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Tissue Engineering

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Integrated Biomaterials Science

Conclusions

Since cartilage has no regenerative properties, tissue engineered replacements which provide to the defect site isolated cells, alone or in conjunction with a structural scaffold of biodegradable biomaterials, allow for long-term integrated repair of the tissue and are thus indicated for the surgical treatment of arthritis, trauma, or congenital abnormalities. Chon-drocytes and mesenchymal stem cells show great potential in the development of cartilage-like tissue both in vitro and in vivo. Bioengineered in vivo tissue transplantation holds advantages over cell therapy since the presence of an ECM matrix may not only provide a stable support for cells, but also ensures that the transplanted cells remain in the treated site and act as a source for growth factors which stimulate correct cell differentiation.

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References

  • Abatangelo, G., Brun, P., Cortivo, R. 1994. Hyaluronan (Hyaluronic acid): an overview, in: Novel Biomaterials Based on Hyaluronic Acid and Its Derivatives (D.F. Williams, ed.), pp. 8–18, Proceedings of a Workshop Held at the Annual Meeting of the European Society for Biomaterials, Pisa, Italy.

    Google Scholar 

  • Adams, J.C., Watt, F.M. 1989. Fibronectin inhibits the terminal differentiation of human keratinocytes, Nature 340, 307–309.

    Article  Google Scholar 

  • Adams, J.C., Watt, F.M. 1993. Regulation of the development and differentiation by extracellular matrix, Development 117, 1183–1198.

    Google Scholar 

  • Aigner, J., Tegeler, J., Hutzler, P., Campoccia, D., Pavesio, A., Hammer, C., Kastenbauer, E., Naumann, A. 1998. Cartilage tissue engineering with novel nonwoven structured bio-material based on hyaluronic acid benzyl ester, J. Biomed. Mater. Res. 42, 172–181.

    Article  Google Scholar 

  • Andreassi, L., Casini, L., Trabucchi, E., Diamantini, S., Rastrelli, A., Donati, L., Tenchini, M.L., Malcovati, M. 1991. Human keratinocytes cultured on membranes composed of benzyl ester of hyaluronic acid suitable for grafting, Wounds 3, 116–126.

    Google Scholar 

  • Andreassi, L., Pianigiani, E., Andreassi, A., Taddeucci, P., Biagioli, M. 1998. A new model of epidermal culture for the surgical treatment of vitiligo, Int. J. Dermatol. 37, 595–598.

    Article  Google Scholar 

  • Angele, P., Nerlich, A., Kujat, R., Faltermeier, H., Moller, H.D., Weigel, B., Nerlich, M. 1998. Chondrocyte differentiation in fibrin-coating on polytetrafluorethylene membranes, in: Biological Matrices and Tissue Regeneration (G.B. Stark, R. Horch, E. Tanczos, eds.), pp. 173–177, Springer-Verlag Berlin, Heidelberg.

    Google Scholar 

  • Argraves, W.S., Tran, H., Burgess, W.H., Dickerson, K. 1990. Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure, J. Cell Biol. 111, 3155–3164.

    Article  Google Scholar 

  • Arias, I.M., Boyer, J.L., Fausto, N., Jakoby, W.B., Schachter, D.A., Shafritz, D.A. 1994. The Liver: Biology and Pathobiology, 3rd edn., Raven Press, New York.

    Google Scholar 

  • Ashammakhi, N., Rokkanen, P. 1997. Absorbable polyglycolide devices in trauma and bone surgery, Biomaterials 18, 3–9.

    Article  Google Scholar 

  • Auger, F.A., Lopez Valle, C.A., Guignard, R., Thremblay, N., Noel, B., Goulet, F., Germain, L. 1995. Skin equivalent produced with human collagen, In Vitro Cell. Dev. Biol. Animal 31, 432–439.

    Article  Google Scholar 

  • Auth, M.K.H., Joplin, R., Fabris, L., Keogh, A., Gallacher, R.E, Neuberger, J.M., McMaster, P., Strain, A.J. 1995a. Structural and functional studies of human hepatocytes and biliary epithelial cells cocultured in collagen gels, Hepatology 22(4), 215–A.

    Google Scholar 

  • Auth, M.K.H., Joplin, R., Wallace, L., Keogh, A., Wilton, J.A., Strain, A.J. 1995b. Coculture of human biliary epithelial cells and hepatocytes in collagen gels, FASEB J. 9(Pt II), A–852.

    Google Scholar 

  • Auth, M.K.H., Sadamoto, T., Okamoto, M., Joplin, R., Neuberger, J.M., Strain, A.J. 1996. Proliferation and formation of polarised luminal ducts by human biliary epithelial cells in vitro, Hepatology 24(4), II, 129–A.

    Google Scholar 

  • Baragi, V.M., Renkievicz, R.R., Jordan, H., Bonadio, J., Hartman, J.W, Roessler, B.J. 1995. Transplantation of transduced chondrocytes protects articular cartilage from interleukin-1 induced extracellular matrix degradation, J. Clin. Invest. 96, 2454–2460.

    Article  Google Scholar 

  • Barbucci, R., Magnani, A., Da Costa, M.L., Bauser, H., Hellwig, G., Martuscelli, E., Cimmino, S. 1993. Physico-chemical surface characterization of hyaluronic acid derivatives as a new class of biomaterials, J. Biomater. Sci. Polym. Ed. 4(3), 245–273.

    Article  Google Scholar 

  • Barry, F.P., and Murphy, J.M. 2000. Chondrogenic differentiation of mesenchymal stem cells on matrices of hyaluronan derivatives, in: New Frontiers in Medical Sciences: Redefining Hyaluronan (G. Abatangelo and P.H. Weigel, (eds.) pp. 247–253, Elsevier Science.

    Google Scholar 

  • Benedetti, L., Cortivo, R., Berti, T., Pea, F., Mazzo, M., Moras, M., Abatangelo, G. 1993. Biocompatibility and biodegradation of different hyaluronan derivatives (Hyaff) implanted in rats, Biomaterials 14(15), 1154–1160.

    Article  Google Scholar 

  • Benya, P.D., Padilla, S.R., Nimni, M.E. 1977. The progeny of rabbit articular chondrocytes synthesize collagen type I and type III and type I trimer, but not type II: verifications by cyanogen bromide peptide analysis, Biochemistry 16, 865–872.

    Article  Google Scholar 

  • Benya, P.D., Padilla, S.R. 1986. Modulation of the rabbit chondrocyte by retinoic acid terminates type II collagen synthesis without including type I collagen: the modulated phenotype differs from that produced by subculture, Dev. Biol. 118(1): 296–305.

