Tissue Engineering

  • Giovanni Abatangelo
  • Paola Brun
  • Marco Radice
  • Roberta Cortivo
  • Marcus K. H. Auth


Since cartilage has no regenerative properties, tissue engineered replacements which provide to the defect site isolated cells, alone or in conjunction with a structural scaffold of biodegradable biomaterials, allow for long-term integrated repair of the tissue and are thus indicated for the surgical treatment of arthritis, trauma, or congenital abnormalities. Chon-drocytes and mesenchymal stem cells show great potential in the development of cartilage-like tissue both in vitro and in vivo. Bioengineered in vivo tissue transplantation holds advantages over cell therapy since the presence of an ECM matrix may not only provide a stable support for cells, but also ensures that the transplanted cells remain in the treated site and act as a source for growth factors which stimulate correct cell differentiation.


Tissue Engineering Hyaluronic Acid Tissue Engineer Nonparenchymal Cell Biliary Epithelial Cell 
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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Giovanni Abatangelo
    • 1
  • Paola Brun
    • 1
  • Marco Radice
    • 1
  • Roberta Cortivo
    • 1
  • Marcus K. H. Auth
    • 2
  1. 1.Institute of Histology and Embryology, Faculty of MedicineUniversity of PadovaPadovaItaly
  2. 2.Universitätskinderklinik, Abteilung Al-lgemeine Kinderheilkunde mit Schwerpunkt, NeuropädiatrieKlinikum der Universitäts-GesamthochschuleEssenGermany

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