D.E., Ahn, K., 2000, Human cytomegalovirus gene products US3 and US6 down-regulate trophoblast class I MHC molecules. J. Immunol. 164:805–811

    PubMed  CAS  Google Scholar 

  • Kärre, K., 1995, Express yourself or die: peptides, MHC molecules, and NK cells. Science 267:978–979

    PubMed  Google Scholar 

  • Kaye, J., Browne, H., Stoffel, M., and Minson, T., 1992, The UL16 gene of human cytomegalovirus encodes a glycoprotein that is dispensable for growth in vitro. J. Virol. 66:6609–6615

    PubMed  CAS  Google Scholar 

  • Kleijnen M., Huppa, J.B., Lucin, P., Mukherjee, P., Farrell, H., Campbell, A., Koszinowski, U.H., Hill, A.B. and Ploegh, H.L., 1997, A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but transported to the cell surface. EMBO J. 16:685–694

    Article  PubMed  CAS  Google Scholar 

  • Krmpotic, A., Bubic, I., Hengel, H., Scalzo, A., Koszinowski, U.H., and Jonjic, S., 2001, The MCMV m152/gp40 glycoprotein achieves simultaneous avoidance of CD8+ and NK cell-mediated immune control. Abstract. International Cytomegalovirus Workshop, Asilomar, CA, USA

    Google Scholar 

  • Krmpotic, A., Messerle, M., Crnkovic-Mertens, I., Polic, B., Jonjic, S., and Koszinowski, U. H., 1999, The immunoevasive function encoded by the mouse cytomegalovirus gene m152 protects the virus against T cell conctrol in vivo. J. Exp. Med. 190:1285–1295

    Article  PubMed  CAS  Google Scholar 

  • Lee, N., Goodlett, D.R., Ishitani, A., Marquardt, H., Geraghty, D.E., 1998b, HLA-E surface expression depends on binding of TAP-dependent peptides derived from certain HLA class I signal sequences. J. Immunol. 160:4951–1960

    PubMed  CAS  Google Scholar 

  • Lehner, P.J., Karttunen, J.T., Wilkinson, G.W.G. and Cresswell, P., 1997, The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocation. Proc. Natl. Acad. Sci. USA 94:6904–6909

    Article  PubMed  CAS  Google Scholar 

  • Lindquist J.A., Jensen, O.N., Mann, M., and Hämmerling, G.J., 1998, ER-60, a chaperone with thiol-dependent reductase activity involved in MHC class I assembly. EMBO J. 17:2186–2195

    Article  PubMed  CAS  Google Scholar 

  • Lucin, P., Pavic, I., Polic, B., Jonjic, S., and Koszinowski, U.H., 1992, Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands. J. Virol. 66:1977–1984

    PubMed  CAS  Google Scholar 

  • Miller, D.M., Rahill, B.M., Boss, J.M., Lairmore, M.D., Durbin, J.E., Waldman, W.J., Sedmak, D.D., 1998, Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway. J. Exp. Med, 187:675–683

    Article  PubMed  CAS  Google Scholar 

  • Mocarski, E.S., 1996, Cytomegaloviruses and their replication. In: Virology, (B.N. Fields, D.M. Knipe, and P.M. Howley, eds.) Volume 2. Lippincott-Raven, Philadelphia; pp. 2447–2492

    Google Scholar 

  • Momburg, F. and Hämmerling, G.J., 1998, Generation and TAP-mediated transport of peptides for major histocompatibility complex class I molecules. Adv. Immunol. 68:191–256

    PubMed  CAS  Google Scholar 

  • Momburg F. and Hengel, H., 2001, Corking the bottle neck: the transporter associated with antigen processing (TAP) as a target for immune subversion by viruses. Curr. Top. Microbiol. Immunol., in press

    Google Scholar 

  • Ortmann, B., Androlewicz, M., and Cresswell, P., 1994, MHC class I / β2-microglobulin complexes associate with TAP transporters before peptide binding. Nature 368:864–867

    Article  PubMed  CAS  Google Scholar 

  • Pavic, I., Polic, B., Crnkovic, I., Lucin, P., Jonjic, S., and Koszinowski, U.H., 1993, Participation of endogenous tumour necrosis factor α in host resistance to cytomegalovirus infection. J. Gen. Virol., 74:2215–2223

    PubMed  CAS  Google Scholar 

  • Ploegh, H.L., 1998, Viral Strategies of immune evasion. Science 280:248–253.

