Infection and Sterilization

  • Roberto Giardino
  • Nicolò Nicoli Aldini


Gamma Irradiation Central Venous Catheter Ethylene Oxide Ultrahigh Molecular Weight Polyethylene Adhesive Action 
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  1. Ahn, C.Y., Ko, C.Y., Wagar, E.A., Wong, R.S., Shaw, W.W. 1996. Microbial evaluation: 139 implants removed from symptomatic patients, Plast. Reconstr. Surg. 98(7), 1225–1229.Google Scholar
  2. Arciola, C.R., Buscaroli, S., Rocca, M., Farinetti, A., Fini, M., Manfrini, M., Giardino, R. 1990. Studio in vivo dell’adesivit dello Staphylococcus epidermidis sui fili di sutura, Giorn. Chir. 11(3), 141–143.Google Scholar
  3. Arens, S., Schlegel, U., Printzen, G., Ziegler, W.J., Perren, S.M., Hansis, M. 1996. Influence of materials for fixation implants on local infection. An experimental study of steel versus titanium DCP in rabbits, J. Bone Jt. Surg. Br. Vol. 78(4), 647–651.Google Scholar
  4. Barker, J. 1995. Ethylene oxide sterilization update, Med. Dev. Technol. 6, 23–24.Google Scholar
  5. Barnard, J. W. 1991. E-Beam processing in the medical device industry, Med. Dev. Technol. 2(5), 34–41.Google Scholar
  6. Berth, L., Wolffbrandt, K. 1992. Improving the ethylene oxide sterilization, Med. Dev. Technol. 3(5), 38–44.Google Scholar
  7. Besong, A.A., Tipper, J.L., Ingham, E., Stone, M.H., Wroblewsky, B.M., Fisher, J. 1998. Quantitative comparison of wear debris from UHMWPE that has and has not been sterilized by gamma irradiation, J. Bone Jt. Surg. Br. Vol. 80(2), 340–344.Google Scholar
  8. Bradley, J., Powers, D., Friedman, R.J. 1997. The prevention of prosthetic infections using a cross-linked albumin coating in a rabbit model, J. Bone Jt. Surg. Br. Vol. 79(5), 816–819.Google Scholar
  9. Brinston, R. 1991. Gaining the competitive edge with Gamma Sterilization, Med. Dev. Technol. 2(5), 28–33.Google Scholar
  10. Buscaroli, S., Arciola, R.C., Ciapetti, G., Fini, M., Rocca, M., Stea, S., Giardino, R. 1990a. In vitro study on the relationship between polymer structure and surgical infections, Proceedings of II World Week of Professional Updating in Surgery and in Surgical and Oncological Disciplines, Milan.Google Scholar
  11. Buscaroli, S., Fini, M., Rocca, M., Maraldi, N.M., Squarzoni, S., Coprticelli, A.S., Rossi, R., Leprotti, S., Giardino, R. 1990b. Cateteri venosi centrali. struttura ed adesività batterica, Atti del VI Congresso Nazionale SIATeC, Bologna.Google Scholar
  12. Buscaroli, S., Fini, M., Leprotti, S., Rocca, M., Squarzoni, S., Maraldi, N.M., Arciola, C.R., Giardino, R. 1991. Central Venous Catheters: technological or acquired defects and bacterial adhesion, Proceedings of 4th European Symposium on Biomaterials, Siena.Google Scholar
  13. Corticelli, A.S., Buscaroli, S., Fini, M., Giardino, R., Maraldi, N.M., Paladini, R., Rocca, M., Rossi, R., Squarzoni, S. 1990. Cateteri venosi centrali e rischio di infezioni: studio clinico e sperimentale, Atti del VI Congresso Nazionale SIATeC, Bologna.Google Scholar
  14. Darouiche, R.O., Landon, G.C., Patti, J.M., Nguyen, L.L., Fernau, R.C., Mcdevitt, D., Greene, C., Foster, T., Klima, M. 1997. Role of staphylococcus aureus surface adhesion in orthopedic device infections. Are results model-dependent?, J. Med. Microbiol. 46(1), 75–79.CrossRefGoogle Scholar
  15. Delmi, M., Vaudaux, P., Lew, D.P., Vasey, H. 1994. Role of fibronectin in staphylococcal adhesion to metallic surfaces used as models of orthopedic devices, J. Orthop. Res. 12(3), 432–438.CrossRefGoogle Scholar
  16. De Lollis, A. 1991. Mezzi di sintesi in acido polilattico, Atti del simposio sui Biomateriali polimerici, Bologna, pp. 168–178.Google Scholar
  17. Dorman Smith V. 1991. Considerations when using ethylene oxide for the sterilization of medical devices, Med. Dev. Technol. 2(5), 42–45.Google Scholar