    Article  Google Scholar 

  • Bernfield, M., Sanderson, R.D. 1990. Syndecan, a developmentally regulated cell surface proteoglycan that binds extracellular matrix and growth factors. Phil. Trans. R. Soc. Lond., Ser. B 327, 171–186.

    Article  Google Scholar 

  • Billingham, R.E., Reynolds, J. 1952. Transplantation studies on sheets of pure epidermal epithelium and on epidermal cell suspensions. Br. J. Plast. Surg. 5, 25–36.

    Article  Google Scholar 

  • Block, G., Locker, J., Bowen, W.C., Peterson B.E., Katyal, S., Strom, S.C., Riley, T., Howard, T.A., Michalopoulos, G.K. 1996. Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and in a chemically defined (HGM) medium, J. Cell Biol. 132(6), 1133–1149.

    Article  Google Scholar 

  • Boyce, S.T., Christianson, D., Hansbrough, J.F.1988. Structure of a collagen-GAG skin substitute optimized for cultured human epidermal keratinocytes, J. Biomed. Mater. Res., 22, 939–957.

    Google Scholar 

  • Breitbart, A.S., Grande, D.A., Kessler, R., Ryaby, J.T., Fitzsimmons, R.J., Grant, R.T. 1998. Tissue engineered bone repair of calvarial defects using cultured periosteal cells, Plast. Reconstr. Surg. 101, 567–574.

    Article  Google Scholar 

  • Brekke, J.H. 1996. A rationale for delivery of osteoinductive proteins, Tissue Eng. 2, 97–114.

    Article  Google Scholar 

  • Brittberg, M., Lindahl, A., Nilsson, A., Ohlsson, C., Isaksson, O., Peterson, L. 1994a. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation, N. Engl. J. Med. 331, 889–895.

    Article  Google Scholar 

  • Brittberg, M., Faxen, E., Peterson, L. 1994b. Carbon fiber scaffolds in the treatment of early knee osteoarthritis, a prospective 4-year follow-up of 37 patients, Clin. Orthop. 307, 155–164.

    Google Scholar 

  • Brun, P., Abatangelo, G., Radice, M., Zacchi, V., Guidolin, D., Daga-Gordini, D., Cortivo, R. 2000. Chondrocyte aggregation and reorganization into three-dimensional scaffolds, J. Biomed. Mater. Res. 46, 337–346.

    Article  Google Scholar 

  • Burgess, E.A., Hollinger, J.O. 1998. Options for tissue engineering bone, in: Frontiers in Tissue Engineering (C.W. Patrick, Jr., A.G. Mikos, L.V. McIntire, eds.), pp. 383–399, Pergamon, New York.

    Chapter  Google Scholar 

  • Butnariu-Ephrat, M., Robinson, D., Mendes, D.G., Halperin, N., Nevo, Z. 1996. Resurfacing of goat articular cartilage by chondrocytes derived from bone marrow, Clin. Orthop. Relat. Res. 330, 234–243.

    Article  Google Scholar 

  • Buttermann, G.R., Glazer, P.A., Bradford, D.S. 1996. The use of bone allografts in the spine, Clin. Orthop. Relat. Res. 324, 75–85.

    Article  Google Scholar 

  • Campoccia, D., Doherty, P., Radice, M., Brun, P., Abatangelo, G., Williams, D.F. 1998. Semisynthetic resorbable materials from hyaluronan derivatization, Biomaterials 19, 2101–2127.

    Article  Google Scholar 

  • Caplan, A.I. 1991. Mesenchymal stem cells, J. Orthop. Res. 9(5), 641–650.

    Article  Google Scholar 

  • Caplan, A.I. 1994. The mesengenic process, Bone Rep. Reg. 21, 429–435.

    Google Scholar 

  • Caplan, A.I., Elyaderani, M., Mochizuki, Y., Wakitani, S., Goldberg, V.M. 1997. Principles of cartilage repair and regeneration, Clin. Orthop. Relat. Res. 342, 254–269.

    Article  Google Scholar 

  • Chu, C.R., Coutts, R.D., Yoshioka, M., Harwood, F.L., Monsov, A.Z., Amiel, D. 1995. Articular cartilage repair using allogenic perichondrocyte-seeded biodegradable porous polylactic acid (PLA): a tissue-engineering study, J. Biomed. Mater. Res. 29, 1147–1154.

    Article  Google Scholar 

  • Clark, E.A., Brugge, J.S. 1995. Integrins and signal transduction pathways: the road taken, Science 268, 233–239.

    Article  Google Scholar 

  • Clement, B., Laurent, M., Guguen-Guillouzo, C., Lebeau, G., Guillouzo, A. 1988a. Types I and IV procollagen gene expression in cultured rat hepatocytes, Collagen Relat. Res. 8, 349–359.

    Google Scholar 

  • Clement, B., Rescan, P.Y., Baffet, G., Loreal, O., Lehry, D., Campion, J.P., Guillouzo, A. 1988b. Hepatocytes may produce laminin in fibrotic liver and in primary culture, Hepatology 8(4), 794–803.

    Article  Google Scholar 

  • Clement, B., Guguen-Guillouzo, C., Campion, J.P., Launois, B., Nicol, M. 1994. Long-term co-cultures of adult human hepatocytes with rat liver epithelial cells: modulation of albumin secretion and accumulation of extracellular material, Hepatology 4(3), 373–380.

    Article  Google Scholar 

  • Cook, S.D., Dalton, J.E., Tan, E.H., Whitecloud, T.S., Rueger, D.C. 1994. In vivo evaluation of recombinant human osteogenic protein (rhOP-1) implants as a bone graft substitute for spinal fusions, Spine 19, 1655–1663.

    Article  Google Scholar 

  • Corlu, A., Kneip, B., Lhadi, C., Leray, G., Glaise, D., Baffet, G., Bourel, D., Guguen-Guillouzo, C. 1991. A plasma membrane protein is involved in cell contact-mediated regulation of tissue-specific genes in adult hepatocytes, J. Cell Biol. 225(2), 505–515.

    Article  Google Scholar 

  • Cortivo, R., De Galateo, A., Castellani, I., Brun, P., Giro, M.G., Abatangelo, G. 1990. Hyaluronic acid promotes chick embryo fibroblast and chondroblast expression, Cell Biol. Int. Rep. 14, 111–122.

    Article  Google Scholar 

  • Cortivo, R., Brun, P., Rastrelli, A., Abatangelo, G. 1991. In vitro studies on biocompatibility of hyaluronic acid esters, Biomaterials 12, 727–730.

    Article  Google Scholar 

  • Damsky, C., Sutherland, A., Fisher, S. 1993. Extracellular matrix 5: Adhesive interactions in early mammalian embryogenesis, implantation and placentation, FASEB J. 7, 1320–1329.

    Google Scholar 

  • Damsky, C.H., Werb, Z. 1992. Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information, Curr. Opin. Cell Biol. 4, 772–781.

    Article  Google Scholar 

  • Dichek, D.A., Anderson, J., Kelly, A.B., Hanson, S.R., Harker, L.A. 1996. Enhanced in vivo antithrombotic effects of endothelial cells expressing recombinant plasminogen activators transduced with retroviral vectors, Circulation 93, 301–309.

    Google Scholar 

  • Diener, B., Beer, N., Durk, H., Traiser, M., Utesch, D., Wieser, R.J., Oesch, F. 1994. Gap junctional intercellular communication of cultured rat-liver parenchymal-cells is stabilized by epithelial-cells and their isolated plasma-membranes, Experientia 50(2), 124–126.

    Article  Google Scholar 

  • Dixon, K.P., Murphy, R.W., Southerland, S.S., Young, H.E., Lucas, P.A. 1996. Recombinant human bone morphogenetic proteins-2 and-4 induce several mesenchymal phenotypes in culture, Wound Rep. Reg. 4, 374–380.

    Article  Google Scholar 

  • Drumheller, P.D., Hubbell, J.A. 1995. Surface immobilization of adhesion ligands for investigations for cell-substrate interactions, in: Biomedical Engineering Handbook (J.D. Bronzino, ed.), pp. 1583–1596, CRC Press, Boca Raton.

    Google Scholar 

  • Dunn, J.C., Yarmush, M.L., Koebe, H.G., Tompkins, R.G. 1989. Hepatocyte function and extracellular matrix geometry: long-term culture in a sandwich configuration, FASEB J. 3, 174–177.

    Google Scholar 

  • Dunn, J.C., Tompkins, R.G., Yarmush, M.L. 1992. Hepatocytes in collagen sandwich: evidence for transcriptional and translational regulation, J. Cell Biol. 116(4), 1043–1053.

    Article  Google Scholar 

  • Eming, S.A., Lee, J., Snow, R.G., Tompkins, R.G., Yarmush, M.L., Morgan, J.R. 1995. Genetically modified human epidermis over-expressing PDGF-A directs the development of a cellular and vascular connective tissue stroma when transplanted to athymic mice, J. Invest. Dermatol. 105, 756–763.

    Article  Google Scholar 

  • Eming, S.A., Snow, R.G., Yarmush, M.L., Morgan, J.R. 1996. Targeted expression of IGF-1 to human keratinocytes: modification of autocrine control of keratinocyte proliferation, J. Invest. Dermatol. 107, 113–120.

    Article  Google Scholar 

  • Engel, J. 1989. EGF-like domains in extracellular matrix proteins: localised signals for growth and differentiation, FEBS Lett. 251, 1–7.

    Article  Google Scholar 

  • Ezzell, R.M., Toner, M., Hendricks, K., Dunn, J.C., Tompkins, R.G., Yarmush, M.L.1993. Effect of collagen gel configuration on the cytoskeleton in cultured rat hepatocytes, Exp. Cell Res. 208, 442–452.

    Google Scholar 

  • Falanga, V., Margolis, D., Alvarez, O., Auletta, M., Maggiacomo, F., Altman, M., Jensen, J., Sabolinsky, M., Hardin-Young, J. 1998. Rapid healing of venous ulcers and lack of clinical rejection with allogeneic cultured human skin equivalent, Arch. Dermatol. 134, 293–300.

    Article  Google Scholar 

  • Ferns, M., Hoch, W., Campanelli, J. T, Rupp, F., Hall, Z.W., Scheller, R.H. 1992. RNA splicing regulates agrin-mediated acetylcholine receptor clustering activity on cultured myotubes, Neuron 8, 1079–1086.

    Article  Google Scholar 

  • Freed, L.E., Marquuis, L.J., Nohria, A., Emmanual, J., Mikos, A.G., Langer, R. 1993. Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers, J. Biomed. Mater. Res. 27, 11–23.

    Article  Google Scholar 

  • Freed, L.E., Grande, D.A., Lingbin, Z., Emmanual, J., Marquis, J.C., Langer, R. 1994. Joint resurfacing using allograft chondrocytes and synthetic biodegradable polymer scaffolds, J. Biomed. Mater. Res. 28, 891–899.

    Article  Google Scholar 

  • Fujisato, T., Sajiki, T., Liu, Q., Ikada, Y. 1996. Effect of basic fibroblast growth factor on cartilage regeneration in chondrocyte-seeded collagen sponge scaffold, Biomaterials 17, 155–162.

    Article  Google Scholar 

  • Fusenig, N.E. 1994. Epithelial-mesenchymal interactions regulate keratinocyte growth and differentiation in vitro, in: The Keratinocyte Handbook (I. Leigh, B. Lane, F.M. Watt, eds.), pp. 71–94, Cambridge University Press, Cambridge.

    Google Scholar 

  • Galassi, G., Brun, P., Radice, M., Cortivo, R., Zanon, G.F., Genovese, P., Abatangelo, G. 2000. In vitro reconstructed dermis implanted in human wounds: degradation studies of the HA-based supporting scaffold, Biomaterials 21, 2183–2191.

    Article  Google Scholar 

  • Gallico, G.G., III, O’connor N.E., Compton, C.C., Kehinde, O., Green, H. 1984. Permanent coverage of large burn wounds with autologous cultured human epithelium, New Engl. J. Med. 311, 448–451.

    Article  Google Scholar 

  • Gallico, G.G., III, Compton, C.C., Remensnyder, J.P., Kehinde, O., Green, H. N.E., 1989. Cultured epithelial autografts for giant congenital nevi, Plast. Reconstr. Surg. 84 1–9.

    Article  Google Scholar 

  • Gerrad, A.J., Hudson, D.J., Brownlee, G.G., Watt, F.M. 1993. Gene therapy for haemophilia B using primary human keratinocytes, Nature 3, 180–183.

    Google Scholar 

  • Giusti, P., Callegaro, L. 1994. World patent Application No. WO 94/ 01468.

    Google Scholar 

  • Gomez-Lechon, M.J., Castelli, J., Guillen, I., Nakamura, T., Fabra, R., Trullenque, R. 1995. Effect of hepatocyte growth factor on the growth and metabolsim of human hepatocytes in primary culture, Hepatology 21, 1248–1254.

    Google Scholar 

  • Gooch, K.J., Blunk, T., Vunjak-Novakovic, G., Langer, R., Freed, L., Tennant, C.J. 1998. Mechanical forces and growth factors utilized in tissue engineering, in: Frontiers in Tissue Engineering (C.W. Patrick, Jr., A.G. Mikos, L.V. McIntire, eds.), pp. 61–82, Pergamon, New York.

    Chapter  Google Scholar 

  • Goulet, F., Normand, C., Morin, O. 1988. Cellular interactions promote tissue-specific function, biomatrix deposition and junctional communication of primary cultured hepatocytes, Hepatology 8(5), 1010–1018.

    Article  Google Scholar 

  • Green, H. 1977. Terminal differentiation of cultured epidermis cells,Cell 11, 405–416.

    Article  Google Scholar 

  • Gressner, A.M., Lahme, B., Brenzel, A. 1995. Molecular dissection of the mitogenic effect of hepatocytes on cultured hepato-stellate cells, Hepatology 22, 1507–1518.

    Article  Google Scholar 

  • Grigoriadis, A.E., Heersche, J.N.M., Aubin, J.E. 1988. Differentiation of muscle, fat, cartilage and bone from progenitor cells present in a bone-derived clonal cell population: effect of dexamethasone, J. Cell Biol. 106, 2139–2151.

    Article  Google Scholar 

  • Guguen-Guillouzo, C, Clement, B., Baffet, G., Beaumont, C., Morel-Chany, E., Glaise, D., Guillouzo, A. 1983. Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type, Exp. Cell Res. 143, 47–54.

    Article  Google Scholar 

  • Guguen-Guillouzo, C., Clement, B., Lescoat, G., Glaise, D., Guillouzo, A. 1984. Modulation of human fetal hepatocytes survival and differentiation by interactions with a rat liver epithelial cell line, Dev. Biol. 105, 211–230.

    Article  Google Scholar 

  • Guillouzo, A., Delers, F., Clement, B., Bernard, N., Engler, R. 1984. Long term production of acute-phase proteins by adult rat hepatocytes co-cultured with another liver cell type in serum-free medium, Biochem. Biophys. Res. Commun. 120(2), 311–317.

    Article  Google Scholar 

  • Gumbiner, B.M. 1996. Cell adhesion: The molecular basis of tissue architecture and morphogenesis, Cell 84, 345–357.

    Article  Google Scholar 

  • Haisch, A., Rathert, T., Schultz, O., Janke, V., Burmester, G.R., Sittinger, M. 1998. In vitro engineered cartilage for reconstructive surgery, using biocompatible, resorbable fibrin glue/polymer structures, in: Frontiers of Tissue Engineering (C.W. Patrick, A.G. Mikos, L.V. McIntire, eds.), pp. 179–187, Pergamon, New York.

    Google Scholar 

  • Hansbrough, J.F., Morgan, J., Greenleaf, G. 1993. Advances in wound coverage using cultured cell technology, Wounds 5, 174–194.

    Google Scholar 

  • Hardingham, T.E., Forsang, A.J. 1992. Proteoglycans: many forms and functions. FASEB J. 6, 861–870.

    Google Scholar 

  • Harris, P.A. 1998. Pre-confluent keratinocyte grafting: the future for cultured skin replacements? Burns 24, 591–593.

    Article  Google Scholar 

  • Harris, P.A., di Francesco, F., Barisoni, D., Leigh, I.M., Navsaria, H.A. 1999. Use of hyaluronic acid and cultured autologous keratinocytes and fibroblasts in extensive burns, Lancet 353, 35–36.

    Article  Google Scholar 

  • Hemler, M.E. 1990. VLA proteins in the integrin family: structures, functions and their role on leukocytes, Annu. Rev. Immunol. 8, 365–400.

    Article  Google Scholar 

  • Hemmen, B., Archer, C.W., Bentley, G. 1991. Repair of articular cartilage defects by carbon fiber plugs loaded with chondrocytes, Trans. Orthop. Res. Soc. 16, 278.

    Google Scholar 

  • Hollinger, J.O., Brekke, J.B., Gruskin, E., Lee, D. 1996. Role of bone substitutes, Clin. Orthop. Relat. Res. 324, 55–65.

    Article  Google Scholar 

  • Horton, W.A., Machado, M.A., Ellard, J., Campbell, D., Puttam, E.A., Aulthause, A.L., Sun, X., Sandell, L.J. 1993. An experimental model of human chondrocyte differentiation, Prog. Clin. Biol. Res. 383B, 533–540.

    Google Scholar 

  • Hu, M.Y., Cipolle, M., Sielaff, T., Lovdahl, M.J., Mann, H.J., Remmel, R.P., Cerra, F.B. 1995. Effects of hepatocyte growth factor on viability and biotransformation functions of hepatocytes in gel entrapped and monolayer, Crit. Care Med. 23, 1237–1242.

    Article  Google Scholar 

  • Hunziker, E.B., Rosenberg, L. 1994. Induction of repair in partial thickness articular lesion by timed release of TGF-β, Trans. Orthop. Res. Soc. 19, 236.

    Google Scholar 

  • Hynes, R.O. 1992. Integrins: versatility, modulation and signalling in cell adhesion, Cell 69, 11–25.

    Article  Google Scholar 

  • Iyoda, K., Miura, T., Nogami, H. 1993. Repair of bone defect with cultured chondrocytes bound to hydroxyapatite, Clin. Orthop. Relat. Res. 288, 287–293.

    Google Scholar 

  • James, N.H., Molloy, C., Soames, A.R., French, N.J., Roberts, R.A. 1992. An in vitro model of rodent nongenotoxic hepatocarcinogenesis, Exp. Cell Res. 203, 407–419.

    Article  Google Scholar 

  • Joplin, R., Hishida, T., Tsubouchi, H., Daikuhara, Y., Ayres, R., Neuberger, J.M., Strain, A.J. 1992. Human biliary epithelial cells proliferate in vitro in response to human hepatocyte growth factor, J. Clin. Invest. 90, 1284–1289.

    Article  Google Scholar 

  • Kaiser, H.W., Stark, G.B., Kopp, J., Balcerkiewicz, A., Spilker, G., Kreysel, H.W. 1994. Cultured autologous keratinocytes in fibrin glue suspension, exclusively and combined with STS-allograft (preliminary clinical and histological report on a new technique, Burns 20, 23–29.

    Article  Google Scholar 

  • Karin, M. 1992. Signal transduction from cell surface to nucleus in development and disease, FASEB J. 6, 2581–2590.

    Google Scholar 

  • Kasugai, S., Todescan, R., Jr., Nagata, T., Yao, K.L., Butler, W.T., Sodek, J. 1991. Expression of bone matrix proteins associated with mineralized tissue formation by adult rat bone marrow cells in vitro: inductive effects of dexamethasone on the osteoblastic phenotype, J. Cell Physiol. 147, 111–120.

    Article  Google Scholar 

  • Kawamura, S., Wakitani, S., Kimura, T., Maeda, A., Caplan, A.I., Shino, K., Ochi, T. 1998. Articular cartilage repair, Acta Orthop. Scand. 69(1), 56–62.