    Article  PubMed  CAS  Google Scholar 

  • Polic, B., Hengel, H., Krmpotic, A., Trgovcich, J., Pavic, I., Lucin, P., Jonjic, S., Koszinowski, U.H., 1988, Hierarchical and redundant lymphocyte subset control precludes cytomegalovirus replication during latent infection. J. Exp. Med. 188:1047–1054

    Google Scholar 

  • Rawlinson, W.D., Farrell, H.E., Barrell, B.C., 1996, Analysis of the complete DNA sequence of murine cytomegalovirus. J. Virol. 70:8833–8849

    PubMed  CAS  Google Scholar 

  • Reddehase, M.J., Mutter, W., Münch, K., Burning, H.J., and Koszinowski, U.H., 1987, CD8 positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity. J. Virol. 61:3102–3108

    PubMed  CAS  Google Scholar 

  • Reddehase, M.J., Weiland, F., Munch, K., Jonjic, S., Lüske, A., and Koszinowki, U.H., 1985, Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs. J. Virol. 55:264–273

    PubMed  CAS  Google Scholar 

  • Reits, E.A., Vos, J.C., Gromme, M., Neefjes, J., 2000, The major substrates for TAP in vivo are derived from newly synthesized proteins. Nature 404:774–778

    Article  PubMed  CAS  Google Scholar 

  • Reusch, U., Muranyi, W., Lucin, P., Burgert, H.G., Hengel, H., and Koszinowski, U.H., 1999, A cytomegalovirus glycoprotein reroutes MHC class I complexes to lysosomes for degradation. EMBO J. 18:1081–1091

    Article  PubMed  CAS  Google Scholar 

  • Riddell, S.R., Watanabe, K.S., Goodrich, J.M., Li, C.R., Agha, M.E., and Greenberg, P.D., 1992, Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones. Science 257:238–241

    PubMed  CAS  Google Scholar 

  • Rock, K.L., and Goldberg, A.L., 1999, Degradation of cell proteins and the generation of MHC class I-presented peptides. Annu. Rev. Immunol. 17:739–779

    Article  PubMed  CAS  Google Scholar 

  • Sadasivan, B., Lehner, P.J., Ortmann B, Spies, T., and Cresswell P., 1996, Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP. Immunity 5:103–114

    Article  PubMed  CAS  Google Scholar 

  • Schust, D.J., Tortorella, D., Seebach, J., Phan, C., and Ploegh, H.L., 1998, Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11. J. Exp. Med. 188:497–503

    Article  PubMed  CAS  Google Scholar 

  • Shamu, C.E., Story, C.M., Rapoport, T.A., and Ploegh, H.L., 1999, The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate. J. Cell Biol. 147:45–57

    Article  PubMed  CAS  Google Scholar 

  • Shellam, G.R., Allan, J.E., Papadimitriou, J.M., and Bancroft, G.J., 1981, Increased susceptibility to cytomegalovirus infection in beige mutant mice. Proc. Natl. Acad. Sci. USA 78:5104–5108

    PubMed  CAS  Google Scholar 

  • Sinzger, C., Grefte, A., Plachter, B., Gouw, A.S.H., The, T.H. and Jahn, G., 1995, Fibroblasts, epithelial cells, endothelial cells and smooth muscle cells are major targets of human cytomegalovirus infection in lung and gastrointestinal tissues. J. Gen. Virol. 76:741–750

    Article  PubMed  CAS  Google Scholar 

  • Story, C.M., Furman, M.H., and Ploegh, H.L., 1999, The cytosolic tail of class I MHC heavy chain is required for its dislocation by the human cytomegalovirus US2 and US 11 gene products. Proc. Natl. Acad. Sci. USA 96:8516–8521

    Article  PubMed  CAS  Google Scholar 

  • Suh, W.K., Cohen-Doyle, M.F., Früh, K., Wang, K., Peterson, P.A., Williams, D.B., 1994, Interaction of MHC class I molecules with the transporter associated with antigen processing. Science 264:1322–1326

    PubMed  CAS  Google Scholar 

  • Thale, R., Szepan, U., Hengel, H., Geginat, G., Lucin, P., Koszinowski, U.H., 1995, Identification of the mouse cytomegalovirus genomic region affecting major histocompatibility complex class I molecule transport. J. Virol. 69:6098–6105

    PubMed  CAS  Google Scholar 

  • Tomasec, P., Braud, V.M., Rickards, C., Powell, M.B., McSharry, B.P., Gadola, S., Cerundolo. V., Borysiewicz, L.K., McMichael, A.J., Wilkinson, G.W., 2000, Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40. Science 287:1031–1033

    Article  PubMed  CAS  Google Scholar 

  • Tomazin, R., Boname, J., Hegde, N., Lewinsohn, D.M., Altschuler, Y., Jones, T.R., Cresswell, P., Nelson, J.A., Riddell, S., and Johnson, D.C., 1999, Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells. Nat. Med. 9:1039–1043.