  18. Doué, B. 1992. Electron Beam Accelerators. A technology adapted for the sterilization of medical devices, Med. Dev. Technol. 3(5), 48–53.Google Scholar
  19. Dougherty, S.H. 1986. Implant infections, in: Handbook of Biomaterial Evaluation (A. van Recum,ed.), pp. 276–289, McMillan Publishing Co., London.Google Scholar
  20. Ernst, R.R., Doyle, J.E. 1968. Sterilization with gaseous Ethylene Oxide: a review of physical and chemical factors, Biotechnol. Bioeng. 10(1)Google Scholar
  21. Fitzgerald, R.H., Peterson, L.F.A. 1984. Wound colonization and deep wound sepsis, in: Infections in Joint Replacement Surgery (N.S. Etekjiar, ed.), pp. 151–165, Mosby, St Louis.Google Scholar
  22. Gabriel, S.E., Woods, J.E., O Fallon, W.M., Beard, C.M., Kurland, L.T., Melton, L.J. 1997. Complications leading to surgery after breast implantation, N. Engl. J. Med. 366(10), 677–682.Google Scholar
  23. Giannini, S., Grimaldi, M., Ceccarelli, F., Bertelli, R. 1994. The manufacturing details and mechanical aspects of the PLLA implants, in: Biodegradable Implants in Fracture Fixation. (Leung Kwok-sui, Hung Leung-kim, Leung Ping-chung, eds.), pp. 59–66, Word Scientific Publishing, Singapore.Google Scholar
  24. Giardino, R., Maraldi, N.M., Squarzoni, S., Corticelli, A.S., Buscaroli, S., Rocca, M., Fini, M. 1990a. Central Venous Catheters and bacterial adhesion: in vitro and in vivo evaluation, Proceedings of the 92° Congrès Francais de Chirurgie, Paris, October 1–4.Google Scholar
  25. Giardino, R., Maraldi, N.M., Squarzoni, S., Sabatelli, P., Corticelli, A.S., Rossi, R., Fini, M., Buscaroli, S., Rocca, M. 1990b. Central venous catheters: an ultrastructural study, Int. J. Artif. Organs 13, 586.Google Scholar
  26. Green, S.A., Ripley, M.J. 1984. Chronic osteomyelitis in pin tracks, J. Bone Jt. Surg., Am. Vol. 66(7), 1092–1098.Google Scholar
  27. Gristina, A., Barth, E., Webb, L. 1989a. Microbial adhesion and the pathogenesis of biomaterial centered infections, in: Orthopaedic Infections: Diagnosis and Treatment (R. Gustilo, R. Gruninger, D. Tsukayama, eds.), W.B. Saunders, Philadelphia.Google Scholar
  28. Gristina, A., Barth, E., Webb, L. 1989b. Microbes, metals and other non-biological substrata in man, in: Orthopedic Infections: Diagnosis and Treatment, (R. Gustilo, R. Gruninger, D. Tsukayama, eds.), W.B. Saunders, Philadelphia.Google Scholar
  29. Halls, N. 1992. The microbiology of irradiation sterilization, Med. Dev. Technol. 3(6), 36–45.Google Scholar
  30. Henon, Y. 1992. Gamma Processing: The state of the art, Med. Dev. Technol. 3(5), 30–37.Google Scholar
  31. Ishigaki, I., Yoshii, F., Makunchi, K., Tamura, N. 1989. Radiation effects on polymeric materials, Proceedings of the International Kilmer Memorial Conference on the Sterilization of Medical Products, Moscow, Sept. 1989.Google Scholar
  32. Jacobsson, S.A., Djerf, K., Wahlstrom, O. 1996. Twenty Year results of Mc Kee-Farrar versus Charnley prosthesis, Clin. Orthop. 329(S), 60–69.Google Scholar
  33. Klock, J.C., Baynton, D.F. 1976. Degranulation and abnormal bactericidal function of granulocytes procured by reversible adhesion to nylon wool. Blood 48, 149.Google Scholar
  34. Leake, E.S., Gristina, A.G., Wright, M.J. 1982. Use of chemotaxis chambers for studying in vitro bacterial colonization of biomaterials, J. Clin. Microbiol. 15(2), 320–323.Google Scholar
  35. Lim, L.Y., Khor, E., Koo, O. 1998. Gamma irradiation of chitosan, J. Biomed. Mater. Res. 43(3), 282–290.CrossRefGoogle Scholar
  36. Link, A., Buttner, K. 1992. Steam sterilization: a suitable alternative, Med. Dev. Technol. 3(5), 45–47.Google Scholar
  37. McClinton, M.A., Helgemo, S.L. 1997. Infection in the presence of skeletal fixation in the upper extremity, Hand Clin. 14(4), 745–760.Google Scholar