    Google Scholar 

  • Kim, W.S., Vacanti, J.P., Cima, L.G., Mooney, D., Upton, J., Puelacher, W.C. 1994. Cartilage engineered in predetermined shapes employing cell transplantation on synthetic biodegradable polymers, Plast. Reconstr. Surg. 94, 233–237.

    Google Scholar 

  • Klagsbrun, M. 1990. The affinity of FGF for heparin: FGF-heparan sulphate interactions in cells and extracellular matrix, Curr. Opin. Cell Biol. 2, 857–863.

    Article  Google Scholar 

  • Knudson, C.B., Knudson, W. 1990. Similar epithelial-stromal interactions in the regulation of hyaluronate production during limb morphogenesis and tumor invasion, Cancer Lett. 52, 113–122.

    Article  Google Scholar 

  • Kolettas, E., Buluwela, L., Bayliss, M.T., Muir, H.I. 1995. Expression of cartilage-specific molecules is retained on long term culture of human chondrocytes, J. Cell Sci. 108, 1991–1999.

    Google Scholar 

  • Lamme, E.N., De Vries, H.J.C., Van Veen, H., Gabbiani, G., Westerhof, W., Middelkoop, E. 1996. Extracellular matrix characterization during healing of full-thickness wounds treated with a collagen/elastin dermal substitute shows improved skin regeneration in pigs, J. Histochem. Cytochem. 44, 1311–1322.

    Google Scholar 

  • Lazarus, H.M., Haynesworth, S.E., Gerson, S.L., Rosenthal, N.S., Caplan, A.I. 1995. Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use, Bone Marrow Transplant. 16, 557–564.

    Google Scholar 

  • Leigh, I.M. 1994. Keratinocyte autografting, allografting and wound healing, in: The Keratinocyte Handbook (I. Leigh, B. Lane, F.M. Watt, eds.), pp. 503–511, Cambridge University Press, Cambridge.

    Google Scholar 

  • Leigh, I.M., Watt, F.M. 1994. The culture of human epidermal keratinocytes, in: The Keratinocyte Handbook (I. Leigh, B. Lane, F.M. Watt, eds.), pp. 43–51, Cambridge University Press, Cambridge.

    Google Scholar 

  • Lescoat, G., Pasdeloup, N., Kneip, B., Guguen-Guillouzo, G. 1987. Modulation of alphafetoprotein, albumin and transferrin gene expression by cellular interactions and dexamethasone in cocultures of fetal rat hepatocytes, Eur. J. Cell Biol. 44(1), 128–134.

    Google Scholar 

  • Liebergall, M., Young, R.G., Ozawa, H. 1994. The effects of cellular manipulation and in a composite bone graft, in: Bone Formation and Repair (C.T. Brighton, G. Friedlaender, J.M. Lane, eds.), pp. 367–378, American Academy of Orthopaedic Surgeons, Rosemont.

    Google Scholar 

  • Limat, A., Mauri, D., Hunziker, T. 1996. Successful treatment of chronic leg ulcers with epidermal equivalents generated from cultured autologous outer root sheath cells, J. Invest. Dermatol. 107, 128–135.

    Article  Google Scholar 

  • Limova, M., Mauro, T. 1995. Treatment of leg ulcers with cultured epithelial autografts: treatment protocol and five year experience, Wounds 7, 170–180.

    Google Scholar 

  • Lin, C.Q., Bissell, M.J. 1993. Multi-faceted regulation of cell differentiation by extracellular matrix, FASEB J. 7, 737–743.

    Google Scholar 

  • Loreal, O., Levavasseur, F., Fromaget, C., Gros, D., Guillouzo, A., Clement, B. 1993. Cooperation of Ito cells and hepatocytes in the deposition of an extracellular matrix in vitro, Am. J. Pathol. 143(2), 538–544.

    Google Scholar 

  • MacKenzie, I. 1994. Epithelial-mesenchymal interactions in the development and maintenance of epithelial tissues, in: The Keratinocyte Handbook (I. Leigh, B. Lane, F.M. Watt, eds.), pp. 243–257, Cambridge University Press, Cambridge.

    Google Scholar 

  • Mankin, H.J., Gebhardt, M.C., Jennings, L.C., Springfield, D.S., Tomford, W.W. 1996. Long-term results of allograft replacement in the management of bone tumors, Clin. Orthop. Relat. Res. 324, 86–97.

    Article  Google Scholar 

  • Mantalaris, A., Keng, P., Bourne, P., Chang, A.Y., Wu, J.H. 1998. Engineering a human bone marrow model: a case study on ex vivo erythropoiesis, Biotechnol. Prog. 14, 126–133.

    Article  Google Scholar 

  • Martin, P. 1997. Wound healing-Aiming for perfect skin regeneration, Science 276, 75–81.

    Article  Google Scholar 

  • Maslen, C.L., Corson, G.M., Maddox, B.K., Glanville, R.W., Sakai, L.Y. 1991. Partial sequence of a candidate gene for the Marfan syndrome, Nature 352, 334–337.

    Article  Google Scholar 

  • Mayhew, T.A., Williams, G.R., Senica, M.A., Kuniholm, G., du Moulin, G.C. 1998. Validation of a quality assurance program for autologous cultured chondrocyte implantation, Tissue Eng. 4(3), 325–334.

    Article  Google Scholar 

  • McPherson, D.T., Morrow, C., Minehan, D.S., Wu, J.G., Hunter, E., Urry, D.W. 1992. Production and purification of a recombinant elastomeric peptide G(VPGVG)19VPGV from Escherichia Coli, Biotech. Prog. 8, 347–352.

    Article  Google Scholar 

  • Mesnil, M., Fraslin, J.M., Piccoli, C., Yamasaki, H., Guguen-Guillouzo, C. 1987. Cell contact but not junctional communication (dye coupling) with biliary epithelial cells is required for hepatocytes to maintain differentiated functions, Exp. Cell Res. 173, 524–533.

    Article  Google Scholar 

  • Messner, K., Gillquist, J. 1996. Cartilage repair, Acta Orthop. Scand. 67, 523–529.

    Google Scholar 

  • Michalopoulos, G., Russell, F., Biles, C. 1979. Primary cultures of hepatocytes on human fibroblasts, In Vitro 15(10), 796–806.

    Google Scholar 

  • Mooney, D., Hansen, L., Vacanti, J., Langer, R., Farmer, S., Ingber, D. 1992. Switching from differentiation to growth in hepatocytes: control by extracellular matrix, J. Cell Physiol. 151, 497–505.

