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Cytokine Activation of Transcription

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Book cover Genetic Engineering: Principles and Methods

Part of the book series: Genetic Engineering ((GEPM,volume 23))

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Conclusions

In this review we have attempted to outline the events leading to cytokine-mediated gene transcription by using that Jak/STAT and theNF-kB pathways as two examples. It is important to remember that cytokine activation of gene transcription is not the result of a single, linear signaling cascade, but involves a complex network of interacting signal-transduction pathways. Integration of numerous, often contradicting instructions received by the cell through a variety of cytokine and growth factor receptors determines the qualitative and quantitative transcriptional response.

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References

  1. Fu, X.-Y., Kessler, D. S., Veals, S. A., Levy, D. E. and Darnell, J. E., Jr. (1990) Proc. Nat. Acad. Sci. U.S.A. 87, 8555–8559.

    CAS  Google Scholar 

  2. Fu, X.-Y. (1992) Cell 70, 323–335.

    Article  PubMed  CAS  Google Scholar 

  3. Lamer, A. C. and Finbloom, D. S. (1995) Biochim. Biophys. Acta 1266, 278–287.

    Google Scholar 

  4. Lamer, A. C., David, M., Feldman, G. M., Igarashi, K., Hackett, R. H., Webb, D. S. A., Sweitzer, S. M., Petricoin, E. F., III and Finbloom, D. S. (1993) Science 261, 1730–1733.

    Google Scholar 

  5. Schindler, C. and Darnell, J. E., Jr. (1995) Annu. Rev. Biochem. 64, 621–51

    Article  PubMed  CAS  Google Scholar 

  6. Heim, M. H., Kerr, I. M., Stark, G. R. and Darnell, J. E., Jr. (1995) Science 267, 1347–1349.

    PubMed  CAS  Google Scholar 

  7. Seidel, H. M., Milocco, L. H., Lamb, P., Darnell, J. E., Jr., Stein, R. B. and Rosen, J. (1995) Proc. Nat. Acad. Sci. U.S.A. 92, 3041–3045.

    CAS  Google Scholar 

  8. Wen, Z., Zhong, Z. and Darnell, J. E., Jr. (1995) Cell 82, 241–250.

    PubMed  CAS  Google Scholar 

  9. David, M., Petricoin, E. F., III, Benjamin, C., Pine, R., Weber, M. J. and Larner, A. C. (1995) Science 269, 1721–1723.

    PubMed  CAS  Google Scholar 

  10. Korzus, E., Torchia, J., Rose, D. W., Xu, L., Kurokawa, R., McInerney, E. M., Mullen, T. M., Glass, C. K. and Rosenfeld, M. G. (1998) Science 279, 703–707.

    Article  PubMed  CAS  Google Scholar 

  11. Zhang, J. J., Zhao, Y., Chait, B. T., Lathem, W. W., Ritzi, M., Knippers, R. and Darnell, J. E., Jr. (1998) EMBO J. 17, 6963–6971.

    PubMed  CAS  Google Scholar 

  12. Velazquez, L., Fellous, M., Stark, G. R. and Pellegrini, S. (1992) Cell 70, 313–322.

    Article  PubMed  CAS  Google Scholar 

  13. Muller, M., Briscoe, J., Laxton, C., Guschin, D., Ziemiecki, A., Silvennoinen, O., Harpur, A. G., Barbieri, G., Withuhn, B. A., Schindler, C., Pellegrini, S., Wilks, A. F., Ihle, J. N., Stark, G. R. and Kerr, I. M. (1993) Nature 366, 129–135.

    Article  PubMed  CAS  Google Scholar 

  14. Watling, D., Guschin, D., Muller, M., Silvennoinen, O., Witthuhn, B. A., Quelle, F. W., Rogers, N. C., Schindler, C., Ihle, J. N., Stark, G. R. and Kerr, I. M. (1993) Nature 366, 166–170.

    Article  PubMed  CAS  Google Scholar 

  15. Kawamura, M., McVicar, D. W., Johnston, J. A., Blake, T. B., Chen, Y.-Q., Lal, B. K., Lloyd, A. R., Kelvin, D. J., Staples, E., Ortaldo, J. R. and O’Shea, J. J. (1994) Proc. Nat. Acad. Sci. U.S.A. 91, 6374–6378.

    CAS  Google Scholar 

  16. Akira, S. (1999) Stem Cells 17, 138–146.

    Article  PubMed  CAS  Google Scholar 

  17. Durbin, J. E., Hackenmiller, R., Simon, M. C. and Levy, D. E. (1996) Cell 84, 443–450.

    Article  PubMed  CAS  Google Scholar 

  18. Meraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., Carver-Moore, K., DuBois, R. N., Clark, R., Aguet, M. and Schreiber, R. D. (1996) Cell 84, 431–442.

    Article  PubMed  CAS  Google Scholar 

  19. Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T. and Akira, S. (1998) J. Immunol. 161, 4652–4660.

    PubMed  CAS  Google Scholar 

  20. Takeda, K., Noguchi, K., Shi, W., Tanaka, T., Matsumoto, M., Yoshida, N., Kishimoto, T. and Akira, S. (1997) Proc. Nat. Acad. Sci. U.S.A. 94, 3801–3804.

    CAS  Google Scholar 

  21. Kaplan, M. H., Sun, Y. L., Hoey, T. and Grusby, M. J. (1996) Nature 382, 174–177.

    Article  PubMed  CAS  Google Scholar 

  22. Thierfelder, W. E., van Deursen, J. M., Yamamoto, K., Tripp, R. A, Sarawar, S. R., Carson, R. T., Sangster, M. Y., Vignali, D. A., Doherty, P. C., Grosveld, G. C. and Ihle, J. N. (1996) Nature 382, 171–174.

    Article  PubMed  CAS  Google Scholar 

  23. Teglund, S., McKay, C., Schuetz, E., van Deursen, J. M., Stravopodis, D., Wang, D., Brown, M., Bodner, S., Grosveld, G. and Ihle, J. N. (1998) Cell 93, 841–850.

    Article  PubMed  CAS  Google Scholar 

  24. Shimoda, K., van Deursen, J., Sangster, M. Y., Sarawar, S. R., Carson, R. T., Tripp, R. A, Chu, C., Quelle, F. W., Nosaka, T., Vignali, D. A. A., Doherty, P. C., Grosveld, G., Paul, W. E. and Ihle, J. N. (1996) Nature 380, 630–633.

    Article  PubMed  CAS  Google Scholar 

  25. Takeda, K., Tanaka, T., Shi, W., Matsumoto, M., Minami, M., Kashiwamura, S., Nakanishi, K., Yoshida, N., Kishimoto, T. and Akira, S. (1996) Nature 380, 627–630.

    Article  PubMed  CAS  Google Scholar 

  26. Neubauer, H., Cumano, A., Muller, M., Wu, H., Huffstadt, U. and Pfeffer, K. (1998) Cell 93, 397–409.

    Article  PubMed  CAS  Google Scholar 

  27. Nosaka, T., A., v. D. J. M., Tripp, R. A., Thierfelder, W. E., Witthun, B. A., McMickle, A. P., Doherty, P. C., Grosveld, G. C. and Ihle, J. N. (1995) Science 270, 800–802.

    PubMed  CAS  Google Scholar 

  28. Russell, S. M., Tayebi, N., Nakajima, H., Riedy, M. C., Roberts, J. L., Aman, M. J., Migone, T.-S., Noguchi, M., Markert, M. L., Buckley, R. H., O’Shea, J. J. and Leonard, W. J. (1995) Science 270, 797–800.

    PubMed  CAS  Google Scholar 

  29. Hilton, D. J. (1999) Cell. Mol. Life Sci. 55, 1568–1577.

    Article  PubMed  CAS  Google Scholar 

  30. Klingmuller, U., Lorenz, U., Cantley, L. C., Neel, B. G. and Lodish, H. F. (1995) Cell 80, 729–738.

    Article  PubMed  CAS  Google Scholar 

  31. David, M., Chen, H. E., Goelz, S., Larner, A. C. and Neel, B. G. (1995) Mol. Cell. Biol. 15, 7050–7058.

    PubMed  CAS  Google Scholar 

  32. David, M., Grimley, P. M., Finbloom, D. S. and Larner, A. C. (1993) Mol. Cell. Biol. 13, 7515–7521.

    PubMed  CAS  Google Scholar 

  33. Chen, X. P., Losman, J. A. and Rothman, P. (2000) Immunity 13, 287–290.

    Article  PubMed  CAS  Google Scholar 

  34. Shuai, K. (2000) Oncogene 19, 2638–2644.

    Article  PubMed  CAS  Google Scholar 

  35. Ghosh, S., May, M. J. and Kopp, E. B. (1998) Annu. Rev. Immunol. 16, 225–260.

    Article  PubMed  CAS  Google Scholar 

  36. Pahl, H. L. (1999) Oncogene 18, 6853–6866.

    Article  PubMed  CAS  Google Scholar 

  37. Karin, M. (1999) J. Biol. Chem. 274, 27339–42

    Article  PubMed  CAS  Google Scholar 

  38. Zandi, E., and Karin, M. (1999) Mol. Cell. Biol. 19, 4547–4551.

    PubMed  CAS  Google Scholar 

  39. Karin, M. (1999) Oncogene 18, 6867–6874.

    Article  PubMed  CAS  Google Scholar 

  40. May, M. J. and Ghosh, S. (1998) Immunol. Today 19, 80–88.

    Article  PubMed  CAS  Google Scholar 

  41. Mercurio, F. and Manning, A. M. (1999) Curr. Opin. Cell Biol. 11, 226–232.

    Article  PubMed  CAS  Google Scholar 

  42. Karin, M. and Delhase, M. (2000) Semin. Immunol. 12, 85–98.

    Article  PubMed  CAS  Google Scholar 

  43. Lee, F. S., Hagler, J., Chen, Z. J. and Maniatis, T. (1997) Cell 88, 213–222.

    Article  PubMed  CAS  Google Scholar 

  44. Israel, A. (2000) Trends Cell Biol. 10, 129–133.

    PubMed  CAS  Google Scholar 

  45. Wallach, D., Varfolomeev, E. E., Malinin, N. L., Goltsev, Y. V., Kovalenko, A. V. and Boldin, M. P. (1999) Annu. Rev. Immunol. 17, 331–367.

    Article  PubMed  CAS  Google Scholar 

  46. Arch, R. H., Gedrich, R. W. and Thompson, C. B. (1998) Genes Dev. 12, 2821–2830.

    PubMed  CAS  Google Scholar 

  47. Barkett, M. and Gilmore, T. D. (1999) Oncogene 18, 6910–6924.

    Article  PubMed  CAS  Google Scholar 

  48. Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K. and Akira, S. (1998) Immunity 9, 143–150.

    Article  PubMed  CAS  Google Scholar 

  49. Ninomiya-Tsuji, J., Kishimoto, K., Hiyama, A., Inoue, J., Cao, Z. and Matsumoto, K. (1999) Nature 398, 252–256.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Biology, Molecular Biology Section University of California, San Diego La Jolla, CA, 92093

    Kerri A. Mowen & Michael David

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  1. Kerri A. Mowen
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  2. Michael David
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  1. Brookhaven National Laboratory, Upton, New York

    Jane K. Setlow

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© 2002 Kluwer Academic Publishers

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Mowen, K.A., David, M. (2002). Cytokine Activation of Transcription. In: Setlow, J.K. (eds) Genetic Engineering: Principles and Methods. Genetic Engineering, vol 23. Springer, Boston, MA. https://doi.org/10.1007/0-306-47572-3_3

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  • DOI: https://doi.org/10.1007/0-306-47572-3_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46645-8

  • Online ISBN: 978-0-306-47572-6

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