  38. Merrit, K., Turner, G.E. 1985. Adherence of bacteria to biomaterials, Abstract, 11 Annual Meeting of the Society for Biomaterials, San Diego.Google Scholar
  39. Merrit, K., Gaind, A., Anderson, J.M. 1996. Detection of bacterial adherence on biomedical polymers, J. Biomed. Mater. Res. 39(3), 415–422.Google Scholar
  40. Moore, W.S. 1977. Experimental studies relating to sepsis in prosthetic vascular grafting in:Infections of Prosthetic Hearth Valves and Vascular Grafts (R.L. Duma, ed.), pp. 267–285, University Park Press, Baltimore.Google Scholar
  41. Morra, M., Cassinelli, C. 1997. Bacterial adhesion to polymer surfaces: a critical review of surface thermodynamic approaches, J. Biomater. Sci. Polym. Ed. 9(1), 55–74.Google Scholar
  42. Muller, T.F., Seitz, M., Eckle, I., Lange, H., Kolb, G. 1998. Biocompatibility differences with respect to the dialyzer sterilization method, Nephron 78(2), 139–142.Google Scholar
  43. Norman, D.C., Yoshikawa, T.T. 1994. Infections of the bone, joint and bursa, Clin. Geriatr. Med. 19(4), 703–718.Google Scholar
  44. Paganetto, G., Mazzullo, S., De Lollis, A., Buscaroli, S., Rocca, M., Fini, M., Giardino, R. 1991. Poly-L-lactic acid: biointeraction and processing variable relationships, Biomateriali 2, 179–183.Google Scholar
  45. Pascaud, R.S., Evans, W.T., McCullagh, P.J., Fitspatrick, D.P. 1997. Influence of gamma irradiation sterilization and temperature on the fracture toughness of ultra-molecular weight-polyethylene, Biomaterials 18(10), 727–735.CrossRefGoogle Scholar
  46. Pearson, L.S. 1996. Sterilization survey, Med. Dev. Technol. 7, 58–64.Google Scholar
  47. Petty, W., Spanier, S., Shuster, J.J., Silverhome, C. 1985. The influence of skeletal implants on incidence of infections. Experiments in a canine model, J Bone Jt. Surg, Am. Vol. 67(8), 1236–1284.Google Scholar
  48. Rao, S.B., Sharma, C.P. 1995. Sterilization of chitosan: implications, J. Biomater. Appl. 10, 136–143.Google Scholar
  49. Rao, S.B., Sharma, C.P. 1997. Use of Chitosan as a biomaterial: study on its safety and hemostatic potential, J. Biomed. Mater. Res. 34, 21–28.CrossRefGoogle Scholar
  50. Ritter, M.A. 1984. Ecology of the operating room, in: Infections in Joint Replacement Surgery N.S. Eftekhar, ed.), pp. 131–148, Mosby, St Louis.Google Scholar
  51. Ross, A., Sadat, T. 1991. Industrial applications of high energy electrons for sterilization, Med. Dev. Technol. 2(8), 20–26.Google Scholar
  52. Shaw, J.A., Greer, R.B. 1994. Complications of total hip replacement, in: Complications Orthopaedic Surgery (C.H. Epps, ed.), Lippincott Company, Philadelphia.Google Scholar
  53. Suwanprateeb, J., Tanner, K.E., Turner, S., Bonfield, W. 1998. Influence of sterilization by gamma irradiation or thermal annealing on creep of hydroxyapatite-reinforced polyethylene composites, J. Biomed. Mater. Res. 39(1), 16–22.CrossRefGoogle Scholar
  54. Tallentire, A. 1980. The spectrum of microbial radiation sensitivity, Radiat. Phys. Chem. 15, 83.Google Scholar
  55. Taylor, S.M., Weatherford, D.A., Langan, E.M., Lokey, J.S. 1996. Outcomes in the management of vascular prosthetic graft infections confined to the groin. A reappraisal, Ann. Vasc. Surg. 10(2), 117–122.CrossRefGoogle Scholar
  56. Wassall, M.A., Santin, M, Isalberti, C., Cannas, M., Denyer, S.P. 1997. Adhesion of bacteria to stainless steel and silver coated orthopedic external fixation pins, J. Biomed. Mater. Res. 5(36), 325–330.Google Scholar
  57. White, S.E., Paxson, R.D., Tanner, M.G., Whiteside, L.A. 1996. Effects of sterilization on wear in total knee arthroplasty, Clin. Orthop. 331, 164–171.Google Scholar

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Roberto Giardino
    • 1
  • Nicolò Nicoli Aldini
    • 1
  1. 1.Experimental Surgery DepartmentCodi-villa-Putti I.O.R. Research InstituteBolognaItaly

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