    Article  Google Scholar 

  • Morgan, J.R., Yarmush, M.L. 1998. Gene therapy in tissue engineering, in: Frontiers in Tissue Engineering (C. W. Patrick, Jr., A.G. Mikos, L.V. McIntire, eds.), pp. 278–310, Pergamon, New York.

    Chapter  Google Scholar 

  • Morgan, J.R., Barrandon, Y., Green, H., Mulligan, R.C. 1987. Transfer and expression of foreign genes in transplantable human epidermal cells, Science 237, 1476–1479.

    Article  Google Scholar 

  • Moriarty, K.P., Crombleholme, T.M., Gallivan, E.K., O’Donnell, C. 1996. Hyaluronic acid-dependent pericellular matrices in fetal fibroblasts: implication for scar-free wound repair, Wound Rep. Reg. 4, 346–352.

    Article  Google Scholar 

  • Morin, O., Normand, C. 1986. Long-term maintenance of hepatocyte functional activity in co-culture: requirements for sinusoidal endothelial cells and dexamethasone, J. Cell Physiol. 129, 103–110.

    Article  Google Scholar 

  • Mundy, G.R. 1996. Regulation of bone formation by bone morphogenetic proteins and other growth factors, Clin. Orthop. Relat. Res. 323, 24–28.

    Article  Google Scholar 

  • Murphy, G.F., Orgill, D.P., Yannas, I.V. 1990. Partial dermal regeneration is induced by biodegradable collagen-glycosaminoglycans graft, Lab. Invest. 63, 305–313.

    Google Scholar 

  • Musat, A.I., Sattler, C.A., Sattler, G.L., Pitot, H.C. 1993. Reestablishment of cell polarity of rat hepatocytes in primary culture, Hepatology 18, 198–205.

    Article  Google Scholar 

  • Myers, S.R., Grady, J., Soranzo, C., Sanders, R., Green, C., Leigh, I.M., Navsaria, H.A. 1997. A hyaluronic acid membrane delivery system for cultured keratinocytes: clinical “take” rates in the porcine kerato-dermal model, J. Burn Care Rehabil. 18, 214–222.

    Article  Google Scholar 

  • Nevo, Z., Robinson, D., Horowitz, S., Hasharoni, A., Yayon, A. 1998. The manipulated mesenchymal stem cells in regenerated skeletal tissues, Cell Transplant. 7, 63–70.

    Article  Google Scholar 

  • Niedzwiedzki, T., Dabrowski, Z., Miszta, H., Pawlikowski, M. 1993. Bone healing after bone marrow stromal cell transplantation to the bone defect, Biomaterials 14, 115–121.

    Article  Google Scholar 

  • Nyberg, S.L., Remmel, R.P., Mann, H.J., Peshwa, M.V., Hu, W.S., Cerra, F.B. 1994. Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver, Ann. Surg. 220(1), 59–67.

    Google Scholar 

  • Oksala, O., Salo, T., Tammi, R., Hakkinen, L., Jalkanen, M., Inki, P., Larjava, H. 1995. Expression of proteoglycans and hyaluronan during wound healing, J. Histochem. Cytochem. 43, 125–135.

    Google Scholar 

  • Okumura, M., Ohgushi, H., Takakura, Y., van Blitterswijk, C.A., Koerten, H.K. 1992. Analysis of primary bone formation in porous alumina: a fluorescence and scanning electron microscopic study of marrow cell induced osteogenesis, Biomed. Mater. Eng. 2, 191–201.

    Google Scholar 

  • Orgill, D.P., Yannas, I.V. 1997. Design of an artificial skin. IV. Use of island graft to isolate organ regeneration from scar synthesis and other processes leading to skin wound closure, J. Biomed. Mater. Res. 39, 531–535.

    Article  Google Scholar 

  • Park, S.-H., Linás, A., Goel, V.K., Keller, J.C. 1995. Hard tissue replacements, in: The Biomedical Engineering Handbook (J.D. Bronzino, ed.), pp. 672–703, CRC Press, Boca Raton.

    Google Scholar 

  • Prockop, D.J. 1997. Marrow stromal cells as stem cells for non hematopoietic tissues, Science 276, 71–74.

    Article  Google Scholar 

  • Puelacher, W.C., Kim, W., Vacanti, J.P., Schloo, B., Mooney, D., Vacanti, C.A. 1994. Tissue engineered growth of cartilage: The effect of varying the concentration of chondrocytes seeded onto synthetic polymer matrices, Oral Maxillofac. Surg. 23, 49–53.

    Article  Google Scholar 

  • Radice, M., Brun, P., Cortivo, R., Scapinelli, R., Bataillard, C., Abatangelo, G. 2000. Hyaluronan based biopolymers as delivery vehicles for bone marrow-derived mesenchymal progenitors, J. Biomed. Mater. Res. 50, 101–109.

    Article  Google Scholar 

  • Raines, E.W., Lane, T.F., Iruela-Arispe, M.L., Ross, R., Sage, E.H. 1992. The extracellular protein SPARC interacts with PDGF-AB and-BB and inhibits the binding of PDGF to its receptor, Proc. Natl. Acad. Sci. USA 89, 1281–1285.

    Article  Google Scholar 

  • Ramdi, H., Legay, C., Lievremont, M. 1993. Influence of matricidal molecules on growth and differentiation of entrapped chondrocytes, Exp. Cell Res. 207, 449–454.

    Article  Google Scholar 

  • Rennekampff, H.O., Kiessig, V., Hansbrough, J.F. 1996. Current concepts in the development of cultured skin replacement, J. Surg. Res. 62, 288–295.

    Article  Google Scholar 

  • Rescan, P.Y., Loreal, O., Hassell, J.R., Yamada, Y., Gillouzo, A., Clement, B. 1993. Distribution and origin of the basement membrane component perlecan in rat liver and primary hepatocyte culture, Am. J. Pathol. 142, 199–208.

    Google Scholar 

  • Rheinwald, J.G., Green, H. 1975. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells, Cell 6, 331–343.

    Article  Google Scholar 

  • Roberts, E.A., Letarte, M., Squire, J., Yang, S. 1994. Characterization of human hepatocyte lines derived form normal liver tissue, Hepatology 19, 1390–1399.

    Article  Google Scholar 

  • Robinson, D., Halperin, N., Nevo, Z. 1990. Regenerating hyaline cartilage in articular defects of old chickens using implants of embryonal chick chondrocytes embedded in a new natural delivery substance, Calcif. Tissue Int. 46, 246–253.

    Article  Google Scholar 

  • Rogers, J.J., Young, H.E., Adkinson, L.R., Lucas, P.A., Black, A.C., Jr. 1995. Differentiation factors induces expression of muscle, fat, cartilage and bone in a clone of mouse pluripotent mesenchymal stem cells, Am. Surg. 61, 231–236.