    Google Scholar 

  • Tomazin, R., Hegde, N., and Johnson, D.C., 2001, Inhibition of MHC class I and II antigen presentation by herpesviruses. Abstract. Keystone Symposium on Molecular Aspects of Viral Immunity, Keystone, Co, USA.

    Google Scholar 

  • Tomazin, R., Hill, A.B., Jugovic, P., York, I., van Endert, P., Ploegh, H.L., Andrews, D.W., Johnson, D.C., 1996, Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP. EMBO J 15:3256–3266

    PubMed  CAS  Google Scholar 

  • Ulbrecht, M., Martinozzi, S., Grzeschik, M., Hengel, H., Ellwart, J.W., Pla, M., Weiss, E.H., 2000, Cutting edge: the human cytomegalovirus UL40 gene product contains a ligand for HLA-E and prevents NK cell-mediated lysis. J. Immunol. 164:5019–5022

    PubMed  CAS  Google Scholar 

  • Warren, A.P, Ducroq, D.H,, Lehner, P.J. and Borysiewicz, L.K., 1994, Human-cytomegalovirus-infected cells have unstable assembly of major histocompatibility complex class I complexes and are resistant to lysis by cytotoxic T lymphocytes. J. Virol. 68:2822–2829.

    PubMed  CAS  Google Scholar 

  • Welsh, R.M., Brubaker, J.O., Vargas-Cortes, M., and O’Donnell, C.L., 1991, Natural Killer (NK) cell responses to virus infections in mice with severe combined immunodeficiency. The stimulation of NK cells and the NK-dependent control of virus infections occur independently of T and B cell funtion. J. Exp. Med. 173:1053–1063

    Article  PubMed  CAS  Google Scholar 

  • Wiertz, E.J H.J., Jones, T.R., Sun, L., Bogyo, M., Geuze, H.J. and Ploegh, H.L., 1996a, The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol. Cell 84:769–779

    Article  PubMed  CAS  Google Scholar 

  • Wiertz, E.J.H.J., Tortorella, D., Bogyo, M., Yu, J., Mothes, W., Jones, T.R., Rapoport, T.A. and Ploegh, H.L., 1996b, Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. Nature 384:432–438

    Article  PubMed  CAS  Google Scholar 

  • Yamashita, Y., Shimokata, K., Mizuno, S., Yamaguchi, H. and Nishiyama, Y., 1993, Down-regulation of the surface expression of class I MHC antigens by human cytomegalovirus. Virology 193:727–736

    Article  PubMed  CAS  Google Scholar 

  • Ziegler, H., Muranyi, W., Burgert, H.-G., Kremmer, E., and Koszinowski, H.U., 2000, The luminal part of the murine cytomegalovirus glycoprotein gp40 catlayzes the retention of MHC class I molecules, EMBO J. 19:870–881

    Article  PubMed  CAS  Google Scholar 

  • Ziegler, H., R. Thäle, P. Lucin, W. Muranyi, T. Flohr, H. Hengel, H. Farell, W. Rawlinson, and U.H. Koszinowski, 1997, A mouse cytomegalovirus glycoprotein retains MHC class I complexes in the ERGIC/cis-Golgi. Immunity 6:57–66

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Viral Infections, Robert Koch-Institut, Nordufer 20, 13353, Berlin, Germany

    Albert Zimmermann, Anne Halenius & Hartmut Hengel

Authors
  1. Albert Zimmermann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anne Halenius
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hartmut Hengel
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Microscopy and Imaging Center Department of Biology Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas

    Andreas Holzenburg

  2. Institut für Klinische and Molekulare Virologie, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany

    Elke Bogner

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Zimmermann, A., Halenius, A., Hengel, H. (2002). Cytomegalovirus Glycoproteins Interacting with MHC Class I Molecules and the MHC-encoded Peptide Transporter. In: Holzenburg, A., Bogner, E. (eds) Structure-Function Relationships of Human Pathogenic Viruses. Springer, Boston, MA. https://doi.org/10.1007/0-306-47650-9_15

Download citation

  • DOI: https://doi.org/10.1007/0-306-47650-9_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46768-4

  • Online ISBN: 978-0-306-47650-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation