Cytokine Activation of Transcription

  • Kerri A. Mowen
  • Michael David
Part of the Genetic Engineering book series (GEPM, volume 23)


In this review we have attempted to outline the events leading to cytokine-mediated gene transcription by using that Jak/STAT and theNF-kB pathways as two examples. It is important to remember that cytokine activation of gene transcription is not the result of a single, linear signaling cascade, but involves a complex network of interacting signal-transduction pathways. Integration of numerous, often contradicting instructions received by the cell through a variety of cytokine and growth factor receptors determines the qualitative and quantitative transcriptional response.


Nuclear Localization Signal Death Domain Stat Protein Cytokine Activation Tumor Necrosis Factor Signal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Kerri A. Mowen
    • 1
  • Michael David
    • 1
  1. 1.Division of BiologyMolecular Biology Section University of CaliforniaSan Diego La Jolla

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