    Google Scholar 

  • Rojkind, M., Novikoff, P.M., Greenwel, P., Rubin, J., Rojas Valencia, L., de Carvalho, A., Stockert, R., Spray, D., Hertzberg, E.L., Wolkoff, A.W. 1995. Characterization and functional studies on rat liver fat-storing cell line and freshly isolated hepatocyte coculture system, Am. J. Pathol. 146, 1508–1520.

    Google Scholar 

  • Rosemberg, S.A. 1992. Immunization of cancer patients using autologous cancer cell modified by insertion of gene for tumor necrosis factor, Human Gene Ther. 3, 57–73.

    Article  Google Scholar 

  • Sandell, L.J., Morris, N., Robbins, J.R., Goldring, M.B. 1991. Alternatively spliced type II procollagen mRNAs define distinct populations of cells during vertebral development: differential expression of the amino-propeptide, J. Cell Biol. 114, 1307–1319.

    Article  Google Scholar 

  • Sasaki, T., Watanabe, C. 1995. Stimulation of osteoinduction in bone wound healing by high-molecular hyaluronic acid, Bone 16, 9–15.

    Article  Google Scholar 

  • Sawhney, A.S., Drumheller, P.D. 1998. Polymer synthesis, in: Frontiers in Tissue Engineering (C.W. Patrick, Jr., A.G. Mikos, L.V. McIntire, eds.), pp. 85–106, Pergamon, New York.

    Chapter  Google Scholar 

  • Scammell, B.E., Roach, H.I. 1996. A new role for the chondrocyte in fracture repair: endochondral ossification includes direct bone formation by former chondrocytes, J. Bone Miner. Res. 11, 737–745.

    Article  Google Scholar 

  • Schwarz, R.P., Goodwin, T.J., Wolf, D.A. 1992. Cell culture for three-dimensional modeling in rotating-wall vessel: an application of simulated biogravity, J. Tissue Cult. Method 14, 51–57.

    Article  Google Scholar 

  • Sciadini, M.F., Dawson, J.M., Johnson, K.D. 1997. Evaluation of bovine-derived protein with a natural coral carrier as a bone-graft substitute in a canine segmental defect model, J. Orthop. Res. 15, 844–857.

    Article  Google Scholar 

  • Shahabeddin, L., Damour, O., Berthod, F., Rousselle, P., Saintigny, G., Collombel, C. 1991. Reconstructed skin from co-cultured human keratinocytes and fibroblasts on a chitosane cross-linked collagen GAG-matrix, J. Mater. Sci. Mater. Med. 2, 222–226.

    Article  Google Scholar 

  • Shimaoka, S., Nakamura, T., Ichihara, A. 1987. Stimulation of growth of primary cultured adult rat hepatocytes without growth factors by coculture with nonparenchymal cells, Exp. Cell Res. 172, 228–242.

    Article  Google Scholar 

  • Shimomura, Y., Yoneda, T., Suzuki, F. 1975. Osteogenesis by chondrocytes from growth cartilage of rat rib, Calcif. Tissue Res. 19, 179–187.

    Article  Google Scholar 

  • Singhvi, R., Kumar, A., Lopez, G.P., Stephanopoulos, G.N., Wang, D.I.C., Whitesides, G.M., Ingber, D.E. 1994. Engineering cell shape and function, Science 264, 696–698.

    Article  Google Scholar 

  • Skalak, R., Fox, C.F. 1988. Tissue Engineering, pp. 55–63, Alan R. Liss, New York.

    Google Scholar 

  • Solchaga, L.A., Goldberg, V.M., Caplan, A.I. 2000. Hyaluronic acid-based biomaterials in tissue engineered cartilage repair, in: New Frontiers in Medical Sciences: Redefining of Hyaluronan (G. Abatangelo and P.H. Weigel, eds.), pp. 233–246.

    Google Scholar 

  • Stange, J., Mitzner, S., Strauss, M., Fischer, U., Lindemann, S., Peters, E., Holtz, M., Drewelow, B., Schmidt, R. 1995. Primary or established liver cells for a hybrid liver? Comparison of metabolic features, ASAIO 41(3), M310–315.

    Article  Google Scholar 

  • Stoker, A.W., Streuli, C.H., Martins-Green, M., Bissel, M.J. 1990. Designer microenvironment for the analysis of the cell and tissue function, Curr. Opin. Cell Biol. 2(5), 864–874.

    Article  Google Scholar 

  • Streuli, C.H., Schmidhauser, C., Kobrin, M., Bissell, M.J., Derynck, R. 1993. Extracellular matrix regulates expression of the TGF-beta 1 gene, J. Cell Biol. 120(1): 253–260.

    Article  Google Scholar 

  • Suhr, ST., Gage, F.H. 1993. Gene therapy for neurological disease, Arch.Neurol. 50(11), 1252–1268.

    Google Scholar 

  • Sussman, N.L., Kelly, J.H. 1993. Improved liver function following treatment with an extracorporeal liver assist device, Artif. Org. 17, 27–30.

    Google Scholar 

  • Toole, B.P. 1991. Proteoglycans and hyaluronan in morphogenesis and differentiation, in: Biology of Extracellular Matrix, 2nd edn. (E.D. Hay, ed.), pp. 305–341, P lenum Press, New York.

    Google Scholar 

  • Toole, B.P. 1997. Hyaluronan in morphogenesis, J. Intern. Med. 242, 35–40.

    Article  Google Scholar 

  • Turner, T.D. 1979. Hospital usage of absorbent dressings, Pharm. J. 222, 421–426.

    Google Scholar 

  • Turner, T.D. 1997. The development of wound management products, in: Chronic Wound Care (D. Krasner, D. Kane, eds.), pp. 124–138, Health Management Publications, Inc., Wayne.

    Google Scholar 

  • Urist, M.R. 1965. Bone formation by autoinduction, Science 150, 893–899.

    Article  Google Scholar 

  • Utesch, D., Oesch, F. 1992. Dependency of the in vitro stabilization of differentiated functions in liver parenchymal cells on the type of cell line used for co-culture, In Vitro Cell Dev. Biol. 28A, 193–198.

    Article  Google Scholar 

  • Utesch, D., Molitor, E., Platt, K.L., Oesch, F. 1991. Differential stabilization of cytochrome-p-450 isoenzymes in primary cultures of adult-rat liver parenchymal-cells, In Vitro Cell Dev. Biol. 27(11), 858–863.

    Article  Google Scholar 

  • Vacanti, C.A., Upton, J. 1994. Tissue-engineered morphogenesis of cartilage and bone by means of cell transplantation using synthetic biodegradable polymer matrices, Bone Rep. Reg. 9, 318–321.

    Google Scholar 

  • Vacanti, C.A., Langer, R., Schloo, B., Vacanti, J.P. 1991. Synthetic polymers seeded with chondrocytes provide a template for a new cartilage formation, Plast. Reconstr. Surg. 88, 753–759.

    Article  Google Scholar 

  • Vacanti, C.A., Cimma, L.G., Ratkowski, D. 1992. Tissue engineered growth of new cartilage in the shape of a human ear using synthetic polymers seeded with chondrocytes, Mater. Res. Soc. 252, 367–373.

    Google Scholar 

  • Vacanti, C.A., Kim, W., Upton, J., Vacanti, M.P., Mooney, D., Schloo, B., Vacanti, J.P. 1993. Tissue-engineered growth of bone and cartilage, Transplant. Proc. 25, 1019–1021.

    Google Scholar 

  • Vaino, S., Muller, U. 1997. Inductive tissue interactions, cell signaling and the control of kidney organogenesis, Cell 90, 975–978.

    Article  Google Scholar 

  • Vaughan, J.M. 1981. The Physiology of Bone, 3rd edn., Clarendon Press, Oxford.

    Google Scholar 

  • Wainwright, D., Madden, M., Luterman, A., Hunt, J., Monafo, W., Heinbach, D., Kagan, R., Sittig, K., Dimick, A., Herndon, D. 1996. Clinical evaluation of an acellular allograft dermal matrix in full-thickness burns, J. Burn Care Rehabil. 17, 124–136.

    Article  Google Scholar 

  • Wakitani, S., Kimura, T., Hirooka, A., Ochi, T., Yuneda, M., Owaki, H., Ono, K., Yasui, N. 1989. Repair of rabbit articular surfaces with allograft chondrocytes embedded in collagen gel, J. Bone Jt. Surg. 71, 74–80.

    Google Scholar 

  • Wakitani, S., Goto, T., Pineda, S.J., Young, R.G., Mansour, J.M., Caplan, A.I., Goldberg, V.M. 1994. Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage, J. Bone Jt. Surg. 76-A, 579–592.

    Google Scholar 

  • Wanson, J.C., Mosselmans, R., Brouwer, A., Knook, D.L. 1979. Interaction of adult rat hepatocytes and sinusoidal cells in coculture, Biol. Cell 36, 7–16.

    Google Scholar 

  • Warejcka, D.J., Harvey, R., Taylor, B.J., Young, H.E., Lucas, P.A. 1996. A population of cells isolated from rat heart capable of differentiating into several mesodermal phenotypes, J. Surg. Res. 62, 233–242.

    Article  Google Scholar 

  • Watt, F.M. 1991. Cell culture models of differentiation, FASEB J. 5, 287–294.

    Google Scholar 

  • Wegner, H., Schareck, W., Bayer-Helms, H., Gebhardt, R. 1992. Different proliferative potential of rat and pig hepatocytes in pure primary culture and coculture, Eur. J. Cell Biol. 58, 411–417.

    Google Scholar 

  • Weigel, P.H., Frost, S.J., McGary, C.T., LeBoeuf, R.D. 1988. The role of hyaluronic acid in inflammation and wound healing, Int. J. Tissue React. 10, 355–365.

    Google Scholar 

  • Widmer, M.S., Mikos, A.G. 1998. Fabrication of biodegradable polymer scaffolds for tissue engineering, in: Frontiers in Tissue Engineering (C.W. Patrick, Jr., A.G. Mikos, L.V. McIntire, eds.), pp. 107–120, Pergamon, New York.

    Chapter  Google Scholar 

  • Wilkins, L.M., Watson, S.R., Prosky, S.J., Meunier, S.F., Parenteau, N.L. 1994. Development of a belayered living skin construct for clinical applications, Biotechnol. Bioeng. 1994, 747–756.

    Article  Google Scholar 

  • Yamaguchi, Y., Mann, D.M., Ruoslathi, E. 1990. Negative regulation of by the proteoglycan decorin, Nature 346, 281–284.

    Article  Google Scholar 

  • Yannas, I.V. 1995. Artificial skin and dermal equivalents, in: Biomedical Engineering Handbook (J.D. Bronzino, ed.), pp. 2025–2038, CRC Press, Boca Raton.

    Google Scholar 

  • Yannas, I.V., Burke, J.F., Gordon, P.L., Huang, C., Rubenstein, R.H. 1980. Design of an artificial skin. II. Control of chemical composition, J. Biomed. Mater. Res. 14, 65–81.

    Article  Google Scholar 

  • Yarmush, M.L., Toner, M., Dunn, J.C.Y., Rotem, A., Hubel, A., Tompkins, R.G. 1992. Hepatic tissue engineering, Ann. N.Y. Acad. Sci. 665, 238–252.

    Article  Google Scholar 

  • Yaszemski, M.J., Payne, R.G., Hayes, W.C., Langer, R., Mikos, A.G. 1996. Evolution of bone transplantation: molecular, cellular and tissue strategies to engineer human bone, Biomaterials 17, 175–185.

    Article  Google Scholar 

  • Young, H.E., Mancini, M.L., Wright, R.P., Smith, J.C., Black, A.C., Jr., Reagan, C.R., Lucas, P.A. 1995. Mesenchymal stem cells reside within the connective tissues of many organs, Dev. Dyn. 202, 137–144.

    Google Scholar 

  • Young, H.E., Wright, R.P., Mancini, M.L., Lucas, P.A., Reagan, C.R., Black, A.C., Jr. 1998. Bioactive factors affect proliferation and phenotypic expression in progenitor and pluri-potent stem cells, Wound Rep. Reg. 6, 65–75.

    Article  Google Scholar 

  • Zacchi, V., Soranzo, C., Cortivo, R., Radice, M., Brun, P., Abatangelo, G. 1998. In Vitro engineering of human skin-like tissue, J. Biomed. Mater. Res. 40, 187–194.

    Article  Google Scholar 

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  1. Institute of Histology and Embryology, Faculty of Medicine, University of Padova, Viale G. Columbo, 3, 35121, Padova, Italy

    Giovanni Abatangelo, Paola Brun, Marco Radice & Roberta Cortivo

  2. Universitätskinderklinik, Abteilung Al-lgemeine Kinderheilkunde mit Schwerpunkt, Neuropädiatrie, Klinikum der Universitäts-Gesamthochschule, Essen, Germany

    Marcus K. H. Auth

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    Rolando Barbucci

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Abatangelo, G., Brun, P., Radice, M., Cortivo, R., Auth, M.K.H. (2002). Tissue Engineering. In: Barbucci, R. (eds) Integrated Biomaterials Science. Springer, Boston, MA. https://doi.org/10.1007/0-306-47583-9_31

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